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Nerve Growth Factor-Induced Neurite Sprouting in PC12 Cells Involves ς-1 Receptors: Implications for Antidepressants

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N-alkyl substituted analogs of the σ receptor ligand BD1008 and traditional σ receptor ligands affect cocaine-induced convulsions and lethality in mice

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Amino acid residues in the transmembrane domain of the type 1 sigma receptor critical for ligand binding

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Antiproliferative effects of SR31747A in animal cell lines are mediated by inhibition of cholesterol biosynthesis at the sterol isomerase step

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MAM: more than just a housekeeper

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The sigma-1 receptor chaperone as an inter-organelle signaling modulator

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Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM)

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A mutation in sigma‐1 receptor causes juvenile amyotrophic lateral sclerosis

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Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes

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New functions of mitochondria associated membranes in cellular signaling

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Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases

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Detergent-Resistant Microdomains Determine the Localization of σ-1 Receptors to the Endoplasmic Reticulum-Mitochondria Junction

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Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism

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The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke

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TMEM41B is a novel regulator of autophagy and lipid mobilization

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Sigma-1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury

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Sigma-1 receptors at galactosylceramide-enriched lipid microdomains regulate oligodendrocyte differentiation

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Functional and morphological impact of ER stress on mitochondria

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The ins and outs of lipid rafts: functions in intracellular cholesterol homeostasis, microparticles, and cell membranes

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The Sigma Receptor: Evolution of the Concept in Neuropsychopharmacology

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σ1 Receptor Modulation of G-Protein-Coupled Receptor Signaling: Potentiation of Opioid Transduction Independent from Receptor Binding

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Sigma-1 Receptors Regulate Bcl-2 Expression by Reactive Oxygen Species-Dependent Transcriptional Regulation of Nuclear Factor κB

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Sigma-1 Receptors Bind Cholesterol and Remodel Lipid Rafts in Breast Cancer Cell Lines

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The σ2 Receptor: A Novel Protein for the Imaging and Treatment of Cancer

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Sigma Receptors and Cancer

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Neuro(active)steroids actions at the neuromodulatory sigma1 (σ1) receptor: Biochemical and physiological evidences, consequences in neuroprotection

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The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease

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Urban planning of the endoplasmic reticulum (ER): How diverse mechanisms segregate the many functions of the ER

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Biochemical Pharmacology of the Sigma-1 Receptor

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Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release

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Sigma receptors [σRs]: biology in normal and diseased states

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Molecular mechanisms involving sigma receptor–mediated induction of MCP-1: implication for increased monocyte transmigration

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Alteration of Endoplasmic Reticulum Lipid Rafts Contributes to Lipotoxicity in Pancreatic β-Cells

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Quantitative Proteomic Analyses of Human Cytomegalovirus-Induced Restructuring of Endoplasmic Reticulum-Mitochondrial Contacts at Late Times of Infection

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Glucosylceramide and galactosylceramide, small glycosphingolipids with significant impact on health and disease

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Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies

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Cyclohexylpiperazine derivative PB28, a σ2 agonist and σ1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer

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Sigmar1’s Molecular, Cellular, and Biological Functions in Regulating Cellular Pathophysiology

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Antiamnesic and Neuroprotective Effects of the Aminotetrahydrofuran Derivative ANAVEX1-41 Against Amyloid β25–35-Induced Toxicity in Mice

Villard, V., Espallergues, J., Keller, E., Alkam, T., Nitta, A., Yamada, K., Nabeshima, T., Vamvakides, A., & Maurice, T. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.212 · Cited by 105 · see citing works

Endoplasmic reticulum chaperones tweak the mitochondrial calcium rheostat to control metabolism and cell death

Gutiérrez, T., & Simmen, T. (2018) · Cell Calcium · doi:10.1016/j.ceca.2017.05.015 · Cited by 104 · see citing works

New Insights into the Role of Mitochondria-Associated Endoplasmic Reticulum Membrane

Fujimoto, M., & Hayashi, T. (2011) · International review of cytology · doi:10.1016/b978-0-12-386033-0.00002-5 · Cited by 103 · see citing works

Cocaine-mediated induction of platelet-derived growth factor: implication for increased vascular permeability

Yao, H., Duan, M., & Buch, S. J. (2010) · Blood · doi:10.1182/blood-2010-10-313593 · Cited by 104 · see citing works

Ca2+ handling at the mitochondria-ER contact sites in neurodegeneration

Lim, D., Dematteis, G., Tapella, L., Genazzani, A. A., Calí, T., Brini, M., & Verkhratsky, A. (2021) · Cell Calcium · doi:10.1016/j.ceca.2021.102453 · Cited by 105 · see citing works

Sigma-1 Receptor-Modulated Neuroinflammation in Neurological Diseases

Jia, J., Cheng, J. G., Wang, C., & Zhen, X. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00314 · Cited by 100 · see citing works

Is Alzheimer's Disease a Disorder of Mitochondria-Associated Membranes?

Schon, E. A., & Área-Gómez, E. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100495 · Cited by 95 · see citing works

σ-1 Receptors Protect RGC-5 Cells from Apoptosis by Regulating Intracellular Calcium, Bax Levels, and Caspase-3 Activation

Tchedre, K. T., & Yorio, T. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1101 · Cited by 94 · see citing works

Cocaine Hijacks σ1 Receptor to Initiate Induction of Activated Leukocyte Cell Adhesion Molecule: Implication for Increased Monocyte Adhesion and Migration in the CNS

Yao, H., Kim, K., Duan, M., Hayashi, T., Guo, M., Morgello, S., Prat, A., Wang, J., Su, T., & Buch, S. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5618-10.2011 · Cited by 93 · see citing works

The potential role of sigma-1 receptors in lipid transport and lipid raft reconstitution in the brain: Implication for drug abuse

Hayashi, T., & Su, T. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.05.009 · Cited by 92 · see citing works

Isolation of Endoplasmic Reticulum, Mitochondria, and Mitochondria‐Associated Membrane and Detergent Resistant Membrane Fractions from Transfected Cells and from Human Cytomegalovirus‐Infected Primary Fibroblasts

Williamson, C. D., Wong, D. S., Bozidis, P., Zhang, A., & Colberg‐Poley, A. M. (2015) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0327s68 · Cited by 92 · see citing works

The sigma1 receptor interacts with N-alkyl amines and endogenous sphingolipids

Ramachandran, S., Chu, U. B., Mavlyutov, T. A., Pal, A., Pyne, S., & Ruoho, A. E. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.03.003 · Cited by 91 · see citing works

An update on the development of drugs for neuropsychiatric disorders: focusing on the σ1receptor ligand

Hayashi, T., & Su, T. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.1.45 · Cited by 91 · see citing works

Stress Responses from the Endoplasmic Reticulum in Cancer

Kato, H., & Nishitoh, H. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00093 · Cited by 83 · see citing works

Conversion of psychological stress into cellular stress response: Roles of the sigma‐1 receptor in the process

Hayashi, T. (2015) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12262 · Cited by 87 · see citing works

Sigma Receptor 1 Modulates Endoplasmic Reticulum Stress in Retinal Neurons

Ha, Y., Dun, Y., Thangaraju, M., Duplantier, J., Dong, Z., Liu, K., Ganapathy, V., & Smith, S. B. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5731 · Cited by 87 · see citing works

Identification of Regions of the σ-1 Receptor Ligand Binding Site Using a Novel Photoprobe

Pal, A., Hajipour, A. R., Fontanilla, D., Ramachandran, S., Chu, U. B., Mavlyutov, T. A., & Ruoho, A. E. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.038307 · Cited by 86 · see citing works

Sigma-2 receptors are specifically localized to lipid rafts in rat liver membranes

Gebreselassie, D., & Bowen, W. D. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.04.005 · Cited by 84 · see citing works

σ‐1 Receptors potentiate epidermal growth factor signaling towards neuritogenesis in PC12 cells: Potential relation to lipid raft reconstitution

Takebayashi, M., Hayashi, T., & Su, T. (2004) · Synapse · doi:10.1002/syn.20041 · Cited by 84 · see citing works

Regulation of σ-1 Receptors and Endoplasmic Reticulum Chaperones in the Brain of Methamphetamine Self-Administering Rats

Hayashi, T., Justinová, Z., Hayashi, E., Cormaci, G., Mori, T., Tsai, S., Barnes, C., Goldberg, S. R., & Su, T. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.159244 · Cited by 84 · see citing works

Expression of a Truncated Form of the Endoplasmic Reticulum Chaperone Protein, σ1 Receptor, Promotes Mitochondrial Energy Depletion and Apoptosis

Shioda, N., Ishikawa, K., Tagashira, H., Ishizuka, T., Yawo, H., & Fukunaga, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.349142 · Cited by 78 · see citing works

The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction

Sambo, D. O., Lebowitz, J. J., & Khoshbouei, H. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.01.009 · Cited by 75 · see citing works

Fixation and permeabilization protocol is critical for the immunolabeling of lipid droplet proteins

Ohsaki, Y., Maeda, T., & Fujimoto, T. (2005) · Histochemistry and Cell Biology · doi:10.1007/s00418-005-0061-5 · Cited by 77 · see citing works

Sigma1 receptor upregulation after chronic methamphetamine self-administration in rats: a study with yoked controls

Stefański, R., Justinová, Z., Hayashi, T., Takebayashi, M., Goldberg, S. R., & Su, T. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1779-9 · Cited by 76 · see citing works

The σ-Receptor Antagonist BD-1063 Decreases Ethanol Intake and Reinforcement in Animal Models of Excessive Drinking

Sabino, V., Cottone, P., Zhao, Y., Iyer, M. R., Steardo, L., Steardo, L., Rice, K. C., Conti, B., Koob, G. F., & Zorrilla, E. P. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.192 · Cited by 74 · see citing works

Decreases in Cocaine Self-Administration with Dual Inhibition of the Dopamine Transporter and σ Receptors

Hiranita, T., Soto, P. L., Kohut, S. J., Kopajtic, T. A., Cao, J., Newman, A. H., Tanda, G., & Katz, J. L. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.185025 · Cited by 74 · see citing works

Opposing roles of cell death-inducing DFF45-like effector B and perilipin 2 in controlling hepatic VLDL lipidation

Li, X., Ye, J., Zhou, L., Gu, W., Fisher, E. A. A., & Li, P. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m026591 · Cited by 74 · see citing works

Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration

Wang, J., SAUL, A. B., Roon, P., & Smith, S. B. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521749113 · Cited by 70 · see citing works

Targeting Sigma Receptors for the Treatment of Neurodegenerative and Neurodevelopmental Disorders

Malar, D. S., Thitilertdecha, P., Ruckvongacheep, K. S., Brimson, S., Tencomnao, T., & Brimson, J. M. (2023) · CNS Drugs · doi:10.1007/s40263-023-01007-6 · Cited by 74 · see citing works

Bi-phasic dose response in the preclinical and clinical developments of sigma-1 receptor ligands for the treatment of neurodegenerative disorders

Maurice, T. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2021.1838483 · Cited by 70 · see citing works

Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders

Sałaciak, K., & Pytka, K. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.037 · Cited by 71 · see citing works

A Role for Sigma Receptors in Stimulant Self Administration and Addiction

Katz, J. L., Su, T., Hiranita, T., Hayashi, T., Tanda, G., Kopajtic, T. A., & Tsai, S. (2011) · Pharmaceuticals · doi:10.3390/ph4060880 · Cited by 71 · see citing works

Differential Effects of σ1 Receptor Blockade on Self-Administration and Conditioned Reinstatement Motivated by Cocaine vs Natural Reward

Martin‐Fardon, R., Maurice, T., Aujla, H., Bowen, W. D., & Weiss, F. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301323 · Cited by 70 · see citing works

Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective

Fallica, A. N., Pittalà, V., Modica, M. N., Salerno, L., Romeo, G., Marrazzo, A., Helal, M. A., & Intagliata, S. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c02265 · Cited by 69 · see citing works

Mitochondrial lipid transport at a glance

Scharwey, M., Tatsuta, T., & Langer, T. (2013) · Journal of Cell Science · doi:10.1242/jcs.134130 · Cited by 68 · see citing works

Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson's Disease

Francardo, V., Geva, M., Bez, F., Denis, Q., Steiner, L., Hayden, M. R., & Cenci, M. A. (2019) · Neurotherapeutics · doi:10.1007/s13311-018-00699-9 · Cited by 68 · see citing works

The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains

Zhemkov, V., Ditlev, J. A., Lee, W.-R., Wilson, M., Liou, J., Rosen, M. K., & Борисович, Б. И. (2021) · eLife · doi:10.7554/elife.65192 · Cited by 66 · see citing works

Demonstration of a Direct Interaction between σ-1 Receptors and Acid-Sensing Ion Channels

Carnally, S. M., Johannessen, M., Henderson, R. M., Jackson, M. B., & Edwardson, J. M. (2010) · Biophysical Journal · doi:10.1016/j.bpj.2009.12.4293 · Cited by 67 · see citing works

Accelerated retinal ganglion cell death in mice deficient in the Sigma-1 receptor.

Mavlyutov, T. A., Nickells, R. W., & Guo, L. (2011) · PubMed Central · Cited by 66 · see citing works

Elements in support of the ‘non-identity’ of the PGRMC1 protein with the σ2 receptor

Abate, C., Niso, M., Infantino, V., Menga, A., & Berardi, F. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.067 · Cited by 66 · see citing works

Cholesterol at the Endoplasmic Reticulum: Roles of the Sigma-1 Receptor Chaperone and Implications thereof in Human Diseases

Hayashi, T., & Su, T. (2010) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-90-481-8622-8_13 · Cited by 66 · see citing works

Sigma 1 receptor: A novel therapeutic target in retinal disease

Smith, S. B., Wang, J., Cui, X., Mysona, B. A., Zhao, J., & Bollinger, K. E. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.07.003 · Cited by 66 · see citing works

Cytoplasmic Lipid Droplets

Fujimoto, T., & Ohsaki, Y. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1377.010 · Cited by 64 · see citing works

Cocaine promotes oxidative stress and microglial-macrophage activation in rat cerebellum

López‐Pedrajas, R., Ramírez-Lamelas, D. T., Muriach, B., Sanchez‐Villarejo, M. V., Almansa, I., Vidal‐Gil, L., Romero, F. J., Barcia, J. M., & Muriach, M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00279 · Cited by 63 · see citing works

The role of sigma-1 receptors in the pathophysiology of neuropsychiatric diseases

Hashimoto (2009) · Journal of Receptor Ligand and Channel Research · doi:10.2147/jrlcr.s8453 · Cited by 63 · see citing works

Molecular Interplay Between the Sigma-1 Receptor, Steroids, and Ion Channels

Morales‐Lázaro, S. L., González‐Ramírez, R., & Rosenbaum, T. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00419 · Cited by 63 · see citing works

Sigma-1 (σ1) Receptor in Memory and Neurodegenerative Diseases

Maurice, T., & Goguadze, N. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_15 · Cited by 62 · see citing works

Role of mitochondrial raft-like microdomains in the regulation of cell apoptosis

Garofalo, T., Manganelli, V., Grasso, M., Mattei, V., Ferri, A., Misasi, R., & Sorice, M. (2015) · APOPTOSIS · doi:10.1007/s10495-015-1100-x · Cited by 61 · see citing works

Intracellular Dynamics of σ-1 Receptors (σ1 Binding Sites) in NG108-15 Cells

Hayashi, T., & Su, T. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.051292 · Cited by 189 · see citing works

The potential role of sigma-1 receptors in lipid transport and lipid raft reconstitution in the brain: Implication for drug abuse

Hayashi, T., & Su, T. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.05.009 · Cited by 92 · see citing works

Detergent-Resistant Microdomains Determine the Localization of σ-1 Receptors to the Endoplasmic Reticulum-Mitochondria Junction

Hayashi, T., & Fujimoto, M. (2010) · Molecular Pharmacology · doi:10.1124/mol.109.062539 · Cited by 219 · see citing works

Sigma-1 Receptor Remodels Endoplasmic Reticulum Membrane

Zhemkov, V., & Борисович, Б. И. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2019.11.1416

Subcellular Localization and Interacellular Dynamics of σ1 Receptors

Hayashi, T., & Su, T. (2007) · Springer eBooks · doi:10.1007/978-0-387-36514-5_8 · Cited by 2 · see citing works