Targeting TrkB neurotrophin receptor to treat depression
Abstract
Background An increasing number of findings point out the key role of the BDNF (brain-derived neurotrophic factor) receptor, tyrosine kinase receptor B (TrkB), in the regulation of antidepressant drug actions. Therefore, targeting TrkB receptors might be a rational strategy to develop novel antidepressant drugs. Objective/methods In this review we will discuss several approaches to targeting the TrkB receptor using existing or novel drugs. We will mainly concentrate on the following issues: i) synthesis, release and cleavage of neurotrophins; ii) augmentation of the actions of neurotrophins; iii) synthesis of TrkB; iv) developing agonists for TrkB; and v) TrkB transactivation. Conclusions Different molecular approaches can be used to screen antidepressant drugs acting through TrkB receptors but it remains to be seen whether they demonstrate therapeutic antidepressant effects.
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Close molecular connections between serotonergic receptors and neurotrophic proteins such as BDNF and intracellular signaling cascades are responsible for cytoskeletal rearrangement.
“Close molecular connections between serotonergic receptors and neurotrophic proteins as brain-derived neurotrophic factor (BDNF) and intracellular signaling cascades are responsible for cytoskeletal rearrangement (Mattson et al., 2004;Rantamaki and Castren, 2008); see Table 1).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Rantamaki and Castren, 2008
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- Authors
- Rantamäki, T., & Castrén, E.
- Affiliations
- University of Helsinki (FI)
- ORCID
- Rantamäki, Tomi
- Venue
- Expert Opinion on Therapeutic Targets
- Publisher
- Informa UK Limited
- Published
- 2008-05-15
- Volume
- 12
- Issue
- 6
- Pages
- 705-715
- ISSN
- 1472-8222 (ISSN-L)
- 1744-7631
- OpenAlex
- W2051770438
- Cited by
- 40
- References
- 18
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 3 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Opinion on Therapeutic Targets (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- TrkB receptor, brain-derived neurotrophic factor, depression, antidepressant drug development, TrkB agonist
- MeSH terms
- Animals, Antidepressive Agents, Depression, Humans, Brain-Derived Neurotrophic Factor, Receptor, trkB
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