Degradation of Endocytosed Epidermal Growth Factor and Virally Ubiquitinated Major Histocompatibility Complex Class I Is Independent of Mammalian ESCRTII

Bowers, Katherine; Piper, Siân C.; Edeling, Melissa A.; Gray, Sally R.; Owen, David J.; Lehner, Paul J.; Luzio, J. Paul

doi:10.1074/jbc.m508632200

Cited by 166

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Degradation of Endocytosed Epidermal Growth Factor and Virally Ubiquitinated Major Histocompatibility Complex Class I Is Independent of Mammalian ESCRTII

Bowers, Katherine, Piper, Siân C., Edeling, Melissa A., Gray, Sally R., Owen, David J., Lehner, Paul J., Luzio, J. Paul·2006·Journal of Biological Chemistry

DOI 10.1074/jbc.m508632200

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USP8/UBPy has been previously implicated in the regulation of EGFR.
“The deubiquitinating enzyme ubiquitin-specific protease 8 (USP8/UBPy) has been previously implicated in the regulation of the epidermal growth factor receptor (EGFR); however, the molecular mechanisms governing its recruitment and activity in this context remain unclear.”
From Regulation of Epidermal Growth Factor Receptor Ubiquitination and Trafficking by the USP8·STAM Complex (2010) · cites this paper as [41]
The current consensus in the literature indicates that USP8 functions to protect EGFR from ligand-induced down-regulation by direct deubiquitination of activated receptors.
“The current consensus in the literature indicates that USP8 functions to protect EGFR from ligand-induced down-regulation by virtue of direct deubiquitination of activated receptors (24,27,41).”
From Regulation of Epidermal Growth Factor Receptor Ubiquitination and Trafficking by the USP8·STAM Complex (2010) · cites this paper as [41]
Our loss-of-function studies indicate a requirement for USP8 in EGFR stabilization and demonstrate that accelerated receptor degradation resulting from USP8 depletion proceeds through a pathway controlled by Hrs.
“In agreement with published evidence, our loss-of-function studies indicate a requirement for USP8 in EGFR stabilization (24,27,41) and demonstrate that accelerated receptor degradation, resulting from USP8 depletion, proceeds through a pathway controlled by Hrs (Fig. 1).”
From Regulation of Epidermal Growth Factor Receptor Ubiquitination and Trafficking by the USP8·STAM Complex (2010) · cites this paper as [41]
USP8 is required to deubiquitinate and protect EGFR from lysosomal degradation.
“USP8 is required to deubiquitinate and, thus, protect EGFR from lysosomal degradation (24,27,41).”
From Regulation of Epidermal Growth Factor Receptor Ubiquitination and Trafficking by the USP8·STAM Complex (2010) · cites this paper as [41]
Two reports described endosomal enlargement when UBPy was knocked down by RNA interference.
“While this work was in progress, two reports also described endosomal enlargement when UBPy was knocked down by RNA interference (7,48)”
From Essential Role of Ubiquitin-Specific Protease 8 for Receptor Tyrosine Kinase Stability and Endocytic Trafficking In Vivo (2007) · cites this paper as [7]

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Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization
Matsuo, H., Chevallier, J., Mayran, N., Le Blanc, I., Ferguson, C., Fauré, J., Blanc, N. S., Matile, S., Dubochet, J., Sadoul, R., et al. (2004) · Science · doi:10.1126/science.1092425 · Cited by 705
TSG101/Mammalian VPS23 and Mammalian VPS28 Interact Directly and Are Recruited to VPS4-induced Endosomes
Bishop, N., & Woodman, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009863200 · Cited by 187

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Authors: Bowers, K., Piper, S. C., Edeling, M. A., Gray, S. R., Owen, D. J., Lehner, P. J., & Luzio, J. P.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2006-02
Volume: 281
Issue: 8
Pages: 5094-5105
ISSN: 0021-9258
DOI: 10.1074/jbc.m508632200
Cited by: 166
References: 2
Language: en
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 5400 d)

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Degradation of Endocytosed Epidermal Growth Factor and Virally Ubiquitinated Major Histocompatibility Complex Class I Is Independent of Mammalian ESCRTII

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