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Apolipoprotein E4 in Macrophages Enhances Atherogenesis in a Low Density Lipoprotein Receptor-dependent Manner
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Increasing LDLR expression in the presence of apoE4 has harmful effects in a mouse model of CVD.
“Given the harmful effects of increasing LDLR expression in the presence of apoE4 in a mouse model of CVD (Altenburg et al., 2007, Johnson et al., 2013, Malloy et al., 2004)”
From Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner (2014) · cites this paper as Altenburg et al., 2007
In mice, introduction of human LDLR results in higher plasma cholesterol and increased cardiovascular complications in the presence of E4.
“In mice, introduction of human LDLR results in higher plasma cholesterol and increased cardiovascular complications in the presence of E4 (Altenburg et al., 2007, Malloy et al., 2004, Johnson et al., 2013).”
From Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner (2014) · cites this paper as Altenburg et al., 2007
The apoE-LDLR interaction appears critical in both cardiovascular disease and Alzheimer's disease.
“The apoE-LDLR interaction appears critical in both CVD and AD.”
From Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner (2014) · cites this paper as Altenburg et al., 2007
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Cites
Apolipoprotein E polymorphism and atherosclerosis.
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Sullivan, P. M., Mezdour, H., Aratani, Y., Knouff, C., Najib, J., Reddick, R. L., Quarfordt, S. H., & Maeda, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.17972 · Cited by 575
Self-citationSullivan, P. M., Mezdour, H., Quarfordt, S. H., & Maeda, N. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2673 · Cited by 264
Self-citationHara, M., Matsushima, T., Satoh, H., Iso-o, N., Noto, H., Togo, M., Kimura, S., Hashimoto, Y., & Tsukamoto, K. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000054199.78458.4b · Cited by 53
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Johnson, L. A., Olsen, R. H. J., Merkens, L. S., DeBarber, A., Steiner, R. D., Sullivan, P. M., Maeda, N., & Raber, J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.12.016 · Cited by 107
Self-citationAPOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses
Friday, C. M., Stephens, I. O., Smith, C. T., Lee, S., Satish, D., Devanney, N. A., Cohen, S., Morganti, J. M., Gordon, S. M., & Johnson, L. A. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106983 · Cited by 33
Self-citation
Metadata
- Authors
- Altenburg, M., Johnson, L., Wilder, J., & Maeda, N.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 282
- Issue
- 11
- Pages
- 7817-7824
- ISSN
- 0021-9258
- Cited by
- 34
- References
- 4
- Language
- en
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