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The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

Miyata, Masaaki, Smith, Jonathan D.·1996·Nature Genetics
DOI 10.1038/ng0996-55
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Abstract

The apolipoprotein E (APOE) E4 allele is associated with Alzheimer's disease, cardiovascular disease, and decreased longevity. To probe the mechanism of these associations, cell lines were created which secrete each apoE isoform. ApoE conditioned media, purified apoE, and commercially obtained apoE protected B12 cells from hydrogen peroxide cytotoxicity with E2 > E3 > E4. Physiological levels of apoE protected cells from beta-amyloid peptides, while higher doses of apoE led to increased cytotoxicity. E2 > E3 > E4 possessed antioxidant activity, and apoE bound certain metal ions. The decreased antioxidant activity of E4 could contribute to its association with Alzheimer's disease, cardiovascular disease and decreased longevity.

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Crossref · 10.1038/ng0996-55

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  • ApoE and apoJ affect Aβ neurotoxicity.

    “In vitro, apoE and apoJ form stable complexes with A␤ (11, 16 -20), alter the aggregation of various A␤ peptides (21)(22)(23), and affect A␤ neurotoxicity (24 -27).”

    From Apolipoprotein E Receptors Mediate the Effects of β-Amyloid on Astrocyte Cultures (2000) · cites this paper as [24]

  • The addition of exogenous apoE protects against Aβ-induced toxicity in neuronal cell cultures and against Aβ-induced activation of astrocyte cultures.

    “The addition of exogenous apoE protects against A␤-induced toxicity in neuronal cell cultures, as well as A␤-induced activation of astrocyte cultures (24,25,38,52,53).”

    From Apolipoprotein E Receptors Mediate the Effects of β-Amyloid on Astrocyte Cultures (2000) · cites this paper as [24]

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Research works printed but not linked: 37

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Metadata

Authors
Miyata, M., & Smith, J. D.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
1996-09
Volume
14
Issue
1
Pages
55-61
ISSN
  • 1061-4036
  • 1546-1718
DOI
10.1038/ng0996-55
Cited by
735
References
9
Language
en
Licence
www.springer.com/tdm (tdm)

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