Doubling expression of the low density lipoprotein receptor by truncation of the 3′-untranslated region sequence ameliorates type iii hyperlipoproteinemia in mice expressing the human apoe2 isoform
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When murine LDLR is replaced with human LDLR, plasma lipids return to normal physiological levels, allowing for study of the ε2 allele in a physiologically relevant context.
“When murine LDLR is replaced with human LDLR, as in this study and others (Knouff et al. 2001), this issue is resolved as plasma lipids return to normal physiological levels, allowing for study of the ε2 allele in a physiologically relevant context.”
From Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner (2014) · cites this paper as Knouff et al. 2001
In mice, the effect of human LDLR introduction on plasma cholesterol and cardiovascular complications does not occur with E3, and with E2 it lowers cholesterol and improves cardiovascular outcomes.
“This effect does not occur in mice expressing E3, and in the presence of E2 actually lowers cholesterol and improves cardiovascular outcomes (Knouff et al., 2001).”
From Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner (2014) · cites this paper as Knouff et al., 2001
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- Authors
- Knouff, C., Malloy, S., Wilder, J., Altenburg, M. K., & Maeda, N.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 276
- Issue
- 6
- Pages
- 3856-3862
- ISSN
- 0021-9258
- Cited by
- 28
- References
- 5
- Language
- en
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