β 1 Integrin-mediated Effects of Tenascin-R Domains EGFL and FN6-8 on Neural Stem/Progenitor Cell Proliferation and Differentiation in Vitro
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Neural stem/progenitor cells (NSCs) have the capacity for self-renewal and differentiation into major classes of central nervous system cell types, such as neurons, astrocytes, and oligodendrocytes. The determination of fate of NSCs appears to be regulated by both intrinsic and extrinsic factors. Mounting evidence has shown that extracellular matrix molecules contribute to NSC proliferation and differentiation as extrinsic factors. Here we explore the effects of the epidermal growth factor-like (EGFL) and fibronectin type III homologous domains 6-8 (FN6-8) of the extracellular matrix molecule tenascin-R on NSC proliferation and differentiation. Our results show that domain FN6-8 inhibited NSC proliferation and promoted NSCs differentiation into astrocytes and less into oligodendrocytes or neurons. The EGFL domain did not affect NSC proliferation, but promoted NSC differentiation into neurons and reduced NSC differentiation into astrocytes and oligodendrocytes. Treatment of NSCs with beta 1 integrin function-blocking antibody resulted in attenuation of inhibition of the effect of FN6-8 on NSC proliferation. The influence of EGFL or FN6-8 on NSCs differentiation was inhibited by beta 1 integrin antibody application, implicating beta 1 integrin in proliferation and differentiation induced by EGFL and FN6-8 mediated triggering of NSCs.
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Tenascin-R is important for new neuron production and synaptic plasticity in the adult hippocampus.
“Tenascin-R, an ECM glycoprotein, is also important for new neuron production and synaptic plasticity in the adult hippocampus.”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Liao et al., 2008
In neural stem cultures, tenascin-R modulates proliferation and differentiation of neural stem cells through interactions with the cell-surface receptor β1 integrin.
“In neural stem cultures, tenascin-R has been shown to modulate proliferation and differentiation of neural stem cells through interactions with the cell-surface receptor β1 integrin (Liao et al., 2008).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Liao et al., 2008
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- Authors
- Liao, H., Huang, W., Schachner, M., Guan, Y., Guo, J., Yan, J., Qin, J., Bai, X., & Zhang, L.
- Affiliations
- China Pharmaceutical University (CN)
- Universität Hamburg (DE)
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Liao, Hong
- Zhang, Luyong
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 283
- Issue
- 41
- Pages
- 27927-27936
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2022944768
- Cited by
- 39
- References
- 45
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 1 · 2019: 2 · 2018: 3 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 4 · 2012: 3
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- National Natural Science Foundation of China (30670793)
- China Pharmaceutical University
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- tenascin-R, beta1 integrin, neural stem/progenitor cells, extracellular matrix, cell proliferation, neuronal differentiation, astrocyte differentiation, oligodendrocyte differentiation, cell fate determination
- MeSH terms
- Animals, Astrocytes, Cell Differentiation, Cells, Cultured, Epidermal Growth Factor, Fibronectins, Neurons, Oligodendroglia, Recombinant Proteins, Stem Cells, Rats, Sprague-Dawley, Protein Structure, Tertiary, Integrin beta1, Tenascin, Mice, Rats
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