Cited by 58Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionEpilepsy research and treatment

Enhanced cortical and hippocampal neuronal excitability in mice deficient in the extracellular matrix glycoprotein tenascin-R

Gurevicius, K., Gureviciene, I., Valjakka, A., Schachner, M., Tanila, H.·2004·Molecular and Cellular Neuroscience

Abstract

Mice deficient in the extracellular matrix protein tenascin-R (TN-R-/- mice) show several indices of impaired perisomatic inhibition in hippocampal slices. The present study examined electroencephalograms (EEGs) and auditory-evoked potentials (AEPs) in freely moving TN-R-/- and wild-type control mice, focusing on the hippocampal CA1 field and cerebral cortex. TN-R-/- mice expressed normal high-frequency oscillations (ripples) in CA1 and only a slight reduction of peak theta frequency. In contrast, their hippocampal gamma oscillations were significantly enhanced in amplitude. Also, the amplitude of the cortical EEG of TN-R-/- mice was increased over a wide frequency range. The amplitude of cortical and, to a lesser degree hippocampal, AEPs was clearly enhanced in TN-R-/- mice. In addition, response habituation to repeated sound stimuli was significantly attenuated in TN-R-/- mice. These findings indicate that tenascin-R is involved in the regulation of certain inhibitory mechanisms in the intact brain.

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Crossref · 10.1016/j.mcn.2003.12.001

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  • Tenascin-R knockout mice have altered synaptic plasticity in the hippocampus, including impaired LTP and increased basal excitatory transmission.

    “Several studies have shown that tenascin-R knockout mice have altered synaptic plasticity in the hippocampus, including impaired LTP and increased basal excitatory transmission (Bukalo et al., 2001; Gurevicius et al., 2004; Saghatelyan et al., 2001).”

    From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Gurevicius et al., 2004

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Authors
Gurevicius, K., Gureviciene, I., Valjakka, A., Schachner, M., & Tanila, H.
Affiliations
  • University of Eastern Finland (FI)
  • Universität Hamburg (DE)
Corresponding author
Tanila, H.
Venue
Molecular and Cellular Neuroscience
Publisher
Elsevier BV
Published
2004-03
Volume
25
Issue
3
Pages
515-523
ISSN
1044-7431 (ISSN-L)
OpenAlex
W2000381670
Cited by
58
References
38
Citations by year
2026: 1 · 2025: 3 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 5 · 2015: 3 · 2014: 4 · 2013: 1 · 2012: 3
FWCI
1.53
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular and Cellular Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Rutgers University Community Repository (Rutgers University) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
Keywords
tenascin-R, extracellular matrix, neuronal excitability, perisomatic inhibition, hippocampal CA1, gamma oscillations, ripples, theta oscillations, auditory evoked potentials, EEG, habituation, inhibition mechanism
MeSH terms
Acoustic Stimulation, Animals, Cerebral Cortex, Electroencephalography, Evoked Potentials, Auditory, Hippocampus, Male, Mice, Inbred C57BL, Neurons, Mice, Knockout, Tenascin, Mice

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