Enhanced cortical and hippocampal neuronal excitability in mice deficient in the extracellular matrix glycoprotein tenascin-R
Abstract
Mice deficient in the extracellular matrix protein tenascin-R (TN-R-/- mice) show several indices of impaired perisomatic inhibition in hippocampal slices. The present study examined electroencephalograms (EEGs) and auditory-evoked potentials (AEPs) in freely moving TN-R-/- and wild-type control mice, focusing on the hippocampal CA1 field and cerebral cortex. TN-R-/- mice expressed normal high-frequency oscillations (ripples) in CA1 and only a slight reduction of peak theta frequency. In contrast, their hippocampal gamma oscillations were significantly enhanced in amplitude. Also, the amplitude of the cortical EEG of TN-R-/- mice was increased over a wide frequency range. The amplitude of cortical and, to a lesser degree hippocampal, AEPs was clearly enhanced in TN-R-/- mice. In addition, response habituation to repeated sound stimuli was significantly attenuated in TN-R-/- mice. These findings indicate that tenascin-R is involved in the regulation of certain inhibitory mechanisms in the intact brain.
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Tenascin-R knockout mice have altered synaptic plasticity in the hippocampus, including impaired LTP and increased basal excitatory transmission.
“Several studies have shown that tenascin-R knockout mice have altered synaptic plasticity in the hippocampus, including impaired LTP and increased basal excitatory transmission (Bukalo et al., 2001; Gurevicius et al., 2004; Saghatelyan et al., 2001).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Gurevicius et al., 2004
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- Authors
- Gurevicius, K., Gureviciene, I., Valjakka, A., Schachner, M., & Tanila, H.
- Affiliations
- University of Eastern Finland (FI)
- Universität Hamburg (DE)
- Corresponding author
- Tanila, H.
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 25
- Issue
- 3
- Pages
- 515-523
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W2000381670
- Cited by
- 58
- References
- 38
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 5 · 2015: 3 · 2014: 4 · 2013: 1 · 2012: 3
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Keywords
- tenascin-R, extracellular matrix, neuronal excitability, perisomatic inhibition, hippocampal CA1, gamma oscillations, ripples, theta oscillations, auditory evoked potentials, EEG, habituation, inhibition mechanism
- MeSH terms
- Acoustic Stimulation, Animals, Cerebral Cortex, Electroencephalography, Evoked Potentials, Auditory, Hippocampus, Male, Mice, Inbred C57BL, Neurons, Mice, Knockout, Tenascin, Mice
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