The extracellular matrix and synapses

Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis

Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688 · see citing works

Induction, assembly, maturation and maintenance of a postsynaptic apparatus

Sanes, J. R., & Lichtman, J. W. (2001) · Nature reviews. Neuroscience · doi:10.1038/35097557 · Cited by 1,025 · see citing works

Reelin and brain development

Tissir, F., & Goffinet, A. M. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1113 · Cited by 748 · see citing works

An adaptive coding model of neural function in prefrontal cortex

Duncan, J. (2001) · UCL Discovery (University College London) · Cited by 738 · see citing works

Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning

Weeber, E. J., Beffert, U., Jones, C., Christian, J. M., Förster, E., Sweatt, J. D., & Herz, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205147200 · Cited by 623 · see citing works

Extracellular matrix molecules and synaptic plasticity

Dityatev, A., & Schachner, M. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1115 · Cited by 564 · see citing works

Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory

Nagy, V., Bozdagi, O., Matynia, A., Balcerzyk, M., Okulski, P., Dzwonek, J., Costa, R. M., Silva, A. J., Kaczmarek, L., & Huntley, G. W. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4359-05.2006 · Cited by 499 · see citing works

Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2

Beffert, U., Weeber, E. J., Durudas, A., Qiu, S., Masiulis, I., Sweatt, J. D., Li, W.-P., Adelmann, G., Frotscher, M., Hammer, R. E., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.007 · Cited by 497 · see citing works

Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product narp.

O’Brien, R. J., Xu, D., Petralia, R. S., Steward, O., Huganir, R. L., & Worley, P. (1999) · Neuron · doi:10.1016/s0896-6273(00)80782-5 · Cited by 471 · see citing works

Thrombospondins: Multifunctional Regulators of Cell Interactions

Adams, J. C. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.25 · Cited by 407 · see citing works

Integrins mediate functional pre- and postsynaptic maturation at a hippocampal synapse

Chavis, P., & Westbrook, G. L. (2001) · Nature · doi:10.1038/35077101 · Cited by 332 · see citing works

PKC signaling mediates global enhancement of excitatory synaptogenesis in neurons triggered by local contact with astrocytes.

Hama, H., Hara, C., Yamaguchi, K., & Miyawaki, A. (2004) · Neuron · doi:10.1016/s0896-6273(04)00007-8 · Cited by 290 · see citing works

Effects of extracellular matrix‐degrading proteases matrix metalloproteinases 3 and 9 on spatial learning and synaptic plasticity

Meighan, S. E., Meighan, P. C., Choudhury, P., Davis, C. J., Olson, M. L., Zornes, P. A., Wright, J. W., & Harding, J. W. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03565.x · Cited by 285 · see citing works

Narp and NP1 Form Heterocomplexes that Function in Developmental and Activity-Dependent Synaptic Plasticity

Xu, D., Hopf, C., Reddy, R., Cho, R. W., Guo, L., Lanahan, A., Petralia, R. S., Wenthold, R. J., O'Brien, R. J., & Worley, P. (2003) · Neuron · doi:10.1016/s0896-6273(03)00463-x · Cited by 265 · see citing works

Polysialylated Neural Cell Adhesion Molecule Promotes Remodeling and Formation of Hippocampal Synapses

Dityatev, A. E., Dityatev, A. E., Sytnyk, V., Delling, M., Toni, N., Nikonenko, I., Müller, D., & Schachner, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1702-04.2004 · Cited by 265 · see citing works

A synaptic laminin–calcium channel interaction organizes active zones in motor nerve terminals

Nishimune, H., Sanes, J. R., & Carlson, S. S. (2004) · Nature · doi:10.1038/nature03112 · Cited by 264 · see citing works

Mice Deficient for Tenascin-R Display Alterations of the Extracellular Matrix and Decreased Axonal Conduction Velocities in the CNS

Weber, P., Bartsch, U., Rasband, M. N., Czaniera, R., Lang, Y., Bluethmann, H., Margolis, R. U., Levinson, S. R., Shrager, P., Montag, D., et al. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04245.1999 · Cited by 247 · see citing works

Modification of extracellular matrix by enzymatic removal of chondroitin sulfate and by lack of tenascin-R differentially affects several forms of synaptic plasticity in the hippocampus

Bukalo, O., Schachner, M., & Dityatev, A. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00082-3 · Cited by 236 · see citing works

Reduced Perisomatic Inhibition, Increased Excitatory Transmission, and Impaired Long-Term Potentiation in Mice Deficient for the Extracellular Matrix Glycoprotein Tenascin-R

Saghatelyan, A. K., Dityatev, A., Schmidt, S., Schuster, T., Bartsch, U., & Schachner, M. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0922 · Cited by 207 · see citing works

Integrin Requirement for Hippocampal Synaptic Plasticity and Spatial Memory

Chan, C.-S., Weeber, E. J., Kurup, S., Sweatt, J. D., & Davis, R. L. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-18-07107.2003 · Cited by 202 · see citing works

Cognitive disruption and altered hippocampus synaptic function in Reelin haploinsufficient mice

QIU, S., KORWEK, K., PRATTDAVIS, A., PETERS, M., BERGMAN, M., & WEEBER, E. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.11.001 · Cited by 202 · see citing works

Properly formed but improperly localized synaptic specializations in the absence of laminin α4

Patton, B. L., Cunningham, J. M., Thyboll, J., Kortesmaa, J., Westerblad, H., Edström, L., Tryggvason, K., & Sanes, J. R. (2001) · Nature Neuroscience · doi:10.1038/88414 · Cited by 187 · see citing works

Impairment of L-type Ca²⁺Channel-Dependent Forms of Hippocampal Synaptic Plasticity in Mice Deficient in the Extracellular Matrix Glycoprotein Tenascin-C

Evers, M. R., Salmen, B., Bukalo, O., Rollenhagen, A., Bösl, M. R., Morellini, F., Bartsch, U., Dityatev, A., & Schachner, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07177.2002 · Cited by 172 · see citing works

β1-Integrins Are Required for Hippocampal AMPA Receptor-Dependent Synaptic Transmission, Synaptic Plasticity, and Working Memory

Chan, C.-S., Weeber, E. J., Zong, L., Fuchs, E., Sweatt, J. D., & Davis, R. L. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4110-05.2006 · Cited by 165 · see citing works

Synaptically Targeted Narp Plays an Essential Role in the Aggregation of AMPA Receptors at Excitatory Synapses in Cultured Spinal Neurons

O'Brien, R., Xu, D., Mi, R., Tang, X., Hopf, C., & Worley, P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04487.2002 · Cited by 160 · see citing works

Regulation of ion channels by protein tyrosine phosphorylation

Davis, M. J., Wu, X. Y., Nurkiewicz, T. R., Kawasaki, J., Gui, P., Hill, M. A., & Wilson, E. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.5.h1835 · Cited by 159 · see citing works

Mice Deficient in Nervous System-specific Carbohydrate Epitope HNK-1 Exhibit Impaired Synaptic Plasticity and Spatial Learning

Yamamoto, S., Oka, S., Inoue, M., Shimuta, M., Manabe, T., Takahashi, H., Miyamoto, M., Asano, M., Sakagami, J., Sudo, K., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200296200 · Cited by 153 · see citing works

Laminin Degradation by Plasmin Regulates Long-Term Potentiation

Nakagami, Y., Abe, K., Nishiyama, N., & Matsuki, N. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-05-02003.2000 · Cited by 145 · see citing works

An inhibitor of integrin receptors blocks long-term potentiation

Staubli, U. V., Vanderklish, P. W., & LYNCH, G. S. (1990) · Behavioral and Neural Biology · doi:10.1016/0163-1047(90)90712-f · Cited by 129 · see citing works

Reelin, Very-Low-Density Lipoprotein Receptor, and Apolipoprotein E Receptor 2 Control Somatic NMDA Receptor Composition during Hippocampal Maturation<i>In Vitro</i>

Sinagra, M., Verrier, D., Frankova, D., Korwek, K. M., Blahos, J., Weeber, E. J., Manzoni, O. J., & Chavis, P. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1757-05.2005 · Cited by 128 · see citing works

Disruption of Laminin β2 Chain Production Causes Alterations in Morphology and Function in the CNS

Libby, R. T., Lavallee, C. R., Balkema, G. W., et al. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09399.1999 · Cited by 121 · see citing works

Functional Dissection of Reelin Signaling by Site-Directed Disruption of Disabled-1 Adaptor Binding to Apolipoprotein E Receptor 2: Distinct Roles in Development and Synaptic Plasticity

Beffert, U., Durudas, A., Weeber, E. J., Stolt, P. C., Giehl, K. M., Sweatt, J. D., Hammer, R. E., & Herz, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4566-05.2006 · Cited by 121 · see citing works

Integrin signaling cascades are operational in adult hippocampal synapses and modulate NMDA receptor physiology

Bernard‐Trifilo, J. A., Kramár, E. A., Torp, R., Lin, C., Pineda, E. A., LYNCH, G. S., & Gall, C. M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03062.x · Cited by 120 · see citing works

The extracellular matrix molecule tenascin‐R and its HNK‐1 carbohydrate modulate perisomatic inhibition and long‐term potentiation in the CA1 region of the hippocampus

Saghatelyan, A., Gorissen, S., Albert, M., Hertlein, B., Schachner, M., & Dityatev, A. E. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00216.x · Cited by 117 · see citing works

Evidence that integrins contribute to multiple stages in the consolidation of long term potentiation in rat hippocampus

Chun, D. E., Gall, C. M., Bi, X., & LYNCH, G. S. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00173-7 · Cited by 111 · see citing works

Integrins Regulate NMDA Receptor-Mediated Synaptic Currents

Lin, B., Arai, A., LYNCH, G. S., & Gall, C. M. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00783.2002 · Cited by 96 · see citing works

Alpha3 integrin receptors contribute to the consolidation of long-term potentiation

Kramár, E. A., Bernard, J. A., Gall, C. M., & LYNCH, G. S. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00540-1 · Cited by 91 · see citing works

Mice Deficient for the HNK-1 Sulfotransferase Show Alterations in Synaptic Efficacy and Spatial Learning and Memory

Senn, C. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1142 · Cited by 76 · see citing works

Agrin plays an organizing role in the formation of sympathetic synapses

Gingras, J., Rassadi, S., Cooper, E., & Ferns, M. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200203012 · Cited by 75 · see citing works

Integrins Modulate Fast Excitatory Transmission at Hippocampal Synapses

Kramár, E. A., Bernard, J. A., Gall, C. M., & LYNCH, G. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210225200 · Cited by 75 · see citing works

Fibronectin Domains of Extracellular Matrix Molecule Tenascin-C Modulate Hippocampal Learning and Synaptic Plasticity

Strekalova, T. V., Sun, M., Sibbe, M., Evers, M. R., Dityatev, A. E., Gass, P., & Schachner, M. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1172 · Cited by 69 · see citing works

Functional analysis of neurotransmission at β2‐laminin deficient terminals

Knight, D., Tolley, L. K., Kim, D. K., Lavidis, N. A., & Noakes, P. G. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.030924 · Cited by 67 · see citing works

Recognition molecule associated carbohydrate inhibits postsynaptic GABAB receptors: a mechanism for homeostatic regulation of GABA release in perisomatic synapses

Saghatelyan, A. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00163-5 · Cited by 61 · see citing works

Differing Mechanisms for Glutamate Receptor Aggregation on Dendritic Spines and Shafts in Cultured Hippocampal Neurons

Mi, R., Tang, X., Sutter, R., Xu, D., Worley, P. F., & O’Brien, R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07606.2002 · Cited by 55 · see citing works

The Synaptic Vesicle Protein SV2 Is Complexed with an α5-Containing Laminin on the Nerve Terminal Surface

Son, Y., Scranton, T. W., Sunderland, W. J., Baek, S. J., Miner, J. H., Sanes, J. R., & Carlson, S. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.451 · Cited by 52 · see citing works

Versican in the Developing Brain: Lamina-Specific Expression in Interneuronal Subsets and Role in Presynaptic Maturation

Yamagata, M., & Sanes, J. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1976-05.2005 · Cited by 47 · see citing works

Augmentation of locomotor activity by chronic phencyclidine is associated with an increase in striatal NMDA receptor function and an upregulation of the NR1 receptor subunit

Hanania, T., Hillman, G. R., & Johnson, K. M. (1999) · Synapse · doi:10.1002/(sici)1098-2396(19990301)31:3 · Cited by 46 · see citing works

Agrin mediates a rapid switch from electrical coupling to chemical neurotransmission during synaptogenesis

Martin, A., Alonso, G., & Guérineau, N. C. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200411054 · Cited by 44 · see citing works

AMPA Receptor-Dependent Clustering of Synaptic NMDA Receptors Is Mediated by Stargazin and NR2A/B in Spinal Neurons and Hippocampal Interneurons

Mi, R., Sia, G.-M., Rosen, K., Tang, X., Moghekar, A., Black, J. L., McEnery, M. W., Huganir, R. L., & O’Brien, R. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.029 · Cited by 41 · see citing works

Integrins regulate neuronal neurotrophin gene expression through effects on voltage-sensitive calcium channels

Gall, C. M., Pinkstaff, J. K., Lauterborn, J. C., Xie, Y., & LYNCH, G. S. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00990-9 · Cited by 39 · see citing works

Enhanced hippocampal GABAergic inhibition in mice overexpressing heparin-binding growth-associated molecule

Pavlov, I., Rauvala, H., & Taira, T. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.11.070 · Cited by 23 · see citing works

Extracellular Matrix: Functions in the Nervous System

Barros, C. S., Franco, S. J., & Muller, U. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005108 · Cited by 506 · see citing works

Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses

Pais-Correia, A.-M., Sachse, M., Guadagnini, S., Robbiati, V., Lasserre, R., Gessain, A., Gout, O., Alcover, A., & Thoulouze, M.-I. (2010) · Nature Medicine · doi:10.1038/nm.2065 · Cited by 344 · see citing works

Protein tyrosine phosphatases PTPδ, PTPσ, and LAR: presynaptic hubs for synapse organization

Takahashi, H., & Craig, A. M. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.06.002 · Cited by 257 · see citing works

Contributions of astrocytes to synapse formation and maturation — Potential functions of the perisynaptic extracellular matrix

Faissner, A., Pyka, M., Geissler, M., Sobik, T., Frischknecht, R., Gundelfinger, E. D., & Seidenbecher, C. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.01.001 · Cited by 207 · see citing works

Extracellular matrix abnormalities in schizophrenia

Berretta, S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.010 · Cited by 179 · see citing works

Shaping Synapses by the Neural Extracellular Matrix

Ferrer-Ferrer, M., & Dityatev, A. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00040 · Cited by 169 · see citing works

Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala

Pantazopoulos, H., Markota, M., Jaquet, F., Ghosh, D., Wallin, A., Santos, A., Caterson, B., & Berretta, S. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.128 · Cited by 153 · see citing works

Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia

Berretta, S., Pantazopoulos, H., Markota, M., Brown, C., & Batzianouli, E. T. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.12.040 · Cited by 152 · see citing works

Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

Dakic, V., Minardi Nascimento, J., Costa Sartore, R., Maciel, R. D. M., de Araujo, D. B., Ribeiro, S., Martins-de-Souza, D., & Rehen, S. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-12779-5 · Cited by 134 · see citing works

Chondroitin sulfate proteoglycans regulate astrocyte‐dependent synaptogenesis and modulate synaptic activity in primary embryonic hippocampal neurons

Pyka, M., Wetzel, C., Aguado, A., Geissler, M., Hatt, H., & Faissner, A. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07690.x · Cited by 131 · see citing works

β 1 Integrin-mediated Effects of Tenascin-R Domains EGFL and FN6-8 on Neural Stem/Progenitor Cell Proliferation and Differentiation in Vitro

Liao, H., Huang, W., Schachner, M., Guan, Y., Guo, J., Yan, J., Qin, J., Bai, X., & Zhang, L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804764200 · Cited by 39 · see citing works

Total number, distribution, and phenotype of cells expressing chondroitin sulfate proteoglycans in the normal human amygdala

Pantazopoulos, H., Murray, E. A., & Berretta, S. (2008) · Brain Research · doi:10.1016/j.brainres.2008.02.036 · Cited by 34 · see citing works

Identification of the novel localization of tenascinX in the monkey choroid plexus and comparison with the mouse

Imura, K., & Sato, I. (2009) · European Journal of Histochemistry · doi:10.4081/ejh.2009.e27 · Cited by 7 · see citing works

Equid Herpesvirus-1 Exploits the Extracellular Matrix of Mononuclear Cells to Ensure Transport to Target Cells

Kamel, M., Pavulraj, S., Fauler, B., Mielke, T., & Azab, W. (2020) · iScience · doi:10.1016/j.isci.2020.101615 · Cited by 7 · see citing works

Roles of Microglia in Synaptogenesis, Synaptic Pruning, and Synaptic Plasticity in Physiological Conditions and Central Nervous System Disorders

Xie, M., Wang, T., Feng, J., Ma, D., Feng, L., & Hao, Y. (2025) · Current Neuropharmacology · doi:10.2174/1570159x23666250225091729 · Cited by 7 · see citing works

Neuromuscular synapse development

Orlando, L. R. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01911-1

Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse

Lin, W., Burgess, R. W., Dominguez, B., Pfaff, S. L., Sanes, J. R., & Lee, K. (2001) · Nature · doi:10.1038/35074025 · Cited by 534 · see citing works

Effects of Exposure to Aluminum on Long-term Potentiation and AMPA Receptor Subunits in Rats in vivo

Сонг, Jing, J., Liu, et al. (2014) · 生物医学与环境科学：英文版 · Cited by 2 · see citing works

Neuregulins and erbB Receptors at Neuromuscular Junctions and at Agrin-Induced Postsynaptic-like Apparatus in Skeletal Muscle

Rimer, M., Cohen, I., Lømo, T., Burden, S. J., & McMahan, U. J. (1998) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1998.0695 · Cited by 67 · see citing works

Temporal and quantitative analysis of the functional expression of Ca2+-permeable AMPA receptors during LTP

Wakazono, Y., Midorikawa, R., & Takamiya, K. (2023) · Neuroscience Research · doi:10.1016/j.neures.2023.07.002 · Cited by 9 · see citing works