Homologous recombination and the repair of DNA double-strand breaks

The double-strand-break repair model for recombination

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Multiple Pathways of Recombination Induced by Double-Strand Breaks in <i>Saccharomyces cerevisiae</i>

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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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Regulation of Homologous Recombination in Eukaryotes

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BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks

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Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

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Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

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The control of DNA repair by the cell cycle

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Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures

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Purified human BRCA2 stimulates RAD51-mediated recombination

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DNA helicase Srs2 disrupts the Rad51 presynaptic filament

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The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments

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Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A

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Chromosome Instability and Defective Recombinational Repair in Knockout Mutants of the Five Rad51 Paralogs

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Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae.

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Nonhomologous DNA end-joining for repair of DNA double-strand breaks

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Rad51 Recombinase and Recombination Mediators

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Efficient copying of nonhomologous sequences from ectopic sites via P-element-induced gap repair.

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RecFOR Proteins Load RecA Protein onto Gapped DNA to Accelerate DNA Strand Exchange

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BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo.

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Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

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BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

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Template switching during break-induced replication

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Rad52 inactivation is synthetically lethal with BRCA2 deficiency

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The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA–ssDNA junction

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Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae

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Targeted Inactivation of Mouse RAD52Reduces Homologous Recombination but Not Resistance to Ionizing Radiation

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Transcription-dependent dynamic supercoiling is a short-range genomic force

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Generating Crossovers by Resolution of Nicked Holliday Junctions

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DNA annealing by Rad52 Protein is stimulated by specific interaction with the complex of replication protein A and single-stranded DNA

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Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration

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How cells ensure correct repair of DNA double-strand breaks

Her, J., & Bunting, S. F. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.tm118.000371 · Cited by 304 · see citing works

End Resection at Double-Strand Breaks: Mechanism and RegulationPreprint

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Rad54, a Swi2/Snf2-like Recombinational Repair Protein, Disassembles Rad51:dsDNA Filaments

Solinger, J. A., Kiianitsa, K., & Heyer, W. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00743-8 · Cited by 264 · see citing works

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA

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Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombinationPreprint

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Domain structure and dynamics in the helical filaments formed by RecA and Rad51 on DNA

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DNA synthesis dependent on genetic recombination: Characterization of a reaction catalyzed by purified bacteriophage T4 proteins

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Drosophila BLM in Double-Strand Break Repair by Synthesis-Dependent Strand Annealing

Adams, M. D., McVey, M., & Sekelsky, J. J. (2003) · Science · doi:10.1126/science.1077198 · Cited by 246 · see citing works

Ca 2+ activates human homologous recombination protein Rad51 by modulating its ATPase activity

Bugreev, D. V., & Mazin, A. V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402105101 · Cited by 245 · see citing works

Double Holliday junctions are intermediates of DNA break repair

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DNA Sequence Alignment by Microhomology Sampling during Homologous Recombination

Qi, Z., Redding, S., Lee, J. Y., Gibb, B., Kwon, Y., Niu, H., Gaines, W. A., Sung, P., & Greene, E. C. (2015) · Cell · doi:10.1016/j.cell.2015.01.029 · Cited by 233 · see citing works

Repair of DNA double-strand breaks by mammalian alternative end-joining pathways

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Superhelicity-Driven Homologous DNA Pairing by Yeast Recombination Factors Rad51 and Rad54

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The Dissolution of Double Holliday JunctionsPreprint

Bizard, A. H., & Hickson, I. D. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016477 · Cited by 216 · see citing works

Holliday Junction ResolvasesPreprint

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Yeast Rad54 Promotes Rad51-dependent Homologous DNA Pairing via ATP Hydrolysis-driven Change in DNA Double Helix Conformation

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Rad51 paralogues Rad55–Rad57 balance the antirecombinase Srs2 in Rad51 filament formation

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Counting RAD51 proteins disassembling from nucleoprotein filaments under tension

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Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes

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Efficient Copying of Nonhomologous Sequences from Ectopic Sites via P-Element-Induced Gap Repair

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A Novel Function of Rad54 Protein

Mazin, A. V., Alexeev, A., & Kowalczykowski, S. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212779200 · Cited by 185 · see citing works

Base triplet stepping by the Rad51/RecA family of recombinases

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Rad54p Is a Chromatin Remodeling Enzyme Required for Heteroduplex DNA Joint Formation with Chromatin

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Functional Interactions among Yeast Rad51 Recombinase, Rad52 Mediator, and Replication Protein A in DNA Strand Exchange

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Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2

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Direct imaging of human Rad51 nucleoprotein dynamics on individual DNA molecules

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Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination

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The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH gene.

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Synapsis and the formation of paranemic joints by E. coli RecA protein

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Eukaryotic DNA Polymerases in Homologous Recombination

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Rad54 Functions as a Heteroduplex DNA Pump Modulated by Its DNA Substrates and Rad51 during D Loop Formation

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Promotion of Homologous Recombination and Genomic Stability by RAD51AP1 via RAD51 \nRecombinase Enhancement

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PCNA Is Required for Initiation of Recombination-Associated DNA Synthesis by DNA Polymerase δ

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Role of DNA Replication Proteins in Double-Strand Break-Induced Recombination in Saccharomyces cerevisiae

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Human Rad51 filaments on double- and single-stranded DNA: correlating regular and irregular forms with recombination function

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Multi-invasions Are Recombination Byproducts that Induce Chromosomal Rearrangements

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RAD51AP1 Is a Structure-Specific DNA Binding Protein that Stimulates Joint Molecule Formation during RAD51-Mediated Homologous Recombination

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The SMX DNA Repair Tri-nuclease

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The importance of being supercoiled: How DNA mechanics regulate dynamic processes

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Bipartite stimulatory action of the Hop2–Mnd1 complex on the Rad51 recombinasePreprint

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Rad52 Promotes Postinvasion Steps of Meiotic Double-Strand-Break Repair

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Top3-Rmi1 Dissolve Rad51-Mediated D Loops by a Topoisomerase-Based Mechanism

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Evidence for Multiple Cycles of Strand Invasion During Repair of Double-Strand Gaps in Drosophila

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Human Rad52-mediated homology search and annealing occurs by continuous interactions between overlapping nucleoprotein complexes

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Rapid Exchange of A:T Base Pairs Is Essential for Recognition of DNA Homology by Human Rad51 Recombination Protein

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Monitoring Homology Search during DNA Double-Strand Break Repair In Vivo

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Mutations in Homologous Recombination Genes Rescue top3 Slow Growth in Saccharomyces cerevisiae

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Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability

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Human Rad54 Protein Stimulates DNA Strand Exchange Activity of hRad51 Protein in the Presence of Ca2+

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DNA Sequence Alignment during Homologous Recombination

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Mechanics and Single-Molecule Interrogation of DNA Recombination

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Presynaptic filament dynamics in homologous recombination and DNA repair

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Acute inactivation of the replicative helicase in human cells triggers MCM8–9-dependent DNA synthesisPreprint

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BRCA2 is epistatic to the RAD51 paralogs in response to DNA damage

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Mechanistic Insights into the Activation of Rad51-Mediated Strand Exchange from the Structure of a Recombination Activator, the Swi5-Sfr1 Complex

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A Conserved N-terminal Motif in Rad54 Is Important for Chromatin Remodeling and Homologous Strand Pairing

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Strand displacement synthesis by yeast DNA polymerase ε

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Two three-strand intermediates are processed during Rad51-driven DNA strand exchange

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Combined optical and topographic imaging reveals different arrangements of human RAD54 with presynaptic and postsynaptic RAD51–DNA filaments

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Ca 2+ improves organization of single-stranded DNA bases in human Rad51 filament, explaining stimulatory effect on gene recombination

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Enhancement of ADP release from the RAD51 presynaptic filament by the SWI5-SFR1 complex

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ATP hydrolysis Promotes Duplex DNA Release by the RecA Presynaptic Complex

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Interchromosomal Crossover in Human Cells Is Associated with Long Gene Conversion Tracts

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The differentiated and conserved roles of Swi5‐Sfr1 in homologous recombination

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The Role of Negative Superhelicity and Length of Homology in the Formation of Paranemic Joints Promoted by RecA Protein

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DNA Dynamics in RecA−DNA Filaments: ATP Hydrolysis-Related Flexibility in DNA

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Swi5-Sfr1 protein stimulates Rad51-mediated DNA strand exchange reaction through organization of DNA bases in the presynaptic filament

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Elastic Behavior of RecA-DNA Helical Filaments

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Human Cell Assays for Synthesis-Dependent Strand Annealing and Crossing over During Double-Strand Break Repair

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DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging

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Heat-shock proteins: chaperoning DNA repair

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Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies

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DNA Damage-Induced Neurodegeneration in Accelerated Ageing and Alzheimer’s Disease

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Structural aspects of DNA repair and recombination in crop improvement

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Architects meets Repairers: the interplay between homeobox genes and DNA repair

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Interaction of nucleotide excision repair factors XPC-HR23B, XPA, and RPA with damaged DNA

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DNA Repair Protein XPA Binds Replication Protein A (RPA)

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Repair of DNA–polypeptide crosslinks by human excision nuclease

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Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage

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Important DNA repair proteins in DNA double-strand break repair pathways

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