Effect of weight reduction on resting energy expenditure, substrate utilization, and the thermic effect of food in moderately obese women
Abstract
It is not known whether the decrease in the thermic effect of food (TEF) in obesity is a consequence of obesity or a factor contributing to the development of obesity. The resting energy expenditure (REE) of 24 obese, nondiabetic, postmenopausal women was 5481 +/- 110 kJ/24 h (1310 +/- 26.4 kcal/24 h). After weight loss (12.7 +/- 0.45 kg) the REE was significantly decreased (4858 +/- 94 kJ/24 h, or 1161 +/- 22.4 kcal/24 h) and equivalent to the REE of 4866 +/- 119 kJ/24 h (1163 +/- 28.5 kcal/24 h) in 24 never-obese, postmenopausal women. The TEF, expressed as a percentage of the calories ingested, was 8.2 +/- 0.50% for obese subjects, 8.7 +/- 0.57% for postobese subjects, and 9.8 +/- 0.54% for never-obese subjects. Compared with never-obese subjects, the TEF was significantly reduced in obese subjects (P = 0.043) and remained unchanged after weight loss (P = 0.341). These findings indicate that the lower TEF in the obese subjects is uncorrected by weight loss, and thus it is a contributor to obesity rather than a consequence of obesity.
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Obese subjects who lose weight by dieting experience a decrease in body mass of multiple tissues and an obligate decrease in energy expenditure.
“First, obese subjects who lose weight by dieting experience a decrease in body mass of multiple tissues and an obligate decrease in energy expenditure (16,17).”
From Long-term Effects of Large-volume Liposuction on Metabolic Risk Factors for Coronary Heart Disease (2008) · cites this paper as [16]
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Weinheimer, E. M., Sands, L. P., & Campbell, W. W. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00298.x · Cited by 391 · see citing works
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Long-term Effects of Large-volume Liposuction on Metabolic Risk Factors for Coronary Heart Disease
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Establishment of a closed artificial ecosystem to ensure human long-term survival on the moon
Fu, Y., Yi, Z., Du, Y., Liu, H., Xie, B., & Liu, H. (2021) · doi:10.1101/2021.01.12.426282 · Cited by 27 · see citing works
- Authors
- Nelson, K., Weinsier, R., James, L., Darnell, B., Hunter, G., & Long, C.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Nelson, KM
- ORCID
- Hunter, G
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 1992-05
- Volume
- 55
- Issue
- 5
- Pages
- 924-933
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1891666168
- Cited by
- 70
- References
- 3
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 2 · 2013: 4 · 2012: 3
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r01dk038491-01a1, 5r01hl032098-03, 5p01ca028103-15)
- National Heart, Lung, and Blood Institute (R01 HL-32098)
- National Cancer Institute (P01 CA28103)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK-38491)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- weight loss, resting energy expenditure, thermic effect of food, substrate utilization, obesity, postmenopausal women, energy metabolism, obesity pathogenesis
- MeSH terms
- Aged, Analysis of Variance, Basal Metabolism, Blood Glucose, Body Composition, Body Temperature Regulation, Energy Intake, Eating, Epinephrine, Female, Humans, Insulin, Middle Aged, Obesity, Oxidation-Reduction, Proteins, Weight Loss, Carbohydrate Metabolism, Lipid Metabolism
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