The DOI matches its Crossref record; 86 of the 89 references it cites were found in a registry or an index.
Adipokines: inflammation and the pleiotropic role of white adipose tissue
Open accessAbstract
White adipose tissue is now recognised to be a multifunctional organ; in addition to the central role of lipid storage, it has a major endocrine function secreting several hormones, notably leptin and adiponectin, and a diverse range of other protein factors. These various protein signals have been given the collective name ‘adipocytokines’ or ‘adipokines’. However, since most are neither ‘cytokines’ nor ‘cytokine-like’, it is recommended that the term ‘adipokine’ be universally adopted to describe a protein that is secreted from (and synthesised by) adipocytes. It is suggested that the term is restricted to proteins secreted from adipocytes, excluding signals released only by the other cell types (such as macrophages) in adipose tissue. The adipokinome(which together with lipid moieties released, such as fatty acids and prostaglandins, constitute the secretome of fat cells) includes proteins involved in lipid metabolism, insulin sensitivity, the alternative complement system, vascular haemostasis, blood pressure regulation and angiogenesis, as well as the regulation of energy balance. In addition, there is a growing list of adipokines involved in inflammation (TNFα, IL-1β, IL-6, IL-8, IL-10, transforming growth factor-β, nerve growth factor) and the acute-phase response (plasminogen activator inhibitor-1, haptoglobin, serum amyloid A). Production of these proteins by adipose tissue is increased in obesity, and raised circulating levels of several acute-phase proteins and inflammatory cytokines has led to the view that the obese are characterised by a state of chronic low-grade inflammation, and that this links causally to insulin resistance and the metabolic syndrome. It is, however, unclear as to the extent to which adipose tissue contributes quantitatively to the elevated circulating levels of these factors in obesity and whether there is a generalised or local state of inflammation. The parsimonious view is that the increased production of inflammatory cytokines and acute-phase proteins by adipose tissue in obesity relates primarily to localised events within the expanding fat depots. It is suggested that these events reflect hypoxia in parts of the growing adipose tissue mass in advance of angiogenesis, and involve the key controller of the cellular response to hypoxia, the transcription factor hypoxia inducible factor-1.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“relative hypoxia in AT mediates a cascade of events that lead to the increased apoptosis and low-grade inflammation seen in obesity”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Trayhurn and Wood, 2004
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Currently, AT is characterized as an important endocrine organ present in the body, related both to the expression of various cytokines and to the regulation and coordination of energy homeostasis, blood pressure, immune function, angiogenesis, mechanical shock protection, and thermogenic function (Prins, 2002; Trayhurn and Wood, 2004).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Trayhurn and Wood, 2004
Experimental — accuracy not yet measuredIn the citing paper
“considerable evidence suggests that obesity and inflammation are significantly related [163,486,575,581,642,647-664]”
In the citing paper
“In a small study involving three healthy volunteers who received 120 mg Fe/d for a week, there were no changes in circulating CRP concentration or leucocyte counts, or in urinary neopterin concentration (725) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [725]
In the citing paper
“in addition, the adipose tissue of obesity exhibits abnormalities in the production of several adipokines that may separately affect insulin resistance and/or modify risk for ASCVD.34”
From Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (2005) · cites this paper as [34]
In the citing paper
“Adipocyte hypertrophy creates areas of local AT microhypoxia at the earliest stages of expansion (19).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [19]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133
Role of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117
Interleukin-6 and the acute phase response
Heinrich, P. C., Castell, J. V., & Andus, T. (1990) · Biochemical Journal · doi:10.1042/bj2650621 · Cited by 2,734
Flagged first, then by citations
3 of the 89 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 601–700 of 1,001
Expression of microRNAs: potential molecular link between obesity, diabetes and cancer
Ali, A. S., Ali, S., Ahmad, A., Bao, B., Philip, P. A., & Sarkar, F. H. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00906.x · Cited by 58
Left ventricular geometry in obesity: Is it what we expect?
SIMONE, G. D., Izzo, R., LUCA, N. D., & Gerdts, E. (2013) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2013.06.012 · Cited by 59
Simiakakis, M., Kapsimalis, F., Chaligiannis, E., Loukides, S., Sitaras, N. M., & Alchanatis, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039172 · Cited by 58
Neuroadipology: A novel component of neuroendocrinology
Chaldakov, G. N., Fiore, M., Tonchev, A. B., & Aloe, L. (2010) · Cell Biology International · doi:10.1042/cbi20100509 · Cited by 58
Hah, Y.-J., Kim, N.-K., Kim, M. K., Kim, H., Hur, S., Yoon, H., Kim, Y.-N., & Park, K. (2011) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2011.35.3.248 · Cited by 58
Pirkola, J., Vääräsmäki, M., Ala‐Korpela, M., Bloigu, A. H., Canoy, D., Hartikainen, A., Leinonen, M., Miettola, S., Paldanius, M., Tammelin, T., et al. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp320 · Cited by 58
Wang, X., & Hai, C. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.07.012 · Cited by 59
Zhao, J., Yi, C., Li, L., Zheng, Y., Wu, K., Liang, L., Xia, W., & Guo, S. (2012) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e31825dbfd3 · Cited by 58
Delgado, C., Chertow, G. M., Kaysen, G. A., Dalrymple, L. S., Kornak, J., Grimes, B. A., & Johansen, K. L. (2017) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2017.06.028 · Cited by 59
Obesity and male infertility: multifaceted reproductive disruption
Chaudhuri, G. R., Das, A., Kesh, S. B., Bhattacharya, K., Dutta, S., Sengupta, P., & Syamal, A. K. (2022) · Middle East Fertility Society Journal · doi:10.1186/s43043-022-00099-2 · Cited by 62
Interferon Family Cytokines in Obesity and Insulin Sensitivity
Huang, L.-Y., Chiu, C.-J., Hsing, C., & Hsu, Y. (2022) · Cells · doi:10.3390/cells11244041 · Cited by 59
An IL-6 link between obesity and cancer
Ghosh, S. (2013) · Frontiers in Bioscience · doi:10.2741/e628 · Cited by 57
Identification of Hypoxia-Induced Genes in Human SGBS Adipocytes by Microarray Analysis
Geiger, K. D., Leiherer, A., Muendlein, A., Stark, N., Geller-Rhomberg, S., Saely, C. H., Wabitsch, M., Fraunberger, P., & Drexel, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026465 · Cited by 57
Peroxisome proliferator-activated receptors: Bridging metabolic syndrome with molecular nutrition
Guri, A. J., Hontecillas, R., & Bassaganya-Riera, J. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.08.006 · Cited by 57
The role of obesity in gastrointestinal cancer: evidence and opinion
Donohoe, C. L., O’Farrell, N. J., Doyle, S. L., & Reynolds, J. V. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x13501786 · Cited by 61
Impact of Doxorubicin Treatment on the Physiological Functions of White Adipose Tissue
Biondo, L. A., de Lima, E. A., de Souza, C. O., Cruz, M. M., Cunha, R. D. C. D. [., Alonso‐Vale, M. I. C., Oyama, L. M., do Nascimento, C. M. O., Pimentel, G. D., dos Santos, R. V. T., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151548 · Cited by 57
Moorthy, A. N., Tan, K. B., Wang, S., Narasaraju, T., & Chow, V. T. K. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00289 · Cited by 57
Free Fatty Acids in Bone Pathophysiology of Rheumatic Diseases
Frommer, K., Hasseli, R., Schäffler, A., Lange, U., Rehart, S., Steinmeyer, J., Rickert, M., Sarter, K., Zaiss, M. M., Culmsee, C., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02757 · Cited by 57
Lotti, F., Corona, G., Colpi, G. M., FILIMBERTI, E., Innocenti, S. D., Mancini, M., Baldi, E., Noci, I., Forti, G., Adorini, L., et al. (2011) · PubMed · doi:10.3275/7855 · Cited by 57
Tsiodras, S., Perelas, A., Wanke, C. A., & Mantzoros, C. S. (2010) · Journal of Infection · doi:10.1016/j.jinf.2010.06.002 · Cited by 57
Palming, J., Gabrielsson, B. G., Jennische, E., Smith, U., Carlsson, B., Carlsson, L. M. S., & Lönn, M. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.02.114 · Cited by 57
Lee, K.-J., Shin, Y., Lee, K.-Y., Jun, T.-W., & Song, W. J. (2010) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.20.4.275 · Cited by 56
Sheng, X., & Mittelman, S. D. (2014) · Frontiers in Pediatrics · doi:10.3389/fped.2014.00053 · Cited by 62
Lilja, H. E., Morrison, W. A., Han, X., Palmer, J. A., Taylor, C. J., Tee, R., Möller, A., Thompson, E. W., & Abberton, K. M. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0451 · Cited by 57
YKL-40 secreted from adipose tissue inhibits degradation of type I collagen
Iwata, T., Kuwajima, M., Sukeno, A., Ishimaru, N., Hayashi, Y., Wabitsch, M., Mizusawa, N., Itakura, M., & Yoshimoto, K. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.08.024 · Cited by 54
Alterations of leptin in the course of inflammation and severe sepsis
Behnes, M., Brueckmann, M., Lang, S., Putensen, C., Saur, J., Borggrefe, M., & Hoffmann, U. (2012) · BMC Infectious Diseases · doi:10.1186/1471-2334-12-217 · Cited by 57
Expression and Regulation of Osteoprotegerin in Adipose Tissue
An, J.-J., Han, D.-H., Kim, D.-M., Kim, S.-H., Rhee, Y., Lee, E. J., & Lim, S.-K. (2007) · Yonsei Medical Journal · doi:10.3349/ymj.2007.48.5.765 · Cited by 56
Preventive mechanism of bioactive dietary foods on obesity-related inflammation and diseases
Sung, J., Ho, C., & Wang, Y. (2018) · Food & Function · doi:10.1039/c8fo01561a · Cited by 58
Hagiwara, M., Miyajima, A., Hasegawa, M., Jinzaki, M., Kikuchi, E., Nakagawa, K., & Oya, M. (2012) · British Journal of Urology · doi:10.1111/j.1464-410x.2012.11274.x · Cited by 56
Doumatey, A. P., Lashley, K., Huang, H., Zhou, J., Chen, G., Amoah, A. G. B., Agyenim‐Boateng, K., Oli, J., Fasanmade, O. A., Adebamowo, C., et al. (2009) · Obesity · doi:10.1038/oby.2009.322 · Cited by 55
Pereira-Fernandes, A., Vanparys, C., Hectors, T. L. M., Vergauwen, L., Knapen, D., Jorens, P. G., & Blust, R. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.02.011 · Cited by 56
High-fat diet disrupts bone remodeling by inducing local and systemic alterations
Montalvany-Antonucci, C. C., Zicker, M. C., Ferreira, A. V. M., Macari, S., Ramos‐Junior, E. S., Gomez, R. S., Pereira, T. S., Madeira, M. F. M., Fukada, S. Y., Andrade, I., et al. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.06.006 · Cited by 55
Adipokines in critical illness: A review of the evidence and knowledge gaps
Alipoor, E., Hosseinzadeh, F. M., & Hosseinzadeh‐Attar, M. J. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.165 · Cited by 56
The immune remodel: Weight loss-mediated inflammatory changes to obesity
Phillips, C. L., & Grayson, B. E. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370219900185 · Cited by 59
Is Obesity a Risk Factor for Periodontal Disease in Adults? A Systematic Review
Abu-Shawish, G., Joseph, B., & Anil, S. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191912684 · Cited by 54
Adipocytes Enhance the Proliferation of Human Leiomyoma Cells Via TNF-α Proinflammatory Cytokine
Nair, S., & Al-Hendy, A. A. (2011) · Reproductive Sciences · doi:10.1177/1933719111408111 · Cited by 54
Sun, X., Morris, K. L., & Zemel, M. B. (2007) · Lifestyle Genomics · doi:10.1159/000109873 · Cited by 54
Metabolism and Breast Cancer Risk: Frontiers in Research and Practice
Patterson, R. E., Rock, C. L., Kerr, J., Natarajan, L., Marshall, S. J., Pakiz, B., & Cadmus‐Bertram, L. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.08.015 · Cited by 54
Increased monocytic CD14+HLADRlow/− myeloid-derived suppressor cells in obesity
Bao, Y., Mo, J., Ruan, L., & Guo, L. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2927 · Cited by 54
Jernås, M., Olsson, B., Sjöholm, K., Sjögren, A., Rudemo, M., Nellgård, B., Carlsson, L. M. S., & Sjöström, C. D. (2008) · Metabolism · doi:10.1016/j.metabol.2008.08.012 · Cited by 55
Emerging role of cathepsin S in obesity and its associated diseases
Taleb, S., & Clément, K. (2007) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2007.083 · Cited by 54
Role of adipose tissues in osteoarthritis
Zapata-Linares, N., Eymard, F., Berenbaum, F., & Houard, X. (2021) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000763 · Cited by 54
A glimpse of the connection between PPARγ and macrophage
Yu, L., Gao, Y., Aaron, N., & Qiang, L. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1254317 · Cited by 61
Obesity and male fertility disorders
Cannarella, R., Crafa, A., Curto, R., Condorelli, R. A., Vignera, S. L., & Calogero, A. E. (2024) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2024.101273 · Cited by 63
Ghrelin Gene‐Related Peptides Modulate Rat White Adiposity
Giovambattista, A., Gaillard, R. C., & Spinedi, E. (2007) · Vitamins and hormones · doi:10.1016/s0083-6729(06)77008-x · Cited by 53
Leuwer, M., Welters, I. D., Marx, G., Rushton, A., Bao, H., Hunter, L., & Trayhurn, P. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0564-8 · Cited by 56
Self-citationArriarán, S., Agnelli, S., Sabater, D., Remesar, X., Fernández–Löpez, J., & Alemany, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119572 · Cited by 53
Núñez, I. N., Galdeano, C. M., de LeBlanc, A. D. M., & Perdigón, G. (2014) · Nutrition · doi:10.1016/j.nut.2014.03.025 · Cited by 56
Kim, S., Sandler, D. P., Galanko, J., Martin, C. F., & Sandler, R. S. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq032 · Cited by 54
Muhidin, S. O., Magan, A. A., Osman, K. A., Syed, S. M., & Ahmed, M. H. (2012) · Journal of Obesity · doi:10.1155/2012/637538 · Cited by 52
Mendizábal, Y., Llorens, S., & Nava, E. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.10.021 · Cited by 52
Obesidade e adipocinas inflamatórias: implicações práticas para a prescrição de exercício
do Prado, W. L., Lofrano‐Prado, M. C., Oyama, L. M., & Dâmaso, A. R. (2009) · Revista Brasileira de Medicina do Esporte · doi:10.1590/s1517-86922009000600012 · Cited by 62
van den Borst, B., Schols, A. M. W. J., de Theije, C. C., Boots, A. W., Köhler, E., Goossens, G. H., & Gosker, H. R. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00460.2012 · Cited by 53
Role of adipokines in obesity‐associated hypertension
Vlasova, M. A., Purhonen, A., Järvelin, M., Rodilla, E., Pascual, J., & Herzig, K. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02171.x · Cited by 53
The importance of synthetic drugs for type 2 diabetes drug discovery
Safavi, M., Foroumadi, A., & Abdollahi, M. R. (2013) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.837883 · Cited by 52
Komolka, K., Albrecht, E., Wimmers, K., Michal, J. J., & Maak, S. (2013) · Journal of Genomics · doi:10.7150/jgen.5260 · Cited by 53
Martino, H. S. D., Dias, M. M. D. S., Noratto, G. D., Talcott, S. T., & Mertens‐Talcott, S. U. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.02.037 · Cited by 52
Epigenetic regulation of metabolism in children born small for gestational age
Holness, M. J., & Sugden, M. C. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000232912.69236.e0 · Cited by 52
Priyanka, A., Sindhu, G., Shyni, G. L., Rani, M., Nisha, V. M., & Raghu, K. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.11.019 · Cited by 53
Emamalipour, M., Seidi, K., Jahanban‐Esfahlan, A., & Jahanban‐Esfahlan, R. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28913 · Cited by 54
Auguet, T., Bertran, L., Binetti, J., Aguilar, C., Martínez, S., Sabench, F., Lopez-Dupla, J. M., Porras, J. A., Riesco, D., Castillo, D. D., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114189 · Cited by 52
Adipose tissue fatty acid metabolism and cardiovascular disease
Frayn, K. N., Fielding, B. A., & Karpe, F. (2005) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000171919.62129.6b · Cited by 52
Reeds, D. N., Mohammed, B. S., Klein, S., Boswell, C., & Young, V. L. (2013) · Aesthetic Surgery Journal · doi:10.1177/1090820x13478630 · Cited by 55
Darimont, C., Avanti, O., Blancher, F., Wagnière, S., Mansourian, R., Zbinden, I., Leone-Vautravers, P., Fuerholz, A., Giusti, V., & Macé, K. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803688 · Cited by 53
Regulation of adipose tissue metabolism in cancer cachexia
Bing, C., & Trayhurn, P. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3282f948e2 · Cited by 51
Self-citationChanges in placental adipocytokine gene expression associated with gestational diabetes mellitus
Meller, M., Qiu, C., Vadachkoria, S., Abetew, D. F., Luthy, D. A., & Williams, M. (2006) · Physiological Research · doi:10.33549/physiolres.930830 · Cited by 52
Impact of Adrenal Steroids on Regulation of Adipose Tissue
Infante, M., Armani, A., Mammi, C., Fabbri, A., & Caprio, M. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160037 · Cited by 58
Obesity, inflammation, and cancer in dogs: Review and perspectives
Marchi, P. H., Vendramini, T. H. A., Perini, M. P., Zafalon, R. V. A., Amaral, A. R., Ochamotto, V. A., da Silveira, J. C., Dagli, M. L., & Brunetto, M. A. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.1004122 · Cited by 69
Ackermann, D., Jones, J. L., Barona, J., Calle, M. C., Kim, J. E., LaPia, B. J., Volek, J. S., McIntosh, M. S., Kalynych, C. J., Najm, W. I., et al. (2011) · Nutrition Research · doi:10.1016/j.nutres.2011.02.004 · Cited by 51
Núñez, I. N., Galdeano, C. M., de LeBlanc, A. D. M., & Perdigón, G. (2015) · Nutrition · doi:10.1016/j.nut.2015.02.006 · Cited by 52
Agabiti-Rosei, C., Ciuceis, C. D., Rossini, C., Porteri, E., Rodella, L. F., Withers, S., Heagerty, A. M., Favero, G., Agabiti‐Rosei, E., Rizzoni, D., et al. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000178 · Cited by 51
Leptin and Adiponectin Levels in Acute Pancreatitis
Tukiainen, E. M., Kylänpää, M., Ebeling, P., Kemppainen, E., Puolakkainen, P. A., & Repo, H. (2006) · Pancreas · doi:10.1097/01.mpa.0000202940.47837.89 · Cited by 51
Lavoie, M.-È., RABASA-LHORET, R. P. R., Doucet, É., Mignault, D., Messier, L., Jp, B., & Faraj, M. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.55 · Cited by 54
Overweight and obesity weakly predict the development of periodontal infection
Saxlin, T., Ylöstalo, P., Suominen‐Taipale, L., Aromaa, A., & Knuuttila, M. L. E. (2010) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01633.x · Cited by 53
Gaudet, M. M., Falk, R. T., Gierach, G. L., Lacey, J. V., Graubard, B. I., Dorgan, J. F., & Brinton, L. A. (2010) · Cancer Epidemiology · doi:10.1016/j.canep.2010.05.014 · Cited by 51
García-Díaz, J. A., Navarrete‐Vázquez, G., García‐Jiménez, S., Hidalgo‐Figueroa, S., Almanza-Pérez, J. C., Alarcón-Aguilar, F. J., Gómez-Zamudio, J. H., Cruz, M., Ibarra-Barajas, M., & Estrada-Soto, S. E. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.07.023 · Cited by 51
Calvert, V. S., Collantes, R. S., Elariny, H. A., Afendy, A., Baranova, A. V., Mendoza, M. V., Goodman, Z. D., Liotta, L. A., Petricoin, E. F., & Younossi, Z. M. (2007) · Hepatology · doi:10.1002/hep.21688 · Cited by 51
Musri, M. M., Gomis, R., & Párrizas, M. (2007) · Biochemistry and Cell Biology · doi:10.1139/o07-068 · Cited by 51
Harvie, M., & Howell, A. (2006) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00207.x · Cited by 51
Bounihi, A., Bitam, A., Bouazza, A., Yargui, L., & Koceir, E. A. (2017) · Pharmaceutical Biology · doi:10.1080/13880209.2016.1226369 · Cited by 50
Sultan, A., Strodthoff, D., Robertson, A.-K. L., Paulsson‐Berne, G., Fauconnier, J., Parini, P., Rydén, M., Thierry‐Mieg, N., Johansson, M. E., Chibalin, A., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.190280 · Cited by 50
Type 2 Diabetes, PUFAs, and Vitamin D: Their Relation to Inflammation
López, A. L. G., Valdés‐Ramos, R., & Martínez‐Carrillo, B. E. (2014) · Journal of Immunology Research · doi:10.1155/2014/860703 · Cited by 53
Hashemzadeh, A. A., Nasoohi, N., Raygan, F., Aghadavod, E., Akbari, E., Taghizadeh, M., Memarzadeh, M. R., & Asemi, Z. (2017) · Lipids · doi:10.1007/s11745-017-4295-5 · Cited by 51
Function and Dysfunction of Adipose Tissue
Matafome, P. N., & Seiça, R. M. F. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-63260-5_1 · Cited by 51
Nasoohi, S., Parveen, K., & Ishrat, T. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180735 · Cited by 51
Lee, T. H.-Y., Formolo, D. A., Kong, T., Lau, S. W.-Y., Ho, C. S.-L., Leung, R. Y. H., Hung, F. H.-Y., & Yau, S. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.06.002 · Cited by 49
Shaito, A. A., Hasan, H. A., Habashy, K. J., Fakih, W., Abdelhady, S., Ahmad, F., Zibara, K., Eid, A. H., EL‐Yazbi, A. F., & Kobeissy, F. H. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102829 · Cited by 50
The Role of Medicinal and Aromatic Plants against Obesity and Arthritis: A Review
Paul, A. K., Jahan, R., Paul, A., Mahboob, T., Bondhon, T. A., Jannat, K., Hasan, A., Nissapatorn, V., Wilairatana, P., Pereira, M. D. L., et al. (2022) · Nutrients · doi:10.3390/nu14050985 · Cited by 50
Kyrgios, I., Galli‐Τsinopoulou, A., Stylianou, C., Papakonstantinou, E., Arvanitidou, M., & Haidich, A. (2011) · Metabolism · doi:10.1016/j.metabol.2011.09.004 · Cited by 49
Hausman, G. J., Barb, C. R., & Dean, R. G. (2008) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2008.01.004 · Cited by 50
Increased Amount of Visceral Fat in Patients with Psoriasis Contributes to Metabolic Syndrome
Balcı, A., Balcı, D. D., Yönden, Z., Korkmaz, İ., Yenin, J. Z., Celik, E., Okumuş, N., & Eğilmez, E. (2009) · Dermatology · doi:10.1159/000254482 · Cited by 49
Nucleotide Oligomerization Domains 1 and 2: Regulation of Expression and Function in Preadipocytes
Stroh, T., Batra, A., Glauben, R., Fedke, I., Erben, U., Kroesen, A. J., Heimesaat, M. M., Bereswill, S., Girardin, S. E., Zeitz, M., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3620 · Cited by 49
Bayliak, M. M., Abrat, O., Storey, J. M., Storey, K. B., & Lushchak, V. I. (2018) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2018.09.027 · Cited by 56
Dermal Drivers of Injury-Induced Inflammation: Contribution of Adipocytes and Fibroblasts
Cooper, P. O., Haas, M. R., Noonepalle, S. K. R., & Shook, B. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041933 · Cited by 70
Potential Biomarkers of Fat Loss as a Feature of Cancer Cachexia
Ebadi, M., & Mazurak, V. C. (2015) · Mediators of Inflammation · doi:10.1155/2015/820934 · Cited by 48
Lee, M.-H., Chen, Y.-Y., Tsai, J.-W., Wang, S.-C., Watanabe, T., & Tsai, Y.-C. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.08.052 · Cited by 49
Erener, S., Mirsaidi, A., Hesse, M., Tiaden, A. N., Ellingsgaard, H., Kostadinova, R., Donath, M. Y., Richards, P. J., & Hottiger, M. O. (2012) · The FASEB Journal · doi:10.1096/fj.11-200212 · Cited by 48
Kostopoulos, C. G., Spiroglou, S. G., Varakis, J. N., Apostolakis, E. E., & Papadaki, H. H. (2014) · Cardiovascular Pathology · doi:10.1016/j.carpath.2014.02.003 · Cited by 48
Adipokines and Systemic Inflammation in Weight-Losing Lung Cancer Patients
Gülen, Ş. T., Karadağ, F., Karul, A., Kılıçarslan, N., Ceylan, E., Kuman, N. K., & Çildağ, O. (2012) · Lung · doi:10.1007/s00408-011-9364-6 · Cited by 48
Bie, J., Zhao, B., Song, J., & Ghosh, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.069781 · Cited by 48
Metadata
- Authors
- Trayhurn, P., & Wood, I. S.
- Affiliations
- University of Liverpool (GB)
- Corresponding author
- Trayhurn, Paul
- ORCID
- Trayhurn, Paul
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2004-09
- Volume
- 92
- Issue
- 3
- Pages
- 347-355
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2130764919
- Cited by
- 2,210
- References
- 89
- Citations by year
- 2026: 34 · 2025: 50 · 2024: 44 · 2023: 66 · 2022: 93 · 2021: 79 · 2020: 91 · 2019: 96 · 2018: 81 · 2017: 97 · 2016: 99 · 2015: 119 · 2014: 140 · 2013: 164 · 2012: 153
- FWCI
- 14.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Buckingham E-Archive of Research (University of Buckingham) (acceptedVersion)
- Funders
- European Commission
- University of Liverpool
- Biotechnology and Biological Sciences Research Council
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipokines, white adipose tissue, adipose tissue endocrine function, adipocyte secretome, inflammation, obesity, low-grade inflammation, acute phase response, insulin resistance, metabolic syndrome, hypoxia, HIF-1, angiogenesis, leptin, adiponectin, inflammatory cytokines
- MeSH terms
- Acute-Phase Proteins, Adipose Tissue, Hypoxia, Humans, Inflammation, Terminology as Topic, Obesity, Proteins, Cytokines, Adipocytes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
