The DOI matches its Crossref record; 86 of the 89 references it cites were found in a registry or an index.
Adipokines: inflammation and the pleiotropic role of white adipose tissue
Open accessAbstract
White adipose tissue is now recognised to be a multifunctional organ; in addition to the central role of lipid storage, it has a major endocrine function secreting several hormones, notably leptin and adiponectin, and a diverse range of other protein factors. These various protein signals have been given the collective name ‘adipocytokines’ or ‘adipokines’. However, since most are neither ‘cytokines’ nor ‘cytokine-like’, it is recommended that the term ‘adipokine’ be universally adopted to describe a protein that is secreted from (and synthesised by) adipocytes. It is suggested that the term is restricted to proteins secreted from adipocytes, excluding signals released only by the other cell types (such as macrophages) in adipose tissue. The adipokinome(which together with lipid moieties released, such as fatty acids and prostaglandins, constitute the secretome of fat cells) includes proteins involved in lipid metabolism, insulin sensitivity, the alternative complement system, vascular haemostasis, blood pressure regulation and angiogenesis, as well as the regulation of energy balance. In addition, there is a growing list of adipokines involved in inflammation (TNFα, IL-1β, IL-6, IL-8, IL-10, transforming growth factor-β, nerve growth factor) and the acute-phase response (plasminogen activator inhibitor-1, haptoglobin, serum amyloid A). Production of these proteins by adipose tissue is increased in obesity, and raised circulating levels of several acute-phase proteins and inflammatory cytokines has led to the view that the obese are characterised by a state of chronic low-grade inflammation, and that this links causally to insulin resistance and the metabolic syndrome. It is, however, unclear as to the extent to which adipose tissue contributes quantitatively to the elevated circulating levels of these factors in obesity and whether there is a generalised or local state of inflammation. The parsimonious view is that the increased production of inflammatory cytokines and acute-phase proteins by adipose tissue in obesity relates primarily to localised events within the expanding fat depots. It is suggested that these events reflect hypoxia in parts of the growing adipose tissue mass in advance of angiogenesis, and involve the key controller of the cellular response to hypoxia, the transcription factor hypoxia inducible factor-1.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“relative hypoxia in AT mediates a cascade of events that lead to the increased apoptosis and low-grade inflammation seen in obesity”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Trayhurn and Wood, 2004
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Currently, AT is characterized as an important endocrine organ present in the body, related both to the expression of various cytokines and to the regulation and coordination of energy homeostasis, blood pressure, immune function, angiogenesis, mechanical shock protection, and thermogenic function (Prins, 2002; Trayhurn and Wood, 2004).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Trayhurn and Wood, 2004
Experimental — accuracy not yet measuredIn the citing paper
“considerable evidence suggests that obesity and inflammation are significantly related [163,486,575,581,642,647-664]”
In the citing paper
“In a small study involving three healthy volunteers who received 120 mg Fe/d for a week, there were no changes in circulating CRP concentration or leucocyte counts, or in urinary neopterin concentration (725) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [725]
In the citing paper
“in addition, the adipose tissue of obesity exhibits abnormalities in the production of several adipokines that may separately affect insulin resistance and/or modify risk for ASCVD.34”
From Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement (2005) · cites this paper as [34]
In the citing paper
“Adipocyte hypertrophy creates areas of local AT microhypoxia at the earliest stages of expansion (19).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [19]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133
Role of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117
Interleukin-6 and the acute phase response
Heinrich, P. C., Castell, J. V., & Andus, T. (1990) · Biochemical Journal · doi:10.1042/bj2650621 · Cited by 2,734
Flagged first, then by citations
3 of the 89 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 301–400 of 1,001
Tkáčová, R. (2010) · Mediators of Inflammation · doi:10.1155/2010/585989 · Cited by 123
Circulating nerve growth factor levels in relation to obesity and the metabolic syndrome in women
Bulló, M., Peeraully, R., Trayhurn, P., Folch, J., & Salas‐Salvadó, J. (2007) · European Journal of Endocrinology · doi:10.1530/eje-06-0716 · Cited by 120
Self-citationLaganà, A. S., Vitale, S. G., Nigro, A., Sofo, V., Salmeri, F. M., Rossetti, P., Rapisarda, A. M. C., Vignera, S. L., Condorelli, R. A., Rizzo, G., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17070999 · Cited by 120
Association between life span and body condition in neutered client-owned dogs
Salt, C., Morris, P., Wilson, D., Lund, E. M., & German, A. J. (2018) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.15367 · Cited by 120
Rouault, C., Pellegrinelli, V., Schilch, R., Cotillard, A., Poitou, C., Tordjman, J., Sell, H., Clément, K., & Lacasa, D. (2013) · Endocrinology · doi:10.1210/en.2012-1415 · Cited by 119
Sarcopenia in chronic liver disease: mechanisms and countermeasures
Allen, S., Quinlan, J. I., Dhaliwal, A., Armstrong, M. J., Elsharkawy, A. M., Greig, C. A., Lord, J. M., Lavery, G. G., & Breen, L. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00373.2020 · Cited by 129
Adipose Tissue in Obesity—An Inflammatory Issue
Trayhurn, P. (2005) · Endocrinology · doi:10.1210/en.2004-1597 · Cited by 118
Self-citationHIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance
Takikawa, A., Mahmood, A., Nawaz, A., Kado, T., Okabe, K., Yamamoto, S., Aminuddin, A., Senda, S., Tsuneyama, K., Ikutani, M., et al. (2016) · Diabetes · doi:10.2337/db16-0012 · Cited by 117
Adipocytokine Levels in Obese and Non-obese Subjects: an Observational Study
Derosa, G., Fogari, E., D’Angelo, A., Bianchi, L., Bonaventura, A., Romano, D., & Maffioli, P. (2013) · Inflammation · doi:10.1007/s10753-013-9620-4 · Cited by 119
Periodontal complications with obesity
Suvan, J. E., Finer, N., & D’Aiuto, F. (2018) · Periodontology 2000 · doi:10.1111/prd.12239 · Cited by 122
Sempere, L., Martínez, J. F., de‐Madaria, E., Lozano, B. R., Sánchez–Payá, J., Jover, R., & Pérez‐Mateo, M. (2008) · Pancreatology · doi:10.1159/000134273 · Cited by 115
Costa, L., Caso, F., Atteno, M., PUENTE, A. D., Darda, M. A., Caso, P., Ortolan, A., Fiocco, U., Ramonda, R., Punzi, L., et al. (2013) · Clinical Rheumatology · doi:10.1007/s10067-013-2369-1 · Cited by 115
Leggate, M., Carter, W. G., Evans, M. J. C., Vennard, R. A., Sribala-Sundaram, S., & Nimmo, M. A. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01080.2011 · Cited by 113
Steckhan, N., Hohmann, C.-D., Keßler, C. S., Dobos, G., Michalsen, A., & Cramer, H. (2015) · Nutrition · doi:10.1016/j.nut.2015.09.010 · Cited by 118
Combinatorial Effects of Diet and Genetics on Inflammatory Bowel Disease Pathogenesis
Dixon, L. J., Kabi, A., Nickerson, K. P., & McDonald, C. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000289 · Cited by 113
Kolnes, K. J., Petersen, M. H., Lien-Iversen, T., Højlund, K., & Jensen, J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.737709 · Cited by 112
Zhang, X., Lam, K. S. L., Ye, H., Chung, S. K., Zhou, M., Wang, Y., & Xu, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.135509 · Cited by 112
Adipose Tissue in Metabolic Syndrome: Onset and Progression of Atherosclerosis
Luna‐Luna, M., Medina-Urrutia, A. X., Vargas‐Alarcón, G., Coss-Rovirosa, F., Vargas‐Barrón, J., & Pérez-Méndez, O. A. (2015) · Archives of Medical Research · doi:10.1016/j.arcmed.2015.05.007 · Cited by 111
Atkin, M., Laight, D. W., & Cummings, M. H. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.01.003 · Cited by 115
Overman, A., Chuang, C.-C., & McIntosh, M. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.272 · Cited by 112
Traish, A. M., Feeley, R. J., & Guay, A. T. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07305.x · Cited by 115
Yang, J., Eliasson, B., Smith, U., Cushman, S. W., & Sherman, A. (2012) · Obesity · doi:10.1038/oby.2011.371 · Cited by 117
Hassing, L. B., Dahl, A., Pedersen, N. L., & Johansson, B. E. A. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000314874 · Cited by 113
Does leptin play a cytokine-like role within the airways of COPD patients?
Bruno, A., Chanez, P., Chiappara, G., Siena, L., Giammanco, S., Gjomarkaj, M., Bonsignore, G., Bousquet, J., & Vignola, A. M. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00092404 · Cited by 108
Culture of Isolated Human Adipocytes and Isolated Adipose Tissue
Carswell, K. A., Lee, M., & Fried, S. K. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-367-7_14 · Cited by 112
Lee, S., Kallianpur, A. R., Xiang, Y., Wen, W., Cai, Q., Liu, D., Fazio, S., Linton, M. F., Zheng, W., & Shu, X. O. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0374 · Cited by 110
Tabung, F. K., Steck, S. E., Liese, A. D., Zhang, J., Ma, Y., Caan, B. J., Chlebowski, R. T., Freudenheim, J. L., Hou, L., Mossavar‐Rahmani, Y., et al. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.98 · Cited by 109
Ruiz, J. R., Ortega, F. B., Wärnberǵ, J., & Sjöstróm, M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803693 · Cited by 107
Metabolically Healthy Obesity—Heterogeneity in Definitions and Unconventional Factors
Brandão, I., Martins, M. J., & Monteiro, R. (2020) · Metabolites · doi:10.3390/metabo10020048 · Cited by 117
Schenk, J. M., Kristal, A. R., Neuhouser, M. L., Tangen, C. M., White, E., Lin, D. W., Kratz, M., & Thompson, I. M. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwp406 · Cited by 109
Adipose Tissue Vascularization: Its Role in Chronic Inflammation
Ye, J. (2011) · Current Diabetes Reports · doi:10.1007/s11892-011-0183-1 · Cited by 113
O’Hara, A., Lim, F.-L., Mazzatti, D. J., & Trayhurn, P. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0693-8 · Cited by 108
Self-citationLafontan, M. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00168.2011 · Cited by 118
Physical activity, exercise and low-grade systemic inflammation
Wärnberǵ, J., Cunningham, K., Romeo, J., & Marcos, A. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s0029665110001928 · Cited by 111
Autoimmune Aspects of Type 2 Diabetes Mellitus - A Mini-Review
Itariu, B. K., & Stulnig, T. M. (2014) · Gerontology · doi:10.1159/000356747 · Cited by 107
Current perspectives between metabolic syndrome and cancer
Micucci, C., Valli, D., Matacchione, G., & Catalano, A. (2016) · Oncotarget · doi:10.18632/oncotarget.8341 · Cited by 115
Marcello, M. A., Cunha, L. L., Batista, F. D. A., & Ward, L. S. (2014) · Endocrine Related Cancer · doi:10.1530/erc-14-0070 · Cited by 106
van den Borst, B., Gosker, H. R., Koster, A., Yu, B., Kritchevsky, S. B., Liu, Y., Meibohm, B., Rice, T. B., Shlipak, M. G., Yende, S. P., et al. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.040774 · Cited by 104
Proinflammatory CXCL12–CXCR4/CXCR7 Signaling Axis Drives Myc-Induced Prostate Cancer in Obese Mice
Saha, A., Ahn, S., Blando, J. M., Su, F., Kolonin, M. G., & DiGiovanni, J. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0284 · Cited by 105
Serum Amyloid A: A Marker of Adiposity‐induced Low‐grade Inflammation but Not of Metabolic Status
Poitou, C., Coussieu, C., Rouault, C., Coupaye, M., Cancello, R., Bedel, J., Gouillon, M., Bouillot, J., Oppert, J., Basdevant, A., et al. (2006) · Obesity · doi:10.1038/oby.2006.40 · Cited by 105
Metabolic Inflammation in Inflammatory Bowel Disease
Gonçalves, P., Magro, F., & Martel, F. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000209 · Cited by 107
Role of histone methylation and demethylation in adipogenesis and obesity
Okamura, M., Inagaki, T., Tanaka, T., & Sakai, J. (2010) · Organogenesis · doi:10.4161/org.6.1.11121 · Cited by 104
Campión, J., Milagro, F. I., & Martínez, J. A. (2010) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-375003-7.00011-x · Cited by 106
Exploring the pathogenesis of IIH: An inflammatory perspective
Sinclair, A. J., Ball, A. K., Burdon, M., Clarke, C. E., Stewart, P. M., Curnow, J., & Rauz, S. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.06.029 · Cited by 107
The obesity epidemic and its cardiovascular consequences
Behn, A., & Ur, E. (2006) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000231406.84554.96 · Cited by 104
Teixeira, L. G., Leonel, A. J., Aguilar, E. C., Batista, N. V., Alves, A. C., Coimbra, C. C., Ferreira, A. V. M., Faria, A. M. C., Cara, D. C., & Alvarez-Leite, J. I. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-204 · Cited by 103
The impact of obesity on skin disease and epidermal permeability barrier status
Guida, B., Nino, M., Perrino, N. R., Laccetti, R., Trio, R., Labella, S., & Balato, N. (2009) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2009.03503.x · Cited by 103
Marrache, F., Vullierme, M., Roy, C., Assoued, Y. E., Couvelard, A., O’Toole, D., Mitry, E., Hentic, O., Hammel, P. R., Lévy, P., et al. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603526 · Cited by 103
Low-grade inflammation and the metabolic syndrome in children and adolescents
Wärnberǵ, J., & Marcos, A. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282f4096b · Cited by 102
Trayhurn, P. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2004406 · Cited by 106
Self-citationTsai, S., Chung, K., Wu, J.-Y., Kuo, C., Lee, H., & Huang, S. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.022 · Cited by 103
Seminal plasma adipokine levels are correlated with functional characteristics of spermatozoa
Thomas, S., Kratzsch, D., Schaab, M., Scholz, M. R., Grunewald, S., Thiery, J., Paasch, U., & Kratzsch, J. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.12.022 · Cited by 102
Hypertension in Metabolic Syndrome: Vascular Pathophysiology
Mendizábal, Y., Llorens, S., & Nava, E. (2013) · International Journal of Hypertension · doi:10.1155/2013/230868 · Cited by 107
The role of testosterone in the metabolic syndrome: A review
Saad, F., & Gooren, L. J. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.12.022 · Cited by 100
The FGF21–adiponectin axis in controlling energy and vascular homeostasis
Hui, X. H., Feng, T., Liu, Q., Gao, Y., & Xu, A. (2016) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjw013 · Cited by 103
Schmidt, S., Monk, J. M., Robinson, L. E., & Mourtzakis, M. (2015) · Obesity Reviews · doi:10.1111/obr.12281 · Cited by 104
Sukumar, P., Sedó, A., Li, J., Wilson, L. A., O'Regan, D., Lippiat, J. D., Porter, K. E., Kearney, M. T., Ainscough, J., & Beech, D. J. (2012) · Circulation Research · doi:10.1161/circresaha.112.270751 · Cited by 101
Endurance training induces depot-specific changes in IL-10/TNF-alpha ratio in rat adipose tissue.
Lira, F. S., Neto, J. C. R., Yamashita, A. S., Koyama, C. H., Júnior, M. L. B., & Seelaender, M. C. L. (2009) · PubMed · doi:10.1016/j.cyto.2008.10.018 · Cited by 100
Adipose tissue, serum adipokines, and ghrelin in patients with ankylosing spondylitis
Toussirot, É., Streit, G., Nguyen, N. U., Dumoulin, G., Lehuédé, G., Saas, P., & Wendling, D. (2007) · Metabolism · doi:10.1016/j.metabol.2007.05.009 · Cited by 102
Adipose tissue dysfunction and hypertriglyceridemia: mechanisms and management
van de Woestijne, A. P., Monajemi, H., Kalkhoven, E., & Visseren, F. L. J. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00900.x · Cited by 100
Obesity, Inflammation, and Vascular Disease
Calabrò, P., & Yeh, E. T. H. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/1-4020-5688-5_3 · Cited by 101
Alam, I., Ng, T. P., & Larbi, A. (2012) · Mediators of Inflammation · doi:10.1155/2012/456456 · Cited by 102
Chung, J. Y., Ain, Q. U., Song, Y., Yong, S., & Kim, Y. (2019) · Genome Research · doi:10.1101/gr.246900.118 · Cited by 102
Sakamoto, Y. S., Kanatsu, J., Toh, M., Naka, A., Kondo, K., & Iida, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149676 · Cited by 98
Yoshida, H., Takamura, N., Shuto, T., Ogata, K., Tokunaga, J., Kawai, K., & Kai, H. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.060 · Cited by 102
SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation
Toubal, A., Clément, K., Fan, R., Ancel, P., Pelloux, V., Rouault, C., Veyrie, N., Hartemann, A., Treuter, E., & Venteclef, N. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64052 · Cited by 97
Karkeni, E., Marcotorchino, J., Tourniaire, F., Astier, J., Peiretti, F., Darmon, P., & Landrier, J. (2015) · Endocrinology · doi:10.1210/en.2014-1647 · Cited by 99
The Role of Adipokines in Understanding the Associations between Obesity and Depression
Taylor, V. H., & MacQUEEN, G. M. (2010) · Journal of Obesity · doi:10.1155/2010/748048 · Cited by 97
Genetics of Oxidative Stress in Obesity
Rupérez, A. I., Gil, Á., & Aguilera, C. M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15023118 · Cited by 96
Croze, M. L., Vella, R., Pillon, N. J., Soula, H. A., Hadji, L., Guichardant, M., & Soulage, C. O. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.01.008 · Cited by 97
Lasselin, J., Magne, E., Beau, C., Ledaguenel, P., Dexpert, S., Aubert, A., Layé, S., & Capuron, L. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2673 · Cited by 96
Gustavsson, N., & Han, W. (2009) · Bioscience Reports · doi:10.1042/bsr20090031 · Cited by 91
Pasarica, M., Rood, J. C., Ravussin, É., Schwarz, J., Smith, S. R., & Redman, L. M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2377 · Cited by 96
The Many Faces of Obesity and Its Influence on Breast Cancer Risk
Agurs‐Collins, T., Ross, S. A., & Dunn, B. K. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00765 · Cited by 102
Metabolic Syndrome and Skin Diseases
Hu, Y., Zhu, Y. X., Lian, N., Chen, M., Bartke, A., & Yuan, R. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00788 · Cited by 137
Chemerin regulation and role in host defense.
Zabel, B. A., Kwitniewski, M., Banaś, M., Zabieglo, K., Murzyn, K., & Cichy, J. (2014) · Europe PMC (PubMed Central) · Cited by 102
New insights into adipose tissue atrophy in cancer cachexia
Bing, C., & Trayhurn, P. (2009) · Proceedings of The Nutrition Society · doi:10.1017/s0029665109990267 · Cited by 96
Self-citationEpidemiology, Etiology, and Prevention of Prostate Cancer
Abouassaly, R., Thompson, I. M., Platz, E. A., & Klein, E. A. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4160-6911-9.00095-5 · Cited by 96
Consequences of Weight Cycling: An Increase in Disease Risk?
Strohacker, K. A., Carpenter, K. C., & McFarlin, B. K. (2009) · International journal of exercise science · doi:10.70252/asaq8961 · Cited by 98
Calcitriol and calcium regulate cytokine production and adipocyte–macrophage cross-talk
Sun, X., & Zemel, M. B. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.05.013 · Cited by 95
Spoto, B., Betta, E. D., Mattace-Raso, F. U. S., Sijbrands, E. J. G., Vilardi, A., Parlongo, R. M., Pizzini, P., Pisano, A., Vermi, W., Testa, A., et al. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.04.017 · Cited by 93
Genetics, epigenetics and transgenerational transmission of obesity in children
Panera, N., Mandato, C., Crudele, A., Bertrando, S., Vajro, P., & Alisi, A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1006008 · Cited by 107
Ryan, K. E., McCance, D. R., Powell, L., McMahon, R., & Trimble, E. R. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.11.007 · Cited by 94
Association of colorectal adenoma with components of metabolic syndrome
Kim, B. C., Shin, A., Hong, C. W., Sohn, D. K., Han, K. S., Ryu, K. H., Park, B.-J., Nam, J. H., Park, J. W., Chang, H. J., et al. (2012) · Cancer Causes & Control · doi:10.1007/s10552-012-9942-9 · Cited by 94
Tatsukawa, Y., Hsu, W., Yamada, M., COLOGNE, J. B., Suzuki, G., Yamamoto, H., Yamane, K., Akahoshi, M., Fujiwara, S., & Kohno, N. (2008) · Hypertension Research · doi:10.1291/hypres.31.1391 · Cited by 92
Wood, I. S., Wang, B., Jenkins, J. R., & Trayhurn, P. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.09.068 · Cited by 94
Self-citationIon Imbalance Is Involved in the Mechanisms of Liver Oxidative Damage in Rats Exposed to Glyphosate
Tang, J., Hu, P., Li, Y., Win‐Shwe, T., & Li, C. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01083 · Cited by 97
van Rooy, M.-J., & Pretorius, E. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666131227162950 · Cited by 95
Trayhurn, P., & Alomar, S. Y. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00019 · Cited by 99
Self-citationLeptin in Atherosclerosis: Focus on Macrophages, Endothelial and Smooth Muscle Cells
Raman, P., & Khanal, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115446 · Cited by 99
Influence of obesity physical inactivity and weight cycling on chronic inflammation
McFarlin, B. K. (2010) · Frontiers in Bioscience-Elite · doi:10.2741/e70 · Cited by 94
What are subcutaneous adipocytes really good for…?
Paus, R., Klein, J. C., Permana, P. A., Owecki, M., Chaldakov, G. N., Böhm, M., Hausman, G., Lapiere, C. M., Atanassova, P. K., Sowiński, J., et al. (2006) · Experimental Dermatology · doi:10.1111/j.1600-0625.2006.00519_1.x · Cited by 101
Lee, K. Y., Gesta, S., Boucher, J., Wang, X. L., & Kahn, C. R. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.006 · Cited by 97
Clementi, A. H., Gaudy, A. M., van Rooijen, N., Pierce, R. H., & Mooney, R. A. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.08.007 · Cited by 95
Ellulu, M. S. (2017) · Inflammopharmacology · doi:10.1007/s10787-017-0314-7 · Cited by 93
Calcaterra, V., Vandoni, M., Rossi, V., Berardo, C., Grazi, R., Cordaro, E., Tranfaglia, V., Pellino, V. C., Cereda, C., & Zuccotti, G. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19116908 · Cited by 100
Obesity, visceral fat and Crohnʼs disease
Bertin, B., Desreumaux, P., & Dubuquoy, L. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32833cf0f4 · Cited by 91
Interleukin-15: A muscle-derived cytokine regulating fat-to-lean body composition1,2
Quinn, L. S. (2008) · Journal of Animal Science · doi:10.2527/jas.2007-0458 · Cited by 91
Starr, M. E., Saito, M., Evers, B. M., & Saitō, H. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu197 · Cited by 90
Lainampetch, J., Phienluphon, P. P., Phosat, C., Chumpathat, N., Prangthip, P., Soonthornworasiri, N., Puduang, S., Wechjakwen, N., & Kwanbunjan, K. (2019) · Journal of Diabetes Research · doi:10.1155/2019/9051929 · Cited by 98
Metadata
- Authors
- Trayhurn, P., & Wood, I. S.
- Affiliations
- University of Liverpool (GB)
- Corresponding author
- Trayhurn, Paul
- ORCID
- Trayhurn, Paul
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2004-09
- Volume
- 92
- Issue
- 3
- Pages
- 347-355
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2130764919
- Cited by
- 2,210
- References
- 89
- Citations by year
- 2026: 34 · 2025: 50 · 2024: 44 · 2023: 66 · 2022: 93 · 2021: 79 · 2020: 91 · 2019: 96 · 2018: 81 · 2017: 97 · 2016: 99 · 2015: 119 · 2014: 140 · 2013: 164 · 2012: 153
- FWCI
- 14.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Buckingham E-Archive of Research (University of Buckingham) (acceptedVersion)
- Funders
- European Commission
- University of Liverpool
- Biotechnology and Biological Sciences Research Council
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipokines, white adipose tissue, adipose tissue endocrine function, adipocyte secretome, inflammation, obesity, low-grade inflammation, acute phase response, insulin resistance, metabolic syndrome, hypoxia, HIF-1, angiogenesis, leptin, adiponectin, inflammatory cytokines
- MeSH terms
- Acute-Phase Proteins, Adipose Tissue, Hypoxia, Humans, Inflammation, Terminology as Topic, Obesity, Proteins, Cytokines, Adipocytes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
