Improvement of the human intestinal flora by ingestion of the probiotic strain Lactobacillus johnsonii La1
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To exert beneficial effects for the host, for example, improving the intestinal microflora, a probiotic must reach the intestine as a viable strain. These properties must be demonstrated by in vitro as well as in vivo methods. However, only a few well-designed human clinical studies have shown these properties.Lactobacillus johnsonii La1 has been shown to give many beneficial effects for the host, but it is unclear whether a viable strain of L. johnsonii La1 has the effect of improving host intestinal microflora. In the present study, a randomised double-blind placebo-controlled cross-over trial was conducted to elucidate the effect of L. johnsonii La1 on human intestinal microflora. Twenty-two young healthy Japanese women were randomly divided into two groups, and either received fermented milk with L. johnsonii La1 or a fermented milk without L. johnsonii La1 (placebo) daily for 21d. Consumption of the fermented milk: (a) increased total Bifidobacterium and Lactobacillus, and decreased lecithinase-positive Clostridium in the faeces; (b) increased the faecal lactic acid concentrations; (c) decreased the faecal pH; (d) increased the defecation frequency. These changes were stronger than those observed with the placebo.L. johnsonii La1 was identified in all subjects only after the consumption of the fermented milk. These results suggest that L. johnsonii La1 can contribute to improve intestinal microflora with probiotic properties.
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The specific fermented milk improves transit time in healthy populations.
“This probiotic food has been shown to improve digestive comfort and symptoms in IBS with predominant constipation (IBS-C) (13,14) as well as transit time in both healthy (15 -17) and IBS-C populations (13) .”
Probiotics have been shown to improve bowel habits or transit time in healthy populations.
“The ability of probiotics to improve bowel habits or transit time has been shown in healthy populations.”
The fermented dairy product studied can shorten transit time in healthy people and in IBS patients.
“The fermented dairy product used in the present study is also able to decrease transit time in both healthy (15 -17) and IBS populations (13) .”
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- Authors
- Yamano, T., Iino, H., Takada, M., Blum, S., Rochat, F., & Fukushima, Y.
- Affiliations
- Showa Women's University (JP)
- Nestlé (Switzerland) (CH)
- Corresponding author
- Fukushima, Yoichi
- ORCID
- Fukushima, Yoichi
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2006-02
- Volume
- 95
- Issue
- 2
- Pages
- 303-312
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2141565032
- Cited by
- 98
- References
- 58
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 1 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 7 · 2018: 1 · 2017: 2 · 2015: 4 · 2014: 6 · 2013: 11 · 2012: 6
- FWCI
- 14.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- reroDoc Digital Library (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- probiotics, gut microbiota, fermented milk, fecal pH, stool frequency, healthy women
- MeSH terms
- Adult, Bacterial Adhesion, Bifidobacterium, Clostridium, Culture Media, Defecation, Double-Blind Method, Feces, Female, Humans, Hydrogen-Ion Concentration, Intestines, Lactobacillus, Cross-Over Studies, Caco-2 Cells, Lactic Acid, Probiotics, Cultured Milk Products
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