The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Putting cardiovascular disease and vitamin D insufficiency into perspective
Open accessAbstract
The aetiology of CVD is still not completely understood. The present review article summarises data supporting the hypothesis that an insufficient vitamin D status may contribute to the worldwide high prevalence of CVD. Human vitamin D status primarily depends on skin exposure to the UVB spectrum of the sunlight. Epidemiological data indicate that geographic latitude, altitude, season, and the place of residence (urban or rural) are associated with CVD mortality. Interestingly, all these factors also have an influence on human UVB exposure and thus on vitamin D status. Several mechanisms might be responsible for a protective role of vitamin D in CVD. These mechanisms include the inhibition of vascular smooth muscle proliferation, the suppression of vascular calcification, the down regulation of pro-inflammatory cytokines, the up regulation of anti-inflammatory cytokines, and the action of vitamin D as a negative endocrine regulator of the renin–angiotensin system. The first intervention trials indicate that vitamin D may suppress cardiovascular risk markers. However, more controlled clinical trials are needed to investigate whether optimal oral vitamin D supplementation is able to reduce CVD morbidity and mortality.
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Cites
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Mortality by cause for eight regions of the world: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07493-4 · Cited by 4,043 · cited 1×
“In 1990, the developing countries contributed 63% of world mortality due to CVD (Murray & Lopez, 1997).”
BackgroundDecreased bioavailability of vitamin D in obesity
Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z., & Holick, M. F. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.690 · Cited by 3,204
1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system
Li, Y. C., Kong, J., Wei, M., Chen, Z.-F., Liu, S. Q., & Cao, L.-P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215219 · Cited by 1,625
Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited
Glerup, H., Mikkelsen, K., Poulsen, L., Hass, E., Overbeck, S., Thomsen, J., Charles, P., & Eriksen, E. F. (2000) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2000.00595.x · Cited by 436
Cited by
Autier, P. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.16.1730 · Cited by 1,104
Hyppönen, E., & Power, C. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.860 · Cited by 756
From space to Earth: Advances in human physiology from 20 years of bed rest studies (1986–2006)
Pavy-Le Traon, A., Heer, M., Narici, M. V., Rittweger, J., & Vernikos, J. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0474-z · Cited by 658
Shea, M. K., Booth, S. L., Massaro, J. M., Jacques, P. F., D'Agostino, R. B., Dawson-Hughes, B., Ordovas, J. M., O'Donnell, C. J., Kathiresan, S., Keaney, J. F., et al. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm306 · Cited by 316
Tomaschitz, A., Pilz, S., Ritz, E., Grammer, T., Drechsler, C., Boehm, B. O., & März, W. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.05.037 · Cited by 246
Metadata
- Authors
- Zittermann, A., Schleithoff, S. S., & Koerfer, R.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2005-10
- Volume
- 94
- Issue
- 4
- Pages
- 483-492
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2157482325
- Cited by
- 419
- References
- 5
- FWCI
- 11.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
