Timing of nutrient restriction and programming of fetal adipose tissue development
Open accessAbstract
It is apparent from epidemiological studies that the timing of maternal nutrient restriction has a major influence on outcome in terms of predisposing the resulting offspring to adult obesity. The present review will consider the extent to which maternal age, parity and nutritional restriction at defined stages of gestation can have important effects on fat deposition and endocrine sensitivity of adipose tissue in the offspring. For example, in 1-year-old sheep the offspring of juvenile mothers have substantially reduced fat deposition compared with those born to adult mothers. Offspring of primiparous adult mothers, however, show increased adiposity compared with those born to multiparous mothers. These offspring of multiparous ewes show retained abundance of the brown adipose tissue-specific uncoupling protein 1 at 1 month of age. A stimulated rate of metabolism in brown fat of these offspring may act to reduce adipose tissue deposition in later life. In terms of defined windows of development that can programme adipose tissue growth, maternal nutrient restriction targetted over the period of maximal placental growth results in increased adiposity at term in conjunction with enhanced abundance of mRNA for the insulin-like growth factor-I and -II receptors. In contrast, nutrient restriction in late gestation, coincident with the period of maximal fetal growth, has no major effect on adiposity but results in greater abundance of specific mitochondrial proteins, i.e. voltage-dependent anion channel and/or uncoupling protein 2. These adaptations may increase the predisposal of these offspring to adult obesity. Increasing maternal nutrition in late gestation, however, can result in proportionately less fetal adipose tissue deposition in conjunction with enhanced abundance of uncoupling protein 1.
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The timing of a nutrient restriction in sheep plays a role in determining the offspring outcome: exposure up to day 110 of sheep gestation promotes adipose tissue deposition in the fetal lamb at term, whereas continuing the nutrient restriction after this time decreases adipose tissue mass.
“Symonds et al. found the timing of a nutrient restriction in sheep plays a role in determining the offspring outcome [26]. They found that exposure to maternal nutrient restriction up to day 110 of sheep gestation (term = 145 days) promoted adipose tissue deposition in the fetal lamb at term, whereas continuing the nutrient restriction after this time decreased adipose tissue mass.”
From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [26]
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- Authors
- Symonds, M. E., Pearce, S., Bispham, J., Gardner, D. S., & Stephenson, T.
- Affiliations
- Queen's Medical Centre (GB)
- Corresponding author
- Symonds, Michael E.
- Venue
- Proceedings of the Nutrition Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2004-08
- Volume
- 63
- Issue
- 3
- Pages
- 397-403
- ISSN
- 0029-6651 (ISSN-L)
- 1475-2719
- OpenAlex
- W2100221045
- Cited by
- 121
- References
- 52
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 9 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 8 · 2014: 6 · 2013: 6 · 2012: 5
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of The Nutrition Society (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- maternal nutrient restriction, fetal programming, adult obesity, maternal age, parity, brown adipose tissue, UCP1, UCP2, IGF-1 receptor, insulin-like growth factor II receptor, placental development, fetal growth, mitochondrial proteins, voltage-dependent anion channel
- MeSH terms
- Adipose Tissue, Adult, Animals, Diet, Reducing, Endocrine System, Female, Embryonic and Fetal Development, Humans, Maternal Age, Obesity, Parity, Pregnancy, Prenatal Exposure Delayed Effects, Maternal Nutritional Physiological Phenomena, Prenatal Nutritional Physiological Phenomena
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