Fatty acids and the metabolic syndrome

Roche, Helen M.

doi:10.1079/pns2004405

Cited by 113Fatty Acid Research and HealthDiet, Metabolism, and DiseaseAdipokines, Inflammation, and Metabolic Diseases

Fatty acids and the metabolic syndrome

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Roche, Helen M.·2005·Proceedings of The Nutrition Society

DOI 10.1079/pns2004405

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Abstract

The metabolic syndrome is a very common condition, characterised by insulin resistance, dyslipidaemia, abdominal obesity and hypertension, that is associated with a high risk of type 2 diabetes mellitus (T2DM) and CVD. Obesity is a key aetiological factor in the development of the metabolic syndrome. In light of the increasing prevalence of obesity, there is a high requirement to reduce the impact of the adverse health effects associated with the metabolic syndrome. The aetiological role of nutrient-derived metabolic stressors, in particular fatty acids, in the development of obesity and the metabolic syndrome is explored. Also, the evidence that pro-inflammatory stressors may predispose to obesity-induced insulin resistance is reviewed. The present paper explores the concept that reducing the impact of metabolic and inflammatory stressors may reduce the adverse health effects of obesity and slow the progression towards the metabolic syndrome and T2DM. Evidence from human dietary intervention studies that have investigated the potential therapeutic effects of dietary fatty acid modification is explored. The present review highlights the requirement to take account of genetic background, within the context of nutrient regulation of gene expression and individual responsiveness to dietary therapy. This approach will further the understanding of the interaction between fatty acids in the pathogenesis and progression of the metabolic syndrome.

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The impact of fatty acids on metabolic health is dictated by their chemical characteristics, with unsaturated, medium- and short-chain fatty acids being beneficial compared to long-chain saturated fatty acids.
“especially considering that the impact of fatty acids on metabolic health is dictated by their chemical characteristics with unsaturated fatty acids, medium- and short-chain fatty acids being proven as beneficial to metabolic health, compared to long-chain saturated fatty acids (Roche, 2005; Holland et al., 2007; van Dijk et al., 2009;”
From Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet (2019) · cites this paper as Roche, 2005

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Authors: Roche, H. M.
Affiliations: Trinity College Dublin (IE)
Corresponding author: Roche, Helen M.
ORCID: Roche, Helen M.
Venue: Proceedings of The Nutrition Society
Publisher: Cambridge University Press (CUP)
Published: 2005-02
Volume: 64
Issue: 1
Pages: 23-29
ISSN: 0029-6651 (ISSN-L)
1475-2719
DOI: 10.1079/pns2004405
OpenAlex: W2135965067
Cited by: 113
References: 58
Citations by year: 2026: 5 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 8 · 2017: 4 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 6 · 2012: 10
FWCI: 0.99
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 764 d)
Locations: Proceedings of The Nutrition Society (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords: metabolic syndrome, fatty acids, obesity, insulin resistance, type 2 diabetes, dyslipidemia, hypertension, abdominal obesity, dietary intervention, inflammation, genetic background
MeSH terms: Animals, Dietary Fats, Fatty Acids, Gene Expression Regulation, Humans, Insulin Resistance, Obesity, Metabolic Syndrome

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