Role of Oxidative and Antioxidative Parameters in Etiopathogenesis and Prognosis of Panic Disorder
Abstract
Free radicals have been implicated in some psychiatric disorders. This study aimed to investigate the role of oxidative and antioxidative parameters in etiopathogenesis and prognosis of panic disorder (PD), using novel methods for measurement of total oxidant and antioxidant statuses. Nineteen PD patients and 40 healthy subjects were recruited. Both total antioxidant status and oxidative stress index, and ceruloplasmin levels of PD patients were significantly higher in PD patients. Total oxidant status and oxidative stress index decreased after treatment. This study suggests an oxidative imbalance in PD and treatment can reverse overall oxidative imbalance.
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Increased oxidative damage occurs quite often in panic disorder.
“panic disorder (PD) [15, 16]”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [15]
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- Authors
- Ersoy, M. A., Selek, S., Celik, H., Erel, O., Kaya, M. C., Savas, H. A., & Herken, H.
- Affiliations
- Ege University (TR)
- Gaziantep University (TR)
- Pamukkale University (TR)
- Venue
- International Journal of Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2008-01
- Volume
- 118
- Issue
- 7
- Pages
- 1025-1037
- ISSN
- 0020-7454 (ISSN-L)
- 1543-5245
- OpenAlex
- W2062643764
- Cited by
- 39
- References
- 27
- Citations by year
- 2023: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 9 · 2014: 5 · 2013: 4 · 2012: 3
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- AYBU AVESIS (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- panic disorder, oxidative stress, antioxidant status, total antioxidant status, oxidative stress index, ceruloplasmin, free radicals, etiopathogenesis, prognosis, treatment response
- MeSH terms
- Adult, Antioxidants, Brain, Brain Chemistry, Ceruloplasmin, Energy Metabolism, Female, Free Radicals, Humans, Male, Middle Aged, Prognosis, Sulfur Compounds, Biomarkers, Up-Regulation, Panic Disorder, Oxidants, Oxidative Stress
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