Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments
Abstract
Background Reactive oxygen species (ROS) may play a role in some neuropsychiatric disorders. There is some evidence that the activation of immune-inflammatory process, increase of monoamines catabolism, and abnormalities in lipid compounds may cause overproduction of ROS and, in turn, antioxidative enzyme activities (AEAs) and lipid peroxidation (LP), and that these phenomena may be related to pathophysiology of major depression.Methods The aims of this study were (i) to examine the AEAs and LP levels of the major depressed (MD) patients, and to compare these with healthy controls; and (ii) to investigate the effect of subchronic treatment with selective serotonin reuptake inhibitors (SSRIs) on AEAs and LP levels in MD subjects. Thirty MD patients, and 32 healthy controls (HC) participated in this study. AEAs and LP levels were determined by measuring several antioxidative enzymes and malondialdehyde (MDA) levels in plasma and/or in red blood cells.Results Major depressed patients, especially melancholic patients, had higher AEA and LP levels than those of healthy controls. After treatment for 3 months with SSRIs, AEA and LP levels of the patients were significantly decreased to normal levels.Conclusion These findings suggest that (i) major depression, especially with melancholia, is associated with elevated AEAs and LP, and that (ii) subchronic treatment with SSRIs may have a suppressive effect on AEA and LP. CLINICAL IMPLICATION AND LIMITATION: AEAs might be used for monitoring SSRIs effects.
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Bilici et al. (2001) reported increased oxidative stress in major depressive patients (n = 32), indexed by higher antioxidant enzyme activities (erythrocyte SOD, GPx, and plasmatic GR) and MDA levels (erythrocyte and plasmatic).
“Bilici et al. (2001) reported increased oxidative stress in major depressive patients (n = 32), indexed by higher antioxidant enzyme activities (erythrocyte SOD, GPx, and plasmatic GR) and MDA levels (erythrocyte and plasmatic).”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [30]
After 12 weeks of treatment with four different SSRIs, plasmatic GPx and MDA levels were restored to control levels in major depressive patients.
“After treatment with four different SSRIs drugs (fluoxetine 20 mg/day, n = 7; sertraline 50 mg/day, n = 13; fluvoxamine 100 mg/day, n = 5; or citalopram 20 mg/day, n = 5), for 12 weeks, antioxidant enzyme activities (plasmatic GPx) and MDA levels (plasma and erythrocyte) were restored to control levels.”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [30]
Plasmatic GR and erythrocyte SOD were significantly decreased in MD patients after 12-week antidepressant treatment.
“Plasmatic GR and erythrocyte SOD were also significantly decreased in MD patients after 12-week antidepressant treatment [30].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [30]
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- Authors
- Bilici, M., Efe, H., Köroğlu, M. A., Uydu, H. A., Bekaroğlu, M., & Değer, O.
- Affiliations
- Karadeniz Technical University (TR)
- Corresponding author
- Bilici, Mustafa
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2001-04
- Volume
- 64
- Issue
- 1
- Pages
- 43-51
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2081363371
- Cited by
- 718
- References
- 51
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 18 · 2023: 22 · 2022: 29 · 2021: 34 · 2020: 41 · 2019: 31 · 2018: 34 · 2017: 41 · 2016: 38 · 2015: 51 · 2014: 56 · 2013: 58 · 2012: 48
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- major depressive disorder, endogenous depression, antioxidant enzymes, lipid peroxidation, reactive oxygen species, selective serotonin reuptake inhibitors, antidepressant treatment, malondialdehyde, oxidative stress, treatment monitoring
- MeSH terms
- Adult, Age Factors, Antidepressive Agents, Catalase, Cholesterol, Major Depressive Disorder, Erythrocyte Count, Female, Glutathione Peroxidase, Glutathione Reductase, Humans, Male, Malondialdehyde, Triglycerides, Lipid Peroxidation, Reactive Oxygen Species
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