The platelet activating factor receptor is not required for exacerbation of bacterial pneumonia following influenza
Open accessAbstract
Pneumonia caused by Streptococcus pneumoniae is a significant cause of morbidity and mortality during influenza virus epidemics. We had previously advanced the hypothesis that interactions of pneumococcus with the receptor for platelet activating factor (PAFR) in the lung were facilitated by antecedent influenza virus infection and play a major role in the pathogenesis of bacterial superinfections. Although influenza enhanced the adherence of pneumococci to respiratory epithelial cells in vitro, chemical or antibody-mediated blockade of the PAFR did not affect adherence. In agreement with these data, mice lacking PAFR had similar bacterial loads within the lung compartment when compared to heterozygous littermates and were not protected from secondary pneumococcal pneumonia after influenza. Lack of support for this hypothesis and the observation of enhanced inflammation during secondary pneumococcal pneumonia in mice lacking PAFR may moderate enthusiasm for treatment strategies targeting the interaction of bacteria with PAFR.
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TLRs play a crucial role in the initiation of immune responses in the respiratory epithelium.
“TLRs play a crucial role in the initiation of immune responses in the respiratory epithelium (45, 175).”
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- Authors
- Mccullers, J. A., Iverson, A. R., Mckeon, R., & Murray, P. J.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Mccullers, Jonathan A.
- Venue
- Scandinavian Journal of Infectious Diseases
- Publisher
- Informa UK Limited
- Published
- 2008-01
- Volume
- 40
- Issue
- 1
- Pages
- 11-17
- ISSN
- 0036-5548 (ISSN-L)
- 1651-1980
- PMC
- PMC2715993
- OpenAlex
- W2073410199
- Cited by
- 36
- References
- 37
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2013: 5 · 2012: 1
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Scandinavian Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- World Health Organization
- American Lebanese Syrian Associated Charities
- National Institute of Allergy and Infectious Diseases (AI-54802, AI66349, R21AI054802, R01AI066349)
- Topics
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- platelet-activating factor receptor, Streptococcus pneumoniae, secondary bacterial infection, influenza virus, bacterial adhesion, airway epithelial cells, lung inflammation, host-pathogen interaction
- MeSH terms
- Animals, Bacterial Adhesion, Disease Models, Animal, Female, Male, Orthomyxoviridae Infections, Platelet Membrane Glycoproteins, Pneumonia, Pneumococcal, Streptococcus pneumoniae, Superinfection, Mice, Knockout, Receptors, G-Protein-Coupled, Mice, Influenza A Virus, H1N1 Subtype
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