Cited by 486Air Quality and Health ImpactsCoal and Its By-productsOccupational and environmental lung diseases

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

SOLUBLE TRANSITION METALS MEDIATE RESIDUAL OIL FLY ASH INDUCED ACUTE LUNG INJURY

Kevin L. Dreher, Richard H. Jaskot,·1997·Journal of Toxicology and Environmental Health

Open this paper in CoChat — free account

Abstract

Identification of constituents responsible for the pulmonary toxicity of fugitive combustion emission source particles may provide insight into the adverse health effects associated with exposure to these particles as well as ambient air particulate pollution. Herein, we describe results of studies conducted to identify constituents responsible for the acute lung injury induced by residual oil fly ash (ROFA) and to assess physical-chemical factors that influence the pulmonary toxicity of these constituents. Biochemical and cellular analyses performed on bronchoalveolar lavage fluid obtained from rats following intratracheal instillation of ROFA suspension demonstrated the presence of severe inflammation, an indicator of pulmonary injury, which included recruitment of neutrophils, eosinophils, and monocytes into the airway. A leachate prepared from ROFA, containing predominantly Fe, Ni, V, Ca, Mg, and sulfate, produced similar lung injury to that induced by ROFA suspension. Depletion of Fe, Ni, and V from the ROFA leachate abrogated its pulmonary toxicity. Correspondingly, minimal lung injury was observed in animals exposed to saline-washed ROFA particles. A surrogate transition metal sulfate solution containing Fe, V, and Ni largely reproduced the lung injury induced by ROFA. Metal interactions and pH were found to influence the severity and kinetics of lung injury induced by ROFA and soluble transition metals. These findings provide direct evidence for the role of soluble transition metals in the pulmonary injury induced by the combustion emission source particulate, ROFA.

Integrity signals

Registry

Crossref · 10.1080/009841097160492

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

An association between air pollution and mortality in six U.S. cities
Dockery, D. W., Pope, C. A., Xu, X., Spengler, J. D., Ware, J. H., Fay, M. E., Ferris, B. G., & Speizer, F. E. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312093292401 · Cited by 8,018
Oxidative mechanisms in the toxicity of metal ions
Stohs, S. J., & Bagchi, D. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00159-h · Cited by 4,219
Activation of Interleukin-6 Gene Expression through the NF-κB Transcription Factor
Libermann, T. A., & Baltimore, D. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.5.2327 · Cited by 1,403
NF-kappa B subunit-specific regulation of the interleukin-8 promoter.
KUNSCH, C. A., & Rosen, C. A. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6137-6146.1993 · Cited by 533
Air Pollution and Hospital Admissions for Cardiovascular Disease in Detroit, Michigan
Schwartz, J. D., & Morris, R. D. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117541 · Cited by 506
Toxic Trace Elements: Preferential Concentration in Respirable Particles
Natusch, D. F. S., Wallace, J. R., & Evans, C. A. (1974) · Science · doi:10.1126/science.183.4121.202 · Cited by 400
Toxic Trace Elements Associated with Airborne Particulate Matter: A Review
Schroeder, W. H., Dobson, M., Kane, D., & Johnson, N. D. (1987) · JAPCA · doi:10.1080/08940630.1987.10466321 · Cited by 321
Associations between Ambient Particulate Sulfate and Admissions to Ontario Hospitals for Cardiac and Respiratory Diseases
Burnett, R. T., Dales, R., Krewski, D. R., Vincent, R., Dann, T. F., & Brook, J. R. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117540 · Cited by 317
Mechanisms of Action of Vanadium
Nechay, B. R. (1984) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.24.040184.002441 · Cited by 300
Modes in the size distributions of atmospheric inorganic aerosol
John, W., Wall, S. M., Ondo, J. L., & Winklmayr, W. (1990) · Atmospheric Environment Part A General Topics · doi:10.1016/0960-1686(90)90327-j · Cited by 269

Show all 32 references

Sorted by citations

Items 201–300 of 485

Cardiopulmonary Responses of Intratracheally Instilled Tire Particles and Constituent Metal Components
Gottipolu, R. R., Landa, E. R., Schladweiler, M. C. J., McGee, J. K., Ledbetter, A. D., Richards, J. H., Wallenborn, G. J., & Kodavanti, U. P. (2008) · Inhalation Toxicology · doi:10.1080/08958370701858427 · Cited by 57
Cardiovascular Outcomes and the Physical and Chemical Properties of Metal Ions Found in Particulate Matter Air Pollution: A QICAR Study
Meng, Q., Richmond‐Bryant, J., Lu, S., Buckley, B., Welsh, W. J., Whitsel, E. A., Hanna, A., Yeatts, K., Warren, J. L., Herring, A. H., et al. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205793 · Cited by 57
“Several of these metal ions (Pb, Hg, Mn, Ni) are wellknown toxicants (Dreher et al. 1997; Ercal et al. 2001; Lippmann et al. 2006; Moriwaki et al. 2008).”
Background
Killer smog of London, 50 years on: particle properties and oxidative capacity
Whittaker, A., BéruBé, K., Jones, T. P., Maynard, R. L., & Richards, R. J. (2004) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2004.04.047 · Cited by 57
Concentrations of Ni and V, other heavy metals, arsenic, elemental and organic carbon in atmospheric fine particles (PM2.5) from Puerto Rico
Figueroa, D. A., Rodríguez-Sierra, C. J., & Jiménez-Velez, B. D. (2006) · Toxicology and Industrial Health · doi:10.1191/0748233706th247oa · Cited by 56
“These metals exist in these particles in an easy soluble form, which makes them bioavailable (Dreher et al., 1997).”
Background
Iron regulates xanthine oxidase activity in the lung
Ghio, A. J., Kennedy, T. P., Stonehuerner, J. G., Carter, J. D., Skinner, K. A., Parks, D. A., & Hoidal, J. R. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00413.2000 · Cited by 55
“This would provide rapid production of urate to complex the iron presented to the lung airway as a consequence of the inhalation of silicates causing pneumoconioses (12-14), coal dust (15), particulate air pollution (9,16) and even iron complexed to humic acid-like substances abundant in cigarette smoke (17).”
Background
Oxidative interactions of synthetic lung epithelial lining fluid with metal-containing particulate matter
Sun, G., Crissman, K. M., Norwood, J., Richards, J. H., Slade, R., & Hatch, G. E. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.281.4.l807 · Cited by 55
“Evidence has accumulated that soluble metals are critical to the toxicity of ROFA (9, 13, 24, 36) and that part of the injury induced by ROFA might be a result of oxidative stress (10, 11, 14, 15, 24, 26).”
Background
Sizing Up Air Pollution Research
LOOMIS, D. P. (2000) · Epidemiology · doi:10.1097/00001648-200001000-00002 · Cited by 55
Pulmonary Immunotoxicology of Select Metals: Aluminum, Arsenic, Cadmium, Chromium, Copper, Manganese, Nickel, Vanadium, and Zinc
Cohen, M. D. (2004) · Journal of Immunotoxicology · doi:10.1080/15476910490438360 · Cited by 55
“While both this ROFA and another with l/30 the level of Zn induced equivalent increases in lung AM, lymphocyte, and eosinophil levels, only “high” Zn ROFA induced significant increases in PMN.”
BackgroundInfluential
Potential mechanisms of some selected heavy metals in the induction of inflammation and autoimmunity
Anka, A. U., Usman, A. B., Kaoje, N. A., Kabir, R. M., Bala, A., Arki, M. K., Hossein‐Khannazer, N., & Azizi, G. (2022) · European Journal of Inflammation · doi:10.1177/1721727x221122719 · Cited by 54
First survey of atmospheric heavy metal deposition in Kosovo using moss biomonitoring
Maxhuni, A., Lazo, P., Kane, S. S., Qarri, F., Marku, E., & Harmens, H. (2015) · Environmental Science and Pollution Research · doi:10.1007/s11356-015-5257-1 · Cited by 54
Hypersensitivity of Prediabetic JCR:LA-cp Rats to Fine Airborne Combustion Particle-Induced Direct and Noradrenergic-Mediated Vascular Contraction
Proctor, S. D., Dreher, K. L., Kelly, S. E., & Russell, J. C. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj100 · Cited by 54
“, 1999) and may be due to transition metals (such as Fe, V, and Zn) contained in particles derived from heavy oil combustion (Dreher et al., 1997).”
BackgroundMethodInfluential
Pollutants from primary sources dominate the oxidative potential of water-soluble PM2.5 in Hong Kong in terms of dithiothreitol (DTT) consumption and hydroxyl radical production
Cheng, Y., Ma, Y., Dong, B., Qiu, X., & Hu, D. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124218 · Cited by 54
Respiratory and Cardiovascular Effects of Metals in Ambient Particulate Matter: A Critical Review
Gray, D. L., Wallace, L. A., Brinkman, M. C., Buehler, S., & Londe, C. L. (2014) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/978-3-319-10638-0_3 · Cited by 53
SULFATE CONTENT CORRELATES WITH IRON CONCENTRATIONS IN AMBIENT AIR POLLUTION PARTICLES
Ghio, J. S. A. J. (1999) · Inhalation Toxicology · doi:10.1080/089583799197104 · Cited by 52
A Comparison of Cytotoxicity and Oxidative Stress from Welding Fumes Generated with a New Nickel-, Copper-Based Consumable versus Mild and Stainless Steel-Based Welding in RAW 264.7 Mouse Macrophages
Badding, M. A., Fix, N. R., Antonini, J. M., & Leonard, S. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101310 · Cited by 51
“it has been shown that soluble transition metals in particulate matter such as residual oil fly ash [47] and diesel exhaust particles [48,49] are likely responsible for the pulmonary injury they induce”
Background
Urban Particle-Induced Apoptosis and Phenotype Shifts in Human Alveolar Macrophages
Holian, A., Hamilton, R. F., Morandi, M. T., Brown, S. D., & Li, L. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106127 · Cited by 51
LUNG INJURY FROM INTRATRACHEAL AND INHALATION EXPOSURES TO RESIDUAL OIL FLY ASH IN A RAT MODEL OF MONOCROTALINE-INDUCED PULMONARY HYPERTENSION
Kodavanti, U. P. (1999) · Journal of Toxicology and Environmental Health · doi:10.1080/009841099157502 · Cited by 51
“19 s g (Hatch et al., 1985; Dreher et al., 1997).”
Background
Vanadium Stimulates Human Bronchial Epithelial Cells to Produce Heparin-Binding Epidermal Growth Factor–Like Growth Factor: A Mitogen for Lung Fibroblasts
Zhang, L., Rice, A. B., Adler, K. B., Sannes, P. L., Martin, L. D., Gladwell, W., Koo, J.-S., Gray, T. E., & Bonner, J. C. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.24.2.4096 · Cited by 51
“Moreover, trace amounts of vanadium compounds are present in air pollution particulate matter that cause airway hyperresponsiveness and inflammation (5, 6).”
Intraurban Variation of Fine Particle Elemental Concentrations in New York City
Ito, K., Johnson, S., Kheirbek, I., Clougherty, J. E., Pezeshki, G., Ross, Z., Eisl, H. M., & Matte, T. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b00599 · Cited by 50
Respirable Uranyl-Vanadate-Containing Particulate Matter Derived From a Legacy Uranium Mine Site Exhibits Potentiated Cardiopulmonary Toxicity
Zychowski, K. E., Kodali, V., Harmon, M. E., Steadman, C. R., Sanchez, B., Suarez, Y. O., Herbert, G., Wheeler, A., Avasarala, S., Cerrato, J. M., et al. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy064 · Cited by 50
Adjuvant activity of ambient particulate matter of different sites, sizes, and seasons in a respiratory allergy mouse model
Steerenberg, P. A. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.04.011 · Cited by 50
Pollution effects on asthmatic children in Europe, the PEACE study
Roemer, W. H., Hoek, & Brunekreef, B. (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00851.x · Cited by 50
Fine Particle Emissions from Heavy Fuel Oil Combustion in a Firetube Package Boiler
Miller, C. A., Linak, W. P., King, C., & WENDT, J. O. L. (1998) · Combustion Science and Technology · doi:10.1080/00102209808924146 · Cited by 50
Airborne particles produced during enamel cleanup after removal of orthodontic appliances
Ireland, A. J., Moreno, T., & Price, R. (2003) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/s0889-5406(03)00623-1 · Cited by 49
Formation of reactive oxygen species in rat epithelial cells upon stimulation with fly ash
Voelkel‐Meiman, K., Krug, H. F., & Diabaté, S. (2003) · Journal of Biosciences · doi:10.1007/bf02970131 · Cited by 49
Metals and Air Pollution Particles
Ghio, A. J., & Samet, J. M. (1999) · Air Pollution and Health · doi:10.1016/b978-012352335-8/50104-6 · Cited by 49
Trace Metals Concentrations at the Atmosphere Particulate Matters in the Southeast Asian Mega City (Dhaka, Bangladesh)
Islam, M. F., Majumder, S. S., Mamun, A. A., Khan, M. B., Rahman, M. A., & Salam, A. (2015) · Open Journal of Air Pollution · doi:10.4236/ojap.2015.42009 · Cited by 47
Contrasting biological potency of particulate matter collected at sites impacted by distinct industrial sources
Thomson, E. M., Breznan, D., Karthikeyan, S., MacKinnon‐Roy, C., Vuong, N. Q., Dąbek-Złotorzyńska, E., Celo, V., Charland, J., Kumarathasan, P., Brook, J. R., et al. (2016) · Particle and Fibre Toxicology · doi:10.1186/s12989-016-0176-y · Cited by 48
“Nevertheless, these associations are in a broad sense consistent with the overall coherence among in vitro, in vivo, and population studies implicating soluble transition metals in adverse health effects of ambient particles [14, 38, 40, 43].”
Background
Anti-oxidative and inflammatory responses induced by fly ash particles and carbon black in lung epithelial cells
Diabaté, S., Bergfeldt, B., Plaumann, D., Übel, C., & Weiß, C. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-5102-4 · Cited by 48
“Instillation of ROFA and CFA in rat lungs induced an acute inflammatory response that was associated with water-soluble transition metals [40].”
BackgroundInfluential
Differential effects of mercury, lead, and cadmium on IL-2 production by Jurkat T cells
Colombo, M., Hamelin, C., Kouassi, É., Fournier, M., & Bernier, J. (2004) · Clinical Immunology · doi:10.1016/j.clim.2004.02.005 · Cited by 47
The combustion of Orimulsion and its generation of air pollutants
Miller, C. A., & Srivastava, R. K. (2000) · Progress in Energy and Combustion Science · doi:10.1016/s0360-1285(99)00014-3 · Cited by 47
Fine particulate matter and cardiovascular disease
Neas, L. (2000) · Fuel Processing Technology · doi:10.1016/s0378-3820(99)00076-4 · Cited by 46
Lung Surfactant Gelation Induced by Epithelial Cells Exposed to Air Pollution or Oxidative Stress
Anseth, J. W., Goffin, A. J., Fuller, G. G., Ghio, A. J., Kao, P. N., & Upadhyay, D. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0365oc · Cited by 47
Vascular effects of ambient particulate matter instillation in spontaneous hypertensive rats
Bagaté, K., Meiring, J. J., Gerlofs-Nijland, M. E., Vincent, R., Cassee, F. R., & Borm, P. J. A. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.02.005 · Cited by 46
“, 2002a), and this inflammation was related to the soluble transition metals (Dreher et al., 1997; Kodavanti et al., 2002b).”
Background
Acute pulmonary and hematological effects of two types of particle surrogates are influenced by their elemental composition
Medeiros, N., Rivero, D. H. R. F., Kasahara, D. I., Saiki, M., Godleski, J. J., Koutrakis, P., Capelozzi, V. L., Saldiva, P. H. N., & Antonângelo, L. (2003) · Environmental Research · doi:10.1016/j.envres.2003.07.007 · Cited by 46
“Gavett et al. (1999) in their study in mice after intratracheal instillation of ROFA observed inflammatory alterations in bronchoalveolar lavage using doses larger than those in our study.”
BackgroundMethod
Residual Oil Fly Ash Increases the Susceptibility to Infection and Severely Damages the Lungs after Pulmonary Challenge with a Bacterial Pathogen
Antonini, J. M. (2002) · Toxicological Sciences · doi:10.1093/toxsci/70.1.110 · Cited by 46
“Intratracheal instillation of ROFA to laboratory animals induces lung injury and inflammation (Dreher et al., 1997; Kodavanti et al., 1998).”
BackgroundInfluential
Genotoxicity, inflammation and physico-chemical properties of fine particle samples from an incineration energy plant and urban air
Sharma, A. K., Jensen, K. A., Rank, J., White, P. A., Lundstedt, S., Gagné, R., Jacobsen, N. R., Kristiansen, J., Vogel, U. B., & Wallin, H. (2007) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2007.05.013 · Cited by 46
ACUTE LUNG INJURY FROM INTRATRACHEAL EXPOSURE TO FUGITIVE RESIDUAL OIL FLY ASH AND ITS CONSTITUENT METALS IN NORMOAND SPONTANEOUSLY HYPERTENSIVE RATS
Kodavanti, U. P., Schladweiler, M. C. J., Richards, J. R., & Costa, D. L. (2001) · Inhalation Toxicology · doi:10.1080/089583701459056 · Cited by 46
Importance of soluble metals and reactive oxygen species for cytokine release induced by mineral particles
Hetland, R. B., Myhre, O., Låg, M., Hongve, D., Schwarze, P. E., & Refsnes, M. (2001) · Toxicology · doi:10.1016/s0300-483x(01)00418-8 · Cited by 46
Lung Mucin Production Is Stimulated by the Air Pollutant Residual Oil Fly Ash
Longphre, M. V., Li, D., Li, J., Matovinovic, E., Gallup, M., Samet, J. M., & Basbaum, C. B. (2000) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8838 · Cited by 46
Particle-induced oxidative damage of indoor PM10 from coal burning homes in the lung cancer area of Xuan Wei, China
Shao, L., Hu, Y., Wang, J., Hou, C., Yang, Y., & Wu, M. (2013) · Atmospheric Environment · doi:10.1016/j.atmosenv.2013.05.079 · Cited by 45
Effect of nickel and iron co-exposure on human lung cells
Salnikow, K., Li, X., & Lippmann, M. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.01.003 · Cited by 46
“Moreover, pulmonary inflammation induced by ROFA was reproduced by intratracheal instillation of a mixture of soluble forms of nickel (Dreher et al., 1997).”
BackgroundInfluential
Metal Ions-Stimulated Iron Oxidation in Hydroxylases Facilitates Stabilization of HIF-1α Protein
Kaczmarek, M. Z., Cachau, R. E., Topol, I. A., Kasprzak, K. S., Ghio, A., & Salnikow, K. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn251 · Cited by 48
“It results in the emission of residual oil fly ash, which contains metal ions, such as Fe(II/III), Mn(II), Ni(II), V(V), Ca(II), Mg(II), and Zn(II) (Dreher et al., 1997).”
Background
Relationships between size-fractionated indoor and outdoor trace elements at four retirement communities in southern California
Polidori, A., Cheung, K., Arhami, M., Delfino, R. J., Schauer, J. J., & Sioutas, C. (2009) · Atmospheric chemistry and physics · doi:10.5194/acp-9-4521-2009 · Cited by 46
“Cu, Cr, and V have been shown to generate reactive oxygen species that can contribute to oxidative DNA damage (Dreher et al., 1997; Nel, 2005).”
Background
Relationship between Radical Generation by Urban Ambient Particulate Matter and Pulmonary Function of School Children
Hogervorst, J. G. F., de Kok, T. M. C. M., Briedé, J. J., Wesseling, G., Kleinjans, J. C. S., & van Schayck, O. C. P. (2005) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390500227431 · Cited by 44
“Representing PM from specific sources, diesel exhaust particles (DEP) (Hiura et al., 1999; Li et al., 2002; Takano et al., 1997; Yang et al., 1999) and residual oil fly ash (ROFA) (Dreher et al., 1997; Kodavanti et al., 1998; Lambert et al., 2000) have been shown to be toxicologically active in pulmonary cells and lab…”
BackgroundInfluential
Particulate matter inhalation exacerbates cardiopulmonary injury in a rat model of isoproterenol-induced cardiomyopathy
Carll, A. P., Haykal-Coates, N., Winsett, D. W., Rowan, W. H., Hazari, M. S., Ledbetter, A. D., Nyska, A., Cascio, W. E., Watkinson, W. P., Costa, D. L., et al. (2010) · Inhalation Toxicology · doi:10.3109/08958370903365692 · Cited by 44
“The increased number of ISO-pretreated rats with bradyarrhythmias after PM exposure—especially atrioventricular block resembling the human Mobitz type II—parallels our recent findings in ROFA-exposed SHRs (Farraj et al., 2009) and those in second-hand smoke-exposed mice (Chen et al., 2008), and may have been linked to…”
BackgroundInfluential
E-Selectin expression in human endothelial cells exposed to PM10: The role of endotoxin and insoluble fraction
Alfaro‐Moreno, E., López‐Marure, R., Montiel‐Dávalos, A., Symonds, P., Osornio-Vargas, Á. R., Rosas, I., & Murray, J. C. (2006) · Environmental Research · doi:10.1016/j.envres.2006.05.004 · Cited by 44
Mechanism of Extracellular Signal–Regulated Kinase (ERK)-1 and ERK-2 Activation by Vanadium Pentoxide in Rat Pulmonary Myofibroblasts
Wang, Y.-Z., & Bonner, J. C. (2000) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.22.5.3882 · Cited by 44
IN VIVO AND IN VITRO CORRELATION OF PULMONARY MAP KINASE ACTIVATION FOLLOWING METALLIC EXPOSURE
Silbajoris, R. A. (2000) · Inhalation Toxicology · doi:10.1080/089583700402860 · Cited by 45
Influence of precipitation scavenging on the PM2.5PM10 ratio at the Kennedy locality of Bogotá, Colombia
Tomas, U. S., Becerra, L. C. B., Gáfaro-Rojas, A. I., de Santander, U. I., Rojas, N. Y., & de Colombia, U. N. (2015) · Revista Facultad de Ingeniería Universidad de Antioquia · doi:10.17533/udea.redin.n76a07 · Cited by 42
“Metals have been mostly associated with fine particles [28, 29].”
Background
In vitro effects of incinerator fly ash on pulmonary macrophages and epithelial cells
Diabaté, S., Mülhopt, S., Paur, H. ‐., Wottrich, R., & Krug, H. F. (2002) · International Journal of Hygiene and Environmental Health · doi:10.1078/1438-4639-00109 · Cited by 42
BIOAVAILABILITY OF IRON FROM COAL FLY ASH: Mechanisms of Mobilization and of Biological Effects
Ball, B. R., Smith, K. R., Veranth, J. M., & Aust, A. E. (2000) · Inhalation Toxicology · doi:10.1080/713856637 · Cited by 42
“In work with ROFA, Carter et al. (1997) discussed the relationship of their cell culture studies to in vivo experiments using rats (Dreher et al., 1997).”
BackgroundMethod
Characterization of Metal and Trace Element Contents of Particulate Matter (PM10) Emitted by Vehicles Running on Brazilian Fuels—Hydrated Ethanol and Gasoline with 22% of Anhydrous Ethanol
da Silva, M. F., de Assunção, J. V., Andrade, M. D. F., & Pesquero, C. R. (2010) · Journal of Toxicology and Environmental Health · doi:10.1080/15287391003744849 · Cited by 41
“Furthermore, metal compounds present in these particles act as an aggravating factor due to their contribution to oxidative stress (Dreher et al., 1997; Valavanidis et al., 2000), as well as to their sensitizing, allergic, and carcinogenic effects (Pope et al.”
Background
Role of Toll-like receptor-4 in genetic susceptibility to lung injury induced by residual oil fly ash
Cho, H., Jedlicka, A., Clarke, R. W., & Kleeberger, S. R. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00037.2005 · Cited by 41
“Intratracheal instillation of ROFA induces airway hyperreactivity and acute pulmonary injury characterized by neutrophilic inflammation, hyperpermeability and edema, and pulmonary fibrosis (8).”
Background
Residual oil fly ash and charged polymers activate epithelial cells and nociceptive sensory neurons
Oortgiesen, M., Veronesi, B., Eichenbaum, G. M., Kiser, P. F., & Simon, S. A. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.278.4.l683 · Cited by 41
“tive radicals (11, 29) may be generated that can sustain”
BackgroundInfluential
EFFECTS OF ENVIRONMENTAL AEROSOLS ON AIRWAY HYPERRESPONSIVENESS IN A MURINE MODEL OF ASTHMA
Carroll-Ann, W. G., Kaoru, H., Yaoyu, N., & Guozhong, Q. (1999) · Inhalation Toxicology · doi:10.1080/089583799196646 · Cited by 41
INCREASED AIRWAY HYPERRESPONSIVENESS AND INFLAMMATION IN A JUVENILE MOUSE MODEL OF ASTHMA EXPOSED TO AIR-POLLUTANT AEROSOL
Hamada, K. (1999) · Journal of Toxicology and Environmental Health · doi:10.1080/009841099157340 · Cited by 41
Increased Nonconducted P-Wave Arrhythmias after a Single Oil Fly Ash Inhalation Exposure in Hypertensive Rats
Farraj, A. K., Haykal-Coates, N., Winsett, D. W., Hazari, M. S., Carll, A. P., Rowan, W. H., Ledbetter, A. D., Cascio, W. E., & Costa, D. L. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.0800129 · Cited by 41
Metals and air pollution
Chen, L., Maciejczyk, P., & Thurston, G. D. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823292-7.00004-8 · Cited by 44
Effects of PM2.5 components in the release of amphiregulin by human airway epithelial cells
Rumelhard, M., Ramgolam, K., AUGER, F., Dazy, A. C., BLANCHET, S., Marano, F., & Baeza‐Squiban, A. (2006) · Toxicology Letters · doi:10.1016/j.toxlet.2006.11.014 · Cited by 40
Chemical characterization of extractable water soluble matter associated with PM10 from Mexico City during 2000
Gutiérrez-Castillo, M. E., Olivos-Ortiz, M., Vizcaya‐Ruíz, A. D., & Cebrián, M. E. (2005) · Chemosphere · doi:10.1016/j.chemosphere.2005.03.063 · Cited by 39
ALTERED GENE EXPRESSION PROFILES OF RAT LUNG IN RESPONSE TO AN EMISSION PARTICULATE AND ITS METAL CONSTITUENTS
Nadadur, S. S., & Kodavanti, U. P. (2002) · Journal of Toxicology and Environmental Health · doi:10.1080/00984100290071559 · Cited by 39
“…harvested from human bronchoalveolar lavage fluid have provided basic toxicity data for certain ambient PM (Imrich et al., 2000; Frampton et al., 2000), surrogate PM, residual oil fly ash (ROFA), and its constituents (Dreher et al., 1997; Broeckaert et al., 1997; Kodavanti et al., 1997, 1998a).”
BackgroundMethodResultInfluential
Physiological fluid interfaces: Functional microenvironments, drug delivery targets, and first line of defense
Bertsch, P., Bergfreund, J., Windhab, E. J., & Fischer, P. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.05.051 · Cited by 38
ANTIOXIDANT DEFENSE MECHANISMS AND THE TOXICITY OF FIBROUS AND NONFIBROUS PARTICLES
Driscoll, K. E., Carter, J. M., & Borm, P. J. A. (2002) · Inhalation Toxicology · doi:10.1080/089583701753338668 · Cited by 38
“…including diesel exhaust particles, residual oil fly ash, and urban air particles, have also been shown to stimulate oxidant production by phagocytic cells and perturb cell function by mechanisms that are blocked by antioxidants (Dreher et al., 1997; Casillas et al. 1999; Jiang et al., 2000).”
Background
Mitochondrial-Mediated Apoptosis Pathway in Alveolar Epithelial Cells Exposed to the Metals in Combustion-Generated Particulate Matter
Visalli, G., Baluce, B., Bertuccio, M. P., Picerno, I., & Pietro, A. D. (2015) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2015.1024081 · Cited by 36
“…population, however, the onset of chronic respiratory diseases, such as COPD, may be produced by exposure to many airborne xenobiotics, including V and other transition metals, which are adsorbed to fine and ultrafine PM (Dreher et al., 1997; Bala and Tabaku, 2010; Nakayama Wong et al., 2011).”
Background
Anthropogenic versus geogenic contribution to total suspended atmospheric particulate matter and its variations during a two-year sampling period in Beijing, China
Schleicher, N., Norra, S., Chai, F., Chen, Y., Wang, S., & Stüben, D. (2009) · Journal of Environmental Monitoring · doi:10.1039/b914739j · Cited by 36
Evaluation of cytokine expression in BEAS cells exposed to fine particulate matter (PM2.5) from specialized indoor environments
Gioda, A., Fuentes‐Mattei, E., & Jiménez-Velez, B. D. (2011) · International Journal of Environmental Health Research · doi:10.1080/09603123.2010.515668 · Cited by 35
“This in turn could induce tissue damage (Ghio et al. 1996; Dreher et al. 1997).”
Smoking Status and Occupational Exposure Affects Oxidative DNA Injury in Boilermakers Exposed to Metal Fume and Residual Oil Fly Ash
Mukherjee, S., Palmer, L. J., Kim, J. Y., Aeschliman, D. B., Houk, R. S., Woodin, M. A., & Christiani, D. C. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.454.13.3 · Cited by 35
Ambient Particulate Matter Affects Cardiac Recovery in a Langendorff Ischemia Model
Bagaté, K., Meiring, J. J., Gerlofs-Nijland, M. E., Cassee, F. R., Wiegand, H., Osornio-Vargas, Á. R., & Borm, P. J. A. (2006) · Inhalation Toxicology · doi:10.1080/08958370600742706 · Cited by 35
“, 2003), and this inflammation was related to the soluble transition metals (Dreher et al., 1997; Kodavanti et al., 2002b).”
Background
Can toxicogenomics provide information on the bioreactivity of diesel exhaust particles?
Reynolds, L. J., & Richards, R. J. (2001) · Toxicology · doi:10.1016/s0300-483x(01)00417-6 · Cited by 35
Air Pollution and Cardiovascular Disease
Knuckles, T. L., Campen, M. J., & Stanek, L. W. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.00722-3 · Cited by 34
Chemical characteristics and mutagenic activity of PM10 in Torino, a Northern Italian City
Gilli, G., Traversi, D., Rovere, R., Pignata, C., & Schilirò, T. (2007) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2007.07.006 · Cited by 34
IN VITRO EFFECTS OF WATER-SOLUBLE METALS PRESENT IN UK PARTICULATE MATTER
Merolla, L., & Richards, R. J. (2005) · Experimental Lung Research · doi:10.1080/01902140591007128 · Cited by 34
“This is rich in bioavailable metals and has been linked to acute and chronic pulmonary disorders in vivo [18] and in vitro [19], as well as allergic sensitization [20].”
Background
Composition of Inhaled Urban Air Particles Determines Acute Pulmonary Responses
Godleski, J. J., Clarke, R. W., Coull, B. A., Saldiva, P. H. N., Jiang, N.-F., Lawrence, J. E., & Koutrakis, P. (2002) · The Annals of Occupational Hygiene · doi:10.1093/annhyg/46.suppl_1.419 · Cited by 34
Role of metal-induced reactive oxygen species generation in lung responses caused by residual oil fly ash
Lewis, A. B., Taylor, M. D., Roberts, J. R., Leonard, S. S., Shi, X., & Antonini, J. M. (2003) · Journal of Biosciences · doi:10.1007/bf02970126 · Cited by 34
Urban PM2.5Surface Chemistry and Interactions with Bronchoalveolar Lavage Fluid
Kendall, M., Guntern, J., Lockyer, N. P., Jones, F. H., Hutton, B. M., Lippmann, M., & Tetley, T. D. (2004) · Inhalation Toxicology · doi:10.1080/08958370490443204 · Cited by 34
“, 2000), and compounds adsorbed at the surface, such as metals (Lambert et al., 2000; Dreher et al., 1997) or (polyaromatic hydrocarbons (PAH) (Zmirou et al.”
Background
Mitochondrial oxidant production by a pollutant dust and NO-mediated apoptosis in human alveolar macrophage
Huang, Y.-C. T., Soukup, J. M., Harder, S. D., & Becker, S. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00139.2002 · Cited by 34
“ROFA contains a significant amount of redox active metals, especially vanadium (14) (32).”
Background
Inhibition of β-Defensin Gene Expression in Airway Epithelial Cells by Low Doses of Residual Oil Fly Ash is Mediated by Vanadium
Klein-Patel, M. E., Diamond, G., Boniotto, M., Saad, S., & Ryan, L. K. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj214 · Cited by 33
“Vanadium pentoxide (V2O5) previously has been demonstrated in ROFA-leachate (Dreher et al., 1997) and has been shown to alter the expression of genes involved in the inflammatory response and innate immunity of airway epithelial cells (Carter et al., 1997; Ghio et al., 1998).”
BackgroundInfluential
Oxidative Injury in The Lungs of Neonatal Rats Following Short-Term Exposure to Ultrafine Iron and Soot Particles
Zhong, C.-Y., Zhou, Y.-M., Smith, K. R., Kennedy, I. M., Chen, C., Aust, A. E., & Pinkerton, K. E. (2010) · Journal of Toxicology and Environmental Health · doi:10.1080/15287391003689366 · Cited by 33
“…in our current study, that exposure to Fe and soot particles induced elevation in proinflammatory cytokine IL-1b, but not in TNF-a, are consistent with the results of previous Fe-containing particle studies (Broeckaert et al., 1997; Dreher et al., 1997; Kodavanti et al., 1997; Zhou et al., 2003).”
Result
In Vitro Cytotoxicity of Various Forms of Cobalt for Rat Alveolar Macrophages and Type II Pneumocytes
Roesems, G., Hoet, P., Dinsdale, D. D., Demedts, M., & Nemery, B. (2000) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8824 · Cited by 33
Acute effects of fine particles on cardiovascular system: Differences between the spontaneously hypertensive rats and wistar kyoto rats
Zhao, J., Xie, Y., Qian, X., Jiang, R., & Song, W. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.12.002 · Cited by 32
Production of hydroxyl radicals from Fe-containing fine particles in Guangzhou, China
Ma, S., Ren, K., Liu, X., Chen, L., Li, M., Li, X., Yang, J., Huang, B., Zheng, M., & Xu, Z. (2015) · Atmospheric Environment · doi:10.1016/j.atmosenv.2015.10.057 · Cited by 32
Elemental Characterization Of Indoor Breathable Particles at a Portuguese Urban Hospital
Slezáková, K., Alvim-Ferraz, M. C. M., & Pereira, M. D. C. (2012) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2012.690707 · Cited by 31
“Although in minor concentrations, the presence of PM metals is relevant, as these may significantly contribute (or eventually even enhance) PM-induced adverse health effects (Dreher et al. 1997).”
Background
Air pollution and doctors’ house calls for respiratory diseases in the Greater Paris area (2000–3)
Chardon, B., Lefranc, A., Granados, D., & Gremy, I. M. (2006) · Occupational and Environmental Medicine · doi:10.1136/oem.2005.026187 · Cited by 31
Trace elements pollution and toxicity of airborne PM 10 in a coal industrial city
Xiaoyan, S., Longyi, S., Shushen, Y., Riying, S., Limei, S., & Cen, S. (2015) · Atmospheric Pollution Research · doi:10.5094/apr.2015.052 · Cited by 31
Fine Oil Combustion Particle Bioavailable Constituents Induce Molecular Profiles of Oxidative Stress, Altered Function, and Cellular Injury in Cardiomyocytes
Knuckles, T. L., & Dreher, K. L. (2007) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390701459213 · Cited by 31
Resistance of hypotransferrinemic mice to hyperoxia-induced lung injury
Yang, F., Coalson, J. J., Bobb, H. H., Carter, J. D., Banu, J., & Ghio, A. J. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.277.6.l1214 · Cited by 31
“Because injury induced by this particle was shown to be metal dependent (9), the hpx/hpx mice may have developed an efficient iron sequestration system(s) independent of transferrin in the lung.”
Background
Particulate matter and heavy metal deposition on the leaves of Euonymus japonicus during the East Asian monsoon in Beijing, China
Zhang, T., Bai, Y., Hong, X., Sun, L., & Liu, Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179840 · Cited by 30
Metal composition and solubility determine lung toxicity induced by residual oil fly ash collected from different sites within a power plant
Antonini, J. M., Taylor, M. D., Leonard, S. S., Lawryk, N. J., Shi, X., Clarke, R. W., & Roberts, J. R. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000007281.32126.2c · Cited by 30
“In a related study, it was observed that the lung damage caused by a mixture of V and Ni was less than the injury caused by Ni alone [6].”
Background
Role of reactive oxygen species in occupational and environmental obstructive pulmonary diseases
van Klaveren, R. J., & Nemery, B. (1999) · Current Opinion in Pulmonary Medicine · doi:10.1097/00063198-199903000-00007 · Cited by 30
In vitro alveolar cytotoxicity of soluble components of airborne particulate matter: effects of serum on toxicity of transition metals
Okeson, C. D., Riley, M. R., & Riley‐Saxton, E. (2004) · Toxicology in Vitro · doi:10.1016/j.tiv.2004.03.006 · Cited by 30
COMBINED AIR POLLUTION PARTICLE AND OZONE EXPOSURE INCREASES AIRWAY RESPONSIVENESS IN MICE
Goldsmith, C. W., Ning, Y., Guozhong, Q., Imrich, A., Lawrence, J. E., Murthy, G. G. K., Catalano, P. J., & Kobzik, L. (2002) · Inhalation Toxicology · doi:10.1080/08958370252870989 · Cited by 30
“…to the adverse effects attributed to particles (Adamson et al., 2000; Bonner et al., 1998; Castranova et al., 1984; Davison et al., 1974; Dreher et al., 1996, 1997; Dye et al., 1999a; Ghio et al., 1999; Goldsmith et al., 1998; Hatch et al., 1985; Imrich et al., 1999; Jimenez et al.,…”
Background
Assessment of geographical variation in the respiratory toxicity of desert dust particles
Taylor, K., Foster, M. L., Law, J. M., Centeno, J. A., Fornero, E., Henderson, M. S., Trager, S. A., Stockelman, M. G., & Dorman, D. C. (2013) · Inhalation Toxicology · doi:10.3109/08958378.2013.797524 · Cited by 29
“For example, vanadium, nickel and iron are the causative constituents of residual oil fly ash (ROFA)-induced acute and, probably, prolonged lung injury (Dreher et al., 1997; Gavett et al., 1997; Kodavanti et al., 1999).”
BackgroundMethodInfluential
Selective TNF-α targeting with infliximab attenuates impaired oxygen metabolism and contractile function induced by an acute exposure to air particulate matter
Marchini, T., D’Annunzio, V., Paz, M. L., Cáceres, L., Garcés, M., Pérez, V., Tasat, D. R., Vanasco, V., Magnani, N., Maglio, D. H. G., et al. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00359.2015 · Cited by 29
Soluble Metals Associated with Residual Oil Fly Ash Increase Morbidity and Lung Injury After Bacterial Infection in Rats
Roberts, J. R., Taylor, M. D., Castranova, V., Clarke, R. W., & Antonini, J. M. (2004) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390490266927 · Cited by 29
“…soluble transition metals of ROFA has been implicated in the development of adverse respiratory responses, and has been shown to play a role in lung inflammation and injury (Dreher et al., 1997; Dye et al., 1999; Gavett et al., 1997; Ghio et al., 1999; Kodavanti et al., 1998; Lewis et al., 2003).”
BackgroundResultInfluential
Energy distributive injustices: Assessing the demographics of communities surrounding renewable and fossil fuel power plants in the United States
Cranmer, Z., Steinfield, L. A., Miranda, J., & Stohler, T. (2023) · Energy Research & Social Science · doi:10.1016/j.erss.2023.103050 · Cited by 28
INFLAMMATION, EDEMA, AND PERIPHERAL BLOOD CHANGES IN LUNG-COMPROMISED RATS AFTER INSTILLATION WITH COMBUSTION-DERIVED AND MANUFACTURED NANOPARTICLES
Evans, S., Al-Mosawi, A., Adams, R. A., & BéruBé, K. (2006) · Experimental Lung Research · doi:10.1080/01902140600959671 · Cited by 28
Toxic Evaluation of Organic Extracts from Airborne Particulate Matter in Puerto Rico
Reyes, D. R., Rosario, O., Rodriguez, J. F., & Jiménez, B. D. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108635 · Cited by 28
“The factors suggested to cause these health effects are the associated organic components (14–17); ultrafine particle constituents (18); the presence of biologic material (19); and the transition metal content of particulate matter (20).”
Background
Genetic susceptibility to nickel-induced acute lung injury
Prows, D. R., McDowell, S. A., Aronow, B. J., & Leikauf, G. D. (2003) · Chemosphere · doi:10.1016/s0045-6535(02)00710-5 · Cited by 28
A LOW-SAMPLE-CONSUMPTION DRY-PARTICULATE AEROSOL GENERATOR FOR USE IN NOSE-ONLY INHALATION EXPOSURES
Killough, A. D. L. P. M. (1998) · Inhalation Toxicology · doi:10.1080/089583798197754 · Cited by 28

Authors: Kevin L. Dreher, R. H. J.
Venue: Journal of Toxicology and Environmental Health
Publisher: Informa UK Limited
Published: 1997-02
Volume: 50
Issue: 3
Pages: 285-305
ISSN: 0098-4108 (ISSN-L)
DOI: 10.1080/009841097160492
OpenAlex: W2169046198
Cited by: 486
References: 32
Citations by year: 2026: 4 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 11 · 2015: 17 · 2014: 9 · 2013: 17 · 2012: 13
FWCI: 34.31
Type: journal article
Language: en
Open access: closed
Locations: Journal of Toxicology and Environmental Health (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Physical Sciences › Earth and Planetary Sciences › Geochemistry and Petrology › Coal and Its By-products
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
Keywords: residual oil fly ash, acute lung injury, iron, nickel, vanadium, pulmonary toxicity, bronchoalveolar lavage fluid, airway inflammation, metal interactions, pH effect, particulate matter pollution
MeSH terms: Acute Disease, Air Pollutants, Animals, Carbon, Chemistry, Physical, Fuel Oils, Inflammation, Lung Diseases, Male, Metals, Particle Size, Solubility, Sulfates, Rats, Sprague-Dawley, Rats, Chemical Phenomena

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

SOLUBLE TRANSITION METALS MEDIATE RESIDUAL OIL FLY ASH INDUCED ACUTE LUNG INJURY

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks