Cited by 486Air Quality and Health ImpactsCoal and Its By-productsOccupational and environmental lung diseases

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SOLUBLE TRANSITION METALS MEDIATE RESIDUAL OIL FLY ASH INDUCED ACUTE LUNG INJURY

Kevin L. Dreher, Richard H. Jaskot,·1997·Journal of Toxicology and Environmental Health

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Abstract

Identification of constituents responsible for the pulmonary toxicity of fugitive combustion emission source particles may provide insight into the adverse health effects associated with exposure to these particles as well as ambient air particulate pollution. Herein, we describe results of studies conducted to identify constituents responsible for the acute lung injury induced by residual oil fly ash (ROFA) and to assess physical-chemical factors that influence the pulmonary toxicity of these constituents. Biochemical and cellular analyses performed on bronchoalveolar lavage fluid obtained from rats following intratracheal instillation of ROFA suspension demonstrated the presence of severe inflammation, an indicator of pulmonary injury, which included recruitment of neutrophils, eosinophils, and monocytes into the airway. A leachate prepared from ROFA, containing predominantly Fe, Ni, V, Ca, Mg, and sulfate, produced similar lung injury to that induced by ROFA suspension. Depletion of Fe, Ni, and V from the ROFA leachate abrogated its pulmonary toxicity. Correspondingly, minimal lung injury was observed in animals exposed to saline-washed ROFA particles. A surrogate transition metal sulfate solution containing Fe, V, and Ni largely reproduced the lung injury induced by ROFA. Metal interactions and pH were found to influence the severity and kinetics of lung injury induced by ROFA and soluble transition metals. These findings provide direct evidence for the role of soluble transition metals in the pulmonary injury induced by the combustion emission source particulate, ROFA.

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Background
Increased Oxidative Burden Associated with Traffic Component of Ambient Particulate Matter at Roadside and Urban Background Schools Sites in London
Pollitt, K. J. G., Harrison, R. M., Evans, T., Baker, T., Dunster, C., Mudway, I., & Kelly, F. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021961 · Cited by 163
“Compositional details of the residual oil fly ash [18–23] and M120 [24,25] control particles have been published elsewhere.”
Background
Health effects of concentrated ambient air particulate matter (CAPs) and its components
Lippmann, M., & Chen, L. (2009) · Critical Reviews in Toxicology · doi:10.3109/10408440903300080 · Cited by 162
Particulate Matter Toxicity Is Nrf2 and Mitochondria Dependent: The Roles of Metals and Polycyclic Aromatic Hydrocarbons
Pardo, M., Qiu, X., Zimmermann, R., & Rudich, Y. (2020) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.0c00007 · Cited by 167
Metal and Sulfate Composition of Residual Oil Fly Ash Determines Airway Hyperreactivity and Lung Injury in Rats
Gavett, S. H., Madison, S. L., Dreher, K. L., Winsett, D. W., McGee, J. K., & Costa, D. L. (1997) · Environmental Research · doi:10.1006/enrs.1997.3732 · Cited by 156
Pulmonary Toxicity of an Atmospheric Particulate Sample Is Due to the Soluble Fraction
Adamson, I. Y. R., Prieditis, H., & Vincent, R. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8658 · Cited by 154
Pivotal Roles of Metal Oxides in the Formation of Environmentally Persistent Free Radicals
Yang, L., Liu, G., Zheng, M., Jin, R., Zhao, Y., Wu, X., & Xu, Y. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b03583 · Cited by 152
Soluble transition metals cause the pro-inflammatory effects of welding fumes in vitro
McNeilly, J., Heal, M. R., Beverland, I. J., Howe, A. M., Gibson, M. D., Hibbs, L. R., MacNee, W., & Donaldson, K. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.11.021 · Cited by 149
“…have demonstrated that the pulmonary toxicity of complex metal-containing particulates can be associated with the soluble forms of transition metals and the dose (Adamson et al., 2000; Carter et al., 1997; Dreher et al., 1997; Hetland et al., 2001; Kennedy et al., 1998; Kodavanti et al., 1997).”
BackgroundInfluential
Impacts of antioxidants on hydroxyl radical production from individual and mixed transition metals in a surrogate lung fluid
Charrier, J. G., & Anastasio, C. (2010) · Atmospheric Environment · doi:10.1016/j.atmosenv.2010.12.021 · Cited by 157
“…correlatedwith the soluble transition metal (TM) content of PM, which has also been correlated with particle-mediated cardiopulmonary toxicity (Carter et al., 1997; Costa and Dreher, 1997; Dreher et al., 1997; Gavett et al., 1997; DiStefano et al., 2009; Vidrio et al., 2009; Zhong et al., 2010).”
Background
Pulmonary Nanoparticle Exposure Disrupts Systemic Microvascular Nitric Oxide Signaling
Nurkiewicz, T. R., Porter, D. W., Hubbs, A. F., Stone, S., Chen, B. T., Frazer, D. G., Boegehold, M. A., & Castranova, V. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp051 · Cited by 149
“one technique, particle or emission condition to affect smooth muscle NO sensitivity, while another does not, is high because numerous biological mechanisms have been identified and/or advanced to help explain how a particle of pulmonary origin can influence a systemic tissue (Brook et al., 2004; Donaldson et al., 200…”
Background
Temporal variability of trace metal mobility of urban particulate matter from Beijing – A contribution to health impact assessments of aerosols
Schleicher, N., Norra, S., Chai, F., Chen, Y., Wang, S., Cen, K., Yu, Y., & Stüben, D. (2011) · Atmospheric Environment · doi:10.1016/j.atmosenv.2011.08.067 · Cited by 153
Rates of Hydroxyl Radical Production from Transition Metals and Quinones in a Surrogate Lung Fluid
Charrier, J. G., & Anastasio, C. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b01606 · Cited by 145
Characterization of Aerosols Containing Zn, Pb, and Cl from an Industrial Region of Mexico City
Moffet, R. C., Desyaterik, Y., Hopkins, R. J., Tivanski, A. V., Gilles, M. K., Wang, Y., Shutthanandan, V. S., Molina, L. T., Gonzalez-Abraham, R., Johnson, K. S., et al. (2008) · Environmental Science & Technology · doi:10.1021/es7030483 · Cited by 145
Generation of hydroxyl radicals from dissolved transition metals in surrogate lung fluid solutions
Vidrio, E., Jung, H., & Anastasio, C. (2008) · Atmospheric Environment · doi:10.1016/j.atmosenv.2008.01.004 · Cited by 142
“PM contains trace amounts of a wide variety of transition metals (Dreher et al., 1997; Song et al., 2003; Valavanidis et al., 2005a, b, 2006).”
BackgroundInfluential
ANALYSIS OF AIR POLLUTION PARTICULATE-MEDIATED OXIDANT STRESS IN ALVEOLAR MACROPHAGES
Imrich, C.-A. W. G. A. (1998) · Journal of Toxicology and Environmental Health · doi:10.1080/009841098158683 · Cited by 141
Particulate Matter Initiates Inflammatory Cytokine Release by Activation of Capsaicin and Acid Receptors in a Human Bronchial Epithelial Cell Line
Veronesi, B., Oortgiesen, M., Carter, J. D., & Devlin, R. B. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1998.8567 · Cited by 140
A Time-Series Analysis of Acidic Particulate Matter and Daily Mortality and Morbidity in the Buffalo, New York, Region
Gwynn, R. C., Burnett, R. T., & Thurston, G. D. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108125 · Cited by 139
Cardiovascular and Thermoregulatory Effects of Inhaled PM-Associated Transition Metals: A Potential Interaction between Nickel and Vanadium Sulfate
Campen, M. J. (2001) · Toxicological Sciences · doi:10.1093/toxsci/64.2.243 · Cited by 139
“Several studies have been conducted that demonstrate the in vivo and in vitro toxicity of various metals, including Ni, V, Fe, and Zn (Campen et al., manuscript in preparation; Dreher et al., 1997; Dye et al., 1999; Kadiiska et al., 1997; Kodavanti et al., 1997).”
Background
Oxidant production from source-oriented particulate matter – Part 1: Oxidative potential using the dithiothreitol (DTT) assay
Charrier, J. G., Richards-Henderson, N. K., Bein, K. J., McFall, A. S., Wexler, A. S., & Anastasio, C. (2015) · Atmospheric chemistry and physics · doi:10.5194/acp-15-2327-2015 · Cited by 138
“Traffic and residual oil fly ash are two sources commonly associated with adverse effects (Hoffmann et al., 2007; Peters et al., 2004; Dreher et al., 1997), possibly due to the ability of transition metals in the PM to cause oxidative stress (Gasser et al., 2009; Antonini et al., 2004; Aust et al.,…”
Background
What Do Epidemiologic Findings Tell Us about Health Effects of Environmental Aerosols?
Pope, C. A. (2000) · Journal of Aerosol Medicine · doi:10.1089/jam.2000.13.335 · Cited by 138
Effects of Asian dust event particles on inflammation markers in peripheral blood and bronchoalveolar lavage in pulmonary hypertensive rats
Lei, Y.-C., Chan, C., Wang, P.-Y., Lee, C.-T., & Cheng, T. (2003) · Environmental Research · doi:10.1016/s0013-9351(03)00136-1 · Cited by 135
International journal of the environment
(1977) · Ceramurgia International · doi:10.1016/0390-5519(77)90077-1 · Cited by 132
Dunkerque City air pollution particulate matter-induced cytotoxicity, oxidative stress and inflammation in human epithelial lung cells (L132) in culture
Garçon, G., Dagher, Z., Zerimech, F., Ledoux, F., Courcot, D., Aboukaı̈s, A., Puskaric, E., & Shirali, P. (2005) · Toxicology in Vitro · doi:10.1016/j.tiv.2005.09.012 · Cited by 133
IN VITRO EFFECTS OF COAL FLY ASHES: Hydroxyl Radical Generation, Iron Release, and DNA Damage and Toxicity in Rat Lung Epithelial Cells
van Maanen, P. J. A. B. J. M. S. (1999) · Inhalation Toxicology · doi:10.1080/089583799196628 · Cited by 133
Effect of Copper Oxide Concentration on the Formation and Persistency of Environmentally Persistent Free Radicals (EPFRs) in Particulates
Kiruri, L. W., Khachatryan, L., Dellinger, B., & Lomnicki, S. M. (2014) · Environmental Science & Technology · doi:10.1021/es404013g · Cited by 130
Inflammatory Effects of Respirable Quartz Collected in Workplaces versus Standard DQ12 Quartz: Particle Surface Correlates
Clouter, A. (2001) · Toxicological Sciences · doi:10.1093/toxsci/63.1.90 · Cited by 131
“, 1996), and residual oil fly ash (Dreher et al., 1997) are considered to generate free radicals via released transition metals, principally iron, and thereby cause lung inflammation.”
Background
HEALTH EFFECTS AND TIME COURSE OF PARTICULATE MATTER ON THE CARDIOPULMONARY SYSTEM IN RATS WITH LUNG INFLAMMATION
Ulrich, M. M. W., Alink, G. M., Kumarathasan, P., Vincent, R., Boere, A. J. F., & Cassee, F. R. (2002) · Journal of Toxicology and Environmental Health · doi:10.1080/00984100290071676 · Cited by 129
“Mechanistic studies using the technique of intratracheal instillation of PM fractions from various sites and composition have been shown to cause pulmonary cytotoxicity, inflammation, and production of reactive oxygen species (Hatch et al., 1985; Ghio et al., 1992; Ghio & Hatch, 1993; Adamson & Bowden, 1982; Adamson e…”
Method
Source apportionment of ambient particle number concentrations in central Los Angeles using positive matrix factorization (PMF)
Sowlat, M. H., Hasheminassab, S., & Sioutas, C. (2016) · Atmospheric chemistry and physics · doi:10.5194/acp-16-4849-2016 · Cited by 133
COMPARATIVE PULMONARY TOXICITY OF VARIOUS SOLUBLE METALS FOUND IN URBAN PARTICULATE DUSTS
Prieditis, H., & Adamson, I. Y. R. (2002) · Experimental Lung Research · doi:10.1080/01902140290096782 · Cited by 125
Ambient Urban Baltimore Particulate-induced Airway Hyperresponsiveness and Inflammation in Mice
Walters, D. M., Breysse, P. N., & Wills-Karp, M. A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.8.2007121 · Cited by 125
Seasonal trends, chemical speciation and source apportionment of fine PM in Tehran
Arhami, M., Hosseini, V., Shahne, M. Z., Bigdeli, M., Lai, A. M., & Schauer, J. J. (2016) · Atmospheric Environment · doi:10.1016/j.atmosenv.2016.12.046 · Cited by 123
Particulate Air Pollution
MacNee, W., & Donaldson, K. (1999) · Air Pollution and Health · doi:10.1016/b978-012352335-8/50105-8 · Cited by 122
Electrocardiographic Changes during Exposure to Residual Oil Fly Ash (ROFA) Particles in a Rat Model of Myocardial Infarction
Wellenius, G. A. (2002) · Toxicological Sciences · doi:10.1093/toxsci/66.2.327 · Cited by 120
“ROFA particles are rich in transition metals, many of which are soluble and have the ability to reach the heart (Dreher et al., 1997).”
Background
Chemical speciation of trace metals emitted from Indonesian peat fires for health risk assessment
Betha, R., Pradani, M., Lestari, P., Joshi, U. M., Reid, J. S., & Balasubramanian‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬, R. (2012) · Atmospheric Research · doi:10.1016/j.atmosres.2012.05.024 · Cited by 126
“Among the chemical components in aerosols, trace metals have attracted great attention due to their potential health effects (Adamson et al., 2000; Betha and Balasubramanian, 2011; Dreher et al., 1997; Dye et al., 2001; Espinosa et al., 2002; Ghio and Devlin, 2001).”
Background
Nanotechnology and Nanotoxicology
Curtis, J. A., Greenberg, M., Kester, J. E., Phillips, S., & Krieger, G. R. (2006) · Toxicological Reviews · doi:10.2165/00139709-200625040-00005 · Cited by 124
Cardiovascular and Systemic Responses to Inhaled Pollutants in Rodents: Effects of Ozone and Particulate Matter
Watkinson, W. P., Campen, M. J., Nolan, J. P., & Costa, D. L. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109s4539 · Cited by 118
Macrophage reactive oxygen species activity of water-soluble and water-insoluble fractions of ambient coarse, PM2.5 and ultrafine particulate matter (PM) in Los Angeles
Wang, D., Pakbin, P., Shafer, M. M., Antkiewicz, D. S., Schauer, J. J., & Sioutas, C. (2013) · Atmospheric Environment · doi:10.1016/j.atmosenv.2013.05.031 · Cited by 118
“Various studies have reported toxicity responses of both soluble (Dreher et al., 1997; Li et al., 2008) and insoluble species (Jalava et al.”
Background
Combustion-Derived Ultrafine Particles Transport Organic Toxicants to Target Respiratory Cells
Penn, A. L., Murphy, G., Barker, S. A., Henk, W. G., & Penn, L. S. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7661 · Cited by 118
“Injury to airway cells and alterations in cytokine gene expression in response to ROFA exposure have been reported (Dreher et al. 1997; Dye et al. 1999; Samet et al. 2002).”
Background
Size distribution and sources of trace metals and n-alkanes in the Athens urban aerosol during summer
Karanasiou, A., Sitaras, I. E., Siskos, P. A., & Eleftheriadis, K. (2007) · Atmospheric Environment · doi:10.1016/j.atmosenv.2006.11.006 · Cited by 115

Authors: Kevin L. Dreher, R. H. J.
Venue: Journal of Toxicology and Environmental Health
Publisher: Informa UK Limited
Published: 1997-02
Volume: 50
Issue: 3
Pages: 285-305
ISSN: 0098-4108 (ISSN-L)
DOI: 10.1080/009841097160492
OpenAlex: W2169046198
Cited by: 486
References: 32
Citations by year: 2026: 4 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 11 · 2015: 17 · 2014: 9 · 2013: 17 · 2012: 13
FWCI: 34.31
Type: journal article
Language: en
Open access: closed
Locations: Journal of Toxicology and Environmental Health (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Physical Sciences › Earth and Planetary Sciences › Geochemistry and Petrology › Coal and Its By-products
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
Keywords: residual oil fly ash, acute lung injury, iron, nickel, vanadium, pulmonary toxicity, bronchoalveolar lavage fluid, airway inflammation, metal interactions, pH effect, particulate matter pollution
MeSH terms: Acute Disease, Air Pollutants, Animals, Carbon, Chemistry, Physical, Fuel Oils, Inflammation, Lung Diseases, Male, Metals, Particle Size, Solubility, Sulfates, Rats, Sprague-Dawley, Rats, Chemical Phenomena

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SOLUBLE TRANSITION METALS MEDIATE RESIDUAL OIL FLY ASH INDUCED ACUTE LUNG INJURY

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