The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
SOLUBLE TRANSITION METALS MEDIATE RESIDUAL OIL FLY ASH INDUCED ACUTE LUNG INJURY
Abstract
Identification of constituents responsible for the pulmonary toxicity of fugitive combustion emission source particles may provide insight into the adverse health effects associated with exposure to these particles as well as ambient air particulate pollution. Herein, we describe results of studies conducted to identify constituents responsible for the acute lung injury induced by residual oil fly ash (ROFA) and to assess physical-chemical factors that influence the pulmonary toxicity of these constituents. Biochemical and cellular analyses performed on bronchoalveolar lavage fluid obtained from rats following intratracheal instillation of ROFA suspension demonstrated the presence of severe inflammation, an indicator of pulmonary injury, which included recruitment of neutrophils, eosinophils, and monocytes into the airway. A leachate prepared from ROFA, containing predominantly Fe, Ni, V, Ca, Mg, and sulfate, produced similar lung injury to that induced by ROFA suspension. Depletion of Fe, Ni, and V from the ROFA leachate abrogated its pulmonary toxicity. Correspondingly, minimal lung injury was observed in animals exposed to saline-washed ROFA particles. A surrogate transition metal sulfate solution containing Fe, V, and Ni largely reproduced the lung injury induced by ROFA. Metal interactions and pH were found to influence the severity and kinetics of lung injury induced by ROFA and soluble transition metals. These findings provide direct evidence for the role of soluble transition metals in the pulmonary injury induced by the combustion emission source particulate, ROFA.
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“many of the particles associated with smoking (and also ingested from other sources) are heavily laden with micro-particulate iron, which, as a major catalyst of hydroxyl radical production, undoubtedly is a substantial contributor as well (see e.g. [1373,1384,1396-1400]).”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [1397]
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Metadata
- Authors
- Kevin L. Dreher, R. H. J.
- Venue
- Journal of Toxicology and Environmental Health
- Publisher
- Informa UK Limited
- Published
- 1997-02
- Volume
- 50
- Issue
- 3
- Pages
- 285-305
- ISSN
- 0098-4108 (ISSN-L)
- OpenAlex
- W2169046198
- Cited by
- 486
- References
- 32
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 11 · 2015: 17 · 2014: 9 · 2013: 17 · 2012: 13
- FWCI
- 34.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Toxicology and Environmental Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Physical Sciences › Earth and Planetary Sciences › Geochemistry and Petrology › Coal and Its By-products
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Keywords
- residual oil fly ash, acute lung injury, iron, nickel, vanadium, pulmonary toxicity, bronchoalveolar lavage fluid, airway inflammation, metal interactions, pH effect, particulate matter pollution
- MeSH terms
- Acute Disease, Air Pollutants, Animals, Carbon, Chemistry, Physical, Fuel Oils, Inflammation, Lung Diseases, Male, Metals, Particle Size, Solubility, Sulfates, Rats, Sprague-Dawley, Rats, Chemical Phenomena
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