Cited by 486Air Quality and Health ImpactsCoal and Its By-productsOccupational and environmental lung diseases

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SOLUBLE TRANSITION METALS MEDIATE RESIDUAL OIL FLY ASH INDUCED ACUTE LUNG INJURY

Kevin L. Dreher, Richard H. Jaskot,·1997·Journal of Toxicology and Environmental Health

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Abstract

Identification of constituents responsible for the pulmonary toxicity of fugitive combustion emission source particles may provide insight into the adverse health effects associated with exposure to these particles as well as ambient air particulate pollution. Herein, we describe results of studies conducted to identify constituents responsible for the acute lung injury induced by residual oil fly ash (ROFA) and to assess physical-chemical factors that influence the pulmonary toxicity of these constituents. Biochemical and cellular analyses performed on bronchoalveolar lavage fluid obtained from rats following intratracheal instillation of ROFA suspension demonstrated the presence of severe inflammation, an indicator of pulmonary injury, which included recruitment of neutrophils, eosinophils, and monocytes into the airway. A leachate prepared from ROFA, containing predominantly Fe, Ni, V, Ca, Mg, and sulfate, produced similar lung injury to that induced by ROFA suspension. Depletion of Fe, Ni, and V from the ROFA leachate abrogated its pulmonary toxicity. Correspondingly, minimal lung injury was observed in animals exposed to saline-washed ROFA particles. A surrogate transition metal sulfate solution containing Fe, V, and Ni largely reproduced the lung injury induced by ROFA. Metal interactions and pH were found to influence the severity and kinetics of lung injury induced by ROFA and soluble transition metals. These findings provide direct evidence for the role of soluble transition metals in the pulmonary injury induced by the combustion emission source particulate, ROFA.

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“the pulmonary effects are relatively minor compared with other occupationally relevant particles such as residual oil fly ash (Dreher et al. 1997).”
Background
Cardiac Arrhythmia Induction after Exposure to Residual Oil Fly Ash Particles in a Rodent Model of Pulmonary Hypertension
Watkinson, W. P. (1998) · Toxicological Sciences · doi:10.1006/toxs.1997.2406 · Cited by 75
Residual Oil Fly Ash Exposure Enhances Allergic Sensitization to House Dust Mite
Lambert, A. L., Dong, W., Winsett, D. W., Selgrade, M. K., & Gilmour, M. I. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8709 · Cited by 75
CARDIAC AND THERMOREGULATORY EFFECTS OF INSTILLED PARTICULATE MATTER-ASSOCIATED TRANSITION METALS IN HEALTHY AND CARDIOPULMONARY-COMPROMISED RATS
Campen, M. J., Nolan, J. P., Schladweiler, M. C. J., Kodavanti, U. P., Costa, D. L., & Watkinson, W. P. (2002) · Journal of Toxicology and Environmental Health · doi:10.1080/00984100290071694 · Cited by 73
“The metals Fe, Ni, and V were subsequently shown to reproduce many of the toxic effects of ROFA, and coadministration of either a metal chelator (deferoxamine mesylate) or a radical scavenger (dimethylthiourea) reduced both ROFA and metal toxicity (Dreher et al., 1997; Dye et al., 1999).”
BackgroundResultInfluential
Particulate Air Pollution from Bushfires: Human Exposure and Possible Health Effects
Karthikeyan, S., Balasubramanian‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬, R., & Kostetski, I. (2006) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390600751264 · Cited by 72
“…fine particles or present on their surfaces play a role in the generation of reactive oxygen species (ROS), and this is also true for coal fly ash particles (Donaldson et al., 1997; Dornisch et al., 1999; Dellinger et al., 2001; Dreher et al., 1997; Goldsmith et al., 1998; Van Maanen et al., 1999).”
Background
Adjuvant Activity of Various Diesel Exhaust and Ambient Particles in Two Allergic Models
Steerenberg, P. A., Withagen, C. E. T., Dormans, J. A. M. A., van Dalen, W. J., Loveren, H. V., & Casee, F. R. (2003) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390306415 · Cited by 72
“DEP and residual oil fly ash (ROFA) represent two important types of environmental pollutants, rich in polycyclic aromatic hydrocarbons (PAH) and transition metals, respectively (Broeckaert et al., 1999; Dreher et al., 1997).”
Background
SOLUBLE COMPONENTS OF UTAH VALLEY PARTICULATE POLLUTION ALTER ALVEOLAR MACROPHAGE FUNCTION IN VIVO AND IN VITRO
Soukup, A. J. G. J. M. (2000) · Inhalation Toxicology · doi:10.1080/089583700196112 · Cited by 72
Expression of β-Defensin Genes in Bovine Alveolar Macrophages
Ryan, L. K., Rhodes, J., Bhat, M., & Diamond, G. (1998) · Infection and Immunity · doi:10.1128/iai.66.2.878-881.1998 · Cited by 72
Ambient particulate air pollution and circulating antioxidant enzymes: A repeated-measure study in healthy adults in Beijing, China
Wu, S., Wang, B., Yang, D., Wei, H., Li, H., Pan, L., Huang, J., Wang, X., Qin, Y., Zheng, C., et al. (2015) · Environmental Pollution · doi:10.1016/j.envpol.2015.06.002 · Cited by 71
Metals Mimic Airway Epithelial Injury Induced by in Vitro Exposure to Utah Valley Ambient Particulate Matter Extracts
Pagan, I., Costa, D. L., McGee, J. K., Richards, J. H., Dye, J. A., & Dykstra, M. J. (2003) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390390213908 · Cited by 71
Impact of the composition of combustion generated fine particles on epithelial cell toxicity: influences of metals on metabolism
Okeson, C. D., Riley, M. R., Fernandez, A., & WENDT, J. O. L. (2003) · Chemosphere · doi:10.1016/s0045-6535(02)00721-x · Cited by 71
PM10 elemental composition and acute respiratory health effects in European children (PEACE project)
Roemer, W. H., Hoek, G., Brunekreef, B., Clench‐Aas, J., Forsberg, B., Pekkanen, J., & Schütz, A. (2000) · European Respiratory Journal · doi:10.1034/j.1399-3003.2000.15.21.x · Cited by 70
Oxidative Stress Mediates Air Pollution Particle-Induced Acute Lung Injury and Molecular Pathology
Roberts, E. S., Richards, J. H., Jaskot, R. H., & Dreher, K. L. (2003) · Inhalation Toxicology · doi:10.1080/08958370390241795 · Cited by 70
“The protein content of the extracts was determined using the Coomassie Plus protein assay (Pierce, Rockland, IL) adapted for use on the Cobas Fara II clinical analyzer (Roche Diagnostics, Branchburg, NJ).”
BackgroundMethodInfluential
Ambient particulate matter and respiratory and cardiovascular illness in adults: particle-borne transition metals and the heart–lung axis,
Chapman, R. S., Watkinson, W. P., Dreher, K. L., & Costa, D. L. (1997) · Environmental Toxicology and Pharmacology · doi:10.1016/s1382-6689(97)10031-x · Cited by 70
Air pollution, PM 2.5 composition, source factors, and respiratory symptoms in asthmatic and nonasthmatic children in Santiago, Chile
Parra, L. P., Yohannessen, K., V, Brea, C., Vidal, D., Pérez, C. U., & Ruiz-Rudolph, P. (2017) · Environment International · doi:10.1016/j.envint.2017.01.021 · Cited by 69
Short-Term Effects of Low-Level Air Pollution on Respiratory Health of Adults Suffering from Moderate to Severe Asthma
Desqueyroux, H., Pujet, J.-C., Prosper, M., Squinazi, F., & Momas, I. (2002) · Environmental Research · doi:10.1006/enrs.2002.4357 · Cited by 68
Residual Oil Fly Ash Amplifies Allergic Cytokines, Airway Responsiveness, and Inflammation in Mice
Gavett, S. H., Madison, S. L., STEVENS, M. A., & Costa, D. L. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.6.9901053 · Cited by 68
Oil Fly Ash-Induced Elevation of Plasma Fibrinogen Levels in Rats
Gardner, S. Y. (2000) · Toxicological Sciences · doi:10.1093/toxsci/56.1.175 · Cited by 68
“Intratracheal instillations were performed as previously described (Dreher et al., 1997 ) was instilled intratracheally in rats (n ϭ 6).”
Influential
Square-wave stripping voltammetry for direct determination of eight heavy metals in soil and indoor-airborne particulate matter
Farghaly, O. A. E.-M., & Ghandour, M. A. (2004) · Environmental Research · doi:10.1016/j.envres.2004.07.007 · Cited by 66
Resistance of Very Young Mice to Inhaled Allergen Sensitization Is Overcome by Coexposure to an Air-Pollutant Aerosol
Hamada, K., Goldsmith, C. W., Goldman, A., & Kobzik, L. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.4.9906137 · Cited by 66
“First, the leachate from ROFA is not representative of all components present in particulate air pollution (31, 32).”
Background
Genetic susceptibility to irritant-induced acute lung injury in mice
Wesselkamper, S. C., Prows, D. R., Biswas, P., Willeke, K., Bingham, E., & Leikauf, G. D. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.3.l575 · Cited by 65
“Recent studies (6, 8, 11) of a particulate matter surrogate, residual oil fly ash, indicate that the water-soluble metals (vanadium, chromium, nickel, and iron) released from this material were responsible for the observed acute lung injury and inflammation.”
Background
Identification of Systemic Markers from A Pulmonary Carbon Nanotube Exposure
Erdely, A., Liston, A., Salmen‐Muniz, R., Hulderman, T., Young, S., Zeidler-Erdely, P. C., Castranova, V., & Simeonova, P. P. (2011) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0b013e31821ad724 · Cited by 64
The Effect of Composition, Size, and Solubility on Acute Pulmonary Injury in Rats Following Exposure to Mexico City Ambient Particulate Matter Samples
Snow, S. J., Vizcaya‐Ruíz, A. D., Osornio-Vargas, Á. R., Thomas, R. F., Schladweiler, M. C. J., McGee, J. K., & Kodavanti, U. P. (2014) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2014.917445 · Cited by 64
“DISCUSSION Examining the role of soluble metals in PM-induced cardiopulmonary injury using oil combustion-derived metal-rich PM has been extensively studied (Dreher et al., 1997; Kodavanti et al., 1998); however, few systematic in vivo studies have been conducted using ambient PM samples.”
BackgroundResultInfluential
Manganese toxicokinetics at the blood-brain barrier.
Yokel, R. A., & Crossgrove, J. S. (2004) · PubMed · Cited by 64
Ambient Particulate Matter Exhibits Direct Inhibitory Effects on Oxidative Stress Enzymes
Hatzis, C., Godleski, J. J., González‐Flecha, B., Wolfson, J. M., & Koutrakis, P. (2006) · Environmental Science & Technology · doi:10.1021/es0518732 · Cited by 63
Chemical constituents and sources of ambient particulate air pollution and biomarkers of endothelial function in a panel of healthy adults in Beijing, China
Wu, S., Yang, D., Pan, L., Shan, J., Li, H., Wei, H., Wang, B., Huang, J., Baccarelli, A., Shima, M., et al. (2016) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2016.03.228 · Cited by 62
CONTRIBUTION OF ENDOTOXIN IN MACROPHAGE CYTOKINE RESPONSE TO AMBIENT PARTICLES IN VITRO
Huang, S., Cheng, W.-L., Lee, C.-T., Huang, H., & Chan, C. (2002) · Journal of Toxicology and Environmental Health · doi:10.1080/152873902760125741 · Cited by 62
Effects of concentrated ambient particles on heart rate and blood pressure in pulmonary hypertensive rats.
Cheng, T., Hwang, J.-S., Wang, P., Tsai, C.-F., Chen, C., Lin, S., & Chan, C. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.5464 · Cited by 61
Assessment of air pollution in Nagasaki city: determination of polycyclic aromatic hydrocarbons and their nitrated derivatives, and some metals
Wada, M., Kido, H., Kishikawa, N., Tou, T., Tanaka, M., Tsubokura, J., Shironita, M., Matsui, M., Kuroda, N., & Nakashima, K. (2001) · Environmental Pollution · doi:10.1016/s0269-7491(01)00093-8 · Cited by 60
Oxidative damage in human epithelial alveolar cells exposed in vitro to oil fly ash transition metals
Pietro, A. D., Visalli, G., Munaò, F., Baluce, B., Maestra, S. L., Primerano, P., Corigliano, F., & Flora, S. D. (2008) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2008.05.005 · Cited by 60
Involvement of NADPH Oxidase and iNOS in Rodent Pulmonary Cytokine Responses to Urban Air and Mineral Particles
Becher, R., Bucht, A., Øvrevik, J., Hongslo, J. K., Dahlman, H. J., Samuelsen, J. T., & Schwarze, P. E. (2007) · Inhalation Toxicology · doi:10.1080/08958370701353528 · Cited by 59
“Previous results have demonstrated that various types of particles induce changes in inflammatory responses with greatly differing potency (Dreher et al., 1997; Sandstrøm, 1995; Yuen et al., 1996).”
Result
Inhalation health effects of fine particles from the co-combustion of coal and refuse derived fuel
Fernandez, A., WENDT, J. O. L., Wolski, N., Hein, K., Wang, S., & Witten, M. L. (2003) · Chemosphere · doi:10.1016/s0045-6535(02)00720-8 · Cited by 60
“It has been suggested that chemical species that leached or dissolved from these particles are an important indicator to potential lung injury (Costa and Dreher, 1997; Dreher et al., 1997).”
Background
Cellular and Biochemical Response of the Human Lung after Intrapulmonary Instillation of Ferric Oxide Particles
Lay, J. C., Bennett, W. D., Ghio, A. J., Bromberg, P. A., Costa, D. L., Kim, C. S., Koren, H. S., & Devlin, R. B. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.4.3355 · Cited by 59
Soot Nanoparticles Promote Biotransformation, Oxidative Stress, and Inflammation in Murine Lungs
Rouse, R. L., Murphy, G., Boudreaux, M. J., Paulsen, D. B., & Penn, A. L. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0057oc · Cited by 59
“Effects of these combustion products have been attributed to metals (13) hydroquinones oxidized to semiquinone radicals that ultimately produce superoxide (29) and other PAH oxidation products.”
Background
Accumulation of Iron in the Rat Lung after Tracheal Instillation of Diesel Particles
Ghio, A. J., Richards, J. H., Carter, J. D., & Madden, M. C. (2000) · Toxicologic Pathology · doi:10.1177/019262330002800416 · Cited by 59
“Using a particle with abundant concentrations of metals (ie, a residual oil fly ash), correlations between metal-catalyzed oxidative stress and cell signaling (33), activation of transcription factors (30), cellular release of inflammatory mediators (4), and lower respiratory injury in vivo (7) have been delineated.”
Background
Fine particle emissions from residual fuel oil combustion: Characterization and mechanisms of formation
Linak, W. P., Miller, C. A., & WENDT, J. O. L. (2000) · Proceedings of the Combustion Institute · doi:10.1016/s0082-0784(00)80684-0 · Cited by 58
Effect of co-exposure to nickel and particulate matter on insulin resistance and mitochondrial dysfunction in a mouse model
Xu, X., Rao, X., Wang, T.-Y., Jiang, S. Y., Ying, Z., Liu, C., Wang, A., Zhong, M., Deiuliis, J. A., Maiseyeu, A., et al. (2012) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-9-40 · Cited by 58
“It has been reported that soluble transition metals, such as iron (Fe), Ni, and vanadium (V), are responsible for the majority of residual oil fly ash toxicity [23,24].”
Background
The study of fine and coarse particles, and metallic elements for the daytime and night-time in a suburban area of central Taiwan, Taichung
Fang, G., Chang, C.-N., Wu, Y., Wang, V., Fu, P. P., Yang, D., Chen, S., & Chu, C. (2000) · Chemosphere · doi:10.1016/s0045-6535(99)00507-x · Cited by 58
Residual Oil Fly Ash Induces Cytotoxicity and Mucin Secretion by Guinea Pig Tracheal Epithelial Cells via an Oxidant-Mediated Mechanism
Jiang, N.-F., Dreher, K. L., Dye, J. A., Li, Y., Richards, J. H., Martin, L. D., & Adler, K. B. (2000) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8886 · Cited by 58
Environmental Particulate (PM2.5) Augments Stiffness-Induced Alveolar Epithelial Cell Mechanoactivation of Transforming Growth Factor Beta
Dysart, M. M., Galvis, B. R., Russell, A. G., & Barker, T. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106821 · Cited by 57
“Both organic and inorganic agents, such as transition metals, hydrocarbons, and endotoxins can contribute to the composition of the PM [40–42].”
Background

Authors: Kevin L. Dreher, R. H. J.
Venue: Journal of Toxicology and Environmental Health
Publisher: Informa UK Limited
Published: 1997-02
Volume: 50
Issue: 3
Pages: 285-305
ISSN: 0098-4108 (ISSN-L)
DOI: 10.1080/009841097160492
OpenAlex: W2169046198
Cited by: 486
References: 32
Citations by year: 2026: 4 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 11 · 2015: 17 · 2014: 9 · 2013: 17 · 2012: 13
FWCI: 34.31
Type: journal article
Language: en
Open access: closed
Locations: Journal of Toxicology and Environmental Health (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Physical Sciences › Earth and Planetary Sciences › Geochemistry and Petrology › Coal and Its By-products
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
Keywords: residual oil fly ash, acute lung injury, iron, nickel, vanadium, pulmonary toxicity, bronchoalveolar lavage fluid, airway inflammation, metal interactions, pH effect, particulate matter pollution
MeSH terms: Acute Disease, Air Pollutants, Animals, Carbon, Chemistry, Physical, Fuel Oils, Inflammation, Lung Diseases, Male, Metals, Particle Size, Solubility, Sulfates, Rats, Sprague-Dawley, Rats, Chemical Phenomena

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SOLUBLE TRANSITION METALS MEDIATE RESIDUAL OIL FLY ASH INDUCED ACUTE LUNG INJURY

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