Cited by 486Air Quality and Health ImpactsCoal and Its By-productsOccupational and environmental lung diseases

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SOLUBLE TRANSITION METALS MEDIATE RESIDUAL OIL FLY ASH INDUCED ACUTE LUNG INJURY

Kevin L. Dreher, Richard H. Jaskot,·1997·Journal of Toxicology and Environmental Health

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Abstract

Identification of constituents responsible for the pulmonary toxicity of fugitive combustion emission source particles may provide insight into the adverse health effects associated with exposure to these particles as well as ambient air particulate pollution. Herein, we describe results of studies conducted to identify constituents responsible for the acute lung injury induced by residual oil fly ash (ROFA) and to assess physical-chemical factors that influence the pulmonary toxicity of these constituents. Biochemical and cellular analyses performed on bronchoalveolar lavage fluid obtained from rats following intratracheal instillation of ROFA suspension demonstrated the presence of severe inflammation, an indicator of pulmonary injury, which included recruitment of neutrophils, eosinophils, and monocytes into the airway. A leachate prepared from ROFA, containing predominantly Fe, Ni, V, Ca, Mg, and sulfate, produced similar lung injury to that induced by ROFA suspension. Depletion of Fe, Ni, and V from the ROFA leachate abrogated its pulmonary toxicity. Correspondingly, minimal lung injury was observed in animals exposed to saline-washed ROFA particles. A surrogate transition metal sulfate solution containing Fe, V, and Ni largely reproduced the lung injury induced by ROFA. Metal interactions and pH were found to influence the severity and kinetics of lung injury induced by ROFA and soluble transition metals. These findings provide direct evidence for the role of soluble transition metals in the pulmonary injury induced by the combustion emission source particulate, ROFA.

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Lung function of primary cooks using LPG or biomass and the effect of particulate matter on airway epithelial barrier integrity
Stapleton, E. M., Puliyakote, A. S. K., Metwali, N., Jeronimo, M., Thornell, I. M., Manges, R. B., Bilas, M., Batcha, M. A. K., Kumaravel, M. S., Durairaj, K., et al. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109888 · Cited by 16
“Three metals associated with chronic and acute lung disease were identified as being elevated in biomass homes compared to LPG. Arsenic (As) has robust respiratory health effects, (Bomberger et al., 2012; Enterline, Henderson, & Marsh, 1987; Mazumdar et al., 2015; Mazumder et al., 2000) as does Iron, (Buonfiglio et al…”
Background
Effects of atorvastatin on fine particle-induced inflammatory response, oxidative stress and endothelial function in human umbilical vein endothelial cells
Zhao, J., Xie, Y., Jiang, R., Kan, H., & Song, W. (2011) · Human & Experimental Toxicology · doi:10.1177/0960327111401050 · Cited by 16
Functional Genomics of Lung Disease
Whitsett, J. A., Bachurski, C. J., Barnes, K. C., Bunn, P. A., Case, L. M., Cook, D. N., Crooks, D. M., Duncan, M. W., Dwyer‐Nield, L. D., Elston, R. C., et al. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0071su · Cited by 16
Thermoregulatory effects following exposure to particulate matter in healthy and cardiopulmonary-compromised rats
Watkinson, W. P., Campen, M. J., Dreher, K. L., Su, W.-Y., Kodavanti, U. P., Highfill, J. W., & Costa, D. L. (2000) · Journal of Thermal Biology · doi:10.1016/s0306-4565(99)00090-x · Cited by 16
Gravimetric and Chemical Features of Airborne PM10 AND PM2.5 in Mainland Portugal
Freitas, M. C., Farinha, M. M., Ventura, M. G., Almeida, S. M., Reis, M. A., & Pacheco, A. M. G. (2005) · Environmental Monitoring and Assessment · doi:10.1007/s10661-005-5841-9 · Cited by 16
“5 (Vincent, 1999) – which in turn are likely to entrain adsorbed, tissueinjuring metals (Dreher et al., 1997) deeper into the airways and eventually down to the inner-lung tissues.”
Background
PARTICULATE MATTER (PM10 AND PM2.5) FROM DIFFERENT AREAS OF PUERTO RICO
Gioda, A., Pérez, U. J., Rosa, Z., & Jiménez-Velez, B. D. (2007) · Cited by 16
Development and Evaluation of a Compact Facility for Exposing Humans to Concentrated Ambient Ultrafine Particles
Misra, C., Fine, P. M., Singh, M., & Sioutas, C. (2003) · Aerosol Science and Technology · doi:10.1080/02786820300984 · Cited by 16
Sources of acellular oxidative potential of water-soluble fine ambient particulate matter in the midwestern United States
Yu, H., Wang, Y., Puthussery, J. V., & Verma, V. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.134763 · Cited by 15
Exposure to Fine Particles by Mine Tailing and Lung Function Effects in a Panel of Schoolchildren, Chañaral, Chile
Yohannessen, K., V, Orellana, S. A., Monsalve, S. M., Vergara, J. K., Zamora, C. S., Vidal, D., & Cáceres, D. (2015) · Journal of Environmental Protection · doi:10.4236/jep.2015.62014 · Cited by 15
Spatial and seasonal distribution of aerosol chemical components in New York City: (1) Incineration, coal combustion, and biomass burning
Peltier, R. E., & Lippmann, M. (2011) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2011.16 · Cited by 15
“5, have produced effects that appear to be related to their relatively low contents of metals and carbonaceous material (Dreher et al., 1997; Ghio et al., 2002; Costa et al., 2006; Gent et al., 2009; Lippmann and Chen, 2009; Patel et al., 2009).”
Background
Induction of pulmonary matrilysin expression by combustion and ambient air particles
Su, W. Y., Jaskot, R. H., Richards, J. H., Abramson, S., Woessner, J. F., Yu, W., & Dreher, K. L. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.1.l152 · Cited by 15
Chemical and morphological characterization by SEM–EDS of PM2.5 collected during winter in Ulaanbaatar, Mongolia
Park, J., Kim, M. S., Yeo, M., Choi, M., Lee, J. Y., Natsagdorj, A., Kim, C., Song, M., & Jang, K. (2023) · Atmospheric Environment · doi:10.1016/j.atmosenv.2023.119752 · Cited by 14
Multiple protein kinase pathways mediate amplified IL-6 release by human lung fibroblasts co-exposed to nickel and TLR-2 agonist, MALP-2
Gao, F., Brant, K. A., Ward, R. M., Cattley, R. T., Barchowsky, A., & Fabisiak, J. P. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.06.007 · Cited by 14
The soluble nickel component of residual oil fly ash alters pulmonary host defense in rats
Roberts, J. R., Young, S., Castranova, V., & Antonini, J. M. (2009) · Journal of Immunotoxicology · doi:10.1080/15476910802630379 · Cited by 14
“, 2002), and fell within the range of concentrations consistently used in other animal studies evaluating the pulmonary responses to ROFA (Dreher et al., 1997; Gavett et al., 1997; Kodavanti et al., 1998).”
BackgroundResult
Evaluation of the Pulmonary Toxicity of Ambient Particulate Matter From Camp Victory, Iraq
Porter, K. L., Green, F. H. Y., Harley, R. A., Vallyathan, V., Castranova, V., Waldron, N. R., Leonard, S. S., Nelson, D. E., Lewis, J. A., & Jackson, D. A. (2015) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2015.1072611 · Cited by 14
“Soluble components have been implicated in the toxicity of other materials including inhaled fly ash and North American ambient dusts (Adamson et al. 2004; Chen and Lippmann 2009; Dreher et al. 1997; Prieditis and Adamson 2002; Pritchard et al. 1996).”
Laboratory investigation of pollutant emissions and PM2.5 toxicity of underground coal fires
Li, K., Zhang, Q., Wang, T., Rong, R., Hu, X., & Zhang, Y. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.155537 · Cited by 14
Direct and Indirect Effect of Air Particles Exposure Induce Nrf2-Dependent Cardiomyocyte Cellular Response In Vitro
Orona, N. S., Astort, F., Maglione, G. A., Yakisich, J. S., & Tasat, D. R. (2019) · Cardiovascular Toxicology · doi:10.1007/s12012-019-09530-z · Cited by 14
Evaluation of cII mutations in lung of male Big Blue mice exposed by inhalation to vanadium pentoxide for up to 8 weeks
Manjanatha, M. G., Shelton, S. D., Haber, L. T., Gollapudi, B. B., MacGregor, J. A., Rajendran, N., & Moore, M. M. (2015) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2015.06.014 · Cited by 14
Association of expired nitric oxide with occupational particulate exposure.
Kim, J. Y., WAND, M. P., Hauser, R. B., Mukherjee, S., Herrick, R. F., & Christiani, D. C. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.5880 · Cited by 14
Residual Oil Fly Ash Inhalation in Guinea Pigs: Influence of Absorbate and Glutathione Depletion
Norwood, J. (2001) · Toxicological Sciences · doi:10.1093/toxsci/61.1.144 · Cited by 14
“Other studies have described the histological features of lung injury induced by ROFA inhalation and intratracheal instillation and have demonstrated the significant role that metals play in its toxicity (Dreher et al., 1997; Kodavanti et al., 1997, 1999).”
Background
In Situ Pulmonary Localization of Air Pollution Particle-induced Oxidative Stress
Roberts, E. S., Malstrom, S. E., & Dreher, K. L. (2007) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390701551357 · Cited by 13
Physicochemical characterization and oxidative potential of size fractionated Particulate Matter: Uptake, genotoxicity and mutagenicity in V-79 cells
Dubey, K., Maurya, R., Mourya, D., & Pandey, A. K. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114205 · Cited by 13
Cellular and molecular mechanisms in environmental and occupational inhalation toxicology.
Riechelmann, H. (2004) · PubMed Central · Cited by 13
Soluble metals in residual oil fly ash alter innate and adaptive pulmonary immune responses to bacterial infection in rats
Roberts, J. R., Young, S., Castranova, V., & Antonini, J. M. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.03.022 · Cited by 13
The effect of PM10 on human lung fibroblasts
Alley, D., Langley-Turnbaugh, S., Gordon, N., Wise, J. P., Epps, G. A. V., & Jalbert, A.-C. (2009) · Toxicology and Industrial Health · doi:10.1177/0748233709103185 · Cited by 13
Toxic Effects of Particulate Matter Derived from Dust Samples Near the Dzhidinski Ore Processing Mill, Eastern Siberia, Russia
Zychowski, K. E., Wheeler, A., Sanchez, B., Harmon, M. E., Steadman, C. R., Herbert, G., Lucas, S., Ali, A.-M. S., Avasarala, S., Kunda, N. K., et al. (2019) · Cardiovascular Toxicology · doi:10.1007/s12012-019-09507-y · Cited by 14
AMBIENT PM 10 EXTRACTS INHIBIT PHAGOCYTOSIS OF DEFINED INERT MODEL PARTICLES BY ALVEOLAR MACROPHAGES
Monn, C., Fendt, R., & Koller, T. (2002) · Inhalation Toxicology · doi:10.1080/08958370252871005 · Cited by 13
“A study by Dreher et al. (1997) revealed the significant role of soluble transitions metals from ROFA in acute lung injury.”
Background
ANIMAL MODELS OF CARDIAC DISEASE: Potential Usefulness for Studying Health Effects of Inhaled Particles
Muggenburg, L. T. B. A. (2000) · Inhalation Toxicology · doi:10.1080/08958370050123225 · Cited by 13
“Components of particles that may influence toxicity include the bioaerosols, organic compounds, metals, and acids (Devlin et al., 2000; Dreher et al., 1997; U.S. Environmental Protection Agency, 1996; Zmirou et al., 1996).”
Background
A comprehensive review on phytoremediation of fly ash and red mud: exploring environmental impacts and biotechnological innovations
Abhishek, S., Ghosh, A., & Pandey, B. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-35217-2 · Cited by 12
“Elemental speciation further modulates toxicity; some species exhibit greater water solubility including Fe, Ni, V, and Zn, alongside toxic metals such as Pb and Cd, thus rendering to their bioavailability (Dreher et al. 1997).”
Effects of Airborne Metals on Lung Function in Inner Mongolian Schoolchildren
Madaniyazi, L., Guo, Y., Ye, X., Kim, D., Zhang, Y., & Pan, X. (2012) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0b013e31826ef177 · Cited by 12
Measurement Artifacts in the Dithiothreitol (DTT) Oxidative Potential Assay Caused by Interactions between Aqueous Metals and Phosphate Buffer
Yalamanchili, J., Hennigan, C. J., & Reed, B. E. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.131693 · Cited by 12
Daily variations of black carbon and element concentrations of atmospheric particles in the Beijing megacity – Part 1: General temporal course and source identification
Schleicher, N., Cen, K., & Norra, S. (2013) · Geochemistry · doi:10.1016/j.chemer.2012.11.006 · Cited by 12
Health Risks of Urban Airborne Particles
Kappos, A. D. (2010) · Environmental science and engineering · doi:10.1007/978-3-642-12278-1_27 · Cited by 14
“Instilled residual oil fly ash (ROFA) produces significant cell damage and inflammation in animal lungs depending on its content of transition metals (Fe, Ni, V, Zn) but in concentrations much higher than in ambient air (Dreher et al. 1997; Kodavanti et al. 1997).”
Background
Microanalysis of Indoor Aerosols and the Impact of a Compact High-Efficiency Particulate Air (HEPA) Filter System
Abraham, M. E. (1999) · Indoor Air · doi:10.1111/j.1600-0668.1999.t01-3-00006.x · Cited by 12
Time course of pulmonary burden in mice exposed to residual oil fly ash
Carvalho, G. M. C., Nagato, L. K. S., Fagundes, S. D. S., dos Santos, F. B., Calheiros, A. S., Malm, O., Bozza, P. T., Saldiva, P. H. N., Faffe, D. S., Rocco, P. R. M., et al. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00366 · Cited by 11
PARTICULATE MATTER AND SULFATE: EVALUATION OF CURRENT CALIFORNIA AIR QUALITY STANDARDS WITH RESPECT TO PROTECTION OF CHILDREN
Thurston, G. D. (2000) · Cited by 11
Emission-particle-induced ventilatory abnormalities in a rat model of pulmonary hypertension.
Gardner, S. Y., McGee, J. K., Kodavanti, U. P., Ledbetter, A. D., Everitt, J. I., Winsett, D. W., Doerfler, D. L., & Costa, D. L. (2004) · Environmental Health Perspectives · doi:10.1289/ehp.6583 · Cited by 11
Urinary metal and polycyclic aromatic hydrocarbon biomarkers in boilermakers exposed to metal fume and residual oil fly ash
Mukherjee, S., Rodrigues, E., Aeschliman, D. B., Houk, R. S., Palmer, L. J., Woodin, M. A., Weker, R. A., & Christiani, D. C. (2005) · American Journal of Industrial Medicine · doi:10.1002/ajim.20161 · Cited by 11
Development and Evaluation of a Compact Facility for Exposing Humans to Concentrated Ambient Ultrafine Particles
Misra, C., Fine, P. M., Singh, M., & Sioutas, C. (2004) · Aerosol Science and Technology · doi:10.1080/02786820490247605 · Cited by 11
“Finally, investigators have suggested that trace metals distributed widely throughout the lung on ultrafine particles could catalyze the formation of oxidants within the lung, which in turn produce tissue damage (Ghio et al. 1996; Dreher et al. 1997).”
Background
Subgroups exposed to systematically different elemental compositions of PM2.5
Edwards, R. D., & Jantunen, M. J. (2009) · Atmospheric Environment · doi:10.1016/j.atmosenv.2009.03.052 · Cited by 10
Health effects of aerosols
Tager, I. B. (2004) · CRC Press eBooks · doi:10.1201/9780203493182.ch24 · Cited by 10
Particle-Mediated Extracellular Oxidative Stress in the Lung
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In Vitro Assessment of the Inflammatory Response of Respiratory Endothelial Cells Exposed to Particulate Matter
Qu, S., Liberda, E. N., Qu, Q., & Chen, L. (2010) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2010.484335 · Cited by 10
“This finding supports the hypothesis that metals present in PM (Dreher et al., 1997) may be responsible for ROS formation and production of inflammatory mediators and therefore are important factors that may significantly influence the cardiovascular toxicities of PM exposure.”
Anthropogenic Vanadium-Chromium-Iron and Cerium-Lanthanum-Iron Particles in Settled Urban House Dust: CCSEM Identification and Analysis
Powell, J. W. D., Hunt, A. G., & Abraham, J. L. (2002) · Water Air & Soil Pollution · doi:10.1023/a:1014710917563 · Cited by 10
PM2.5: Epigenetic Alteration in Lung Physiology and Lung Cancer Pathogenesis
Parida, T., Gopamma, D., Murapala, D., Kolli, S. K., Malla, R. R., & Srinivas, N. (2023) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2023049651 · Cited by 10

Authors: Kevin L. Dreher, R. H. J.
Venue: Journal of Toxicology and Environmental Health
Publisher: Informa UK Limited
Published: 1997-02
Volume: 50
Issue: 3
Pages: 285-305
ISSN: 0098-4108 (ISSN-L)
DOI: 10.1080/009841097160492
OpenAlex: W2169046198
Cited by: 486
References: 32
Citations by year: 2026: 4 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 11 · 2015: 17 · 2014: 9 · 2013: 17 · 2012: 13
FWCI: 34.31
Type: journal article
Language: en
Open access: closed
Locations: Journal of Toxicology and Environmental Health (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
Physical Sciences › Earth and Planetary Sciences › Geochemistry and Petrology › Coal and Its By-products
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
Keywords: residual oil fly ash, acute lung injury, iron, nickel, vanadium, pulmonary toxicity, bronchoalveolar lavage fluid, airway inflammation, metal interactions, pH effect, particulate matter pollution
MeSH terms: Acute Disease, Air Pollutants, Animals, Carbon, Chemistry, Physical, Fuel Oils, Inflammation, Lung Diseases, Male, Metals, Particle Size, Solubility, Sulfates, Rats, Sprague-Dawley, Rats, Chemical Phenomena

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SOLUBLE TRANSITION METALS MEDIATE RESIDUAL OIL FLY ASH INDUCED ACUTE LUNG INJURY

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