Characterization and neuroprotective properties of alkaloid extract of Vernonia amygdalina Delile in experimental models of Alzheimer’s disease

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,460 · see citing works

Antioxidant activity applying an improved ABTS radical cation decolorization assay

Re, R., Pellegrini, N., Proteggente, A. R., Pannala, A. S., Yang, M. H., & Rice-Evans, C. A. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00315-3 · Cited by 26,298 · see citing works

THE COLORIMETRIC DETERMINATION OF PHOSPHORUS

Fiske, C. H., & Subbarow, Y. (1925) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)84756-1 · Cited by 19,155 · see citing works

Biostatistical Analysis.

Feinleib, M., & Zar, J. H. (1975) · Journal of the American Statistical Association · doi:10.2307/2285423 · Cited by 12,671 · see citing works

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061 · see citing works

Colorimetric assay of catalase

Sinha, A. K. (1972) · Analytical Biochemistry · doi:10.1016/0003-2697(72)90132-7 · Cited by 5,574 · see citing works

Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung

Cushman, D. W., & Cheung, H. S. (1971) · Biochemical Pharmacology · doi:10.1016/0006-2952(71)90292-9 · Cited by 2,633 · see citing works

Oxidative stress and neurodegeneration: where are we now?

Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614 · see citing works

[51] Assays for differentiation of glutathione S-Transferases

Habig, W. H., & Jakoby, W. B. (1981) · Methods in Enzymology · doi:10.1016/s0076-6879(81)77053-8 · Cited by 2,419 · see citing works

Phytochemical Methods. A Guide to Modern Techniques of Plant Analysis.

Paterson (1999) · Plant Pathology · doi:10.1046/j.1365-3059.1999.00318.x · Cited by 2,126 · see citing works

Indian Journal of Medical Research

(2024) · The Indian Journal of Medical Research · doi:10.25259/ijmr · Cited by 1,754 · see citing works

The role of acetylcholine in learning and memory

Hasselmo, M. E. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.09.002 · Cited by 1,693 · see citing works

Mechanism of Oxidative Stress in Neurodegeneration

Gandhi, S., & Abramov, A. Y. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/428010 · Cited by 964 · see citing works

Role of neuroinflammation in neurodegenerative diseases (Review)

Chen, W., Zhang, X., & Huang, W. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4948 · Cited by 933 · see citing works

Alkaloids: An overview of their antibacterial, antibiotic-enhancing and antivirulence activities

Cushnie, T. P. T., Cushnie, B., & Lamb, A. J. (2014) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2014.06.001 · Cited by 896 · see citing works

Free-radical scavenging action of medicinal herbs from Ghana

Gyamfi, M. A., Yonamine, M., & Aniya, Y. (1999) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(98)00238-9 · Cited by 872 · see citing works

Phytochemical Screening and Antioxidant Activities of Some Selected Medicinal Plants Used for Malaria Therapy in Southwestern Nigeria

Adesegun, S., Ayoola, G. A., Coker, H., Adepoju-Bello, A. A., Obaweya, K., Ezennia, E., & Atangbayila, T. (2008) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v7i3.14686 · Cited by 851 · see citing works

Amyloid β-peptide (1-42)-induced Oxidative Stress and Neurotoxicity: Implications for Neurodegeneration in Alzheimer's Disease Brain. A Review

Allan Butterfield, D. (2002) · Free Radical Research · doi:10.1080/1071576021000049890 · Cited by 786 · see citing works

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease

Lovell, M. A., Ehmann, W. D., Butler, S. M., & Markesbery, W. R. (1995) · Neurology · doi:10.1212/wnl.45.8.1594 · Cited by 644 · see citing works

Targeting the β secretase BACE1 for Alzheimer's disease therapy

Yan, R., & Vassar, R. J. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70276-x · Cited by 628 · see citing works

Acetylcholinesterase inhibitors from plants and fungi

Houghton, P. J., Ren, Y., & Howes, M.-J. (2006) · Natural Product Reports · doi:10.1039/b508966m · Cited by 584 · see citing works

beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies.

Bartolini, M., Bertucci, C., Cavrini, V., & Andrisano, V. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01514-9 · Cited by 523 · see citing works

Acta Neurologica Belgica

(2013) · Acta Neurologica Belgica · doi:10.1007/13760.2240-2993 · Cited by 462 · see citing works

In-vitro Inhibition of Human Erythrocyte Acetylcholinesterase by Salvia lavandulaefolia Essential Oil and Constituent Terpenes

Perry, N. S. L., Houghton, P. J., Theobald, A. E., Jenner, P. G., & Perry, E. K. (2000) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357001774598 · Cited by 458 · see citing works

The role of the nitric oxide pathway in brain injury and its treatment — From bench to bedside

Garry, P. S., Ezra, M., Rowland, M. J., Westbrook, J., & Pattinson, K. T. S. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2014.10.017 · Cited by 380 · see citing works

Therapeutic approaches to Alzheimer's disease

Klafki, H., Staufenbiel, M., Kornhuber, J., & Wiltfang, J. (2006) · Brain · doi:10.1093/brain/awl280 · Cited by 359 · see citing works

Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer’s disease

Ahmed, T., & Gilani, A.-H. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.09.010 · Cited by 301 · see citing works

African indigenous plants with chemotherapeutic potentials and biotechnological approach to the production of bioactive prophylactic agents

Olatunde Farombi, E. (2003) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb2003.000-1122 · Cited by 299 · see citing works

Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide

Melo, J. B., Agostinho, P. M., & Oliveira, C. R. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00201-8 · Cited by 271 · see citing works

Drosophila melanogaster as a model organism for Alzheimer’s disease

Prüßing, K., Voigt, A., & Schulz, J. B. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-35 · Cited by 271 · see citing works

Complementary and alternative medicine in chronic liver disease

Seeff, L. B., Lindsay, K. L., Bacon, B. R., Kresina, T. F., & Hoofnagle, J. H. (2001) · Hepatology · doi:10.1053/jhep.2001.27445 · Cited by 270 · see citing works

Effect of grape antioxidant dietary fiber on the total antioxidant capacity and the activity of liver antioxidant enzymes in rats

Alía, M., Horcajo, C., Bravo, L., & Goya, L. (2003) · Nutrition Research · doi:10.1016/s0271-5317(03)00131-3 · Cited by 265 · see citing works

An investigation into thee mechanism of citrateFE2+-dependent lipid peroxidation

Minotti, G., & Aust, S. D. (1987) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(87)90016-5 · Cited by 252 · see citing works

β-Secretase inhibition for the treatment of Alzheimer's disease – promise and challenge

Citron, M. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2003.12.004 · Cited by 194 · see citing works

Tyramine in foods and monoamine oxidase inhibitor drugs: A crossroad where medicine, nutrition, pharmacy, and food industry converge

McCabe‐Sellers, B., Staggs, C. G., & Bogle, M. L. (2006) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2005.12.008 · Cited by 181 · see citing works

Involvement of nitric oxide in learning & memory processes.

Paul, V., & Perumal, E. (2011) · PubMed · Cited by 176 · see citing works

A colorimetric method for the estimation of monoamine oxidase

Green, A. L., & Haughton, T. M. (1961) · Biochemical Journal · doi:10.1042/bj0780172 · Cited by 160 · see citing works

Natural Product Inhibitors of Acetylcholinesterase

Hostettmann, K., Borloz, A., Urbain, A., & Marston, A. (2006) · Current Organic Chemistry · doi:10.2174/138527206776894410 · Cited by 152 · see citing works

Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging

Araujo, J. A., Studzinski, C. M., & Milgram, N. W. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.12.008 · Cited by 140 · see citing works

Efficacy of aqueous leaf extract of vernonia amygdalina on plasma lipoprotein and oxidative status in diabetic rat models.

Nwanjo, H. U. (2012) · PubMed · Cited by 135 · see citing works

New Benzodiazepines Alter Acetylcholinesterase and ATPDase Activities

Schetinger, M. R. C., Porto, N. M., Moretto, M. B., Morsch, V. M., da Rocha, J. B. T., Vieira, V. L. P., Moro, F., Neis, R. T., Bittencourt, S. R. T., Bonacorso, H. G., et al. (2000) · Neurochemical Research · doi:10.1023/a:1007500424392 · Cited by 126 · see citing works

Hippocampal acetylcholine release correlates with spatial learning performance in freely moving rats

Fadda, F., Cocco, S., & Stancampiano, R. (2000) · Neuroreport · doi:10.1097/00001756-200007140-00040 · Cited by 122 · see citing works

Oriental Pharmacy and Experimental Medicine

Mehta, A., & Agrawal, B. (2013) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/13596.2211-1069 · Cited by 113 · see citing works

Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones

Kong, L. D., Cheng, C. H. K., & Tan, R. X. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.01.013 · Cited by 112 · see citing works

Antioxidant properties of polar and non‐polar extracts of some tropical green leafy vegetables

Oboh, G., Raddatz, H., & Henle, T. (2008) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.3367 · Cited by 109 · see citing works

Angiotensin‐converting enzyme inhibition reduces oxidative stress and protects dopaminergic neurons in a 6‐hydroxydopamine rat model of Parkinsonism

López-Real, A. M., Rey, P., Soto‐Otero, R., Méndez‐Álvarez, E., & Labandeira-García, J. L. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20598 · Cited by 107 · see citing works

Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission

Pereira, D. M., Ferreres, F., Oliveira, J. M. A., Gaspar, L., Faria, J. R. C., Valentão, P., Sottomayor, M., & Andrade, P. B. (2009) · Phytomedicine · doi:10.1016/j.phymed.2009.10.008 · Cited by 106 · see citing works

Effect of a centrally active angiotensin-converting enzyme inhibitor, perindopril, on cognitive performance in a mouse model of Alzheimer's disease.

Yamada, K., Uchida, S., Takahashi, S., Takayama, M., Nagata, Y., Suzuki, N., Shirakura, S., & Kanda, T. (2010) · Brain Research · doi:10.1016/j.brainres.2010.07.006 · Cited by 102 · see citing works

Immunolocalization of ecto-nucleoside triphosphate diphosphohydrolase 3 in rat brain: Implications for modulation of multiple homeostatic systems including feeding and sleep–wake behaviors

Belcher, S. M., Zsarnovszky, A., Crawford, P. A., Hemani, H. J., Spurling, L., & Kirley, T. L. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.086 · Cited by 98 · see citing works

Polyphenolic Contents and Antioxidant Potential of Stem Bark Extracts from Jatropha curcas (Linn)

Igbinosa, O. O., Igbinosa, I. H., Chigor, V. N., Uzunuigbe, O. E., Oyedemi, S. O., Odjadjare, E. E. O., Okoh, A. I., & Igbinosa, E. O. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12052958 · Cited by 93 · see citing works

Effect of caffeine, caffeic acid and their various combinations on enzymes of cholinergic, monoaminergic and purinergic systems critical to neurodegeneration in rat brain—In vitro

Akomolafe, S. F., Akinyemi, A. J., Ogunsuyi, O. B., Oyeleye, S. I., Oboh, G., Adeoyo, O. O., & Allismith, Y. R. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.04.008 · Cited by 89 · see citing works

Anti-amnestic Effect of Curcumin in Combination with Donepezil, an Anticholinesterase Drug: Involvement of Cholinergic System

Akinyemi, A. J., Oboh, G., Oyeleye, S. I., & Ogunsuyi, O. (2017) · Neurotoxicity Research · doi:10.1007/s12640-017-9701-5 · Cited by 82 · see citing works

Angiotensin converting enzyme inhibition partially prevents deficits in water maze performance, hippocampal synaptic plasticity and cerebral blood flow in streptozotocin-diabetic rats

Manschot, S., Biessels, G. J., Cameron, N. E., Cotter, M. A., Kamal, A., Kappelle, L. J., & Gispen, W. H. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04211-7 · Cited by 80 · see citing works

Antioxidant Constituents inVernonia amygdalina. Leaves

Erasto, P., Grierson, D. S., & Afolayan, A. J. (2007) · Pharmaceutical Biology · doi:10.1080/13880200701213070 · Cited by 75 · see citing works

Aqueous extracts of avocado pear ( Persea americana Mill.) leaves and seeds exhibit anti-cholinesterases and antioxidant activities in vitro

Oboh, G., Odubanjo, V. O., Bello, F. O., Ademosun, A. O., Oyeleye, S. I., Nwanna, E. E., & Ademiluyi, A. O. (2016) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2015-0049 · Cited by 74 · see citing works

Protective Effects of Extracts of Vernonia amygdalina, Hibiscus sabdariffa and Vitamin C against Radiation-induced Liver Damage in Rats

Adaramoye, O. A., OGUNGBENRO, B., ANYAEGBU, O., & Fafunso, M. A. (2008) · Journal of Radiation Research · doi:10.1269/jrr.07062 · Cited by 72 · see citing works

Brain renin-angiotensin system in cognitive function: pre-clinical findings and implications for prevention and treatment of dementia.

Ciobica, A. S., Bild, W., Hriţcu, L., & Haulica, I. D. (2009) · PubMed · Cited by 66 · see citing works

Central angiotensin converting enzyme facilitates memory impairment in intracerebroventricular streptozotocin treated rats.

Tota, S., Kamat, P. K., Saxena, G., Hanif, K., Najmi, A. K., & Nath, C. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.047 · Cited by 64 · see citing works

Altered synapses in a Drosophila model of Alzheimer's disease

Mhatre, S. D., Satyasi, V., Killen, M., Paddock, B. E., Moir, R. D., Saunders, A. J., & Marenda, D. R. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.012104 · Cited by 62 · see citing works

Moringa oleifera supplemented diet modulates nootropic-related biomolecules in the brain of STZ-induced diabetic rats treated with acarbose

Oboh, G., Oyeleye, S. I., Akintemi, O. A., & Olasehinde, T. A. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0198-2 · Cited by 62 · see citing works

KD-501, a standardized extract of Scrophularia buergeriana has both cognitive-enhancing and antioxidant activities in mice given scopolamine

Jeong, E. J., Ma, C. J., Lee, K. Y., Kim, S. H., Sung, S. H., & Kim, Y. C. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.10.006 · Cited by 58 · see citing works

Neuroprotective effect of SuHeXiang Wan in Drosophila models of Alzheimer's disease

Hong, Y. K., Park, S. H., Lee, S., Hwang, S., Lee, M. J., Kim, D., Lee, J. H., Han, S. Y., Kim, S. T., Kim, Y., et al. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.02.012 · Cited by 55 · see citing works

Alkaloid extracts from Jimson weed ( Datura stramonium L.) modulate purinergic enzymes in rat brain

Ademiluyi, A. O., Ogunsuyi, O. B., & Oboh, G. (2016) · NeuroToxicology · doi:10.1016/j.neuro.2016.06.012 · Cited by 55 · see citing works

In vitro neuroprotective properties of some commonly consumed green leafy vegetables in Southern Nigeria

Nwanna, E. E., Oyeleye, S. I., Ogunsuyi, O. B., Oboh, G., Boligon, A. A., & Athayde, M. L. (2015) · NFS Journal · doi:10.1016/j.nfs.2015.12.002 · Cited by 53 · see citing works

Poly-Electrophilic Sesquiterpene Lactones fromVernonia amygdalina: New Members and Differences in Their Mechanism of Thiol Trapping and in Bioactivity

Sinisi, A., Millán, E., Abay, S. M., Habluetzel, A., Appendino, G., Muñóz, E., & Taglialatela‐Scafati, O. (2015) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b00179 · Cited by 49 · see citing works

Blanching alters the phenolic constituents and in vitro antioxidant and anticholinesterases properties of fireweed (Crassocephalum crepidioides)

Adedayo, B. C., Oboh, G., Oyeleye, S. I., Ejakpovi, I. I., Boligon, A. A., & Athayde, M. L. (2015) · Journal of Taibah University Medical Sciences · doi:10.1016/j.jtumed.2015.09.003 · Cited by 47 · see citing works

Phenolic Composition and Evaluation of Methanol and Aqueous Extracts of Bitter Gourd ( Momordica charantia L) Leaves on Angiotensin-I-Converting Enzyme and Some Pro-oxidant-Induced Lipid Peroxidation In Vitro

Shodehinde, S. A., Adefegha, S. A., Oboh, G., Oyeleye, S. I., Olasehinde, T. A., Nwanna, E. E., Adedayo, B. C., & Boligon, A. A. (2016) · Journal of Evidence-Based Complementary & Alternative Medicine · doi:10.1177/2156587216636505 · Cited by 46 · see citing works

Green leafy vegetables from two Solanum spp. (Solanum nigrum L and Solanum macrocarpon L) ameliorate scopolamine‐induced cognitive and neurochemical impairments in rats

Ogunsuyi, O. B., Ademiluyi, A. O., Oboh, G., Oyeleye, S. I., & Dada, F. A. (2018) · Food Science & Nutrition · doi:10.1002/fsn3.628 · Cited by 46 · see citing works

Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: Involvement in hippocampal neuronal loss in Alzheimer's disease

Antequera, D., Bolós, M., Spuch, C., Pascual, C., Ferrer, I., Fernández‐Bachiller, M. I., Rodrı́guez-Franco, M. I., & Carro, E. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.009 · Cited by 45 · see citing works

Cholinesterase (ChE) inhibition in pumpkinseed (Lepomis gibbosus) as environmental biomarker: ChE characterization and potential neurotoxic effects of xenobiotics

Rodrigues, S., Caldeira, C., Castro, B. B., Gonçalves, F. J. M., Nunes, B., & Antunes, S. C. (2010) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2010.12.002 · Cited by 44 · see citing works

ACE activity in CSF of patients with mild cognitive impairment and Alzheimer disease

He, M., Ohrui, T., Maruyama, M., Tomita, N., Nakayama, K. I., Higuchi, M., Furukawa, K., & Arai, H. (2006) · Neurology · doi:10.1212/01.wnl.0000238102.04582.ec · Cited by 43 · see citing works

Angiotensin Converting Enzyme Inhibitors and the Reduced Risk of Alzheimer's Disease in the Absence of Apolipoprotein E4 Allele

Qiu, W. Q., Mwamburi, M., Besser, L. M., Zhu, H., Li, H., Wallack, M., Phillips, L., Qiao, L., Budson, A. E., Stern, R. A., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130716 · Cited by 42 · see citing works

Phenolic Extracts fromClerodendrum volubileLeaves Inhibit Cholinergic and Monoaminergic Enzymes Relevant to the Management of Some Neurodegenerative Diseases

Oboh, G., Ogunruku, O. O., Oyeleye, S. I., Olasehinde, T. A., Ademosun, A. O., & Boligon, A. A. (2016) · Journal of Dietary Supplements · doi:10.1080/19390211.2016.1237401 · Cited by 42 · see citing works

2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors

Lühr, S., Vilches‐Herrera, M., Fierro, A., Ramsay, R. R., Edmondson, D. E., Reyes-Parada, M. I., Cassels, B. K., & Iturriaga‐Vásquez, P. (2010) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2010.01.029 · Cited by 41 · see citing works

Effect of Andrographis paniculata and Phyllanthus amarus leaf extracts on selected biochemical indices in Drosophila melanogaster model of neurotoxicity

Adedayo, B. C., Ogunsuyi, O. B., Akinniyi, S. T., & Oboh, G. (2020) · Drug and Chemical Toxicology · doi:10.1080/01480545.2019.1708377 · Cited by 38 · see citing works

Jimson weed (Datura stramonium L.) alkaloid extracts modulate cholinesterase and monoamine oxidase activities in vitro: possible modulatory effect on neuronal function

Ademiluyi, A. O., Ogunsuyi, O. B., Oboh, G., & Agbebi, O. J. (2016) · Comparative Clinical Pathology · doi:10.1007/s00580-016-2257-6 · Cited by 37 · see citing works

Comparative Effects of Alkaloid Extracts fromAframomum melegueta(Alligator Pepper) andAframomum danielli(Bastered Melegueta) on Enzymes Relevant to Erectile Dysfunction

Adefegha, S. A., Oboh, G., Okeke, B. M., & Oyeleye, S. I. (2017) · Journal of Dietary Supplements · doi:10.1080/19390211.2016.1272661 · Cited by 37 · see citing works

Nutritive Value, Antioxidant and Antimicrobial Properties of Struchium sparganophora Leaves

Oboh, G. (2006) · Journal of Medicinal Food · doi:10.1089/jmf.2006.9.276 · Cited by 34 · see citing works

Development and characterization of an aged onset model of Alzheimer's disease in Drosophila melanogaster

Mhatre, S. D., Michelson, S. J., Gomes, J., Tabb, L. P., Saunders, A. J., & Marenda, D. R. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.08.021 · Cited by 31 · see citing works

Does caffeine influence the anticholinesterase and antioxidant properties of donepezil? Evidence from in vitro and in vivo studies

Oboh, G., Ogunsuyi, O. B., & Olonisola, O. E. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-9951-1 · Cited by 30 · see citing works

Gypenoside TN-2 ameliorates scopolamine-induced learning deficit in mice

Hong, S.-W., Yang, J.-H., Joh, E., Kim, H. J., & Kim, D. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.02.002 · Cited by 28 · see citing works

HPLC Separation of Isoquinoline Alkaloids for Quality Control of Corydalis species

Kim, E.-K., Jeong, E., Han, S.-B., Jung, J.-H., & Hong, J. (2011) · Bulletin of the Korean Chemical Society · doi:10.5012/bkcs.2011.32.10.3597 · Cited by 27 · see citing works

In vitro anticholinesterase, antimonoamine oxidase and antioxidant properties of alkaloid extracts from kola nuts ( Cola acuminata and Cola nitida )

Oboh, G., Ademosun, A. O., Ogunsuyi, O. B., Oyedola, E. T., Olasehinde, T. A., & Oyeleye, S. I. (2018) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2016-0155 · Cited by 27 · see citing works

Polyphenolic compositions and in vitro angiotensin-I-converting enzyme inhibitory properties of common green leafy vegetables: A comparative study

Oboh, G., Akinyemi, A. J., Adeleye, B., Oyeleye, S. I., Ogunsuyi, O. B., Ademosun, A. O., Ademiluyi, A. O., & Boligon, A. A. (2016) · Food Science and Biotechnology · doi:10.1007/s10068-016-0197-1 · Cited by 26 · see citing works

Effect of dietary inclusions of bitter kola seed on geotactic behavior and oxidative stress markers in Drosophila melanogaster

Oboh, G., Ogunsuyi, O. B., Ojelade, M. T., & Akomolafe, S. F. (2018) · Food Science & Nutrition · doi:10.1002/fsn3.782 · Cited by 26 · see citing works

Combined Efficacy of Gallic Acid and MiADMSA with Limited Beneficial Effects over MiADMSA against Arsenic-induced Oxidative Stress in Mouse

Pachauri, V., & Flora, S. J. S. (2015) · Biochemistry Insights · doi:10.4137/bci.s30505 · Cited by 22 · see citing works

Lead Finding for Acetyl Cholinesterase Inhibitors from Natural Origin: Structure Activity Relationship and Scope

Mukherjee, P. K., Satheeshkumar, N., Venkatesh, P., & Venkatesh, M. (2011) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955711795049880 · Cited by 20 · see citing works

The food and medicinal values of indigenous leafy vegetables

Oboh, G., Oyeleye, S. I., & Ademiluyi, A. O. (2019) · Acta Horticulturae · doi:10.17660/actahortic.2019.1238.15 · Cited by 15 · see citing works

Thyme (Thymus vulgaris) leaf extract modulates purinergic and cholinergic enzyme activities in the brain homogenate of 5-fluorouracil administered rats

Adefegha, S. A., Oyeleye, S. I., Akintemi, A., Okeke, B. M., & Oboh, G. (2019) · Drug and Chemical Toxicology · doi:10.1080/01480545.2019.1659310 · Cited by 11 · see citing works

Alzheimer’s Disease: A Review

Sharma, I. K., & Singh, K. (2019) · Indo Global Journal of Pharmaceutical Sciences · doi:10.35652/igjps.2019.92s51 · Cited by 11 · see citing works

Modulation of cholinergic, monoaminergic, and purinergic enzymes of the brain functions by bitter (Vernonia amygdalina) and water bitter (Struchium sparganophora) leaves extracts: comparison of phenolic constituents versus nootropic potentials

Ademosun, A. O., Oboh, G., Oyeleye, S. I., Ejakpovi, I. I., & Adewuni, T. M. (2017) · Comparative Clinical Pathology · doi:10.1007/s00580-017-2518-z · Cited by 10 · see citing works

V. Amygdalina: Folk Medicine, Analysis, and Potential Application for Cancer Treatment

Izevbigie, E. B., Howard, C., & Lee, K. (2008) · Current Pharmaceutical Analysis · doi:10.2174/157341208783497579 · Cited by 6 · see citing works

Medicinal Plants for Anti-neurodegenerative diseases in West Africa

Ayeni, E. A., Gong, Y., Yuan, H., Hu, Y., Bai, X., & Liao, X. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114468 · Cited by 58 · see citing works

Nutraceuticals-based therapeutic approach: recent advances to combat pathogenesis of Alzheimer’s disease

Talebi, M., Kakouri, E., Talebi, M., Tarantilis, P. Α., Farkhondeh, T., İlgün, S., Pourbagher‐Shahri, A. M., & Samarghandian, S. (2021) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2021.1923479 · Cited by 39 · see citing works

Phytochemicals Targeting Oxidative Stress, Interconnected Neuroinflammatory, and Neuroapoptotic Pathways Following Radiation

Fakhri, S., Piri, S., Moradi, S. Z., & Khan, H. Z. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210809103346 · Cited by 39 · see citing works

Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review

ALNasser, M. N., Alboraiy, G. M., Alsowig, E. M., & Alqattan, F. M. (2025) · Brain Sciences · doi:10.3390/brainsci15020215 · Cited by 35 · see citing works

Targeting Neuroinflammation as Disease Modifying Approach to Alzheimer’s Disease: Potential and Challenges

Jain, S., Singh, R., Paliwal, S., & Sharma, S. K. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557523666230511122435 · Cited by 31 · see citing works

Nutritional therapy can reduce the burden of depression management in low income countries: A review

Ekong, M. B., & Iniodu, C. F. (2021) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2021.06.002 · Cited by 28 · see citing works

African Medicinal Plants Useful for Cognition and Memory: Therapeutic Implications for Alzheimer’s Disease

Enogieru, A. B., & Momodu, O. I. (2021) · The Botanical Review · doi:10.1007/s12229-021-09246-2 · Cited by 23 · see citing works

The promising guide to LC–MS analysis and cholinesterase activity of Luffa cylindrica (L.) fruit using in vitro and in-silico analyses

Singh, S. A., & Vellapandian, C. (2023) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-023-00478-0 · Cited by 19 · see citing works

Citrus spp . essential oils improve behavioral pattern, repressed cholinesterases and monoamine oxidase activities, and production of reactive species in fruit fly ( Drosophila melanogaster ) model of Alzheimer’s Disease

Oyeleye, S. I., Ogunsuyi, O. B., Adedeji, V., Olatunde, D., & Oboh, G. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13558 · Cited by 16 · see citing works

Dopamine and central dopaminergic circuitry in neurodegenerative diseases: Roles and mechanisms of action of natural phytochemicals

Ang, J.-J., Low, B., & Wong, P. (2024) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2024.100050 · Cited by 13 · see citing works

Effect of alkaloid extract from Andrographis paniculata (Burm. f.) Nees and Phyllanthus amarus Schumach. & Thonn. on cognitive related biochemicals in the brain of streptozotocin-induced diabetic rats

Adedayo, B. C., Ajiboye, O. M., Oyeleye, S. I., Ojo, R. O., & Oboh, G. (2023) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2023.100314 · Cited by 12 · see citing works

Neuroprotective properties of solanum leaves in transgenic Drosophila melanogaster model of Alzheimer's disease

Ogunsuyi, O. B., Olasehinde, T. A., & Oboh, G. (2022) · Biomarkers · doi:10.1080/1354750x.2022.2077446 · Cited by 11 · see citing works

Zingiber officinale and Vernonia amygdalina Infusions Improve Redox Status in Rat Brain

Rotimi, D. E., Ben-Goru, G. M., Evbuomwan, I. O., Elebiyo, T. C., Alorabi, M., Farasani, A. M., Batiha, G. E., & Adeyemı, O. S. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/9470178 · Cited by 7 · see citing works

Unlocking nature’s medicine cabinet through Drosophila–Driven exploration

Sheng, X. Q., He, J., & Zhang, L. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157123 · Cited by 5 · see citing works

Evaluation of Biological Potency of two Endemic Species Integrated with in vitro and in silico Approches: LC–MS/MS Analysis of the Plants

Kısa, D., Topcu, K. S. B., Tunçkol, B., Genç, N., & İmamoğlu, R. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202301351 · Cited by 5 · see citing works

Phytochemical, Pharmacological, Phyto-cosmeceutical, Toxicity, and In silico Toxicological Evaluations of Vernonia amygdalina Delile – A Review

Atolanı, O., Banerjee, P., Ayenı, A. E., Usman, M. A., Adejumo, O. J., Erukainure, O. L., Preißner, R., Sokoudjou, J. B., Ologe, M. O., Adeyemı, O. S., et al. (2024) · Journal of the Turkish Chemical Society Section A Chemistry · doi:10.18596/jotcsa.1247620 · Cited by 5 · see citing works

Cola accuminata: Phytochemical Constituents, Nutritional Characteristics, Scientific Validated Pharmacological Properties, Ethnomedicinal Uses, Safety Considerations, and Commercial Values

Jacob, D. E., Nеlson, I. U., & Izah, S. C. (2023) · Reference series in phytochemistry · doi:10.1007/978-3-031-21973-3_59-1 · Cited by 4 · see citing works

Evaluation of different almond ( Terminalia catappa ) extracts against oxidative stress induced by cyclosporine in brain and liver of rats

Dada, F. A., Oyeleye, S. I., Adefegha, S. A., Babatola, L. J., & Adebayo, A. A. (2021) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2020-0193 · Cited by 4 · see citing works

Editan ( Lasianthera africana ) leaf‐inclusive diets modulate some neuronal enzyme activities and antioxidant status of cyclophosphamide‐treated Wistar rats

Nwanna, E. E., Oyeleye, S. I., & Oboh, G. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13427 · Cited by 4 · see citing works

Identification of a novel GSK-3β inhibitor for Alzheimer’s disease using In-Silico prediction and experiment cycling, validated in a streptozotocin-induced Alzheimer’s disease mouse model

Chauhan, N., Jain, S., Gupta, P., Dwivedi, J., Paliwal, S., Sharma, S., Mishra, A., Singh, S. K., Beth, M. R. M., & Arunraj, M. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05073-7 · Cited by 3 · see citing works

Parkia biglobosa Jacq. (Locust Bean) leaves and seeds extracts attenuates diabetic-linked cognitive dysfunction in streptozotocin-induced male wistar rats

Ajiboye, O. M., Ogunwenmo, K. O., ADEWUMI, A. G., & Mohanye, C. C. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01514-5 · Cited by 2 · see citing works

A Systematic Review of Phytochemistry, Pharmacology, and Applications of Vernonia Amygdalina Del

Fu, T., Wu, F., Shen, D., Yang, J., Liu, B., & Xu, F. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202502034 · Cited by 2 · see citing works

Complementary neuroprotective effects of semaglutide and papaya in diabetic encephalopathy via antioxidant and insulin-signaling pathways

Zeweil, M. M., Ali, M. M., Shamaa, M. M., Mohammed, F. N., Kamal, M., Zaki, M. S. A., Alharthi, A., Ahmed, A., Elkelish, A., Abdel-Maksoud, M. S., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-42791-7 · Cited by 2 · see citing works

Effect of Cananga odorata modulates cholinergic, purinergic enzymes, and elevates antioxidant markers in diabetes-induced cognitive disorder rat brain

Saliu, J. A., Ojo, O. R., Oyeleye, S. I., & Oboh, G. (2025) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2025.100607 · Cited by 2 · see citing works

Potential Therapeutics from Ayurveda, Siddha, and Homeopathic Medical System for Alzheimer’s Disease

Chandrani, S., & Thenmozhi, A. J. (2023) · Nutritional neurosciences · doi:10.1007/978-981-99-0677-2_12 · Cited by 1 · see citing works

Influence of cooking on the neuroprotective properties of pepper (bird pepper and cayenne pepper) varieties in scopolamine‐induced neurotoxicity in rats

Ademiluyi, A. O., Oyesomi, A. A., Ogunsuyi, O. B., Oyeleye, S. I., & Oboh, G. (2020) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.14959

Chemical composition of the essential oil of Vernonia gracilis Kunth from Venezuela

Colmenares, A. P., Rojas, L. B., Aparicio, R., & Obregón-Díaz, Y. (2023) · Journal of Essential Oil and Plant Composition · doi:10.58985/jeopc.2023.v01i02.09

Alzheimer's disease: A role of biomarkers in early diagnosis and evidences from African ethnomedicinal knowledge

Balkrishna, A., Verma, S., Singh, S. K., & Arya, V. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16050

In-Silico Discovery of Potential Dual Inhibitors Targeting Human Acetylcholinesterase and Butyrylcholinesterase for Alzheimer's Disease: A Pharmacophore-Based Virtual Screening and Molecular Docking ApproachPreprint

Yadav, P., & Jaiswal, S. (2023) · Research Square · doi:10.21203/rs.3.rs-3757327/v1

Cola accuminata: Phytochemical Constituents, Nutritional Characteristics, Scientific Validated Pharmacological Properties, Ethnomedicinal Uses, Safety Considerations, and Commercial Values

Jacob, D. E., Nеlson, I. U., & Izah, S. C. (2024) · Reference series in phytochemistry · doi:10.1007/978-3-031-43199-9_59

Ethnic Plants as Therapeutic Agents for Human Diseases

Swapna, B., Ramakrishna, M., Kameswaran, S., & Krishna, P. G. (2024) · Interdisciplinary biotechnological advances · doi:10.1007/978-981-97-4600-2_7

New Prospects of Alternative Medicine from Plant Sources in Management of Alzheimer’s Disease

Kipkemoi, D. J. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1006997

Phytochemical and Biological Evaluation of Cyanus celikhanensis Extract: An in Silico and in Vitro Approach

Topcu, K. S. B., Sağ, V., Genç, N., Çelik, A., İmamoğlu, R., & Kısa, D. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202402247

Ferulago angulata Extract Protects against Beta-amyloid-induced Memory Impairment Through Modulation of Monoaminoxidase Enzymes in the Rat’s Hippocampus

Mashhadi-Sharif, N., Soodi, M., Mirnajafi‐Zadeh, J., Shadboorestan, A., Ebadi-Ramsheh, H., & Bakhtiarzadeh, F. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04365-3

Neuroprotective properties of solanum leaves in transgenic Drosophila melanogaster model of Alzheimer's disease

Ogunsuyi, O. B., Olasehinde, T. A., & Oboh, G. (2022) · Biomarkers · doi:10.1080/1354750x.2022.2077446 · Cited by 11 · see citing works

Neuroprotective Effect of Centella Asiatica Leaf Alkaloid Extract on Enzymes Linked with Aluminium-Induced Alzheimer's Disease in Drosophila Melanogaster

Babatola, L. J., Adegoke, O. O., Ogunsuyi, O. B., & Oboh, G. (2025) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.18165879

Protective Effect of the Leaves ofSolanum torvumswartz onDrosophila melanogasteragainst β-Amyloid Induced Alzheimer Disease

Periyanayagam, K., Gokila, S., Balasubramaniam, K. G., Jagatheeswary, P. A. T., Suriakumar, J., & Parameshwari, R. (2015) · Research Journal of Pharmacy and Technology · doi:10.5958/0974-360x.2015.00114.6 · Cited by 12 · see citing works

Multimodal Evaluation of Ouret lanata (L.) Kuntze against Scopolamine-induced Alzheimer’s-like Neurocognitive dysfunction in Wistar Albino Rats

Thirupathi, A. T., Shenbagavel, A., Rajakumar, J. B., Ganesh, J. R., & Bhavithra, M. (2026) · International Journal of Drug Delivery Technology · doi:10.25258/ijddt.16.88s.21

Neuroprotective Effects of Fenugreek Leaf Extract in a Drosophila Model of Alzheimer's Disease Expressing Human Aβ-42

Varshney, H., Gaur, K., Subhan, I., Fatima, J., Jyoti, S., Mantasha, I., Shahid, M., Rahul, & Siddique, Y. H. (2025) · Current Alzheimer Research · doi:10.2174/0115672050385870250721072643 · Cited by 1 · see citing works