Verbal semantics and the left dorsolateral anterior temporal lobe: a longitudinal case of bilateral temporal degeneration
Open accessAbstract
BACKGROUND: Semantic variant primary progressive aphasia (svPPA), a clinical syndrome characterized by loss of semantic knowledge, is associated with neurodegeneration that starts in the anterior temporal lobe (ATL) and gradually spreads towards posterior temporal and medial frontal areas. At the earliest stages, atrophy may be predominantly lateralized to either the left or right ATL, leading to different clinical profiles with greatest impairment of word comprehension or visual/social semantics, respectively. METHODS & PROCEDURES: We report the in-depth longitudinal investigation of cognitive and neuroanatomical features of JB, an unusual case of ATL neurodegeneration with relative sparing of left lateral ATL regions. OUTCOMES & RESULTS: Over the course of nine years, neurodegeneration progressed to involve bilateral temporo-lateral and frontal regions, resulting in a relatively symmetric and diffuse frontotemporal atrophy pattern. In parallel, JB developed greater behavioral, cognitive, and language impairments, as well as signs of motor neuron disease at her last evaluation. Episodic memory and socio-emotional processing deficits arose, likely secondary to semantic verbal deficits, while visuospatial processing, executive function, and non-semantic language abilities remained largely unaffected throughout the course of the disease. CONCLUSIONS: The details of this rare case of early medial more than lateral ATL degeneration are consistent with a bilateral organization of the semantic system and, crucially, with a functional dissociation between medial paralimbic and lateral neocortical temporal regions. Cases of frontotemporal dementia (FTD) such as JB, who initially do not meet current clinical criteria for svPPA and instead present with some features of behavioral variant FTD, highlight the need for specific criteria for the right temporal variant of FTD that we propose could be called semantic variant FTD.
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The bilateral ATLs have been linked extensively to their role in semantic processing; the lATL has been largely associated with verbal semantics, whereas the rATL has been largely associated with nonverbal semantics, particularly regarding visual and socioemotional knowledge.
“The bilateral ATLs have been linked extensively to their role in semantic processing42; the lATL has been largely associated with verbal semantics, whereas the rATL has been largely associated with nonverbal semantics, particularly regarding visual and socioemotional knowledge.8,43”
From Automated Speech Analysis to Differentiate Frontal and Right Anterior Temporal Lobe Atrophy in Frontotemporal Dementia (2025) · cites this paper as [8]
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Experimental — accuracy not yet measuredsbvFTD is characterized by rATL atrophy and nonverbal semantic loss related to socioemotional concepts.
“new criteria have been proposed for a syndrome named semantic behavioral-variant FTD (sbvFTD), characterized by rATL atrophy and nonverbal semantic loss related to socioemotional concepts.3,7-9”
From Automated Speech Analysis to Differentiate Frontal and Right Anterior Temporal Lobe Atrophy in Frontotemporal Dementia (2025) · cites this paper as [8]
The Discussion describes right-predominant anterior temporal atrophy alongside nonverbal and social-semantic impairment, including changes in emotion processing. It proposes the name “semantic variant FTD” and calls for specific diagnostic criteria; it does not propose criteria for a syndrome named “semantic behavioral-variant FTD” (sbvFTD). (LLM, conf=0.85)
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Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589 · see citing works
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · cited 1× · see citing works
“A functional assessment of the severity of her dementia symptoms was made using the Clinical Dementia Rating Scale (CDR; Morris, 1993) through a semi-structured interview with her spouse.”
MethodA fast diffeomorphic image registration algorithm
Ashburner, J. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.007 · Cited by 8,122 · cited 1× · see citing works
“…older adults (ages 44–86, M± SD: 67.2 ± 7.3; 113 males, 186 females) scanned with one of three magnet strengths (1.5T, 3T, 4T), using affine and nonlinear transformations with the help of the Diffeomorphic Anatomical Registration through Exponentiated Lie algebra (DARTEL) toolbox (Ashburner, 2007).”
MethodInfluentialVALIDITY OF THE TRAIL MAKING TEST AS AN INDICATOR OF ORGANIC BRAIN DAMAGE
Reitan, R. M. (1958) · Perceptual and Motor Skills · doi:10.2466/pms.1958.8.3.271 · Cited by 7,925 · cited 2× · see citing works
“…edition (WMSIII; Wechsler, 1997), the incongruent version of the Stroop test in 60 s, and a modified version of the Trails sequencing task (Reitan, 1958), in which one had to alternately connect numbers and days of the week within 120 s. Semantic knowledge was evaluated using various…”
MethodSensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221 · cited 5× · see citing works
“hyperorality and dietary changes, or 6) executive/generation deficits with relative sparing of memory and visuospatial functions (Rascovsky et al., 2011).”
BackgroundInfluentialSelf-citationClassification of primary progressive aphasia and its variants
Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., Ogar, J. M., Rohrer, J. D., Black, S., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821103e6 · Cited by 5,141 · see citing works
Self-citationKaplan, E., Goodglass, H., Weintraub, S., & Segal, O. (2001) · doi:10.1007/springerreference_183640 · Cited by 4,981
Meeting of minds: the medial frontal cortex and social cognition
Amodio, D. M., & Frith, C. D. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1884 · Cited by 3,782 · cited 1× · see citing works
“More specifically, social functioning has been linked to the anterior rostral medial frontal cortex (e.g., Amodio & Frith, 2006), and emotion processing to the ventromedial prefrontal andmedial orbitofrontal cortices, as well as the amygdala (e.g., Britton et al., 2006; Northoff et al., 2000).”
BackgroundCognition and anatomy in three variants of primary progressive aphasia
Gorno‐Tempini, M. L., Dronkers, N. F., Rankin, K. P., Ogar, J. M., Phengrasamy, L., Rosen, H. J., Johnson, J. K., Weiner, M. W., & Miller, B. L. (2004) · Annals of Neurology · doi:10.1002/ana.10825 · Cited by 1,608 · see citing works
Self-citationThe Selective Impairment of Semantic Memory
Warrington, E. (1975) · Quarterly Journal of Experimental Psychology · doi:10.1080/14640747508400525 · Cited by 1,509 · cited 2× · see citing works
“The semantic variant of primaryprogressive aphasia (svPPA) is a clinical syndromemarkedby progressive selective impairment of semantic memory (Hodges, Patterson, Oxbury, & Funnell, 1992; Snowden, Goulding, & Neary, 1989; Warrington, 1975).”
BackgroundRapport, L. J., Millis, S., & Bonello, P. J. (1998) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.20.2.211.1169 · Cited by 911 · cited 1× · see citing works
“Visuospatial processing was tested with the Benson complex figure, which is a modified version of the Rey-Osterrieth complex figure, and the Number Location test from the Visual Object Space Perception (VOSP) battery (Warrington & James, 1991).”
MethodSemantic dementia: a form of circumscribed cerebral atrophy
Snowden, J. (1995) · Neurocase · doi:10.1093/neucas/1.1.39-y · Cited by 868 · see citing works
Representation of Pleasant and Aversive Taste in the Human Brain
O’Doherty, J. P., Rolls, E. T., Francis, S., Bowtell, R. W., & McGlone, F. P. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.3.1315 · Cited by 674 · see citing works
Mcdonald (2003) · doi:10.1097/00001199-200305000-00001 · Cited by 657 · see citing works
Response inhibition and impulsivity: An fMRI study
Horn, N. R., Dolan, M., Elliott, R., Deakin, J. F. W., & Woodruff, P. W. R. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(03)00077-0 · Cited by 604 · see citing works
Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia
Galton, C. J., Patterson, K., Graham, K., Lambon-Ralph, M. A., Williams, G., Antoun, N., Sahakian, B. J., & Hodges, J. R. (2001) · Neurology · doi:10.1212/wnl.57.2.216 · Cited by 582 · cited 1× · see citing works
“…semantic knowledge for famous people (Binney et al., 2016; Brambati et al., 2009; Chan et al., 2009; Evans, Heggs, Antoun, & Hodges, 1995; Gainotti, Barbier, &Marra, 2003; Galton et al., 2001; Gorno-Tempini et al., 2004; Perry et al., 2001; Snowden, Thompson, & Neary, 2004; Thompson et al., 2004).”
Baldo, J., Schwartz, S., Wilkins, D., & Dronkers, N. (2006) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617706061078 · Cited by 570 · see citing works
Boston Naming Test: shortened versions for use in Alzheimer's disease.
Mack, W., Freed, D., Williams, B. W., & Henderson, V. W. (1992) · Journal of Gerontology · doi:10.1093/geronj/47.3.p154 · Cited by 560 · see citing works
Impairment in facial recognition in patients with cerebral disease.
Benton, A., & van Allen, M. V. (1968) · Transactions of the American Neurological Association · doi:10.1016/s0010-9452(68)80018-8 · Cited by 551 · see citing works
Ikeda, M. (2002) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.73.4.371 · Cited by 499 · see citing works
Neural Systems Underlying the Recognition of Familiar and Newly Learned Faces
Leveroni, C. L., Seidenberg, M., Mayer, A. R., Mead, L. A., Binder, J. R., & Rao, S. M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00878.2000 · Cited by 494 · cited 1× · see citing works
“…the right inferior temporal regions that extent to a network including right inferior and superior frontal regions and right parietal regions (Andreasen et al., 1996; Andrews & Ewbank, 2004; Borghesani et al., 2019; Evans et al., 1995; Gorno-Tempini et al., 1998, 2004; Leveroni et al., 2000).”
BackgroundHorton, A., & Larrabee, G. J. (1999) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/14.5.473 · Cited by 471 · cited 1× · see citing works
“Executive functioning was examined with forward and backward Digit Span tasks from the Wechsler Memory Scale-third edition (WMSIII; Wechsler, 1997), the incongruent version of the Stroop test in 60 s, and a modified version of the Trails sequencing task (Reitan, 1958), in which one had to…”
MethodThe neural systems sustaining face and proper-name processing
Tempini, M. L. G. (1998) · Brain · doi:10.1093/brain/121.11.2103 · Cited by 461 · see citing works
Self-citationTranel, D., Bechara, A., & Denburg, N. L. (2002) · Cortex · doi:10.1016/s0010-9452(08)70024-8 · Cited by 441 · see citing works
Typical and atypical pathology in primary progressive aphasia variants
Spinelli, E. G., Mandelli, M. L., Miller, Z. A., Santos‐Santos, M. A., Wilson, S. M., Agosta, F., Grinberg, L. T., Huang, E. J., Trojanowski, J. Q., Meyer, M., et al. (2017) · Annals of Neurology · doi:10.1002/ana.24885 · Cited by 409 · cited 3× · see citing works
“This could explain why the behavioral symptoms observed in individuals with the right variant of ATL degeneration can overlap with those detected in the bvFTD (Rascovsky et al., 2011), even though the underlying pathology greatly differs (Perry et al., 2017; Spinelli et al., 2017).”
BackgroundSelf-citationThe clinical profile of right temporal lobe atrophy
Chan, D., Anderson, V., Pijnenburg, Y., Whitwell, J., Barnes, J., Scahill, R., Stevens, J. M., Barkhof, F., Scheltens, P., Rossor, M. N., et al. (2009) · Brain · doi:10.1093/brain/awp037 · Cited by 377 · cited 4× · see citing works
“SvPPA has been associated with bilateral neurodegeneration of the anterior temporal lobe (ATL), yet early cases often present with atrophy lateralized to either the left or right hemisphere (e.g., Chan et al., 2009).”
BackgroundInfluentialKnowledge of famous faces and names in semantic dementia.
Snowden, J., Thompson, J. C., & Neary, D. (2004) · Brain : a journal of neurology · doi:10.1093/brain/awh099 · Cited by 372 · see citing works
Andrews, T. J., & Ewbank, M. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.060 · Cited by 351 · cited 1× · see citing works
“…the right inferior temporal regions that extent to a network including right inferior and superior frontal regions and right parietal regions (Andreasen et al., 1996; Andrews & Ewbank, 2004; Borghesani et al., 2019; Evans et al., 1995; Gorno-Tempini et al., 1998, 2004; Leveroni et al., 2000).”
BackgroundThe natural history of temporal variant frontotemporal dementia
Seeley, W., Bauer, A., Miller, B. L., Gorno-Tempini, M., Kramer, J., Weiner, M., & Rosen, H. (2005) · Neurology · doi:10.1212/01.wnl.0000158425.46019.5c · Cited by 318 · cited 1× · see citing works
“However, as the disease progresses towards bilateral atrophy of the temporal and frontal lobes, left-sided and right-sided variants overlap in their clinical profiles (Chan et al., 2009; Seeley et al., 2005).”
BackgroundSelf-citationClinicopathological correlations in behavioural variant frontotemporal dementia
Perry, D. C., Brown, J. A., Possin, K. L., Datta, S., Trujillo, A., Radke, A., Karydas, A., Kornak, J., Sias, A. C., Rabinovici, G. D., et al. (2017) · Brain · doi:10.1093/brain/awx254 · Cited by 309 · cited 1× · see citing works
“This could explain why the behavioral symptoms observed in individuals with the right variant of ATL degeneration can overlap with those detected in the bvFTD (Rascovsky et al., 2011), even though the underlying pathology greatly differs (Perry et al., 2017; Spinelli et al., 2017).”
BackgroundSelf-citationNeural correlates of social and nonsocial emotions: An fMRI study
Britton, J. C., Phan, K. L., Taylor, S. F., Welsh, R. C., Berridge, K. C., & Liberzon, I. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.11.027 · Cited by 301 · cited 1× · see citing works
“More specifically, social functioning has been linked to the anterior rostral medial frontal cortex (e.g., Amodio & Frith, 2006), and emotion processing to the ventromedial prefrontal andmedial orbitofrontal cortices, as well as the amygdala (e.g., Britton et al., 2006; Northoff et al., 2000).”
BackgroundNorthoff, G. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.1.93 · Cited by 262 · see citing works
Large-scale brain networks of the human left temporal pole: a functional connectivity MRI study.
Pascual, B., Masdeu, J. C., Hollenbeck, M., Makris, N., Insausti, R., Ding, S.-L., & Dickerson, B. (2015) · Cerebral Cortex · doi:10.1093/cercor/bht260 · Cited by 238 · cited 3× · see citing works
“functional and structural connectivity profiles (Papinutto et al., 2016; Pascual et al., 2015).”
BackgroundPerry, R., Rosen, H. R., Kramer, J., Beer, J. S., Levenson, R., & Miller, B. L. (2001) · Neurocase · doi:10.1093/neucas/7.2.145 · Cited by 235 · cited 1× · see citing works
“…semantic knowledge for famous people (Binney et al., 2016; Brambati et al., 2009; Chan et al., 2009; Evans, Heggs, Antoun, & Hodges, 1995; Gainotti, Barbier, &Marra, 2003; Galton et al., 2001; Gorno-Tempini et al., 2004; Perry et al., 2001; Snowden, Thompson, & Neary, 2004; Thompson et al., 2004).”
Self-citationBrambati, S. M., Rankin, K. P., Narvid, J. A., Seeley, W. W., Dean, D., Rosen, H. J., Miller, B. L., Ashburner, J., & Gorno‐Tempini, M. L. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.014 · Cited by 230 · cited 2× · see citing works
“As expected, this evolution was accompanied by a worsening of verbal semantic knowledge (Brambati et al., 2009; Kumfor et al., 2016).”
BackgroundSelf-citationOn the right side? A longitudinal study of left- versus right-lateralized semantic dementia
Kumfor, F., Landin-Romero, R., Devenney, E., Hutchings, R., Grasso, R., Hodges, J. R., & Piguet, O. (2016) · Brain · doi:10.1093/brain/awv387 · Cited by 224 · cited 2× · see citing works
“Thus, despite the initial differences, the two variants are better conceived as extremes along a continuum within the same disorder rather than two distinct syndromes (Binney et al., 2016; Kumfor et al., 2016).”
BackgroundInhibition of action, thought, and emotion: A selective neurobiological review
Dillon, D. G., & Pizzagalli, D. A. (2007) · Applied and Preventive Psychology · doi:10.1016/j.appsy.2007.09.004 · Cited by 211 · cited 1× · see citing works
“JB’s early behavioral symptoms included becoming more extroverted, talkative, and disinhibited, all consistently linked to the right ventrolateral prefrontal cortex (e.g., Dillon & Pizzagalli, 2007; Horn, Dolan, Elliott, Deakin, & Woodruff, 2003).”
BackgroundGainotti, G., Barbier, A., & Marra, C. (2003) · Brain : a journal of neurology · doi:10.1093/brain/awg092 · Cited by 204 · see citing works
Noppeney, U., Patterson, K., TYLER, L. K., Moss, H. E., Stamatakis, E. A., Bright, P., Mummery, C. J., & Price, C. J. (2006) · Brain · doi:10.1093/brain/awl344 · Cited by 191 · see citing works
Ding, S., Van Hoesen, G. W., Cassell, M. D., & Poremba, A. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.22053 · Cited by 191 · cited 4× · see citing works
“The ATL is known to be a heterogeneous region in terms not only of its cytoarchitectonic and chemo-architectonic characteristics (Ding et al., 2009), but also with respect to its”
BackgroundInfluentialNeural Correlates of Syntactic Processing in the Nonfluent Variant of Primary Progressive Aphasia
Wilson, S. M., Dronkers, N. F., Ogar, J. M., Jang, J. Y., Growdon, M. E., Agosta, F., Henry, M. L., Miller, B. L., & Gorno‐Tempini, M. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2547-10.2010 · Cited by 191 · see citing works
Self-citationTDP-43 subtypes are associated with distinct atrophy patterns in frontotemporal dementia
Rohrer, J. D., Geser, F., Zhou, J., Gennatas, E. D., Sidhu, M., Trojanowski, J. Q., DeArmond, S. J., Miller, B. L., & Seeley, W. W. (2010) · Neurology · doi:10.1212/wnl.0b013e318202038c · Cited by 187 · cited 2× · see citing works
“probability of underlying pathologies, a differential diagnosis between the two conditions is clinically relevant (Rohrer et al., 2010; Spinelli et al., 2017).”
BackgroundSelf-citationGraded specialization within and between the anterior temporal lobes
Rice, G. E., Hoffman, P., & Ralph, M. A. L. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12951 · Cited by 173 · see citing works
Cognitive and behavioral profile in a case of right anterior temporal lobe neurodegeneration
Gorno-Tempini, M. L., Rankin, K. P., Woolley, J. D., Rosen, H. J., Phengrasamy, L., & Miller, B. L. (2004) · Cortex · doi:10.1016/s0010-9452(08)70159-x · Cited by 164 · cited 6× · see citing works
“Scores from controls were derived from Gorno-Tempini et al. (2004) for the MMSE, Benson complex figure tasks, CVLT, Digit Span tasks, BNT, verbal fluency tasks (semantic and letter), Western Aphasia Battery tests, and Pyramids & Palm Trees test, from Watson et al. (2018) for the Stroop and PPVT,…”
BackgroundMethodInfluentialSelf-citationAdlam, A., Patterson, K. E., Bozeat, S., & Hodges, J. R. (2010) · Neurocase · doi:10.1080/13554790903405693 · Cited by 159 · see citing works
Ranasinghe, K. G., Rankin, K. P., Pressman, P. S., Perry, D. C., Lobach, I. V., Seeley, W. W., Coppola, G., Karydas, A. M., Grinberg, L. T., Shany-Ur, T., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.2016 · Cited by 151 · cited 2× · see citing works
“Critically, appropriate semantically driven personal evaluations have been linked with the integrity of the so-called semantic appraisal network (SAN) including temporal poles, orbitofrontal cortex, and ventral striatum (Ranasinghe et al., 2016; Seeley, Zhou, & Kim, 2012; Yeo et al., 2011).”
BackgroundSelf-citationSeeley, W. W., Zhou, J. H., & Kim, E. J. (2011) · The Neuroscientist · doi:10.1177/1073858411410354 · Cited by 147 · see citing works
NATURAL SELECTION: THE IMPACT OF SEMANTIC IMPAIRMENT ON LEXICAL AND OBJECT DECISION
Rogers, T., Ralph, M. L., Hodges, J., & Patterson, K. (2004) · Cognitive Neuropsychology · doi:10.1080/02643290342000366 · Cited by 145 · see citing works
VBM signatures of abnormal eating behaviours in frontotemporal lobar degeneration
Whitwell, J. L., Sampson, E. L., Loy, C. T., Warren, J. E., Rossor, M. N., Fox, N. C., & Warren, J. D. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.006 · Cited by 130 · cited 2× · see citing works
“bilateral posterolateral orbitofrontal cortex and right anterior insula (Whitwell et al., 2007), which indeed parallels with the emergence JB’s pathological sweet tooth.”
BackgroundKamminga, J., Kumfor, F., Burrell, J. R., Piguet, O., Hodges, J. R., & Irish, M. (2015) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-309120 · Cited by 129 · see citing works
Thompson, S., Graham, K., Williams, G. B., Patterson, K., Kapur, N., & Hodges, J. (2004) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2003.08.004 · Cited by 121 · cited 3× · see citing works
“recognition of familiar faces is only present, and therefore characteristic, of predominantly right semantic variants (e.g., Kamminga et al., 2015; Thompson et al., 2004).”
BackgroundGeevasinga, N., Loy, C. T., Menon, P., de Carvalho, M. A., Swash, M., Schrooten, M., Damme, P. V., Gaweł, M., Sonoo, M., Higashihara, M., et al. (2016) · Clinical Neurophysiology · doi:10.1016/j.clinph.2016.04.005 · Cited by 112 · see citing works
Assessment of Eating Behavior Disturbance and Associated Neural Networks in Frontotemporal Dementia
Ahmed, R. M., Irish, M., Henning, E., Dermody, N., Bartley, L., Kiernan, M. C., Piguet, O., Farooqi, S., & Hodges, J. R. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2015.4478 · Cited by 110 · cited 2× · see citing works
“preference changes observed in bvFTD, where there is a marked preference for carbohydrates and sweets often accompanied by a profound gain in weight (Ahmed et al., 2016; Aiello, Silani, & Rumiati, 2016; Piguet, 2011).”
BackgroundResultRice, G. E., Caswell, H. L., Moore, P., Hoffman, P., & Ralph, M. L. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhx362 · Cited by 108 · cited 1× · see citing works
“…the Stroop and PPVT, from Corbett, Jefferies, Burns, and Lambon Ralph (2015) for the Cambridge battery, from Binney et al. (2016) for the CATS, from Rice et al. (2018) for the OOT, and from 10 age-matched controls for the Number Location subtest of the Visual Object and Space Perception Battery…”
Method(2020) · Definitions · doi:10.1201/b13196-79 · Cited by 103
Neural substrates of facial recognition.
Andreasen, N., O'Leary, D. S., Arndt, S., Cizadlo, T., Hurtig, R., Rezai, K., Watkins, G., Ponto, L., & Hichwa, R. (1996) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.8.2.139 · Cited by 98 · cited 1× · see citing works
“…the right inferior temporal regions that extent to a network including right inferior and superior frontal regions and right parietal regions (Andreasen et al., 1996; Andrews & Ewbank, 2004; Borghesani et al., 2019; Evans et al., 1995; Gorno-Tempini et al., 1998, 2004; Leveroni et al., 2000).”
BackgroundBinney, R. J., Henry, M. L., Babiak, M. C., Pressman, P., Santos‐Santos, M., Narvid, J. A., Mandelli, M. L., Strain, P. J., Miller, B. L., Rankin, K. P., et al. (2016) · Cortex · doi:10.1016/j.cortex.2016.05.014 · Cited by 98 · see citing works
Self-citationVonk, J. M. J., Rizvi, B. M., Lao, P. J., Budge, M., Manly, J. J., Mayeux, R. P., & Brickman, A. M. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy138 · Cited by 90 · see citing works
Self-citationProgressive prosopagnosia associated with selective right temporal atrophy: a new syndrome?
Evans, J. (2002) · doi:10.1093/neucas/8.3.179-a · Cited by 85 · cited 1×
“…the right inferior temporal regions that extent to a network including right inferior and superior frontal regions and right parietal regions (Andreasen et al., 1996; Andrews & Ewbank, 2004; Borghesani et al., 2019; Evans et al., 1995; Gorno-Tempini et al., 1998, 2004; Leveroni et al., 2000).”
BackgroundBorghesani, V., Narvid, J. A., Battistella, G., Shwe, W., Watson, C., Binney, R. J., Sturm, V. E., Miller, Z., Mandelli, M. L., Miller, B. L., et al. (2019) · Cortex · doi:10.1016/j.cortex.2019.01.006 · Cited by 74 · cited 3× · see citing works
“or politician) in a triplet matching task (Borghesani et al., 2019; Gorno-Tempini et al., 2004).”
BackgroundSelf-citationPapinutto, N., Galantucci, S., Mandelli, M. L., Gesierich, B. G., Jovicich, J., Caverzasi, E., Henry, R. G., Seeley, W. W., Miller, B. L., Shapiro, K. A., et al. (2016) · Human Brain Mapping · doi:10.1002/hbm.23167 · Cited by 69 · cited 8× · see citing works
“…portions of the ATL and relatively sparing of the left dorsolateral neocortical ones, providing evidence in support of the ATL parcellation suggested by cytoarchitectonic markers as well as structural and functional imaging findings (Ding et al., 2009; Papinutto et al., 2016; Pascual et al., 2015).”
BackgroundMethodInfluentialSelf-citationVisuospatial Functioning in the Primary Progressive Aphasias
Watson, C., Possin, K., Allen, I., Hubbard, H., Meyer, M., Welch, A. E., Rabinovici, G., Rosen, H., Rankin, K. P., Miller, Z., et al. (2017) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617717000984 · Cited by 59 · see citing works
Self-citationClinical Phenomenology and Neuroimaging Correlates in ALS-FTD
Lomen-Hoerth, C. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9636-x · Cited by 52 · cited 1× · see citing works
“Overlap between the two syndromes occurs in up to 15% of individuals who first present with frontotemporal dementia and up to 30% of individuals who first present with motor neuron disease (Lomen-Hoerth, 2011).”
BackgroundEating Disturbance in Behavioural-Variant Frontotemporal Dementia
Piguet, O. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9547-x · Cited by 43 · cited 2× · see citing works
“preference changes observed in bvFTD, where there is a marked preference for carbohydrates and sweets often accompanied by a profound gain in weight (Ahmed et al., 2016; Aiello, Silani, & Rumiati, 2016; Piguet, 2011).”
BackgroundResultShinagawa, S., Ikeda, M., Nestor, P. J., Shigenobu, K., Fukuhara, R., Nomura, M., & Hodges, J. R. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.165332 · Cited by 41 · cited 1× · see citing works
“This unhealthy change would be a typical symptom of bvFTD (Rascovsky et al., 2011; Shinagawa et al., 2009).”
BackgroundPage, T. K. W., Gitcho, M. A., Mosaheb, S., Carter, D. R., Chakraverty, S., Perry, R. H., Bigio, E. H., Gearing, M., Ferrer, I., Goate, A., et al. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9549-8 · Cited by 25 · see citing works
Corbett, F., Jefferies, E., Burns, A., & Ralph, M. L. (2015) · Journal of Neuropsychology · doi:10.1111/jnp.12047 · Cited by 21 · see citing works
You stole my food! Eating alterations in frontotemporal dementia
Aiello, M., Silani, V., & Rumiati, R. I. (2016) · Neurocase · doi:10.1080/13554794.2016.1197952 · Cited by 20 · see citing works
Viskontas, I. V., & Miller, B. L. (2007) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000267237.15122.52 · Cited by 9 · see citing works
Self-citation
Flagged first, then by citations
6 of the 76 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Delis DC, Kramer JH, Kaplan E, & Ober BA (2000). California Verbal Learning Test - Second Edition. The Psychological Corporation: San Antonio, TX
- Yeo BT, Krienen FM, Sepulcre J, Sabuncu MR, Lashkari D, Hollinshead M, … Buckner RL. (2011). The organization of the human cerebral cortex estimated by intrinsic functional connectivity. Journal of Neurophysiology, 106(3), 1125– 1165. doi: 10.1152/jn.00338.2011 21653723 PMC3174820 · DOI · Paper page
Cited by
Sorted by citations
Younes, K., Borghesani, V., Montembeault, M., Spina, S., Mandelli, M. L., Welch, A. E., Weis, E., Callahan, P., Elahi, F. M., Hua, A. Y., et al. (2022) · Brain · doi:10.1093/brain/awac217 · Cited by 152 · see citing works
Self-citationDing, J., Chen, K., Liu, H., Huang, L., Chen, Y., Lv, Y., Yang, Q., Guo, Q., Han, Z., & Lambon Ralph, M. A. (2020) · Nature Communications · doi:10.1038/s41467-020-16089-9 · Cited by 62 · see citing works
Vonk, J. M. J., Bouteloup, V., Mangin, J., Dubois, B., Blanc, F., Gabelle, A., Ceccaldi, M. P., Annweiler, C., Krolak‐Salmon, P., Belin, C., et al. (2020) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12066 · Cited by 48 · see citing works
Self-citationUniform data set language measures for bvFTD and PPA diagnosis and monitoring
Staffaroni, A. M., Weintraub, S., Rascovsky, K., Rankin, K. P., Taylor, J., Fields, J. A., Casaletto, K. B., Hillis, A. E., Lukic, S., Gorno‐Tempini, M. L., et al. (2021) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1002/dad2.12148 · Cited by 33 · see citing works
Self-citationMapping behavioural, cognitive and affective transdiagnostic dimensions in frontotemporal dementia
Ramanan, S., El-Omar, H., Roquet, D., Ahmed, R. M., Hodges, J. R., Piguet, O., Ralph, M. A. L., & Irish, M. (2022) · Brain Communications · doi:10.1093/braincomms/fcac344 · Cited by 26 · see citing works
Carelli, L., Solca, F., Tagini, S., Torre, S., Verde, F., Ticozzi, N., Consonni, M., Ferrucci, R., Pravettoni, G., Poletti, B., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11101356 · Cited by 22 · see citing works
“One study describes a patient with anterior temporal lobe degeneration and ALS [20].”
InfluentialÇini, N., Pennisi, M., Genç, S., Spandidos, D. A., Falzone, L., Mitsias, P., Tsatsakis, A., & Taghizadehghalehjoughi, A. (2024) · Oncology Report · doi:10.3892/or.2024.8798 · Cited by 17 · see citing works
“It has been reported that the brain regions involved in visual word processing are lateralized to the left hemisphere, which is considered logical considering that in the majority of individuals, language‑related cortical structures are later‑ alized to the left hemisphere (17).”
BackgroundPelgrim, T. A. D., Beran, M., Twait, E. L., Geerlings, M. I., & Vonk, J. M. J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101449 · Cited by 20 · see citing works
“…have shown that individuals in the preclinical phase of Alzheimer ’ s disease exhibit a profound deficit in episodic memory (Gallagher and Koh, 2011; Greene et al., 1996; Zakzanis, 1998) and, although to a lesser extent, a decline in semantic memory (Tchakoute et al., 2017; Vonk et al., 2019b).”
Self-citationDysgraphic features in motor neuron disease: a review
Aiello, E. N., Feroldi, S., Preti, A. N., Zago, S., & Appollonio, I. M. (2021) · Aphasiology · doi:10.1080/02687038.2021.1942774 · Cited by 16 · see citing works
Primary progressive aphasia and motor neuron disease: A review
Aiello, E. N., Feroldi, S., Luca, G. D., Guidotti, L., Arrigoni, E., Appollonio, I. M., Solca, F., Carelli, L., Poletti, B., Verde, F., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1003792 · Cited by 18 · see citing works
Vonk, J. M. J., Morin, B. T., Pillai, J., Rosado Rolon, D., Bogley, R., Baquirin, D. P., Ezzes, Z., Tee, B. L., de Leon, J., Wauters, L., et al. (2025) · Neurology · doi:10.1212/wnl.0000000000213556 · Cited by 10 · see citing works
Self-citationIkos Test: New Tool for the Assessment of Semantic Knowledge in Early Alzheimer Disease
Cejudo, J. C., Samaniego, M., Almeria, M., Castrillo, S., Medina, L., & Gil, D. (2022) · Journal of Alzheimer's Disease · doi:10.3233/jad-220516 · Cited by 1 · see citing works
Younes, K., Borghesani, V., Montembeault, M., Spina, S., Welch, A. E., Weis, E., Callahan, P., Elahi, F., Hua, A. Y., Perry, D. C., et al. (2021) · medRxiv · doi:10.1101/2021.06.07.21258432
Self-citation
- Authors
- Vonk, J. M. J., Borghesani, V., Battistella, G., Younes, K., DeLeon, J., Welch, A., Hubbard, H. I., Miller, Z. A., Miller, B. L., & Gorno-Tempini, M. L.
- Affiliations
- University of California, San Francisco (US)
- University of Kentucky (US)
- Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
- Corresponding author
- Vonk, Jet M. J.
- ORCID
- Venue
- Aphasiology
- Publisher
- Informa UK Limited
- Published
- 2019-09-04
- Volume
- 34
- Issue
- 7
- Pages
- 865-885
- ISSN
- 0268-7038 (ISSN-L)
- 1464-5041
- PMC
- PMC7529336
- OpenAlex
- W2971370546
- Cited by
- 16
- References
- 76
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 4 · 2020: 3
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Aphasiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Funders
- National Institute of Neurological Disorders and Stroke (R01 NS050915)
- National Institute on Aging (P50 AG023501)
- National Institute on Deafness and Other Communication Disorders (K24 DC015544)
- Alzheimer Nederland (NA)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- semantic dementia, frontotemporal atrophy, episodic memory impairment, behavioral variant frontotemporal dementia, longitudinal case study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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