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Cited by 191Neuroscience and Music PerceptionMemory and Neural MechanismsMedical and Biological Sciences

Parcellation of human temporal polar cortex: a combined analysis of multiple cytoarchitectonic, chemoarchitectonic, and pathological markers

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Ding, Song‐Lin, Van Hoesen, Gary W., Cassell, Martin D., Poremba, Amy·2009·Journal of Comparative Neurology
DOI 10.1002/cne.22053PMC PMC3665344
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Abstract

Although the human temporal polar cortex (TPC), anterior to the limen insulae, is heavily involved in high‐order brain functions and many neurological diseases, few studies on the parcellation and extent of the human TPC are available that have used modern neuroanatomical techniques. The present study investigated the TPC with combined analysis of several different cellular, neurochemical, and pathological markers and found that this area is not homogenous, as at least six different areas extend into the TPC, with another area being unique to the polar region. Specifically, perirhinal area 35 extends into the posterior TPC, whereas areas 36 and TE extend more anteriorly. Dorsolaterally, an area located anterior to the typical area TA or parabelt auditory cortex is distinguishable from area TA and is defined as area TAr (rostral). The polysensory cortical area located primarily in the dorsal bank of the superior temporal sulcus, separate from area TA, extends for some distance into the TPC and is defined as the TAp (polysensory). Anterior to the limen insulae and the temporal pyriform cortex, a cortical area, characterized by its olfactory fibers in layer Ia and lack of layer IV, was defined as the temporal insular cortex and named as area TI after Beck (J. Psychol. Neurol. 1934;41:129–264). Finally, a dysgranular TPC region that capped the tip with some extension into the dorsal aspect of the TPC is defined as temporopolar area TG. Therefore, the human TPC actually includes areas TAr and TI, anterior parts of areas 35, 36, TE, and TAp, and the unique temporopolar area TG. J. Comp. Neurol. 514:595–623, 2009. © 2009 Wiley‐Liss, Inc.

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  • NeuN immunoreactivity was previously shown to anticorrelate with pTau pathology.

    “Immunoreactivity to neuronal nuclear protein (NeuN-ir) was previously shown to anticorrelate with pTau pathology42.”

    From Integrated multimodal cell atlas of Alzheimer’s disease (2024) · cites this paper as [42]

    The Methods (Double labeling; page unavailable) state that AT8 labels abnormally phosphorylated tau and that AT8-labeled cells would not be labeled by NeuN. This supports an inverse relationship at the cell-labeling level, but the paper does not report a quantitative anticorrelation between NeuN immunoreactivity and pTau pathology. (LLM, conf=0.84)

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  • The affective network, in which the amygdala and temporal poles have the largest region weights, is especially involved in linking emotion/mood to visceral function.

    “The affective network in which the amygdala and temporal poles exhibit the greatest region weights is particularly involved in the relationship of emotion/mood to visceral function (Ongu ¨r et al., 2003;Olson et al., 2007;Ding et al., 2009).”

    From Identifying major depression using whole-brain functional connectivity: a multivariate pattern analysis (2012) · cites this paper as Ding et al., 2009

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Research works printed but not linked: 4

  1. Afifi AK Bergman PA Functional neuroanatomy: test and atlas 1998 McGraw-Hill Companies New York
  2. Stephan H Bargmann W Allocortex Handbuch der Mikroskpoischen Anatomie des Menschen 1975 Vol. 4 Springer Berlin, Germany
  3. Van Hoesen GW Ben-Ari Y The differential distribution, diversity and sprouting of cortical projections to the amygdala of the rhesus monkey The amygdaloid complex 1981 77 90 Elsevier/North Holland Biomedical Press Amsterdam
  4. Von Economo C Koskinas GN Die Cytoarchitecktonik der Grosshirnrinde des erwachsenen Menschen 1925 Springer Berlin

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Authors
Ding, S., Van Hoesen, G. W., Cassell, M. D., & Poremba, A.
Affiliations
University of Iowa (US)
Corresponding author
Ding, Song‐Lin
ORCID
Ding, Song‐Lin
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
2009-04-10
Volume
514
Issue
6
Pages
595-623
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.22053
PMC
PMC3665344
OpenAlex
W2136139627
Cited by
191
References
94
Citations by year
2026: 5 · 2025: 11 · 2024: 8 · 2023: 8 · 2022: 9 · 2021: 11 · 2020: 6 · 2019: 12 · 2018: 4 · 2017: 12 · 2016: 21 · 2015: 15 · 2014: 18 · 2013: 17 · 2012: 15
FWCI
5.50
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (MH065452, R01MH065452)
  • National Institute on Deafness and Other Communication Disorders (DC0007156, R01DC007156)
  • National Institute of Neurological Disorders and Stroke (P01NS019632, P0 NS 19632, R01NS014944, NS-14944)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
Keywords
cortical parcellation, cytoarchitecture, chemoarchitecture, superior temporal sulcus, layer 4, human brain
MeSH terms
Aged, Aged, 80 and over, Aging, Alzheimer Disease, Female, Histocytochemistry, Humans, Immunohistochemistry, Male, Nerve Tissue Proteins, Temporal Lobe, Thiazoles, Pyramidal Cells, Tauopathies, Receptors, N-Acetylglucosamine, Antigens, Nuclear, Plant Lectins, Benzothiazoles

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