Adrenarche is associated with decreased 3β-hydroxysteroid dehydrogenase expression in the adrenal reticularis
Abstract
The increased production of adrenal dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) which occurs during the prepubertal period is known as adrenarche. One hypothesis for adrenarche is that alterations in intra-adrenal expression of steroidogenic enzymes within the inner reticularis zone leads to the increased production of 19-carbon steroids. We tested the hypothesis that at the time of adrenarche there is decreased expression of 3 beta HSD in the reticularis. Immunohistochemical localization of 3 beta HSD was performed and staining intensities compared between adrenal glands from children ages 4 months to 7 years (N = 11) and ages 8 to 11 years (N = 6). No difference was observed between the levels of staining in the glomerulosa and fasciculata from either age group. However, the reticularis from the older children exhibited diminished 3 beta HSD immunoreactivity. These findings suggest that as children mature there is a decreased level of 3 beta HSD in the adrenal reticularis which may contribute to the increased production of DHEA and DHEAS seen during adrenarche.
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Adrenarche is due to the development of the zona reticularis, which is characterised by an increase in the expression of CYB5A and SULT2A1, and a decrease in the expression of HSD3B2, which in combination favours the biosynthesis of DHEA and DHEAS.
“Adrenarche is due to the development of the zona reticularis which is characterised by an increase in the expression of CYB5A (encoding cytochrome b5) and SULT2A1, and a decrease in the expression of HSD3B2, which in combination favours the biosynthesis of DHEA and DHEAS (Bird, 2012, Gell et al., 1996, Nakamura et al., 2009a).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Gell et al., 1996
Cites
SKLAR, C. A., KAPLAN, S. L., & GRUMBACH, M. M. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-3-548 · Cited by 245 · see citing works
PERETTI, E. D., & Forest, M. G. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-43-5-982 · Cited by 185 · see citing works
The Prepuberal and Puberal Growth of the Adrenal (Adrenarche)
Dhom, G. (1973) · Beiträge zur Pathologie · doi:10.1016/s0005-8165(73)80086-1 · Cited by 170 · see citing works
Parker, L. N. (1991) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30282-2 · Cited by 104 · see citing works
Compartmentalization of type 117β-hydroxysteroid oxidoreductase in the human ovary
Sawetawan, C., Milewich, L., Word, R. A., Carr, B. R., & Rainey, W. E. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90004-3 · Cited by 80 · see citing works
Self-citationSCHIEBINGER, R. J., CHROUSOS, G. P., CULTER, G. B., & LORIAUX, D. L. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-62-1-202 · Cited by 73 · see citing works
Immunolocalization of 3β-hydroxysteroid dehydrogenase in human adrenal cortex and in its disorders
Sasano, H., Mason, J. L., Sasano, N., & Nagura, H. (1990) · Endocrine Pathology · doi:10.1007/bf02915624 · Cited by 61 · see citing works
Self-citationHauffa, B., Kaplan, S. L., & Grumbach, M. M. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91873-7 · Cited by 57 · see citing works
Parker, L. (1995) · Seminars in Reproductive Medicine · doi:10.1055/s-2007-1016370 · Cited by 11 · see citing works
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Molecular biology of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 –isomerase gene family
Simard, J., Ricketts, M.-L., Gingras, S., Soucy, P., Feltus, F. A., & Melner, M. H. (2005) · Endocrine Reviews · doi:10.1210/er.2002-0050 · Cited by 620 · see citing works
Dorn, L. D., Dahl, R. E., Woodward, H. R., & Biro, F. (2006) · Applied Developmental Science · doi:10.1207/s1532480xads1001_3 · Cited by 477 · see citing works
Intracrine androgen biosynthesis, metabolism and action revisited
Schiffer, L., Arlt, W., & Storbeck, K.-H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.08.016 · Cited by 217 · see citing works
“Because of the high concentrations of circulating DHEAS one might assume that STS is a main gate keeper of peripheral androgen metabolism and action.”
InfluentialAdrenarche and the evolution of human life history
Campbell, B. (2006) · American Journal of Human Biology · doi:10.1002/ajhb.20528 · Cited by 150 · see citing works
Gell, J. S., Carr, B. R., Sasano, H., Atkins, B., Margraf, L. R., Mason, J. I., & Rainey, W. E. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.10.5070 · Cited by 136 · see citing works
Self-citationAdrenal Androgens and Androgen Precursors-Definition, Synthesis, Regulation and Physiologic Actions
Turcu, A., Smith, J. M., Auchus, R., & Rainey, W. E. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140006 · Cited by 113 · see citing works
Self-citationThe steroid metabolome of adrenarche
Rege, J., & Rainey, W. E. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0183 · Cited by 97 · see citing works
Self-citationAdrenal changes associated with adrenarche
Nakamura, Y., Gang, H. X., Suzuki, T., Sasano, H., & Rainey, W. E. (2009) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-008-9092-2 · Cited by 84 · see citing works
Self-citationHui, X.-G., Akahira, J.-I., Suzuki, T., Nio, M., Nakamura, Y., Suzuki, H., Rainey, W. E., & Sasano, H. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0127 · Cited by 83 · see citing works
Self-citationNonhuman primates as models for human adrenal androgen production: Function and dysfunction
Abbott, D. H., & Bird, I. M. (2008) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-008-9099-8 · Cited by 61 · see citing works
Samandari, E., Kempná, P., Nuoffer, J., Hofer, G., Mullis, P. E., & Flück, C. E. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0166 · Cited by 60 · see citing works
Bird, I. M., Mason, J. I., & Rainey, W. E. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.5.4825 · Cited by 54 · see citing works
Self-citationDAX1 and its network partners: exploring complexity in development
Clipsham, R. C., & McCabe, E. R. B. (2003) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2003.08.023 · Cited by 49 · see citing works
Disruption of steroidogenesis: Cell models for mechanistic investigations and as screening tools
Odermatt, A., Strajhar, P., & Engeli, R. T. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.01.009 · Cited by 48 · see citing works
Steroid biomarkers in human adrenal disease
Rege, J., Turcu, A. F., Else, T., Auchus, R. J., & Rainey, W. E. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.01.018 · Cited by 46 · see citing works
Self-citationAging of the human adrenal cortex
Hornsby, P. J. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(01)00007-1 · Cited by 46 · see citing works
Dardis, A., Saraco, N., Rivarola, M. A., & Belgorosky, A. (1999) · Pediatric Research · doi:10.1203/00006450-199903000-00016 · Cited by 45 · see citing works
Adrenal androgens, adrenarche, and zona reticularis: A human affair?
Dumontet, T., & Martinez, A. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111239 · Cited by 40 · see citing works
Pattison, J. C., Wendy Saltzman, A., Abbott, D. H., Hogan, B. K., Nguyen, A. D., Husen, B., Einspanier, A., Conley, A. J., & Bird, I. M. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.023 · Cited by 38 · see citing works
Effect of Estradiol on DHEAS Production in the Human Adrenocortical Cell Line, H295R
Gell, J. S., Oh, J., Rainey, W. E., & Carr, B. R. (1998) · Journal of the Society for Gynecologic Investigation · doi:10.1016/s1071-5576(98)00002-1 · Cited by 38 · see citing works
Self-citationPattison, J. C., Abbott, D. H., Wendy Saltzman, A., Nguyen, A. D., Henderson, G. L., Jing, H., Pryce, C. R., Allen, A. J., Conley, A. J., & Bird, I. M. (2004) · Endocrinology · doi:10.1210/en.2004-0689 · Cited by 32 · see citing works
Pattison, J. C., Abbott, D. H., Wendy Saltzman, A., Conley, A. J., & Bird, I. M. (2009) · Journal of Endocrinology · doi:10.1677/joe-08-0554 · Cited by 30 · see citing works
Kempná, P., Marti, N., Udhane, S., & Flück, C. E. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.12.015 · Cited by 29 · see citing works
Bird, I. M., Mason, J. I., & Rainey, W. E. (1998) · Endocrine Research · doi:10.3109/07435809809032614 · Cited by 27 · see citing works
Self-citationDisorders of Growth and Development
Richmond, E. J., & Rogol, A. D. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-277-7_21 · Cited by 13 · see citing works
Schulte, S., Schreiner, F., Plamper, M., Kasner, C., Gruenewald, M., Bartmann, P., Fimmers, R., Hartmann, M. F., Wudy, S. A., Stoffel‐Wagner, B., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa480 · Cited by 10 · see citing works
Gizard, F., Morier-teissier, E., Dufort, I., Luc, G., Luu-The, V., Staels, B., & Hum, D. (2004) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0320557 · Cited by 10 · see citing works
Cherry, B. A., Cadigan, B., Mansourian, N., Nelson, C., & Bradley, E. L. (2002) · General and Comparative Endocrinology · doi:10.1016/s0016-6480(02)00528-2 · Cited by 6 · see citing works
Langdon, D. R. (1999) · Clinical Pediatrics · doi:10.1177/000992289903800411 · Cited by 5 · see citing works
- Authors
- Gell, J. S., Atkins, B., Margraf, L., Mason, J. I., Sasano, H., Rainey, W. E., & Carr, B. R.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Children's Medical Center (US)
- University of Edinburgh (GB)
- Tohoku University (JP)
- Venue
- Endocrine Research
- Publisher
- Informa UK Limited
- Published
- 1996-11
- Volume
- 22
- Issue
- 4
- Pages
- 723-728
- ISSN
- 0743-5800 (ISSN-L)
- 1532-4206
- OpenAlex
- W2163422305
- Cited by
- 31
- References
- 9
- Citations by year
- 2021: 1 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2014: 3 · 2012: 1
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 43140)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- adrenarche, 3β-hydroxysteroid dehydrogenase, dehydroepiandrosterone, DHEA sulfate, steroidogenic enzyme expression, adrenal cortex, prepubertal children
- MeSH terms
- Adrenal Glands, Child, Child, Preschool, Dehydroepiandrosterone, Humans, Immunohistochemistry, Infant, 3-Hydroxysteroid Dehydrogenases, Zona Reticularis, Dehydroepiandrosterone Sulfate
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