Determinants of serum brain-derived neurotrophic factor.
Abstract
Background Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of growth factors and affects the survival and plasticity of neurons in the adult central nervous system. The high correlation between cortical and serum BDNF levels has led to many human studies on BDNF levels in various populations, however knowledge about determinants that influence BDNF is lacking.Aims To gain insight into the factors that influence BDNF levels in humans.Methods In 1168 people aged 18 through 65, free of antidepressants and current psychiatric disease, from the Netherlands study of depression and anxiety four categories of determinants (sampling, sociodemographics, lifestyle indicators and diseases) were measured as well as BDNF level. We used univariate analyses as well as multivariate linear regression analyses in particular to determine which of the possible determinants significantly influenced serum BDNF levels.Results The mean BDNF level was 8.98ng/ml (SD 3.1ng/ml) with a range from 1.56ng/ml through 18.50ng/ml. Our final multivariate regression analysis revealed that a non-fasting state of blood draw (β=-.067; p=.019), later measurement (β=-.065; p=.022), longer sample storage (β=-.082; p=.004) and being a binge drinker (β=-.063; p=.035) all resulted in attenuated BDNF levels. This was in contrast to smoking (β=.098; p=.001) and living in an urban area (β=.109; p<.001), which resulted in increased BDNF levels. Moreover we found that older subjects also had higher BDNF levels, but this only applied to women (β=.226; p<.001).Conclusions Future studies on serum levels of BDNF in humans should correct for the time of blood withdrawal, storage, urbanicity, age, sex, smoking status and food and alcohol intake.
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BDNF release is influenced by several other non-modifiable factors, such as sex, or non-exercise-related modifiable factors, such as sleep or nutrition, that are known to influence neuroplasticity in general.
“BDNF release is also influenced by several other non-modifiable (e.g., sex Trajkovska et al., 2007; Komulainen et al., 2010; Bus et al., 2011) or non-exercise-related modifiable factors (e.g., sleep or nutrition; Giese et al., 2013, 2014; Walsh et al., 2015; Schmitt et al., 2016) that are known to influence neuroplasticity in general”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Bus et al., 2011
Analyses were adjusted for a priori covariates including age, sex, education, physical activity, smoking status, and components of the Framingham Stroke Risk Profile.
“Because factors such as age, sex, education, physical activity, and smoking status may determine social relationships and also influence BDNF levels, dementia risk, and stroke risk, we parsimoniously adjusted for a priori variables [4], [25], [26].”
From Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia (2017) · cites this paper as [26]
Cites
International physical activity questionnaire: 12-country reliability and validity
CRAIG, C. L., MARSHALL, A. L., SJ??STR??M, M., BAUMAN, A. E., BOOTH, M. L., AINSWORTH, B. E., PRATT, M., EKELUND, U., YNGVE, A., SALLIS, J. F., et al. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000078924.61453.fb · Cited by 21,619 · see citing works
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.169404 · Cited by 11,961 · see citing works
The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire
HEATHERTON, T. F., KOZLOWSKI, L. T., FRECKER, R. C., & FAGERSTROM, K. (1991) · British Journal of Addiction · doi:10.1111/j.1360-0443.1991.tb01879.x · Cited by 10,738 · see citing works
Signal transduction by receptors with tyrosine kinase activity
Ullrich, A., & Schlessinger, J. (1990) · Cell · doi:10.1016/0092-8674(90)90801-k · Cited by 5,435 · see citing works
Wittchen, H.-U. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90036-1 · Cited by 2,348 · see citing works
Neurotrophins and their receptors: A convergence point for many signalling pathways
Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298 · see citing works
Binder (2004) · doi:10.1080/08977190410001723308 · Cited by 1,481 · see citing works
Transport of brain-derived neurotrophic factor across the blood–brain barrier
Pan, W., Banks, W. A., Fasold, M. B., Bluth, J., & Kastin, A. J. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00141-5 · Cited by 1,354 · see citing works
Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF
Maisonpierre, P. C., Belluscio, L., Squinto, S., Ip, N. Y., Furth, M. E., Lindsay, R. M., & Yancopoulos, G. D. (1990) · Science · doi:10.1126/science.2321006 · Cited by 1,322 · see citing works
Decreased serum brain-derived neurotrophic factor levels in major depressed patients
Karege, F., Perret, G., Bondolfi, G., Schwald, M., Bertschy, G., & Aubry, J.-M. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00005-7 · Cited by 1,232 · see citing works
Sen, S., Duman, R., & Sanacora, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.005 · Cited by 1,232 · see citing works
Shimizu, E., Hashimoto, K., Okamura, N., Koike, K., Komatsu, N., Kumakiri, C., Nakazato, M., Watanabe, H., Shinoda, N., Okada, S.-I., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00181-1 · Cited by 1,151 · see citing works
The current status of urban‐rural differences in psychiatric disorders
Peen, J., Schoevers, R. A., Beekman, A. T. F., & Dekker, J. (2009) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01438.x · Cited by 1,068 · see citing works
Kerschensteiner, M., Gallmeier, E., Behrens, L., Vargas-Leal, V., Misgeld, T., Klinkert, W. E. F., Kolbeck, R., Hoppe, E., Oropeza-Wekerle, R. L., Bartke, I., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.5.865 · Cited by 1,019 · see citing works
Brunoni, A. R., Lopes, M., & Fregni, F. (2008) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009309 · Cited by 972 · see citing works
The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods
Penninx, B. W. J. H., Beekman, A. T. F., Smit, J. H., Zitman, F. G., Nolen, W. A., Spinhoven, P., Cuijpers, P. J., de Jong, P. J., van Marwijk, H., Assendelft, W. J., et al. (2008) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.256 · Cited by 918 · see citing works
Self-citationErnfors, P., Wetmore, C., Olson, L., & Persson, H. (1990) · Neuron · doi:10.1016/0896-6273(90)90090-3 · Cited by 819 · see citing works
Postnatal Developmental Profile of Brain-Derived Neurotrophic Factor in Rat Brain and Platelets
Karege, F., Schwald, M., & Cisse, M. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00529-3 · Cited by 799 · see citing works
Brain-derived Neurotrophic Factor Is Stored in Human Platelets and Released by Agonist Stimulation
Fujimura, H., Chen, R., Nakamura, T., Nakahashi, T., Kambayashi, J.-I., Sun, B., Altar, C., & Tandon, N. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613072 · Cited by 777 · see citing works
Brain-derived neurotrophic factor (BDNF) and type 2 diabetes
Krabbe, K. S., Nielsen, A. R., Krogh‐Madsen, R., Plomgaard, P., Rasmussen, P., Erikstrup, C., Fischer, C. P., Lindegaard, B., Petersen, A. M. W., Taudorf, S., et al. (2006) · Diabetologia · doi:10.1007/s00125-006-0537-4 · Cited by 703 · see citing works
Maisonpierre, P. C., Beau, M. M. L., Espinosa, R., Ip, N. Y., Belluscio, L., de la Monte, S. M., Squinto, S. P., Furth, M. E., & Yancopoulos, G. D. (1991) · Genomics · doi:10.1016/0888-7543(91)90436-i · Cited by 511 · see citing works
Molendijk, M. L., Bus, B. A. A., Spinhoven, P., Penninx, B. W. J. H., Kenis, G., Prickaerts, J., Voshaar, R. O., & Elzinga, B. M. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.98 · Cited by 437 · see citing works
Self-citationDonovan, M. J., Lin, M. I., Wiegn, P., Ringstedt, T., Kraemer, R. T., Hahn, R. T., Wang, S., Ibáñez, C. F., Rafii, S., & Hempstead, B. L. (2000) · Development · doi:10.1242/dev.127.21.4531 · Cited by 435 · see citing works
Vascular endothelial cells synthesize and secrete brain‐derived neurotrophic factor
Nakahashi, T., Fujimura, H., Altar, C. A., Li, J., Kambayashi, J.-I., Tandon, N. N., & Sun, B. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01302-8 · Cited by 430 · see citing works
Gratacòs, M., González, J. R., Mercader, J. M., de Cid, R., Urretavizcaya, M., & Estivill, X. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.025 · Cited by 428 · see citing works
Nowak, J., MURRAY, J. J., Oates, J. A., & FitzGerald, G. A. (1987) · Circulation · doi:10.1161/01.cir.76.1.6 · Cited by 382 · see citing works
Human platelets contain brain-derived neurotrophic factor
Yamamoto, H., & Gurney, M. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-11-03469.1990 · Cited by 304 · see citing works
Estrogen–BDNF interactions: Implications for neurodegenerative diseases
Sohrabji, F., & Lewis, D. K. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.09.003 · Cited by 284 · see citing works
Serum neurotrophins—A study on the time course and influencing factors in a large old age sample
Ziegenhorn, A. A., Schulte‐Herbrüggen, O., Danker‐Hopfe, H., Malbranc, M., Hartung, H.-D., Anders, D., Lang, U. E., Steinhagen‐Thiessen, E., Schaub, R., & Hellweg, R. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.011 · Cited by 277 · see citing works
Sartorius, A., Hellweg, R., Litzke, J., Vogt, M., Dormann, C., Vollmayr, B., Danker-Hopfe, H., & Gass, P. (2009) · Pharmacopsychiatry · doi:10.1055/s-0029-1224162 · Cited by 276 · see citing works
Babor, T., Kranzler, H., & Lauerman, R. (1989) · Addictive Behaviours · doi:10.1016/0306-4603(89)90043-9 · Cited by 251 · see citing works
Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression
Mößner, R., Mikova, O., Koutsilieri, E., Saoud, M., Ehlis, A., Müller, N., Fallgatter, A. J., & Riederer, P. F. (2007) · The World Journal of Biological Psychiatry · doi:10.1080/15622970701263303 · Cited by 248 · see citing works
Tang, S. W., Chu, E., Hui, T. C. K., Helmeste, D. M., & Law, C. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.11.019 · Cited by 247 · see citing works
Machado‐Vieira, R., Dietrich, M. O., Leke, R., Cereser, V. H., Zanatto, V. C., Kapczinski, F. P., Souza, D. O., Portela, L. V., & Gentil, V. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.070 · Cited by 223 · see citing works
Godfrey, R., & Julien, M. (2005) · Clinical Medicine · doi:10.7861/clinmedicine.5-2-137 · Cited by 223 · see citing works
Lang, U. E., Hellweg, R., & Gallinat, J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300382 · Cited by 219 · see citing works
Chaldakov, G. N., Fiore, M., Stankulov, I. S., Manni, L., Hristova, M. G., Antonelli, A., Ghenev, P., & Aloe, L. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)46018-4 · Cited by 211 · see citing works
Measurements of brain-derived neurotrophic factor. Methodological aspects and demographical data.
Trajkovska, V., Marcussen, A. B., Vinberg, M., Hartvig, P., Aznar, S., & Knudsen, G. M. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.03.009 · Cited by 203 · see citing works
Suwa, M., Kishimoto, H., Nofuji, Y., Nakano, H., Sasaki, H., Radak, Z. O., & Kumagai, S. (2006) · Metabolism · doi:10.1016/j.metabol.2006.02.012 · Cited by 203 · see citing works
Azoulay, D., Vachapova, V., Shihman, B., Miler, A., & Karni, A. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.07.001 · Cited by 193 · see citing works
Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromes
Manni, L., Nikolova, V., Vyagova, D., Chaldakov, G. N., & Aloe, L. (2005) · International Journal of Cardiology · doi:10.1016/j.ijcard.2004.10.041 · Cited by 188 · see citing works
Kuzumaki, N., Ikegami, D., Tamura, R., Hareyama, N., Imai, S., Narita, M., Torigoe, K., Niikura, K., Takeshima, H., Ando, T., et al. (2010) · Hippocampus · doi:10.1002/hipo.20775 · Cited by 185 · see citing works
Serum BDNF, TNF-α and IL-1β levels in dementia patients
Yasutake, C., Kuroda, K., Yanagawa, T., Okamura, T., & Yoneda, H. (2006) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-006-0652-8 · Cited by 177 · see citing works
Low brain‐derived neurotrophic factor (BDNF) levels in serum of Huntington's disease patients
Ciammola, A., Sassone, J., Cannella, M., Calza, S., Poletti, B., Frati, L., Squitieri, F., & Silani, V. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30501 · Cited by 171 · see citing works
Purification and Identification of Brain-Derived Neurotrophic Factor from Human Serum
Rosenfeld, R. D., Zeni, L., Haniu, N., Talvenheimo, J., Radka, S. F., Bennett, L., Miller, J. A., & Welcher, A. A. (1995) · Protein Expression and Purification · doi:10.1006/prep.1995.1062 · Cited by 164 · see citing works
Possible Role of Brain-Derived Neurotrophic Factor in the Pathogenesis of Coronary Artery Disease
Ejiri, J., Inoue, N., Kobayashi, S., Shiraki, R., Otsui, K., Honjo, T., Takahashi, M., Ohashi, Y., Ichikawa, S., Terashima, M., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.476903 · Cited by 163 · see citing works
Ethanol–BDNF interactions: Still more questions than answers
Davis, M. I. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.01.003 · Cited by 159 · see citing works
Fujinami, A., Ohta, K., Obayashi, H., Fukui, M., Hasegawa, G., Nakamura, N., Kozai, H., Imai, S., & Ohta, M. (2008) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2008.03.003 · Cited by 156 · see citing works
Autry, A. E., Adachi, M., Cheng, P., & Monteggia, L. M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.007 · Cited by 154 · see citing works
Decreased levels of serum brain-derived neurotrophic factor in female patients with eating disorders
Nakazato, M., Hashimoto, K., Shimizu, E., Kumakiri, C., Koizumi, H., Okamura, N., Mitsumori, M., Komatsu, N., & Iyo, M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01746-8 · Cited by 150 · see citing works
Ikeda, Y., Yahata, N., Ito, I., Nagano, M., Toyota, T., Yoshikawa, T., Okubo, Y., & Suzuki, H. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.01.017 · Cited by 142 · see citing works
Scarisbrick, I. A., Jones, E. G., & Isackson, P. J. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-03-00875.1993 · Cited by 140 · see citing works
Currie, J. M. S., Ramsbottom, R., Ludlow, H., Nevill, A. M., & Gilder, M. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.12.043 · Cited by 135 · see citing works
Piccinni, A., Marazziti, D., Debbio, A. D., Bianchi, C., Roncaglia, I., Mannari, C., Origlia, N., Dell’Osso, M. C., Massimetti, G., Domenici, L., et al. (2008) · Chronobiology International · doi:10.1080/07420520802387773 · Cited by 134 · see citing works
Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism
Hashimoto, K., Iwata, Y., Nakamura, K., Tsujii, M., Tsuchiya, K. J., Sekine, Y., Suzuki, K., Minabe, Y., Takei, N., Iyo, M., et al. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.06.018 · Cited by 131 · see citing works
Wojnar, M., Brower, K. J., Strobbe, S., Ilgen, M., Matsumoto, H., Nowosad, I., Sliwerska, E., & Burmeister, M. (2009) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00886.x · Cited by 125 · see citing works
Brain-derived Neurotrophic Factor in Platelets and Airflow Limitation in Asthma
Lommatzsch, M., Schloetcke, K., Klotz, J., Schuhbaeck, K., Zingler, D., Zingler, C., Schulte‐Herbrüggen, O., Gill, H., Schuff‐Werner, P., & Virchow, J. C., Jr. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200406-758oc · Cited by 121 · see citing works
Inverse Correlation of Brain and Blood BDNF Levels in a Genetic Rat Model of Depression
Elfving, B., Plougmann, P. H., Müller, H. K., Mathé, A. A., Rosenberg, R., & Wegener, G. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990721 · Cited by 119 · see citing works
Increased BDNF serum concentration in fibromyalgia with or without depression or antidepressants
Laske, C., Stransky, E., Eschweiler, G. W., Klein, R., Wittorf, A., Leyhe, T., Richartz, E., Köhler, N., Bartels, M., Buchkremer, G., et al. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.02.007 · Cited by 118 · see citing works
Increased Plasma Concentration of Brain-Derived Neurotrophic Factor With Electroconvulsive Therapy
Marano, C. M., Phatak, P., Vemulapalli, U. R., Sassan, A., Nalbandyan, M. R., Ramanujam, S., Soekadar, S. R., Demosthenous, M., & Regenold, W. T. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0404 · Cited by 109 · see citing works
Chan, K. L., Tong, R. K., & Yip, S. P. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.10.013 · Cited by 107 · see citing works
Association of the met66 allele of brain-derived neurotrophic factor (BDNF) with smoking
Lang, U. E., Sander, T., Lohoff, F. W., Hellweg, R., Bajbouj, M., Winterer, G., & Gallinat, J. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0647-1 · Cited by 95 · see citing works
Kim, T. S., Kim, D., Lee, H., & Kim, Y. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.05.064 · Cited by 88 · see citing works
Metabolic syndrome – Neurotrophic hypothesis
Hristova, M., & Aloe, L. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.08.055 · Cited by 87 · see citing works
Changes in plasma brain-derived neurotrophic factor levels in smokers after smoking cessation
Bhang, S., Choi, S., & Ahn, J. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.10.046 · Cited by 78 · see citing works
Aydemır, Ö., Deveci, A., Taşkın, O., Taneli, F., & Esen-Danacı, A. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.02.013 · Cited by 62 · see citing works
BDNF-mediated enhancement of inflammation and injury in the aging heart
Cai, D., Holm, J. M., Duignan, I. J., et al. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00165.2005 · Cited by 60 · see citing works
Expression of mRNAs for Neurotrophins and Their Receptors in Developing Rat Heart
Hiltunen, J. O., Arumäe, U., Moshnyakov, M., & Saarma, M. (1996) · Circulation Research · doi:10.1161/01.res.79.5.930 · Cited by 55 · see citing works
Gene Expression of Neurotrophins and Their Receptors in Cultured Rat Vascular Smooth Muscle Cells
Nemoto, K., Fukamachi, K., Nemoto, F., Miyata, S., Hamada, M., Nakamura, Y., Senba, E., & Ueyama, T. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8418 · Cited by 52 · see citing works
Umene‐Nakano, W., Yoshimura, R., Ikenouchi, A., Hori, H., Hayashi, K., Ueda, N., & Nakamura, J. (2009) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1035 · Cited by 44 · see citing works
Chaldakov, G. N., Tonchev, A. B., Manni, L., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0706-0 · Cited by 36 · see citing works
Brain-derived neurotrophic factor and the metabolic syndrome: More than just a hypothesis
Geroldi, D., Minoretti, P., & Emanuele, E. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.02.001 · Cited by 36 · see citing works
The BDNF Val66Met polymorphism and smoking
Montag, C., Basten, U., Stelzel, C., Fiebach, C. J., & Reuter, M. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.06.064 · Cited by 32 · see citing works
Neurotrophin receptor proteins immunoreactivity in human gastrointestinal endocrine cells
Esteban, I., Hannestad, J. O., Levanti, B., Soto, M. D. V., Naves, F. J., & Vega, J. A. (1995) · Brain Research Bulletin · doi:10.1016/0361-9230(95)02025-9 · Cited by 30 · see citing works
Brain derived neurotrophic factor circulating levels in patients undergoing IVF
Monteleone, P., Artini, P. G., Simi, G., Cela, V., Casarosa, E., Begliuomini, S., Ninni, F., Pluchino, N., Luisi, M., & Genazzani, A. R. (2007) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-007-9169-y · Cited by 28 · see citing works
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Bathina, S., & Das, U. N. (2015) · Archives of Medical Science · doi:10.5114/aoms.2015.56342 · Cited by 1,381 · see citing works
Molendijk, M. L., Spinhoven, P., Polak, M., Bus, B. A. A., Penninx, B. W. J. H., & Elzinga, B. M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.105 · Cited by 702 · see citing works
Self-citationPolyakova, M., Stuke, K., Schuemberg, K., Mueller, K., Schoenknecht, P., & Schroeter, M. L. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.11.044 · Cited by 488 · see citing works
Huang, T., Larsen, K. T., Ried‐Larsen, M., Møller, N. C., & Andersen, L. B. (2014) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12069 · Cited by 485 · see citing works
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Weinstein, G., Beiser, A. S., Choi, S. H., Preis, S. R., Chen, T. C., Vorgas, D., Au, R., Pikula, A., Wolf, P. A., DeStefano, A. L., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.4781 · Cited by 289 · see citing works
Polacchini, A., Metelli, G., Francavilla, R., Baj, G., Florean, M., Mascaretti, L. G., & Tongiorgi, E. (2015) · Scientific Reports · doi:10.1038/srep17989 · Cited by 263 · see citing works
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Munkholm, K., Vinberg, M., & Kessing, L. V. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.54 · Cited by 157 · see citing works
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Zuccato, C., Marullo, M., Vitali, B., Tarditi, A., Mariotti, C., Valenza, M., Lahiri, N., Wild, E. J., Sassone, J., Ciammola, A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022966 · Cited by 138 · see citing works
Hirsch, M. A., van Wegen, E. E. H., Newman, M. A., & Heyn, P. C. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0112-1 · Cited by 134 · see citing works
Bus, B. A. A., Molendijk, M. L., Tendolkar, I., Penninx, B. W. J. H., Prickaerts, J., Elzinga, B. M., & Voshaar, R. C. O. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.83 · Cited by 133 · see citing works
Self-citationMolecular mechanisms of brain-derived neurotrophic factor in neuro-protection: Recent developments
Zhao, H., Alam, A., San, C.-Y., Eguchi, S., Chen, Q., Lian, Q., & Ma, D. (2017) · Brain Research · doi:10.1016/j.brainres.2017.03.029 · Cited by 122 · see citing works
Salinas, J., Beiser, A., Himali, J. J., Satizabal, C. L., Aparicio, H. J., Weinstein, G., Mateen, F. J., Berkman, L. F., Rosand, J., & Seshadri, S. (2017) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.03.001 · Cited by 87 · see citing works
Patas, K., Penninx, B. W. J. H., Bus, B. A. A., Vogelzangs, N., Molendijk, M. L., Elzinga, B. M., Bosker, F. J., & Oude Voshaar, R. C. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.10.007 · Cited by 80 · see citing works
Self-citationMedeiros, G. C., Gould, T. D., Prueitt, W. L., Nanavati, J., Grunebaum, M. F., Farber, N. B., Singh, B., Selvaraj, S., Machado-Vieira, R., Achtyes, E. D., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01652-1 · Cited by 75 · see citing works
Christian, L. M., Mitchell, A. M., Gillespie, S. L., & Palettas, M. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.08.025 · Cited by 73 · see citing works
Effect of childhood maltreatment and brain-derived neurotrophic factor on brain morphology
van Velzen, L. S., Schmaal, L., Jansen, R., Milaneschi, Y., Opmeer, E. M., Elzinga, B. M., van der Wee, N. J. A., Veltman, D. J., & Penninx, B. W. J. H. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw086 · Cited by 58 · see citing works
Self-citationAssociation between BDNF levels and suicidal behaviour: a systematic review and meta-analysis
Eisen, R. B., Perera, S., Banfield, L., Anglin, R., Minuzzi, L., & Samaan, Z. (2015) · Systematic Reviews · doi:10.1186/s13643-015-0179-z · Cited by 51 · see citing works
Thomas, M., Knoblich, N., Wallisch, A., Glowacz, K., Becker-Sadzio, J., Gundel, F., Brückmann, C., & Nieratschker, V. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0544-6 · Cited by 51 · see citing works
Kudlek Mikulic, S., Mihaljevic-Peles, A., Sagud, M., Bajs Janovic, M., Ganoci, L., Grubisin, J., Kuzman Rojnic, M., Vuksan Cusa, B., Bradaš, Z., & Božina, N. (2017) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2017.1340518 · Cited by 25 · see citing works
Carlino, D., Francavilla, R., Baj, G., Kulak, K., d’Adamo, P., Ulivi, S., Cappellani, S., Gasparini, P., & Tongiorgi, E. (2015) · PeerJ · doi:10.7717/peerj.1252 · Cited by 23 · see citing works
Weinstein, G., Preis, S. R., Beiser, A. S., Kaess, B., Chen, T. C., Satizabal, C., Rahman, F., Benjamin, E. J., Vasan, R. S., & Seshadri, S. (2017) · Current Alzheimer Research · doi:10.2174/1567205014666170203094520 · Cited by 17 · see citing works
Smit, A. J. T., Wu, G. W. Y., Rampersaud, R., Reus, V. I., Wolkowitz, O. M., & Mellon, S. H. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107045 · Cited by 9 · see citing works
- Authors
- Bus, B. A. A., Molendijk, M. L., Penninx, B. J. W. H., Buitelaar, J. K., Kenis, G., Prickaerts, J., Elzinga, B. M., & Voshaar, R. C. O.
- Affiliations
- Radboud University Medical Center (NL)
- Leiden University (NL)
- Maastricht University (NL)
- Corresponding author
- Bus, B.A.A.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 36
- Issue
- 2
- Pages
- 228-239
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2139407404
- Cited by
- 279
- References
- 75
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 11 · 2023: 16 · 2022: 15 · 2021: 13 · 2020: 19 · 2019: 19 · 2018: 17 · 2017: 28 · 2016: 28 · 2015: 14 · 2014: 31 · 2013: 22 · 2012: 13
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- VU Research Portal (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- brain-derived neurotrophic factor, serum BDNF, blood sampling timing, blood storage, binge drinking, smoking, urbanicity, age and sex differences, lifestyle factors, neurotrophins
- MeSH terms
- Adolescent, Adult, Aged, Coronary Artery Disease, Female, Health Status Indicators, Humans, Life Style, Lung Diseases, Male, Middle Aged, Netherlands, Socioeconomic Factors, Epidemiologic Factors, Brain-Derived Neurotrophic Factor, Young Adult
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