Healthy excursions outside the thermal comfort zone
Open accessAbstract
The concepts of comfort and health may be related but are not synonyms. New knowledge has been gathered regarding metabolic health effects of temperature exposure outside the human thermal comfort zone. Mild cold and warm environments increase metabolism, thereby targeting obesity by counterbalancing excess energy intake. Furthermore, mild cold influences glucose metabolism. Ten days of intermittent mild cold exposure in type 2 diabetes patients increased insulin sensitivity, and thereby glucose handling by more than 40%. This is comparable with the best available pharmaceutical or physical activity therapies. Lastly, there are indications that cardiovascular parameters may be positively affected by regular exposure to heat and cold. Does this mean that we have to suffer from discomfort in order to become healthy? Probably not. Firstly, prolonged temporal excursions outside the thermal comfort zone result in acclimatization resulting in increased comfort ratings. Secondly, low or high temperatures in a dynamic thermal environment may be perceived as acceptable or even pleasant (evoking thermal alliesthesia). The study of dynamic thermal conditions is advocated: linking this to the adaptive comfort model, and monitoring these conditions in actual living conditions. This information is needed to support the design of healthy, comfortable and energy-friendly indoor environments.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works
Thermal Environmental Conditions for Human Occupancy
Ashrae, S. (1992) · Medical Entomology and Zoology · Cited by 6,092 · see citing works
Cold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452 · see citing works
Self-citationFunctional Brown Adipose Tissue in Healthy Adults
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058 · see citing works
(1998) · eScholarship (California Digital Library) · Cited by 1,934 · see citing works
High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans
Saito, M., Okamatsu-Ogura, Y., Matsushita, M., Watanabe, K., Yoneshiro, T., Nio-Kobayashi, J., Iwanaga, T., Miyagawa, M., Kameya, T., Nakada, K., et al. (2009) · Diabetes · doi:10.2337/db09-0530 · Cited by 1,848 · see citing works
Brown adipose tissue activity controls triglyceride clearance
Bartelt, A., Bruns, O. T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Weller, H., Waurisch, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2297 · Cited by 1,608 · cited 2× · see citing works
“Hints also come from animal studies, showing that increased BAT activity prevents both obesity and type 2 diabetes (Bartelt et al., 2011; Stanford et al., 2013).”
BackgroundCabanac, M. (1971) · Science · doi:10.1126/science.173.4002.1103 · Cited by 1,521 · see citing works
Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
Stanford, K. I., Middelbeek, R. J. W., Townsend, K. L., An, D., Nygaard, E. B., Hitchcox, K. M., Markan, K. R., Nakano, K., Hirshman, M. F., Tseng, Y.-H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62308 · Cited by 1,180 · see citing works
Physiological adaptations to interval training and the role of exercise intensity
MacInnis, M. J., & Gibala, M. J. (2017) · The Journal of Physiology · doi:10.1113/jp273196 · Cited by 1,124 · see citing works
Recruited brown adipose tissue as an antiobesity agent in humans
Yoneshiro, T., Aita, S., Matsushita, M., Kayahara, T., Kameya, T., Kawai, Y., Iwanaga, T., & Saito, M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67803 · Cited by 957 · see citing works
Cold acclimation recruits human brown fat and increases nonshivering thermogenesis
van der Lans, A. A. J. J., Joris Hoeks, J., Brans, B. T., Vijgen, G. H. E. J., Visser, M. G. W., Vosselman, M. J., Hansen, J., Jörgensen, J. A., Wu, J., Mottaghy, F. M., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68993 · Cited by 841 · see citing works
Singh, G. M., Danaei, G., Farzadfar, F., Stevens, G. A., Woodward, M., Wormser, D., Kaptoge, S., Whitlock, G., Qiao, Q., Lewington, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065174 · Cited by 772 · see citing works
Nielsen, B., Hales, J. R. S., Strange, S., Christensen, N. J., Warberg, J., & Saltin, B. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019482 · Cited by 716 · see citing works
Ten Putative Contributors to the Obesity Epidemic
McAllister, E. J., Dhurandhar, N. V., Keith, S. W., Aronne, L. J., Barger, J., Baskin, M., Benca, R. M., Biggio, J., Boggiano, M. M., Eisenmann, J. C., et al. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903372599 · Cited by 710 · see citing works
Putative contributors to the secular increase in obesity: exploring the roads less traveled
Keith, S. W., Redden, D. T., Katzmarzyk, P. T., Boggiano, M. M., Hanlon, E. C., Benca, R. M., Ruden, D. M., Pietrobelli, A., Barger, J. L., Fontaine, K. R., et al. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803326 · Cited by 633 · see citing works
Scholander, P. F., Hock, R. J., Walters, V., & Irving, L. (1950) · Biological Bulletin · doi:10.2307/1538742 · Cited by 603 · see citing works
Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus
Hanssen, M. J. W., Joris Hoeks, J., Brans, B. T., van der Lans, A. A. J. J., Schaart, G., van den Driessche, J. J., Jörgensen, J. A., Boekschoten, M. V., Hesselink, M. K. C., Havekes, B., et al. (2015) · Nature Medicine · doi:10.1038/nm.3891 · Cited by 587 · see citing works
Self-citationHSP72 protects against obesity-induced insulin resistance
Chung, J., Nguyen, A.-K., Henstridge, D. C., Holmes, A. G., Chan, M. H. S., Mesa, J. L., Lancaster, G. I., Southgate, R. J., Bruce, C. R., Duffy, S. J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705799105 · Cited by 553 · see citing works
Yoneshiro, T., Aita, S., Matsushita, M., Okamatsu‐Ogura, Y., Kameya, T., Kawai, Y., Miyagawa, M., Tsujisaki, M., & Saito, M. (2011) · Obesity · doi:10.1038/oby.2011.125 · Cited by 503 · see citing works
A review of the corrective power of personal comfort systems in non-neutral ambient environments
Zhang, H., Arens, E. A., & Zhai, Y. (2015) · Building and Environment · doi:10.1016/j.buildenv.2015.03.013 · Cited by 418 · see citing works
Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans
Lee, P., Smith, S., Linderman, J. D., Courville, A. B., Brychta, R. J., Dieckmann, W., Werner, C., Chen, K. Y., & Celi, F. S. (2014) · Diabetes · doi:10.2337/db14-0513 · Cited by 398 · see citing works
Schellen, L., Van Marken Lichtenbelt, W. D., Loomans, M. G. L. C., Toftum, J., & De Wit, M. H. (2010) · Indoor Air · doi:10.1111/j.1600-0668.2010.00657.x · Cited by 377 · see citing works
Self-citationMeex, R. C. R., Schrauwen-Hinderling, V. B., Moonen-Kornips, E., Schaart, G., Mensink, M., Phielix, E., van de Weijer, T., Sels, J.-P., Schrauwen, P., & Hesselink, M. K. C. (2010) · Diabetes · doi:10.2337/db09-1322 · Cited by 355 · see citing works
Revisiting an old hypothesis of human thermal perception: alliesthesia
de Dear, R. (2011) · Building Research & Information · doi:10.1080/09613218.2011.552269 · Cited by 333 · see citing works
Taylor, N. A. S. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130022 · Cited by 331 · see citing works
Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans
Hanssen, M. J. W., van der Lans, A. A. J. J., Brans, B. T., Joris Hoeks, J., Jardon, K. M. C., Schaart, G., Mottaghy, F. M., Schrauwen, P., & Lichtenbelt, W. D. V. M. (2015) · Diabetes · doi:10.2337/db15-1372 · Cited by 293 · see citing works
Self-citationBasal Metabolism, Radiation, Convection and Vaporization at Temperatures of 22 to 35°C.
Hardy, J. D., Bois, E. F. D., & Soderstrom, G. F. (1938) · Journal of Nutrition · doi:10.1093/jn/15.5.477 · Cited by 290 · see citing works
Thermal comfort as part of a self-regulating system
Nicol, F., & Humphreys, M. (1973) · Batiment International Building Research and Practice · doi:10.1080/09613217308550237 · Cited by 287 · see citing works
Kox, M., van Eijk, L. T., Zwaag, J., van den Wildenberg, J., Sweep, F. C. G. J., van der Hoeven, J. G., & Pickkers, P. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322174111 · Cited by 268 · see citing works
Thermal pleasure in built environments: physiology of alliesthesia
Parkinson, T., & de Dear, R. (2015) · Building Research & Information · doi:10.1080/09613218.2015.989662 · Cited by 263 · see citing works
Hot-Tub Therapy for Type 2 Diabetes Mellitus
Hooper, P. L. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411216 · Cited by 208 · see citing works
The thermoneutral zone implications for metabolic studies
Kingma, B. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e518 · Cited by 170 · see citing works
Self-citationSeasonal changes in metabolic and temperature responses to cold air in humans
VANOOIJEN, A., VANMARKENLICHTENBELT, W., VANSTEENHOVEN, A., & Westerterp, K. R. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.05.001 · Cited by 165 · see citing works
Self-citationEvolving opportunities for providing thermal comfort
Brager, G. S., Zhang, H., & Arens, E. A. (2015) · Building Research & Information · doi:10.1080/09613218.2015.993536 · Cited by 164 · see citing works
Immune changes in humans during cold exposure: effects of prior heating and exercise
Brenner, I., Castellani, J. W., Gabaree, C. L. V., Young, A., Zamecnik, J., Shephard, R. J., & Shek, P. N. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.2.699 · Cited by 164 · see citing works
Chamber cold acclimatization in man
Davis, T. R. A. (1961) · Journal of Applied Physiology · doi:10.1152/jappl.1961.16.6.1011 · Cited by 157 · see citing works
The thermoneutral zone: implications for metabolic studies
Kingma, B. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/518 · Cited by 153 · see citing works
Self-citationCold-activated brown adipose tissue in human adults: methodological issues
van der Lans, A. A. J. J., Wierts, R., Vosselman, M. J., Schrauwen, P., Brans, B. T., & Lichtenbelt, W. D. V. M. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00021.2014 · Cited by 145 · see citing works
Could increased time spent in a thermal comfort zone contribute to population increases in obesity?
Johnson, F., Mavrogianni, A., Ucci, M., Vidal‐Puig, A., & Wardle, J. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00851.x · Cited by 139 · see citing works
Heat acclimation improves cutaneous vascular function and sweating in trained cyclists
Lorenzo, S., & Minson, C. T. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00725.2010 · Cited by 135 · see citing works
Autonomic Nervous Function During Whole-Body Cold Exposure Before and After Cold Acclimation
Mäkinen, T., Mäntysaari, M., Pääkkönen, T., Jokelainen, J. J., Palinkas, L. A., Hassi, J., Leppäluoto, J., Tahvanainen, K. U. O., & Rintamäki, H. (2008) · Aviation Space and Environmental Medicine · doi:10.3357/asem.2235.2008 · Cited by 134 · see citing works
Williams, G., & Pickup, J. C. (1999) · Cited by 132 · see citing works
Influence of mild cold on 24 h energy expenditure, resting metabolism and diet-induced thermogenesis
Dauncey, M. J. (1981) · British Journal Of Nutrition · doi:10.1079/bjn19810102 · Cited by 126 · see citing works
Thermoregulatory responses of middle-aged and young men during dry-heat acclimation
Pandolf, K. B., Cadarette, B. S., Sawka, M. N., Young, A. J., Francesconi, R. P., & Gonzalez, R. R. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.65.1.65 · Cited by 122 · see citing works
Cold exposure – an approach to increasing energy expenditure in humans
Lichtenbelt, W. D. V. M., Kingma, B., van der Lans, A. A. J. J., & Schellen, L. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.01.001 · Cited by 107 · see citing works
Self-citationWeller, A. S., Linnane, D. M., Jonkman, A. G., & Daanen, H. A. M. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0563-z · Cited by 106 · see citing works
The influence of light on thermal responses
te Kulve, M., Schellen, L., Schlangen, L. J. M., & van Marken Lichtenbelt, W. D. (2016) · Acta Physiologica · doi:10.1111/apha.12552 · Cited by 105 · see citing works
Self-citationIndividual variation in body temperature and energy expenditure in response to mild cold
Lichtenbelt, W. D. V. M., Schrauwen, P., van de Kerckhove, S., & Westerterp‐Plantenga, M. S. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00020.2001 · Cited by 103 · see citing works
Celi, F. S., Brychta, R. J., Linderman, J. D., Butler, P. W., Alberobello, A. T., Smith, S., Courville, A. B., Lai, E. W., Costello, R., Skarulis, M. C., et al. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0627 · Cited by 97 · see citing works
Bae, C., & Chun, C. (2009) · Building and Environment · doi:10.1016/j.buildenv.2009.04.003 · Cited by 96 · see citing works
Explaining the spread of residential air conditioning, 1955–1980
Biddle, J. E. (2008) · Explorations in Economic History · doi:10.1016/j.eeh.2008.02.004 · Cited by 92 · see citing works
The Critical Temperature in Naked Man
Erikson, H., EIROG, J., Andersen, K. L., et al. (1956) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1956.tb01339.x · Cited by 83 · see citing works
Adaptation to Heat and Exercise Performance Under Cooler Conditions: A New Hot Topic
Corbett, J., Neal, R. A., Massey, H. C., & Tipton, M. (2014) · Sports Medicine · doi:10.1007/s40279-014-0212-8 · Cited by 77 · see citing works
Kingma, B., Frijns, A. A., Saris, W. H. M., van Steenhoven, A. A., & Lichtenbelt, W. D. V. M. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02336.x · Cited by 74 · see citing works
Self-citationMavrogianni, A., Johnson, F., Ucci, M., Marmot, A., Wardle, J., Oreszczyn, T., & Summerfield, A. J. (2011) · Indoor and Built Environment · doi:10.1177/1420326x11425966 · Cited by 65 · see citing works
Bilous, R., & Donnelly, R. (2010) · Wiley eBooks · doi:10.1002/9781444391374 · Cited by 62 · see citing works
Unander, F., Ettestøl, I., Ting, M., et al. (2003) · Energy Policy · doi:10.1016/s0301-4215(03)00106-x · Cited by 61 · see citing works
Kolařík, J., Toftum, J., Olesen, B. W., et al. (2011) · Energy and Buildings · doi:10.1016/j.enbuild.2011.07.008 · Cited by 59 · see citing works
Combatting type 2 diabetes by turning up the heat
Schrauwen, P., & Lichtenbelt, W. D. V. M. (2016) · Diabetologia · doi:10.1007/s00125-016-4068-3 · Cited by 59 · see citing works
Influence of mild cold on 24 h energy expenditure in ‘normally’ clothed adults
Warwick, P. M., & Busby, R. (1990) · British Journal Of Nutrition · doi:10.1079/bjn19900135 · Cited by 58 · see citing works
Thermophysiological adaptations to passive mild heat acclimation
Pallubinsky, H., Schellen, L., Kingma, B., Dautzenberg, B., van Baak, M. A., & Lichtenbelt, W. D. V. M. (2017) · Temperature · doi:10.1080/23328940.2017.1303562 · Cited by 55 · see citing works
Self-citationVANMARKENLICHTENBELT, W., Westerterp‐Plantenga, M. S., & VANHOYDONCK, P. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00477-2 · Cited by 48 · see citing works
Self-citationIs thermogenesis a significant causal factor in preventing the “globesity” epidemic?
Hansen, J. C., Gilman, A. P., & Odland, J. Ø. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.02.033 · Cited by 48 · see citing works
Building and occupant energetics: a physiological hypothesis
Lichtenbelt, W. D. V. M., & Kingma, B. (2013) · Architectural Science Review · doi:10.1080/00038628.2012.759377 · Cited by 29 · see citing works
Self-citationVosselman, M. J., Vijgen, G. H. E. J., Kingma, B. R. M., Brans, B., & van Marken Lichtenbelt, W. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101653 · Cited by 27 · see citing works
Self-citationThermal, cardiac and adrenergic responses to repeated local cooling
Janský, L., Matoušková, E., Vávra, V., et al. (2006) · Physiological Research · doi:10.33549/physiolres.930825 · Cited by 25 · see citing works
The effect of warmth acclimation on behaviour, thermophysiology and perception
Pallubinsky, H., Kingma, B., Schellen, L., Dautzenberg, B., van Baak, M. A., & Lichtenbelt, W. D. V. M. (2017) · Building Research & Information · doi:10.1080/09613218.2017.1278652 · Cited by 24 · see citing works
Self-citationCold acclimation affects immune composition in skeletal muscle of healthy lean subjects
van der Lans, A. A. J. J., Boon, M. R., Haks, M. C., et al. (2015) · Physiological Reports · doi:10.14814/phy2.12394 · Cited by 20 · see citing works
Exploring internal body heat balance to understand thermal sensation
Kingma, B., Schweiker, M., Wagner, A., & Lichtenbelt, W. D. V. M. (2017) · Building Research & Information · doi:10.1080/09613218.2017.1299996 · Cited by 20 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Drivers of diversity in human thermal perception – A review for holistic comfort models
Schweiker, M., Huebner, G. M., Kingma, B. R. M., Kramer, R., & Pallubinsky, H. (2018) · Temperature · doi:10.1080/23328940.2018.1534490 · Cited by 231 · see citing works
Self-citationEhsan, S., Abbas, F., Ibrahim, M., Ahmad, B., & Farooque, A. A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18052535 · Cited by 36 · see citing works
“Nicol and Roaf [23] explained the concepts of understanding behind the thermal relationship between people and buildings, socio-economic aspects [24], psychology [25], physiology [26] which underlies the related health effects and the ways to interpret the body’s response to the environment either as comfort or discom…”
BackgroundThe associations between thermal variety and health: Implications for space heating energy use
Kennard, H. R., Huebner, G. M., Shipworth, D., & Oreszczyn, T. (2020) · PLOS ONE · doi:10.1371/journal.pone.0236116 · Cited by 4 · see citing works
- Authors
- van Marken Lichtenbelt, W., Hanssen, M., Pallubinsky, H., Kingma, B., & Schellen, L.
- Affiliations
- Department of Human Biology, NUTRIM School, Maastricht University Medical Center
- Maastricht University Medical Centre (NL)
- Avans University of Applied Sciences (NL)
- Venue
- Building Research & Information
- Publisher
- Informa UK Limited
- Published
- 2017-04-25
- Volume
- 45
- Issue
- 7
- Pages
- 819-827
- ISSN
- 0961-3218 (ISSN-L)
- 1466-4321
- OpenAlex
- W2609909083
- Cited by
- 109
- References
- 70
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 8 · 2023: 15 · 2022: 20 · 2021: 17 · 2020: 14 · 2019: 7 · 2018: 8 · 2017: 2
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Building Research & Information (publishedVersion, cc-by-nc-nd)
- Research Publications (Maastricht University) (publishedVersion, cc-by-nc-nd)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- TKI Solar Energy project (TEGBj13023)
- European Union’s Horizon 2020 Framework programme (723032)
- EU FP7 (HEALTH-F2-2011-278373)
- Netherlands Organization for Scientific Research (TOP 91209037)
- AgentschapNL
- TKI Energo
- Topics
- Physical Sciences › Engineering › Building and Construction › Building Energy and Comfort Optimization
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- thermal comfort, metabolic health, cold exposure, warm environment, obesity, glucose metabolism, type 2 diabetes, insulin sensitivity, cardiovascular effects, acclimatization, adaptive comfort model, indoor environment design, energy efficiency
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review