Cited by 327Gut microbiota and healthTryptophan and brain disordersGastrointestinal motility and disorders

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Fecal microbiota transplantation from chronic unpredictable mild stress mice donors affects anxiety-like and depression-like behavior in recipient mice via the gut microbiota-inflammation-brain axis

Open access

Li, Nannan, Wang, Qi, Wang, Yan, Sun, Anji, Lin, Yiwei, Jin, Ye, Li, Xiaobai·2019·Stress

DOI 10.1080/10253890.2019.1617267

Open this paper in CoChat — free account Open PDF

Abstract

Recent studies have demonstrated that there are significant changes in the gut microbiota (GM) of humans with depression and animal models of depression and chronic stress. In our present study, we determined whether an alteration in GM is a decisive factor in anxiety-like and depression-like behavior and its impact on brain neurochemistry. An antibiotic cocktail was used to deplete the GM of mice before they were colonized, via fecal microbiota transplantation (FMT), by the GM of control mice or mice that had been exposed to chronic unpredictable mild stress (CUMS donors). The CUMS-donor group of mice and the mice that were colonized by their microbiota (the CUMS-recipient group) both showed higher levels of anxiety- and depression-like behavior compared to the controls. The GM community of the CUMS-donor and CUMS-recipient was distinctively different from the controls, with the CUMS group characterized by a lower relative abundance of Lactobacillus and a higher relative abundance of Akkermansia. Interestingly, FMT affected both behavior and neuroinflammation. Mice given the CUMS microbiota had significant elevations of interferon-γ (IFN-γ) and the tumor necrosis factor-alpha (TNF-α) in the hippocampus, which were accompanied by upregulated indoleamine 2,3-dioxygenase 1 (IDO1) in the hippocampus. These results suggest that GM modulates pro-inflammatory cytokines in the hippocampus through dysfunctional microbiota–gut–brain axis, exacerbating anxiety- and depression-like phenotypes.Key PointsChronic unpredictable mild stress increased anxiety- and depression-like behavior in mice.Mice colonized with gut microbiota (GM) from stressed mice showed similar behaviors.The GM composition of the donor and recipient mice was also comparable.Their relative pattern of two bacteria has been tied to neuroinflammatory activity.The results suggest a link between GM, brain function, and anxiety and depression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1080/10253890.2019.1617267

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22
Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614
Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275
Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism
Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., Zeng, L., Chen, J., Fan, S., Du, X., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.44 · Cited by 2,023
The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat
Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683
Correlation between the human fecal microbiota and depression
Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linløkken, A., Wilson, R., & Rudi, K. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12378 · Cited by 1,044
Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
Schneeberger, M., Everard, A., Gómez-Valadés, A. G., Matamoros, S., Ramírez, S., Delzenne, N. M., Gomis, R., Claret, M., & Cani, P. D. (2015) · Scientific Reports · doi:10.1038/srep16643 · Cited by 798
Gut microbiota depletion from early adolescence in mice: implications for brain and behaviour
Desbonnet, L., Clarke, G., Traplin, A., O’Sullivan, O., Crispie, F., Moloney, R. D., Cotter, P. D., Dinan, T. G., & Cryan, J. F. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.004 · Cited by 760
Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress
Liang, S., Wang, T., Hu, X., Luo, J., Li, W., Wu, X., Duan, Y., & Jin, F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.033 · Cited by 651
Modulation of Mucosal Immune Response, Tolerance, and Proliferation in Mice Colonized by the Mucin-Degrader Akkermansia muciniphila
Derrien, M., van Baarlen, P., Hooiveld, G. J. E. J., Norin, E. L., Müller, M. M., & de Vos, W. M. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00166 · Cited by 595

Show all 55 references

Research works printed but not linked: 1

Hay S.I., 2017, Lancet, 389, , E1

Sorted by citations

The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857
Perturbations in Gut Microbiota Composition in Psychiatric Disorders
Nikolova, V. L., Smith, M. R. B., Hall, L. J., Cleare, A. J., Stone, J. M., & Young, A. H. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.2573 · Cited by 777
Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment
Bisgaard, T. H., Allin, K. H., Keefer, L., Ananthakrishnan, A. N., & Jess, T. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00634-6 · Cited by 572
Brain–gut–microbiota axis in depression: A historical overview and future directions
Chang, L., Wei, Y., & Hashimoto, K. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.02.004 · Cited by 407
Gut–Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions
Kanmani, S., & Koo, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207551 · Cited by 392
Effect of fecal microbiota transplant on symptoms of psychiatric disorders: a systematic review
Chinna Meyyappan, A., Forth, E., Wallace, C. J. K., & Milev, R. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02654-5 · Cited by 254
Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy
Campbell, C., Kandalgaonkar, M. R., Golonka, R. M., Yeoh, B. S., Vijay–Kumar, M., & Saha, P. (2023) · Biomedicines · doi:10.3390/biomedicines11020294 · Cited by 270
Psychological stress in inflammatory bowel disease: Psychoneuroimmunological insights into bidirectional gut–brain communications
Ge, L., Liu, S., Li, S., Yang, J., Hu, G., Xu, C., & Song, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1016578 · Cited by 187
Microbiota metabolites modulate the T helper 17 to regulatory T cell (Th17/Treg) imbalance promoting resilience to stress-induced anxiety- and depressive-like behaviors
Westfall, S., Caracci, F., Zhao, D., Wu, Q.-L., Frolinger, T., Simon, J. E., & Pasinetti, G. M. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.10.013 · Cited by 164
Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression
Bertollo, A. G., Santos, C. F., Bagatini, M. D., & Ignácio, Z. M. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1541075 · Cited by 183
Evolution of the Human Diet and Its Impact on Gut Microbiota, Immune Responses, and Brain Health
Olmo, B. M. G., Butler, M. J., & Barrientos, R. M. (2021) · Nutrients · doi:10.3390/nu13010196 · Cited by 161
Investigating causality with fecal microbiota transplantation in rodents: applications, recommendations and pitfalls
Gheorghe, C. E., Ritz, N. L., Martin, J. A., Wardill, H. R., Cryan, J. F., & Clarke, G. A. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1941711 · Cited by 156
Inflammation, Lifestyle Factors, and the Microbiome‐Gut‐Brain Axis: Relevance to Depression and Antidepressant Action
Donoso, F., Cryan, J. F., Olavarría‐Ramírez, L., Nolan, Y. M., & Clarke, G. A. (2022) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2581 · Cited by 155
Western Diet: Implications for Brain Function and Behavior
López-Taboada, I., González‐Pardo, H., & Conejo, N. M. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.564413 · Cited by 154
The Microbiota–Gut–Brain Axis in Depression: The Potential Pathophysiological Mechanisms and Microbiota Combined Antidepression Effect
Zhu, F., Tu, H., & Chen, T. (2022) · Nutrients · doi:10.3390/nu14102081 · Cited by 123
The Microbiota–Gut–Brain Axis: Psychoneuroimmunological Insights
Marano, G., Mazza, M., Lisci, F. M., Ciliberto, M., Traversi, G., Kotzalidis, G. D., Berardis, D. D., Laterza, L., Sani, G., Gasbarrini, A., et al. (2023) · Nutrients · doi:10.3390/nu15061496 · Cited by 116
Gut microbiota alteration and modulation in psychiatric disorders: Current evidence on fecal microbiota transplantation
Settanni, C. R., Ianiro, G., Bibbò, S., Cammarota, G., & Gasbarrini, A. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110258 · Cited by 106
Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis
Tan, C., Yan, Q., Ma, Y., Fang, J., & Yang, Y. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.1015175 · Cited by 120
Manipulations of the gut microbiome alter chemotherapy-induced inflammation and behavioral side effects in female mice
Grant, C. V., Loman, B. R., Bailey, M. T., & Pyter, L. M. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.04.014 · Cited by 105
The multiple effects of fecal microbiota transplantation on diarrhea-predominant irritable bowel syndrome (IBS-D) patients with anxiety and depression behaviors
Lin, H., Guo, Q., Wen, Z., Tan, S., Chen, J., Lin, L., Chen, P., He, J., Wen, J., & Chen, Y. (2021) · Microbial Cell Factories · doi:10.1186/s12934-021-01720-1 · Cited by 103
Tryptophan metabolites in depression: Modulation by gut microbiota
Lukić, I., Ivković, S., Mitić, M., & Adžić, M. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.987697 · Cited by 113
Crocin-I alleviates the depression-like behaviors probably via modulating “microbiota-gut-brain” axis in mice exposed to chronic restraint stress
Xiao, Q., Shu, R., Wu, C., Tong, Y., Xiong, Z., Zhou, J., Yu, C., Xie, X., & Fu, Z. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.07.041 · Cited by 93
Gut microbiota alteration in adolescent anorexia nervosa does not normalize with short‐term weight restoration
Schulz, N., Belheouane, M., Dahmen, B., Ruan, V., Specht, H. E., Dempfle, A., Herpertz‐Dahlmann, B., Baines, J. F., & Seitz, J. (2020) · International Journal of Eating Disorders · doi:10.1002/eat.23435 · Cited by 90
Bibliometric and Visual Analysis of Research on the Links Between the Gut Microbiota and Depression From 1999 to 2019
Zhu, X., Hu, J., Deng, S., Tan, Y., Qiu, C., Zhang, M., Ni, X., Lu, H., Wang, Z., Li, L., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.587670 · Cited by 92
Stress gets into the belly: Early life stress and the gut microbiome
Hantsoo, L. V., & Zemel, B. S. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113474 · Cited by 97
The Microbiota–Gut–Brain Axis and Neurological Disorders: A Comprehensive Review
Nakhal, M. M., Yassin, L. K., Alyaqoubi, R., Saeed, S., Alderei, A., Alhammadi, A., Alshehhi, M., Almehairbi, A., Houqani, S. A., BaniYas, S., et al. (2024) · Life · doi:10.3390/life14101234 · Cited by 136
Gut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression- and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner
Zhang, K.-K., Chen, L., Yang, J.-Z., Liu, J., Li, J.-H., Liu, Y., Li, X., Chen, L., Hsu, C., Zeng, J., et al. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.09.010 · Cited by 90
Self-citation
Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway
Shan, B., Ai, Z., Zeng, S., Song, Y., Song, J., Zeng, Q., Liao, Z., Wang, T., Huang, C. C., & Su, D. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104699 · Cited by 86
Major depressive disorder as a neuro-immune disorder: Origin, mechanisms, and therapeutic opportunities
Réus, G. Z., Manosso, L. M., Quevedo, J., & Carvalho, A. F. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105425 · Cited by 94
Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice
Geng, J., Liu, J., Yuan, X., Liu, W., & Guo, W. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114688 · Cited by 82
The brain-gut-microbiota interplay in depression: A key to design innovative therapeutic approaches
Varesi, A., Campagnoli, L. I. M., Chirumbolo, S., Candiano, B., Carrara, A., Ricevuti, G., Esposito, C., & Pascale, A. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106799 · Cited by 88
Gut-brain axis: A matter of concern in neuropsychiatric disorders…!
Naveed, M., Zhou, Q.-G., Chu, X., Taleb, A., Meng, F. J., Ahmed, B., Zhang, Y., Fukunaga, K., & Han, F. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110051 · Cited by 82
Dysbiosis of the gut microbiota and its effect on α-synuclein and prion protein misfolding: consequences for neurodegeneration
Mahbub, N. U., Islam, M. M., Hong, S., & Chung, H. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1348279 · Cited by 90
Indoxyl sulfate caused behavioral abnormality and neurodegeneration in mice with unilateral nephrectomy
Sun, C., Li, J., Wang, Y., Lin, S., Ou, Y., Lin, C., Wang, J., Liao, S., & Chen, C. (2021) · Aging · doi:10.18632/aging.202523 · Cited by 79
Self-citation
Epigallocatechin-3-gallate ameliorates polystyrene microplastics-induced anxiety-like behavior in mice by modulating gut microbe homeostasis
Yang, J.-Z., Zhang, K.-K., Liu, Y., Li, X., Chen, L., Liu, J.-L., Li, J.-H., Chen, L., Hsu, C., Zeng, J., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164619 · Cited by 77
Self-citation
Microbiome Gut-Brain-Axis: Impact on Brain Development and Mental Health
Ramadan, Y. N., Alqifari, S. F., Alshehri, K., Alhowiti, A., Mirghani, H. O., Alrasheed, T., Aljohani, F., Alghamdi, A. M., & Hetta, H. F. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04846-0 · Cited by 100
Multi-strain Probiotic Formulation Reverses Maternal Separation and Chronic Unpredictable Mild Stress-Generated Anxiety- and Depression-like Phenotypes by Modulating Gut Microbiome–Brain Activity in Rats
Dandekar, M. P., Palepu, M. S. K., Satti, S., Jaiswal, Y., Singh, A. A., Dash, S. P., Gajula, S. N. R., & Sonti, R. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00143 · Cited by 75
How Oxidative Stress Induces Depression?
Ji, N., Lei, M., Chen, Y., Tian, S., Li, C., & Zhang, B. (2023) · ASN NEURO · doi:10.1177/17590914231181037 · Cited by 84
New avenues for Parkinson's disease therapeutics: disease-modifying strategies based on the gut microbiota
Lorente-Picón, M., & Laguna, A. (2021) · Biomolecules · doi:10.3390/biom11030433 · Cited by 69
Probiotics for the treatment of depression and its comorbidities: A systemic review
Gao, J., Zhao, N., Cheng, Y., Lei, W., Wang, Y., Liu, X., Zheng, N., Shao, L., Chen, X., Sun, Y., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1167116 · Cited by 81
Self-citation
Therapeutic effect of fecal microbiota transplantation on chronic unpredictable mild stress-induced depression
Cai, T., Zheng, S.-P., Shi, X., Yuan, L., Hu, H., Bai, Z., Xiao, S.-L., & Wang, F. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.900652 · Cited by 67
Inflammation, stress and depression: An exploration of ketamine’s therapeutic profile
Johnston, J. N., Greenwald, M. S., Henter, I. D., Kraus, C., Mkrtchian, A., Clark, N. G., Park, L. T., Gold, P. W., Zarate, C. A., & Kadriu, B. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103518 · Cited by 68
Stress and the gut-brain axis: an inflammatory perspective
Morys, J., Małecki, A., & Nowacka-Chmielewska, M. M. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1415567 · Cited by 81
Reduced stress-associated FKBP5 DNA methylation together with gut microbiota dysbiosis is linked with the progression of obese PCOS patients
Fu, C., Chen, Z., Chen, M., Chen, G., Huang, Q., Yang, X., Yin, H., Chen, L., Zhang, W., Lin, H., et al. (2021) · npj Biofilms and Microbiomes · doi:10.1038/s41522-021-00231-6 · Cited by 61
Novel aspects of enteric serotonergic signaling in health and brain-gut disease
Colle, A. D., Israelyan, N., & Margolis, K. G. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00173.2019 · Cited by 69
Gut microbiota and neuropsychiatric disorders: Implications for neuroendocrine-immune regulation
Ge, T., Yao, X., Zhao, H., Yang, W., Zou, X., Peng, F., Li, B., & Cui, R. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105909 · Cited by 62
Priming of microglia with dysfunctional gut microbiota impairs hippocampal neurogenesis and fosters stress vulnerability of mice
He, H., He, H., Mo, L., You, Z., & Zhang, J. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.10.031 · Cited by 62
Beneficial Effect of Alkaloids From Sophora alopecuroides L. on CUMS-Induced Depression Model Mice via Modulating Gut Microbiota
Zhang, M., Li, A., Yang, Q., Li, J., Wang, L., Liu, X., Huang, Y., & Liu, L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.665159 · Cited by 58
Biogeography of the large intestinal mucosal and luminal microbiome in cynomolgus macaques with depressive-like behavior
Teng, T., Clarke, G. A., Maes, M. H. J., Jiang, Y., Wang, J., Li, X., Yin, B., Xiang, Y., Fan, L., Liu, X., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01366-w · Cited by 54
Self-citation
Fecal microbiota transplantation in non-communicable diseases: Recent advances and protocols
Hamamah, S., Gheorghita, R. E., Lobiuc, A., Sîrbu, I. O., & Covașă, M. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.1060581 · Cited by 57
Impacts of microbiota and its metabolites through gut-brain axis on pathophysiology of major depressive disorder
Chen, C.-Y., Wang, Y., Lei, L., & Zhang, Y. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122815 · Cited by 54
Self-citation
Sex, puberty, and the gut microbiome
Sisk-Hackworth, L., Kelley, S. T., & Thackray, V. G. (2022) · Reproduction · doi:10.1530/rep-22-0303 · Cited by 52
Dietary inulin alleviated constipation induced depression and anxiety-like behaviors: Involvement of gut microbiota and microbial metabolite short-chain fatty acid
Zou, H. L., Gao, H., Liu, Y., Zhang, Z., Zhao, J. W., Wang, W., Ren, B., & Tan, X. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129420 · Cited by 50
Combined probiotics attenuate chronic unpredictable mild stress-induced depressive-like and anxiety-like behaviors in rats
Huang, L., Lv, X., Ze, X., Ma, Z., Zhang, X., He, R., Fan, J., Zhang, M., Sun, B., Wang, F., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.990465 · Cited by 51
Lactobacillus rhamnosus: An emerging probiotic with therapeutic potential for depression
Feng, J. B., Cen, Q., Cui, Y., Hu, X., Li, M., Wang, L., Wei, J., Sun, N., Wang, J., & Zhang, A. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107541 · Cited by 51
Anxiolytic- and antidepressant-like effects of Bacillus coagulans Unique IS-2 mediate via reshaping of microbiome gut-brain axis in rats
Satti, S., Palepu, M. S. K., Singh, A. A., Jaiswal, Y., Dash, S. P., Gajula, S. N. R., Chaganti, S., Samanthula, G., Sonti, R., & Dandekar, M. P. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105483 · Cited by 45
Gut microbiota decreased inflammation induced by chronic unpredictable mild stress through affecting NLRP3 inflammasome
Huang, L., Ma, Z., Ze, X., Zhao, X., Zhang, M., Lv, X., Zheng, Y., & Liu, H. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1189008 · Cited by 46
Prebiotic Consumption Alters Microbiota but Not Biological Markers of Stress and Inflammation or Mental Health Symptoms in Healthy Adults: A Randomized, Controlled, Crossover Trial
Mysonhimer, A. R., Cannavale, C. N., Bailey, M. A., Khan, N. A., & Holscher, H. D. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.02.015 · Cited by 49
Review article: bugs, inflammation and mood—a microbiota‐based approach to psychiatric symptoms in inflammatory bowel diseases
Thomann, A., Mak, J. W. Y., Zhang, J., Wüstenberg, T., Ebert, M. P., Sung, J. J. �., Bernstein, C. N., Reindl, W., & Ng, S. C. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15787 · Cited by 44
Discovering the Potential Mechanisms of Medicinal Mushrooms Antidepressant Activity: A Review
Lazur, J., Hnatyk, K., Kała, K., Sułkowska‐Ziaja, K., & Muszyńska, B. (2023) · Antioxidants · doi:10.3390/antiox12030623 · Cited by 44
Lactobacillus-Based Probiotics Reduce the Adverse Effects of Stress in Rodents: A Meta-analysis
Mindus, C., Ellis, J. L., van Staaveren, N., & Harlander-Matauschek, A. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.642757 · Cited by 41
Physical Exercise and Diet: Regulation of Gut Microbiota to Prevent and Treat Metabolic Disorders to Maintain Health
Zhang, L., Liu, Y., Xinzhou, W., & Zhang, X. (2023) · Nutrients · doi:10.3390/nu15061539 · Cited by 49
Effects of enriched environment on depression and anxiety-like behavior induced by early life stress: A comparison between different periods
Huang, H., Wang, Q., Guan, X., Zhang, X., Zhang, Y., Cao, J., & Li, X. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113389 · Cited by 47
Self-citation
Co-decoction of Lilii bulbus and Radix Rehmannia Recens and its key bioactive ingredient verbascoside inhibit neuroinflammation and intestinal permeability associated with chronic stress-induced depression via the gut microbiota-brain axis
Mao, Q., Zhang, H., Zhang, Z., Lu, Y., Pan, J., Guo, D., Huang, L., Tian, H., & Ma, K. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155510 · Cited by 39
Current landscape of fecal microbiota transplantation in treating depression
Zhang, Q., Bi, Y., Zhang, B., Jiang, Q., Mou, C. K., Lei, L., Deng, Y., Li, Y., Yu, J., Liu, W., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1416961 · Cited by 38
Gut microbiota mediates anxiety-like behaviors induced by chronic infection of Toxoplasma gondii in mice
Luo, X., Yang, X., Tan, S., Zhang, Y., Liu, Y., Tian, X., Huang, Y., Zhou, Y., He, C., Yin, K., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2391535 · Cited by 38
Self-citation
Zhi Zi Chi decoction (Gardeniae fructus and semen Sojae Praeparatum) attenuates anxious depression via modulating microbiota–gut–brain axis in corticosterone combined with chronic restraint stress ‐induced mice
Tian, X., Wang, G., Teng, F., Xue, X., Pan, J., Mao, Q., Guo, D., Song, X., & Ma, K. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14519 · Cited by 37
Oxytetracycline induces anxiety-like behavior in adult zebrafish
Gusso, D., Altenhofen, S., Fritsch, P. M., Rübensam, G., & Bonan, C. D. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115616 · Cited by 39
Social overcrowding impacts gut microbiota, promoting stress, inflammation, and dysglycemia
Delaroque, C., Chervy, M., Gewirtz, A. T., & Chassaing, B. (2021) · Gut Microbes · doi:10.1080/19490976.2021.2000275 · Cited by 42
The Role of MicroRNA and Microbiota in Depression and Anxiety
Rosa, J. M., Formolo, D. A., Yu, J., Lee, T. H.-Y., & Yau, S. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.828258 · Cited by 38
Colitis-associated microbiota drives changes in behaviour in male mice in the absence of inflammation
Vicentini, F., Szamosi, J. C., Rossi, L., Griffin, L., Nieves, K., Bihan, D. G., Lewis, I. A., Pittman, Q. J., Swain, M. G., Surette, M. G., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.03.001 · Cited by 38
Integrative Analysis of Long Non-coding RNAs, Messenger RNAs, and MicroRNAs Indicates the Neurodevelopmental Dysfunction in the Hippocampus of Gut Microbiota-Dysbiosis Mice
Liu, L., Wang, H., Chen, X., Zhang, Y., Li, W., Rao, X., Liu, Y., Zhao, L., Pu, J., Gui, S., et al. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.745437 · Cited by 36
Neuroendocrine pathogenesis of perimenopausal depression
Han, Y., Gu, S., Li, Y., Qian, X., Wang, F., & Huang, J. H. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1162501 · Cited by 40
The role of gut microbiota in the pathogenesis and treatment of postpartum depression
Zhang, S., Lu, B., & Wang, G. (2023) · Annals of General Psychiatry · doi:10.1186/s12991-023-00469-8 · Cited by 34
Metformin reprograms tryptophan metabolism via gut microbiome-derived bile acid metabolites to ameliorate depression-Like behaviors in mice
Xie, X., Li, W., Xiong, Z., Xu, J., Liao, T., Sun, L., Xu, H., Zhang, M., Zhou, J., Xiong, W., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.09.014 · Cited by 35
The Microbiota‐Gut‐Brain Connection: A New Horizon in Neurological and Neuropsychiatric Disorders
Faysal, M. F., Zehravi, M., Sutradhar, B., Amin, M. A., Shanmugarajan, T. S., Arjun, U. V. N. V., Ethiraj, S., Durairaj, A., Dayalan, G., Ahamad, S. K., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70593 · Cited by 41
The microbiota-gut-brain axis in depression: unraveling the relationships and therapeutic opportunities
Zhu, Z., Cheng, Y., Liu, X., Xu, X., Ding, W., Ling, Z., Liu, J., & Cai, G. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1644160 · Cited by 40
Maternal microbiome disturbance induces deficits in the offspring’s behaviors: a systematic review and meta-analysis
Hassib, L., de Oliveira, C. L., Rouvier, G. A., Kanashiro, A., Guimarães, F. S., & Ferreira, F. R. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2226282 · Cited by 33
Study on Lactiplantibacillus plantarum R6-3 from Sayram Ketteki to prevent chronic unpredictable mild stress-induced depression in mice through the microbiota–gut–brain axis
Zhao, L., Li, D., Chitrakar, B., Li, C., Zhang, N., Zhang, S., Wang, X., Wang, M., Tian, H., & Luo, Y. (2023) · Food & Function · doi:10.1039/d2fo03708d · Cited by 33
A gut (microbiome) feeling about addiction: Interactions with stress and social systems
García‐Cabrerizo, R., & Cryan, J. F. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100629 · Cited by 32
Altered Fecal Metabolites and Colonic Glycerophospholipids Were Associated With Abnormal Composition of Gut Microbiota in a Depression Model of Mice
Gong, X., Huang, C., Yang, X., Chen, J., Pu, J., He, Y., & Xie, P. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.701355 · Cited by 30
The Microbiota–Gut–Brain Axis: Gut Microbiota Modulates Conspecific Aggression in Diversely Selected Laying Hens
Hu, J., Johnson, T. A., Zhang, H., & Cheng, H. W. (2022) · Microorganisms · doi:10.3390/microorganisms10061081 · Cited by 29
Gut microbiota from sigma-1 receptor knockout mice induces depression-like behaviors and modulates the cAMP/CREB/BDNF signaling pathway
Li, J.-H., Liu, J.-L., Li, X., Liu, Y., Yang, J.-Z., Chen, L., Zhang, K.-K., Xie, X., & Wang, Q. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1143648 · Cited by 29
Self-citation
Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: A narrative review
Rust, C., Malan‐Müller, S., van den Heuvel, L. L., Tonge, D. P., Seedat, S., Pretorius, E., & Hemmings, S. M. J. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578155 · Cited by 31
Beneficial Effects of Limosilactobacillus reuteri PBS072 and Bifidobacterium breve BB077 on Mood Imbalance, Self-Confidence, and Breastfeeding in Women during the First Trimester Postpartum
Vicariotto, F., Malfa, P., Torricelli, M., Lungaro, L., Caio, G., & Leo, V. D. (2023) · Nutrients · doi:10.3390/nu15163513 · Cited by 36
Gut microbiota regulate stress resistance by influencing microglia-neuron interactions in the hippocampus
He, H., He, H., Mo, L., Yuan, Q., Xiao, C., Ma, Q., Yi, S., Zhou, T., You, Z., & Zhang, J. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100729 · Cited by 30
Chronic Systemic Low-Grade Inflammation and Modern Lifestyle: The Dark Role of Gut Microbiota on Related Diseases with a Focus on COVID-19 Pandemic
Mundula, T., Russo, E., Curini, L., Giudici, F., Piccioni, A., Franceschi, F., & Amedei, A. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220430131018 · Cited by 29
Implications of gut microbiota dysbiosis and fecal metabolite changes in psychologically stressed mice
Zhang, Y., Zhang, J., Wu, J., Zhu, Q., Chen, C., & Li, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1124454 · Cited by 28
Alzheimer’s Disease Treatment: The Search for a Breakthrough
Reiss, A. B., Muhieddine, D., Jacob, B., Mesbah, M., Pinkhasov, A., Gomolin, I. H., Stecker, M. M., Wısnıewskı, T., & Leon, J. D. (2023) · Medicina · doi:10.3390/medicina59061084 · Cited by 31
Gut feeling: Exploring the intertwined trilateral nexus of gut microbiota, sex hormones, and mental health
Leão, L. L., Miri, S., & Hammami, R. (2024) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2024.101173 · Cited by 29
Modifying the Microbiome as a Potential Mechanism of Photobiomodulation: A Case Report
Bicknell, B. T., Laakso, E., Liebert, A. D., & Kiat, H. (2021) · Photobiomodulation Photomedicine and Laser Surgery · doi:10.1089/photob.2021.0057 · Cited by 27
Exogenous microbiota-derived metabolite trimethylamine N-oxide treatment alters social behaviors: Involvement of hippocampal metabolic adaptation
Luo, Y., Zhao, P., Dou, M., Mao, J., Zhang, G., Su, Y., Wang, Q., Wang, Q., Wang, Y., Sun, R., et al. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108563 · Cited by 26
Self-citation
Involvement of mucosal flora and enterochromaffin cells of the caecum and descending colon in diarrhoea-predominant irritable bowel syndrome
Yang, J., Wang, P., Liu, T., Lin, L., Li, L., Kou, G., Zhou, R., Li, P., & Li, Y. (2021) · BMC Microbiology · doi:10.1186/s12866-021-02380-2 · Cited by 27
Cuscutae semen alleviates CUS-induced depression-like behaviors in mice via the gut microbiota-neuroinflammation axis
Hou, L., Liu, Y., Zhu, C., Miao, J., Zhou, W., Tang, Y., Meng, H., & Liu, S. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1107781 · Cited by 28
What we need to know about the germ-free animal models
Aghighi, F., & Salami, M. (2024) · AIMS Microbiology · doi:10.3934/microbiol.2024007 · Cited by 29
The gut–brain connection: microbes’ influence on mental health and psychological disorders
Ataei, P., Kalantari, H., Bodnar, T. S., & Turner, R. J. (2026) · Frontiers in Microbiomes · doi:10.3389/frmbi.2025.1701608 · Cited by 33
What Makes a Successful Donor? Fecal Transplant from Anxious-Like Rats Does Not Prevent Spinal Cord Injury-Induced Dysbiosis
Schmidt, E. K. A., Raposo, P. J. F., Madsen, K. L., Fenrich, K. K., Kabarchuk, G., & Fouad, K. (2021) · Biology · doi:10.3390/biology10040254 · Cited by 24
Studies on irritable bowel syndrome associated with anxiety or depression in the last 20 years: A bibliometric analysis
Chen, Y., Lian, B., Li, P., Yao, S., & Hou, Z. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.947097 · Cited by 25
Lactiplantibacillus plantarum CR12 attenuates chronic unforeseeable mild stress induced anxiety and depression-like behaviors by modulating the gut microbiota-brain axis
Ma, J., Chen, Y., Wang, Z., Wang, R., & Dong, Y. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105710 · Cited by 25
Lacticaseibacillus rhamnosus KY16 Improves Depression by Promoting Intestinal Secretion of 5-HTP and Altering the Gut Microbiota
Xie, S., Wang, C., Song, J., Zhang, Y., Wang, H., Chen, X., & Suo, H. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c03870 · Cited by 27

Authors: Li, N., Wang, Q., Wang, Y., Sun, A., Lin, Y., Jin, Y., & Li, X.
Affiliations: First Hospital of China Medical University (CN)
China Medical University (CN)
Corresponding author: Li, Xiaobai
ORCID: Li, Nannan
Wang, Qi
Wang, Yan
Jin, Ye
Li, Xiaobai
Venue: Stress
Publisher: Informa UK Limited
Published: 2019-05-24
Volume: 22
Issue: 5
Pages: 592-602
ISSN: 1025-3890 (ISSN-L)
1607-8888
DOI: 10.1080/10253890.2019.1617267
OpenAlex: W2945891876
Cited by: 327
References: 55
Citations by year: 2026: 29 · 2025: 67 · 2024: 75 · 2023: 59 · 2022: 44 · 2021: 38 · 2020: 9 · 2019: 6
FWCI: 8.02
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Stress (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: fecal microbiota transplantation, chronic unpredictable mild stress, anxiety-like behavior, depression-like behavior, gut microbiota, microbiota-gut-brain axis, neuroinflammation, hippocampus, inflammatory cytokines, interferon-gamma, TNF-α, IDO1, Akkermansia, Lactobacillus, antibiotic-induced microbiota depletion, depression
MeSH terms: Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Animals, Anxiety, Brain, Depression, Disease Models, Animal, Hippocampus, Humans, Inflammation, Male, Mice, Inbred C57BL, Stress, Psychological, Cytokines, Mice, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Fecal microbiota transplantation from chronic unpredictable mild stress mice donors affects anxiety-like and depression-like behavior in recipient mice via the gut microbiota-inflammation-brain axis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks