Cited by 327Gut microbiota and healthTryptophan and brain disordersGastrointestinal motility and disorders

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Fecal microbiota transplantation from chronic unpredictable mild stress mice donors affects anxiety-like and depression-like behavior in recipient mice via the gut microbiota-inflammation-brain axis

Open access

Li, Nannan, Wang, Qi, Wang, Yan, Sun, Anji, Lin, Yiwei, Jin, Ye, Li, Xiaobai·2019·Stress

DOI 10.1080/10253890.2019.1617267

Open this paper in CoChat — free account Open PDF

Abstract

Recent studies have demonstrated that there are significant changes in the gut microbiota (GM) of humans with depression and animal models of depression and chronic stress. In our present study, we determined whether an alteration in GM is a decisive factor in anxiety-like and depression-like behavior and its impact on brain neurochemistry. An antibiotic cocktail was used to deplete the GM of mice before they were colonized, via fecal microbiota transplantation (FMT), by the GM of control mice or mice that had been exposed to chronic unpredictable mild stress (CUMS donors). The CUMS-donor group of mice and the mice that were colonized by their microbiota (the CUMS-recipient group) both showed higher levels of anxiety- and depression-like behavior compared to the controls. The GM community of the CUMS-donor and CUMS-recipient was distinctively different from the controls, with the CUMS group characterized by a lower relative abundance of Lactobacillus and a higher relative abundance of Akkermansia. Interestingly, FMT affected both behavior and neuroinflammation. Mice given the CUMS microbiota had significant elevations of interferon-γ (IFN-γ) and the tumor necrosis factor-alpha (TNF-α) in the hippocampus, which were accompanied by upregulated indoleamine 2,3-dioxygenase 1 (IDO1) in the hippocampus. These results suggest that GM modulates pro-inflammatory cytokines in the hippocampus through dysfunctional microbiota–gut–brain axis, exacerbating anxiety- and depression-like phenotypes.Key PointsChronic unpredictable mild stress increased anxiety- and depression-like behavior in mice.Mice colonized with gut microbiota (GM) from stressed mice showed similar behaviors.The GM composition of the donor and recipient mice was also comparable.Their relative pattern of two bacteria has been tied to neuroinflammatory activity.The results suggest a link between GM, brain function, and anxiety and depression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1080/10253890.2019.1617267

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22
Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614
Altered fecal microbiota composition in patients with major depressive disorder
Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275
Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism
Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., Zeng, L., Chen, J., Fan, S., Du, X., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.44 · Cited by 2,023
The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat
Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683
Correlation between the human fecal microbiota and depression
Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linløkken, A., Wilson, R., & Rudi, K. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12378 · Cited by 1,044
Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
Schneeberger, M., Everard, A., Gómez-Valadés, A. G., Matamoros, S., Ramírez, S., Delzenne, N. M., Gomis, R., Claret, M., & Cani, P. D. (2015) · Scientific Reports · doi:10.1038/srep16643 · Cited by 798
Gut microbiota depletion from early adolescence in mice: implications for brain and behaviour
Desbonnet, L., Clarke, G., Traplin, A., O’Sullivan, O., Crispie, F., Moloney, R. D., Cotter, P. D., Dinan, T. G., & Cryan, J. F. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.004 · Cited by 760
Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress
Liang, S., Wang, T., Hu, X., Luo, J., Li, W., Wu, X., Duan, Y., & Jin, F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.033 · Cited by 651
Modulation of Mucosal Immune Response, Tolerance, and Proliferation in Mice Colonized by the Mucin-Degrader Akkermansia muciniphila
Derrien, M., van Baarlen, P., Hooiveld, G. J. E. J., Norin, E. L., Müller, M. M., & de Vos, W. M. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00166 · Cited by 595

Show all 55 references

Research works printed but not linked: 1

Hay S.I., 2017, Lancet, 389, , E1

Sorted by citations

Items 201–300 of 327

Mechanisms of Ketogenic Diet Action
Williams, R. S. B., Boison, D., Masino, S. A., & Rho, J. M. (2024) · Oxford University Press eBooks · doi:10.1093/med/9780197549469.003.0079 · Cited by 9
Administration time modify the anxiolytic and antidepressant effects of inulin via gut-brain axis
Chen, P., Chen, F., Hou, T., Hu, X., Xia, C., Zhang, J., Shen, S., Li, C., & Li, K. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138698 · Cited by 9
Association of anxiety status and anxiety duration with constipation in adult Americans: a cross-sectional study using data from the NHANES 2007–2010
Li, X., Bian, C., Dai, H., Chen, X., Qian, H., & Zhang, D. (2025) · BMC Gastroenterology · doi:10.1186/s12876-024-03575-3 · Cited by 7
Self-citation
From Physiology to Psychiatry: Key Role of Vagal Interoceptive Pathways in Emotional Control
Krieger, J.-P., & Skibicka, K. P. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.04.012 · Cited by 12
Plateau Environment, Gut Microbiota, and Depression: A Possible Concealed Connection?
Qiao, Y., Cheng, R., Li, X., Zheng, H., Guo, J., Wei, L., Gao, T., & Bi, H. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47070487 · Cited by 9
Self-citation
Postoperative kinesiophobia in elderly patients with femoral neck fractures: a prospective study of psychological and social determinants
Guo, K., Zhou, L., Zhang, M., Hu, X., Han, Y., Hou, J., Cheng, J., Shen, X., Wang, Q., & Zhang, Q. (2025) · Frontiers in Psychology · doi:10.3389/fpsyg.2025.1622585 · Cited by 7
Self-citation
Cisplatin-Induced Anorexia and Pica Behavior in Rats Enhanced by Chronic Stress Pretreatment
Guo, Z., Duan, J., Chen, Y., Cai, W., Yang, C., Yang, Z., Liu, X., & Xu, F. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.913124 · Cited by 7
Holistic Fitness: Microbiomes are Part of the Holobiont’s Fitness
ROSENBERG, E. B. (2021) · The microbiomes of humans, animals, plants, and the environment · doi:10.1007/978-3-030-65317-0_4 · Cited by 7
The Effects of Consuming White Button Mushroom Agaricus bisporus on the Brain and Liver Metabolome Using a Targeted Metabolomic Analysis
Solano-Aguilar, G. I., Lakshman, S., Jang, S., Gupta, R., Molokin, A., Schroeder, S., Gillevet, P. M., & Urban, J. F. (2021) · Metabolites · doi:10.3390/metabo11110779 · Cited by 7
Connection of pre-competition anxiety with gut microbiota and metabolites in wrestlers with varying sports performances based on brain-gut axis theory
Fu, P., Wang, C., Zheng, S., Qiao, L., Gao, W., & Gong, L. (2024) · BMC Microbiology · doi:10.1186/s12866-024-03279-4 · Cited by 8
Mechanistic insights into the anti-depressant effect of quercetin: an integrated bibliometrics, bioinformatics, and animal experimentation
Song, Z., Wu, Y., Luo, L., Hu, Q., Wu, S., Wu, M., & Zhang, G. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1612746 · Cited by 6
Molecular Crosstalk of Vitamin D3 with cGAS–STING and BDNF Pathways in a Rat Model of Chronic Stress
Alrashed, M. M., Tabassum, H., Aldisi, D. A., & Abulmeaty, M. M. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110436 · Cited by 6
Gut microbiota mediated neuroinflammation in psychiatric disorders: Current perspectives and challenges
Nayak, A., Bera, S., Purohit, S., & Jain, C. K. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.116019 · Cited by 11
Suppressive effects of bilobalide on depression-like behaviors induced by chronic unpredictable mild stress in mice
Li, S., Yang, C., Wu, Z., Chen, Y., He, X., Liu, R., Ma, W., Deng, S., Li, J., Liu, Q.-S., et al. (2023) · Food & Function · doi:10.1039/d3fo02681g · Cited by 6
Self-citation
Protective Effects of Lacticaseibacillus rhamnosus IDCC3201 on Motor Functions and Anxiety Levels in a Chronic Stress Mouse Model
Song, J. G., Mun, D., Lee, B., Song, M., Oh, S., Kim, J., Yang, J., Kim, Y., & Kim, H. W. (2023) · Food Science of Animal Resources · doi:10.5851/kosfa.2023.e54 · Cited by 8
Adolescent male rats show altered gut microbiota composition associated with depressive-like behavior after chronic unpredictable mild stress: Differences from adult rats
Wang, J., Li, F., Teng, T., Wu, H., Liu, X., Yin, B., Li, X., Jiang, Y., Zhao, J., Wu, Q., et al. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.03.026 · Cited by 6
Self-citation
Proteostasis and resilience: on the interphase between individual’s and intracellular stress
Díaz-Hung, M.-L., & Hetz, C. A. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.02.003 · Cited by 7
From shared mechanisms to treatment gaps: a review of the comorbidity between eating disorders and PTSD
Ouyang, H., Wang, Y., & Chen, J. (2025) · Journal of Eating Disorders · doi:10.1186/s40337-025-01454-0 · Cited by 6
Self-citation
Mechanisms of chronic abdominal pain in inflammatory bowel disease and implications for treatment
Defaye, M., Nasser, Y., & Altier, C. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01139-8 · Cited by 7
Antidepressant-Like Effects of Mongolian Medical Warm Acupuncture via Remodeling the Gut Microbiota–Metabolite–Barrier Axis in CUMS Rats
Wu, R.-N., Bao, Q., Ba, Y., Chaoketu, S., Si, L., & Runa, A. (2025) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s566386 · Cited by 6
Effects of a Lacticaseibacillus Mix on Behavioural, Biochemical, and Gut Microbial Outcomes of Male Mice following Chronic Restraint Stress
Letenneur, V., Monnoye, M., Philippe, C., Holowacz, S., Rabot, S., Lepage, P., Jacouton, E., & Naudon, L. (2023) · Nutrients · doi:10.3390/nu15214635 · Cited by 6
Structural Alteration of Gut Microbiota During the Amelioration of Chronic Psychological Stress-Aggravated Diabetes-Associated Cognitive Decline by a Traditional Chinese Herbal Formula, ZiBu PiYin Recipe
Zhou, W., Zhan, L., Xu, H., & Zhang, L. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220692 · Cited by 6
Should we consider microbiota-based interventions as a novel therapeutic strategy for schizophrenia? A systematic review and meta-analysis
Hassib, L., Kanashiro, A., Pedrazzi, J. F. C., Vercesi, B. F., Higa, S., Arruda, Í., Soares, Y., de Souza, A. P., Jordão, A. A., Guimarães, F. S., et al. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100923 · Cited by 6
Metronidazole and ciprofloxacin differentially affect chronic unpredictable mild stress-induced changes in the colon, cecum and ileum microbiota
Chen, M., Dong, C., & Liu, H. (2021) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-021-11685-1 · Cited by 5
Bioactive composition and modulatory effects of Hed-Tean-Rad Mushroom, Macrocybe crassa on gut microbiota
Ayimbila, F., Prayoonthien, P., Inyod, T., Haltrich, D., & Keawsompong, S. (2022) · 3 Biotech · doi:10.1007/s13205-022-03388-9 · Cited by 5
Novel opportunity of treatment for psycho-cardiologic disease by gut microbiome
Lai, Y., Fang, C., Jiang, Y., Yang, C., Zhou, Q., Cai, Y., Yan, W., & Fan, X. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1604962 · Cited by 4
A study on the efficacy and safety of fecal microbiota transplantation as an adjunctive therapy for treating depressive episodes
Wang, L., Zhang, S., Liu, Y., Li, D., Tian, G., Li, X., & Li, Y. (2026) · Scientific Reports · doi:10.1038/s41598-026-41801-y · Cited by 7
Self-citation
Chronic stress enhances glycolysis and promotes tumorigenesis
Qin, Q., Li, S., Zhong, Y., Bai, J., An, L., Yang, L., Gu, W., Deng, D., Zhao, J., Zhang, R., et al. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1543872 · Cited by 4
Microbiota–gut–brain axis and anxiety or depression: A perspective from bibliometric and visual analysis
Lu, R., Zhou, H., Yuan, J., & Ding, Z. (2025) · Medicine · doi:10.1097/md.0000000000043221 · Cited by 5
Umbelliprenin attenuates comorbid behavioral disorders in acetic acid-induced colitis in mice: mechanistic insights into hippocampal oxidative stress and neuroinflammation
Hajheidari, N., Lorigooini, Z., Mohseni, R., & Amini-Khoei, H. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03416-w · Cited by 4
Ghrelin in Depression: A Promising Therapeutic Target
Kore, M. S., Mamsa, R., Patil, D., & Bhatt, L. K. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04554-1 · Cited by 4
Subacute symptoms of depression and anxiety in stress-exposed mice: Role of Schinus terebinthifolia Raddi leaf lectin (SteLL)
de Lima, B. R. F., Patriota, L. L. D. S., Marinho, A. D. O., da Costa, J. A., Ribeiro, B. G., Santos, V. B. D. S., Napoleão, D. C., Cavalcanti, J. V. F. L., Filho, L. D. V., Pereira, M. C., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119343 · Cited by 4
Gut Feelings: Linking Dysbiosis to Depression—A Narrative Literature Review
Bibolar, A. C., Nechita, V.-I., Lung, F. C., Crecan-Suciu, B. D., & Paunescu, R. (2025) · Medicina · doi:10.3390/medicina61081360 · Cited by 7
Influence of the Microbiota Through the Gut-Brain Axis in Neurological Diseases
Guarnotta, V., Mandarino, F. V., Fasulo, E., Maida, M. F., Laterza, L., Sferrazza, S., Raimondo, D., & Sinagra, E. (2024) · Integrated science · doi:10.1007/978-3-031-73061-0_20 · Cited by 3
A new perspective on Wendan decoction: attenuation of CUMS-induced anxiety in mice by regulating gut microbiota and neuroinflammation
Guo, Z., Wang, Q., Cao, Y., Wang, B., Zhang, B., Huang, J., Niu, Y., Huang, J., Wang, Z., & Feng, S. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1708868 · Cited by 3
Self-citation
Mechanisms of aerobic exercise effects on the gut microbiota and its metabolites in anxiety disorders
Zheng, Y., Qu, Y., Yao, M., Li, K., Dong, Y., Xing, X., Yang, T., Guo, H., & Huang, P. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1721497 · Cited by 4
Psychobiotics in Health, Longevity, and Neurological Disorders
Mohankumar, A., Kalaiselvi, D., Thiruppathi, G., Patteswari, D., Tawata, S., & Sundararaj, P. (2022) · Nutritional neurosciences · doi:10.1007/978-981-16-8158-5_2 · Cited by 3
Enduring sex-dependent implications of pubertal stress on the gut-brain axis and mental health
Dworsky‐Fried, M., Tchida, J. A., Krnel, R., & Ismail, N. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1285475 · Cited by 3
Advances in neuroscience research and big data's analysis on anxiety disorder
Yu, Q., Ruan, M., Chen, Y., & Wang, C. (2024) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1692 · Cited by 3
Environmental restraint: A hidden risk factor for stress-induced depression in rats
Mochizuki‐Kawai, H., Nakazawa, S., Oike, H., Kimoto, H., Tomita, S., Toyoshima, M., Xiong, T., & Yamada, K. (2025) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2025.05.002 · Cited by 3
The Microbiota-Gut-Brain Axis: A New Direction in Research on Depression
Chen, E., & Clark, R. E. (2021) · Journal of Student Research · doi:10.47611/jsrhs.v10i2.1504 · Cited by 3
Cross-sex cecal microbiota transfer alters depressive-like behaviours in mice
Hinks, M., Martin, Y. H., Burke, F. F., Bambico, F. R., & Swift‐Gallant, A. (2023) · Behavioural Processes · doi:10.1016/j.beproc.2023.104960 · Cited by 3
The effects of venlafaxine on depressive-like behaviors and gut microbiome in cuprizone-treated mice
Du, C., Zhang, T., Feng, C., Sun, Q., Chen, Z., Shen, X., Liu, Y., Dai, G., Zhang, X., & Tang, N. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1347867 · Cited by 4
A pharmacovigilance study on probiotic preparations based on the FDA Adverse Event Reporting System from 2005 to 2023
Wang, Y., Tan, W., Li, X., Yang, G., Wang, Y., Liao, J., Lu, A., Zhang, G., Chen, K., Yang, L., et al. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1455735 · Cited by 2
Self-citation
Effects of ultrasound-induced stress on gut microbiota of mice
Chernukha, I. M., Vasilevskaya, E. R., Klimina, K. M., Yunes, R. А., Kupaeva, N. V., Сергеевна, Т. Г., Kibitkina, A. A., Даниленко, В. Н., Karabanov, S. Y., & Fedulova, L. (2023) · Veterinary World · doi:10.14202/vetworld.2023.929-938 · Cited by 2
Elucidating the role of probiotics in modulating depression pathophysiology: insights from animal models and clinical trials - a narrative review
Dong, S., Hao, F., Xue, B., Wu, S., Zhong, R., Liao, Z., Han, H., & Fang, X. (2025) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250201 · Cited by 2
Both obesogenic and isocalorically-controlled diets drive changes in microbiota composition in a sex-dependent manner in mice
Loeven, A. M., Brown, A. N., Ebuara, F. U., Jones, K. M., & Fadool, D. A. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.115062 · Cited by 2
Analysis of a new anti-depression mechanism of Chaigui granules based on multi-omics integration: In-depth mining of intestinal microbiota-metabolite interaction network
Wu, Z.-N., Zhao, H., Wang, Q., Chen, J., Ren, Y., Qin, X., & Tian, J. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120319 · Cited by 2
Self-citation
Phlorizin Alleviates Depression-like Behaviors via Gut Microbiota Reprogramming-Induced Methionine to Inhibit Neuroinflammation in Mice Hippocampus
Li, L., Chen, J., Zhang, X., Zhang, X., Fu, Y., Jiang, H., Yin, T., Zhang, Y., Li, X., Hu, M., et al. (2025) · Pharmaceuticals · doi:10.3390/ph18091395 · Cited by 3
Self-citation
Association Between Ultra-Processed Food Consumption and Risk of Developing Depression in Adults: A Systematic Review
Karim, S., Alam, A. S., & Syed, A. M. (2025) · EMJ Gastroenterology · doi:10.33590/emjgastroenterol/ivvg9805 · Cited by 2
O papel da microbiota intestinal nos distúrbios neuropsiquiátricos e neurodegenerativos
Ferreira, V. G., & Cardoso, A. M. (2024) · Revista Brasileira Militar de Ciências · doi:10.36414/rbmc.v10i24.177 · Cited by 5
Gut Microbiota and Mental Health: A Review of the Impact of Gut Bacteria on Depression and Anxiety Disorders
Pelczarska, A., Kaczorowski, R., Forenc, T., Hunia, J., Górny, J., Janiszewski, M., Jurek, J., Komorowski, M., & Kapciak, A. (2024) · Quality in Sport · doi:10.12775/qs.2024.36.56589 · Cited by 2
Probiotic supplementation prevents stress-impaired spatial learning and enhances the effects of environmental enrichment
Flynn, C. M., Blackburn, L. M., & Yuan, Q. (2025) · Frontiers in Microbiomes · doi:10.3389/frmbi.2025.1454909 · Cited by 3
A INTRÍNSECA RELAÇÃO DA MICROBIOTA INTESTINAL COM A SAÚDE MENTAL
Moura, M. M. D. A., Mendonça, M. A., Novaes, M. R. L., de Sousa, M. R., & dos Santos, M. S. (2023) · Revista Ibero-Americana de Humanidades, Ciências e Educação · doi:10.51891/rease.v9i3.8704 · Cited by 2
role of the gut microbiota in pathogenesis and treatment of depression
Bogusz, K., Baran, N., Maksymowicz, M., BIELAK, A., NOWAK, A., CYWKA, Ł., Szwed, W., Nowak, A., & Machowiec, P. A. (2023) · Journal of Education Health and Sport · doi:10.12775/jehs.2023.31.01.006 · Cited by 2
Role reversals: non-canonical roles for immune and non-immune cells in the gut
Tearle, J. L. E., Tang, A., Vasanthakumar, A., & James, K. R. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2023.11.004 · Cited by 2
Antidepressant-like effects of the leaf extract of Mallotus oppositifolius (Geiseler) Müll. Arg. (Euphorbiaceae) in the chronic unpredictable stress model: A role of gut-brain axis.
Kwofie, B., Debrah, P., Amoateng, P., Adongo, D. W., Adukpo, S., & Kukuia, K. K. E. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.09.024 · Cited by 2
Evening inulin treatment alleviate anxiety and depression via gut-brain axis: A crucial role for microbiota and amino acids metabolismPreprint
Chen, P., Chen, F., Hou, T., Hu, X., Xia, C., Zhang, J., Shen, S., Li, C., & Li, K. (2024) · Research Square · doi:10.21203/rs.3.rs-4157149/v1 · Cited by 2
DNA metabarcoding technology for the identification of the fecal microbiome in patients with chronic stress
Urruchi, A. E. P., Elizalde, L. E. R., Cornejo, F. D. M. Z., Calvet, M. M., Cuba, M. V. B., & Domínguez, F. F. (2024) · Health Psychology Research · doi:10.52965/001c.117647 · Cited by 1
Prophylactic effects of edible Lilium-egg yolk compound powder on depression-like behaviors in rats exposed to chronic unpredictable mild stress: a role of gut-brain axis
Huang, Y., Luo, Y., Tian, S.-N., Xie, M., Li, L., Jiang, M.-X., & Yuan, Z. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250184 · Cited by 1
An insightful comparison of the current neuroimmune mechanism(s) with the thoughts of differential syndromes from traditional Chinese medicine for the treatment of MDD
Xu, J., Zhang, Y., Li, L., Zhao, X., Huang, F., & Du, J. (2024) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2024.100100 · Cited by 1
The role of microbiome in gut-brain-axis dysbiosis causing depression: From mechanisms to treatment
Mi, J., Morys, J., Nowacka-Chmielewska, M. M., & Burek, M. (2025) · International review of neurobiology · doi:10.1016/bs.irn.2025.03.006 · Cited by 1
Gut microbiota diversity is altered in a sex-dependent manner in Shank3B heterozygote mice
Turner, F., Williams, M., Gregoretti, S., Bielamowicz, D., Roach, K., Gehner, L., Kunnatha, A., Phillips, S., Hagel, R., Harshman, R., et al. (2025) · Frontiers in Microbiomes · doi:10.3389/frmbi.2025.1628819 · Cited by 1
Profiling of research domain criteria-based behaviors following single prolonged stress in male C57BL/6J mice
O’Hara, K., King, S. M., Penrod, R. D., Rinker, J. A., & Mulholland, P. J. (2025) · Stress · doi:10.1080/10253890.2025.2538466 · Cited by 1
Milk fat globule membrane ameliorates depressive-like behaviors in chronic unpredictable mild stress rats by modulating the microbiota-gut-brain axis
Huang, L. Y., Zheng, Y., Liu, Q., Feng, Y., Ma, Z., Zhao, X., Xinru, W. E. I., Xinyue, Y. U., Xia, L. V., Lv, J., et al. (2025) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2025-031 · Cited by 1
ISRIB inhibits endoplasmic reticulum stress to ameliorate chronic restraint stress–induced intestinal inflammation
Xie, L., Zhou, W., Tang, Y., Yi, Y., Cao, W., Zhong, X., & Chen, L. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178236 · Cited by 1
Neuroprotective effects of empagliflozin against lipopolysaccharide-induced depressive-like behavior: Role of TLR4 signaling pathway in modulating neuroinflammation and oxidative stress
Borikar, S. P., Bokade, B. A., Jain, S. P., Zore, P. S., Tapre, D. N., Paliwal, N. P., & Shelke, S. P. (2025) · Next research. · doi:10.1016/j.nexres.2025.101210 · Cited by 1
Lactobacillus-rich microbiota promotes adaptive behavioral responses to multifactorial stress and preserves gut function, while antibiotic-induced dysbiosis suppresses these effects in mice
Marques, L. S., Jung, J. T., Carlin, M., de Albuquerque, M. C. B. F., & Nogueira, C. W. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111590 · Cited by 1
Relief from Chronic Unpredictable Mild Stress-Induced Constipation by Fluoxetine and Butyrate and Their Impact on Gut Microecology
Li, X., Suo, J., Yao, S., Tian, B., Zhao, Z., Wang, Y., Li, X., Jin, D., & Yang, X. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s552593 · Cited by 2
Self-citation
Xiaochaihu decoction alleviates chronic stress-induced depressive-like behavior in mice by modulating the gut microbiota-brain axis
Zhao, X., Liang, J., Zhou, T. T., Hou, J., Yu, J., Shi, J., Du, J., Wang, H., Zhang, X., & Shang, X. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116046 · Cited by 1
Oxytocin attenuates isolation-evoked emotional and social behavioral dysregulation through neural, immune, and microbiota mechanisms
Li, J., Wu, C., Li, Y., Chai, K., Yao, D., Chen, K., & Xia, Y. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-03888-9 · Cited by 1
Lack of Structural Change in Olfactory Circuitry Following Fecal Microbiome Transplant From Donors Subjected to Diet‐induced Obesity
Loeven, A. M., Pacheco, F. A., Brown, A. N., & Fadool, D. A. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70396 · Cited by 1
Gut microbiota mediates the antidepressant-like effects of xiaochaihutang: mechanisms involving inhibition of inflammation and enhancement of barrier function
Pang, J., Ma, X., Hong, N., Shen, Z., Li, S., Li, X., Wang, S., Cong, H., Zhang, K., Yang, J., et al. (2026) · Journal of Natural Medicines · doi:10.1007/s11418-026-02037-2 · Cited by 1
Self-citation
Homicide or Happiness: Did Folate Fortification and Public Health Campaigns Influence Homicide Rates and the Great American Crime Decline?
Schoenthaler, S. J., Prescott, S. L., & Logan, A. C. (2024) · Nutrients · doi:10.3390/nu16071075 · Cited by 1
Update Review of the Relationship Between Gut Microbiota and Neurodegenerative Diseases
Wang, Y., Jing, G., Fu, Y., Li, Y., & Wu, C. (2024) · Diseases & Research · doi:10.54457/dr.202401007 · Cited by 1
Self-citation
The impact of BDNF and CD4 + T cell crosstalk on depression
Mickael, M., Kubick, N., Dragan, M., Atanasov, A. G., Ławiński, M., Paszkiewicz, J., Horbańczuk, J. O., Religa, P., Thorne, A., & Sacharczuk, M. (2024) · Immunologic Research · doi:10.1007/s12026-024-09514-4 · Cited by 1
Enteroendocrine Cells Sense Sucrose and Alter Enteric Neuron Excitability via Insulin Signaling
Snyder, J. R., Ahmed, M., Bhave, S. M., Hotta, R., Koppes, R. A., Goldstein, A. M., & Koppes, A. N. (2024) · Advanced Biology · doi:10.1002/adbi.202300566 · Cited by 1
Associations between blood systemic inflammatory markers and anxiety in Helicobacter pylori-infected patients
Gong, J., Chen, F., Jiang, B., Zhou, B., Ma, X., Wang, M., Dai, Q., Wang, S., Yang, X., & Zhao, E. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1671858 · Cited by 1
Prospects of Herbal Remedies in Neuropsychiatric Diseases from the Gut–Brain Communication Perspective
Wong, W., Chan, B., Lee, M. M., Yee, B. K., & Tai, W. (2021) · Springer eBooks · doi:10.1007/978-3-030-61721-9_26 · Cited by 1
Defining the role of individual gut commensal microbes and host-microbe interactions
Ju, T. (2019) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-fhw9-mj96 · Cited by 1
Microbiote intestinal chez le porc, facteurs de variation et relations avecles performances des animaux
Sciellour, M. L. (2019) · theses.fr (ABES) · doi:10.70675/9856b9fbz4b6fz4178zb870z35e3676a87e0 · Cited by 1
Open Journal of Bacteriology
Tiburcio, Á., Ruiz, H., & Reyes-López, P. A. (2019) · Open Journal of Bacteriology · doi:10.17352/ojb.000010
Stress-Induced Despair Behavior Develops Independently of the AHR-RORgt Axis in CD4+ cellsPreprint
Rivet-Noor, C. R., Merchak, A. R., Li, S., Beiter, R. M., Lee, S., Thomas, J. A., Fernández-Castañeda, A., Shin, J., & Gaultier, A. (2022) · Research Square · doi:10.21203/rs.3.rs-1181536/v1
Characterization of Gut Microbiota in Newly Diagnosed Patients with Depression: Does the Depressed Gut Exist?
Knudsen, J. K. (2021) · VBN Forskningsportal (Aalborg Universitet) · doi:10.54337/aau455013245
Factors That Affect Methylphenidate Treatment Adherence in Attention Deficit Hyperactivity Disorder: A Retrospective Study
Kale, M. K., Sapmaz, Ş. Y., Erten, T., Akar, E., Bılaç, Ö., & Kandemır, H. (2022) · Çocuk ve Gençlik Ruh Sağlığı Dergisi / Turkish Journal of Child and Adolescent Mental Health · doi:10.4274/tjcamh.galenos.2021.46338
Chronic Stress Induced Gut Microbial Dysbiosis Disturbs Vitamin B6 Metabolism and Results in Abnormal Behaviors in RatsPreprint
Qing, W., Chen, H., Ma, X., Chen, J., Le, Y., Chen, H., Tong, J., Duan, K., Ma, D., Ouyang, W., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4191368
Changes in the Gut Microbiota of Mice Under the Action of Ultrasonic-induced Stress
Karabanov, S. Y., & Kibitkina, A. A. (2022) · Journal Biomed · doi:10.33647/2074-5982-18-3-18-21
The potentially important role of intestinal brain (gut microbiota) in neuropsychiatric health
Petrić, D. (2023) · Microenvironment and Microecology Research · doi:10.53388/mmr2023001
The gut microbiota mediates triptolide-induced liver injury via the gut-liver axisPreprint
Wang, Y., Hu, Y., Liu, Y., Zhang, H., Liu, X., Zhou, H., Liu, C., & Yang, T. (2023) · Research Square · doi:10.21203/rs.3.rs-2902171/v1
Self-citation
Factors Affecting the Diversity and Density of the Microbiomes
Saar, R., & Dodd, S. A. S. (2023) · doi:10.1002/9781119862611.ch4
Fecal microbiota transplantation for treatment of irritable bowel syndrome: Current advances and future perspectives
Liu, X., & Wu, S. (2023) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v31.i22.922
Exploring the shared gene signatures and potential molecular mechanisms between chronic endometritis and recurrent pregnancy loss based on transcriptomic analysisPreprint
She, J., Liu, X., Li, D., Guo, Y., Su, D., Shuai, L., & Diao, R. (2023) · Research Square · doi:10.21203/rs.3.rs-3741574/v1
CO-OCCURRENCE OF INFLAMMATORY BOWEL DISEASE AND PSYCHIATRIC DISEASES
Bisgaard, T. H. (2023) · VBN Forskningsportal (Aalborg Universitet) · doi:10.54337/aau614553280
Correlação entre microbiota intestinal e distúrbios neurológicos
Leite, C. D. A. E. A., dos Santos, J. P. L., Armada, L., Leite, M. A. A., Barcellos, C. T., Tavares, T. D. M., & Orsini, M. A. (2024) · Enfermagem Brasil · doi:10.33233/eb.v22i6.5570
The Effect and Potential Mechanism of Microbiota in Major Depressive Disorder
Jiang, Y. Y. (2023) · Transactions on Materials Biotechnology and Life Sciences · doi:10.62051/qr5j3s93
Synergistic Effect of Salvianolic Acid B and Paeonol on Hippocampal Injury of Cums-Induced DepressionPreprint
Ling, C., Xu, X., Yang, Z., Xiang, Z., Ling, J., Wang, S., Zhao, Y., Fan, J., Li, Q., Xu, Q., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4889796
Role of microbiota-gut-brain axis in migraine and possible interventions
Raikwar, S., & Jain, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21680-0.00010-9
Both Obesogenic and Isocalorically-Control Diets Drive Changes in Microbiota Composition in a Sex-Dependent Manner in MicePreprint
Loeven, A. M., Brown, A. N., Ebuara, F. U., Jones, K. M., & Fadool, D. A. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5339087
The Role of Gut Microbiota in Suicidality: Mechanisms, Evidence, and Future Directions
Baldini, V., Gnazzo, M., Santangelo, G., Varallo, G., Ronchi, D. D., & Carotenuto, M. (2025) · Psychiatry International · doi:10.3390/psychiatryint6030084
Zinc and Cobalt exposure influence Akkermansia muciniphila growth and short-chain fatty acid metabolismPreprint
Eggers, S. I., Eggers, J., Banas, M. J., Gennings, C., & Midya, V. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.06.668965

Authors: Li, N., Wang, Q., Wang, Y., Sun, A., Lin, Y., Jin, Y., & Li, X.
Affiliations: First Hospital of China Medical University (CN)
China Medical University (CN)
Corresponding author: Li, Xiaobai
ORCID: Li, Nannan
Wang, Qi
Wang, Yan
Jin, Ye
Li, Xiaobai
Venue: Stress
Publisher: Informa UK Limited
Published: 2019-05-24
Volume: 22
Issue: 5
Pages: 592-602
ISSN: 1025-3890 (ISSN-L)
1607-8888
DOI: 10.1080/10253890.2019.1617267
OpenAlex: W2945891876
Cited by: 327
References: 55
Citations by year: 2026: 29 · 2025: 67 · 2024: 75 · 2023: 59 · 2022: 44 · 2021: 38 · 2020: 9 · 2019: 6
FWCI: 8.02
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Stress (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: fecal microbiota transplantation, chronic unpredictable mild stress, anxiety-like behavior, depression-like behavior, gut microbiota, microbiota-gut-brain axis, neuroinflammation, hippocampus, inflammatory cytokines, interferon-gamma, TNF-α, IDO1, Akkermansia, Lactobacillus, antibiotic-induced microbiota depletion, depression
MeSH terms: Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Animals, Anxiety, Brain, Depression, Disease Models, Animal, Hippocampus, Humans, Inflammation, Male, Mice, Inbred C57BL, Stress, Psychological, Cytokines, Mice, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Fecal microbiota transplantation from chronic unpredictable mild stress mice donors affects anxiety-like and depression-like behavior in recipient mice via the gut microbiota-inflammation-brain axis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks