Cited by 147Stress Responses and CortisolAdrenal Hormones and DisordersEstrogen and related hormone effects

The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.

Glucocorticoid Receptor Function In Vitro in Patients with Major Depression

Open access

Pariante, Carmine M.·2004·Stress

Open this paper in CoChat — free account Open PDF

Abstract

Clinical studies have demonstrated an impairment of glucocorticoid receptor (GR)-mediated negative feedback on the hypothalamic--pituitary--adrenal (HPA) axis in patients with major depression (GR resistance), and its resolution by antidepressant treatment. Interestingly, a number of studies have also demonstrated that GR function is reduced in vitro, in peripheral tissues of depressed patients, as shown by a decreased sensitivity to the effects of glucocorticoids on immune and metabolic functions. This paper reviews the in vitro studies that have examined GR function in patients with major depression, and the possible molecular mechanisms involved in GR resistance. Since several studies have demonstrated similar regulation of GR in the brain and in peripheral tissues in humans, and given limited access to brain GR in clinical populations, this review claims that in vitro studies are of particular relevance to understand the molecular mechanisms underlying GR abnormalities in patients with major depression and its regulation by antidepressant treatment.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1080/10253890500069650

Cites

100 of 100 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
The Corticosteroid Receptor Hypothesis of Depression
Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181
When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders
Raison, C. L., & Miller, A. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1554 · Cited by 1,197
Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147
Self-citation
Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
Binder, E. B., Salyakina, D., Lichtner, P., Wochnik, G. M., Ising, M., Pütz, B., Papiol, S., Seaman, S., Lucae, S., Kohli, M. A., et al. (2004) · Nature Genetics · doi:10.1038/ng1479 · Cited by 977
Molecular Determinants of Glucocorticoid Receptor Function and Tissue Sensitivity to Glucocorticoids
Bamberger, C. M., Schulte, H. M., & Chrousos, G. P. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-3-245 · Cited by 912
The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions
McEwen, B. S., Biron, C. A., Brunson, K. W., Bulloch, K., Chambers, W. H., Dhabhar, F. S., Goldfarb, R. H., Kitson, R. P., Miller, A. H., Spencer, R. L., et al. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00012-4 · Cited by 837
Minireview: 11 -Hydroxysteroid Dehydrogenase Type 1-- A Tissue-Specific Amplifier of Glucocorticoid Action
Seckl, J. R., & Walker, B. R. (2001) · Endocrinology · doi:10.1210/endo.142.4.8114 · Cited by 741
Untitled work
(2000) · PubMed · Cited by 676
Untitled work
(1996) · PubMed · Cited by 547

Show all 100 references

Research works printed but not linked: 17

Bourgeois S., 1993, Mol. Endocrinol., 7, 840
Brooksbank B.W., 1973, Steroids Lipids Res, 4, 162
Coupland N.J., 2003, J. Psychiatry Neurosci., 28, 364
Czar M.J., 1995, Mol. Endocrinol., 9, 1549
Denny W.B., 2000, Endocrinology, 141, 4107, 10.1210/endo.141.11.7785 · DOI · Paper page
Herr A.S., 2003, Antidepressants differentially influence the transcriptional activity of the glucocorticoid receptor in vitro, Neuroendocrinology, 78, 12
de Kloet E.R., 1998, Endocr. Rev., 19, 269
Lopez J.F., 1998, Psychiatry, 43, 547
Miller A.H., 1987, Psychopharmacol. Bull., 23, 502
Miller A.H., 1999, Med. Biol., 461, 107
Nemeroff C.B., 1996, Mol. Psychiatry, 1, 336
Pariante C.M., 1999, Endocrinology, 140, 4359, 10.1210/endo.140.9.6986 · DOI · Paper page
Rangarajan P.N., 1992, Mol. Endocrinol., 6, 1451
Sallee F.R., 1995, Psychopharmacol. Bull., 31, 339
Sanchez E.R., 1994, Mol. Endocrinol., 8, 408
Webster M.J., 2002, Psychiatry, 7, 985
Yang J., 1996, Mol. Endocrinol., 10, 3

Sorted by citations

Salivary cortisol as a biomarker in stress research
Hellhammer, D. H., Wüst, S., & Kudielka, B. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.026 · Cited by 1,925
The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704
The human stress response
Russell, G., & Lightman, S. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0228-0 · Cited by 1,032
Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior
Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000
Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression
Pace, T. W. W., Hu, F., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.08.009 · Cited by 621
The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications
Moylan, S., Maes, M., Wray, N. R., & Berk, M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.33 · Cited by 529
Childhood Adversity and Epigenetic Modulation of the Leukocyte Glucocorticoid Receptor: Preliminary Findings in Healthy Adults
Tyrka, A. R., Price, L. H., Marsit, C., Walters, O. C., & Carpenter, L. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030148 · Cited by 486
Neural control of chronic stress adaptation
Herman, J. P. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00061 · Cited by 384
Immune suppression and immune activation in depression
Blume, J., Douglas, S. D., & Evans, D. L. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.008 · Cited by 338
Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability
de Punder, K., & Pruimboom, L. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00223 · Cited by 321
Approaching the shared biology of obesity and depression: the stress axis as the locus of gene–environment interactions
Bornstein, S. R., Schuppenies, A., Wong, M., & Licinio, J. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001873 · Cited by 278
Neuroimmune mechanisms of cytokine-induced depression: Current theories and novel treatment strategies
Loftis, J. M., Huckans, M. S., & Morasco, B. J. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.015 · Cited by 259
Origin of ultradian pulsatility in the hypothalamic–pituitary–adrenal axis
Walker, J. J., Terry, J. R., & Lightman, S. L. (2010) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2009.2148 · Cited by 239
“…been demonstrated by data showing a blunting of endogenous glucocorticoid inhibition following the administration of the synthetic glucocorticoid dexamethasone, or an inhibition of the ACTH response in the dexamethasone-CRH test (Nemeroff 1996; Holsboer 2000; Pariante & Miller 2001; Pariante 2004).”
Background
Biomarkers in bipolar disorder: a positional paper from the international society for bipolar disorders biomarkers task force.
Frey, B. N., Andreazza, A. C., Houenou, J., Jamain, S., Goldstein, B. I., Frye, M. A., Leboyer, M., Berk, M., Malhi, G. S., Lopez-Jaramillo, C., et al. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413478217 · Cited by 234
Shortened onset of action of antidepressants in major depression using acetylsalicylic acid augmentation: a pilot open-label study
Mendlewicz, J., Kriwin, P., Oswald, P., Souery, D., Alboni, S., & Brunello, N. (2006) · International Clinical Psychopharmacology · doi:10.1097/00004850-200607000-00005 · Cited by 229
A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks
Karin, O., Raz, M., Tendler, A., Bar, A., Korem Kohanim, Y., Milo, T., & Alon, U. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209510 · Cited by 200
Fluoxetine effects on molecular, cellular and behavioral endophenotypes of depression are driven by the living environment
Alboni, S., van Dijk, R. M., Poggini, S., Milior, G., Perrotta, M., Drenth, T., Brunello, N., Wolfer, D. P., Limatola, C., Amrein, I., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2015.142 · Cited by 207
The glucocorticoid receptor: part of the solution or part of the problem?
Pariante, C. M. (2006) · Journal of Psychopharmacology · doi:10.1177/1359786806066063 · Cited by 192
Self-citation
Risk Factors for Development of Depression and Psychosis
Pariante, C. M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04978.x · Cited by 186
Self-citation
Glucocorticoid Dysregulations and Their Clinical Correlates: From Receptors to Therapeutics
Marques, A. H., Silverman, M. N., & Sternberg, E. M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04987.x · Cited by 158
Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression
Bertollo, A. G., Santos, C. F., Bagatini, M. D., & Ignácio, Z. M. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1541075 · Cited by 183
Different responses to dexamethasone and prednisolone in the same depressed patients
Juruena, M. F., Cleare, A. J., Papadopoulos, A. S., Poon, L., Lightman, S., & Pariante, C. M. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0555-4 · Cited by 147
Self-citation
Glucocorticoid sensitivity of cognitive and inflammatory processes in depression and posttraumatic stress disorder
Rohleder, N., Wolf, J. M., & Wolf, O. T. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.12.003 · Cited by 150
Major depression, cognitive dysfunction and Alzheimer's disease: Is there a link?
Sierksma, A. S. R., van den Hove, D. L. A., Steinbusch, H. W. M., & Prickaerts, J. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.10.021 · Cited by 139
Acute and chronic stress induced changes in sensitivity of peripheral inflammatory pathways to the signals of multiple stress systems – 2011 Curt Richter Award Winner
Rohleder, N. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.015 · Cited by 136
The HPA Axis as Target for Depression
Menke, A. (2024) · Current Neuropharmacology · doi:10.2174/1570159x21666230811141557 · Cited by 131
“To reinstate homeostasis after stress response, negative feedback mechanisms are activated; cortisol binds to GR of the pituitary, the hippocampus, and the PVN, and inhibits the further release of CRH [43, 44].”
Background
The putative neurodegenerative links between depression and Alzheimer's disease
Wuwongse, S., Chang, R. C., & Law, A. C. K. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.005 · Cited by 126
Intranasal Immune Challenge Induces Sex-Dependent Depressive-Like Behavior and Cytokine Expression in the Brain
Tonelli, L. H., Holmes, A., & Postolache, T. T. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301488 · Cited by 126
Successful Antidepressant Therapy Restores the Disturbed Interplay Between TNF-α System and HPA Axis
Himmerich, H., Binder, E. B., Kunzel, H. E., Schuld, A., Lucae, S., Uhr, M., Pollmächer, T., Holsboer, F., & Ising, M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.075 · Cited by 122
Leukocyte glucocorticoid receptor expression and immunoregulation in veterans with and without post-traumatic stress disorder
de Kloet, C. S., Vermetten, E., Bikker, A., Meulman, E., Geuze, E., Kavelaars, A., Westenberg, H. G. M., & Heijnen, C. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001934 · Cited by 98
Endocrine and immune substrates of depressive symptoms and fatigue in multiple sclerosis patients with comorbid major depression
Gold, S. M., Kruger, S., Ziegler, K. J., Krieger, T., Schulz, K., Otte, C., & Heesen, C. (2011) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.230029 · Cited by 98
The acceleration of amygdala kindling epileptogenesis by chronic low-dose corticosterone involves both mineralocorticoid and glucocorticoid receptors
Kumar, G., Couper, A., O'Brien, T. J., Salzberg, M. R., Jones, N. C., Rees, S. M., & Morris, M. J. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.05.011 · Cited by 95
Moderate perinatal arsenic exposure alters neuroendocrine markers associated with depression and increases depressive-like behaviors in adult mouse offspring
Martinez, E. J., Kolb, B., Bell, A., Savage, D. D., & Allan, A. M. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2008.05.004 · Cited by 94
Depression and Alzheimer's Disease: Is Stress the Initiating Factor in a Common Neuropathological Cascade?
Aznar, S., & Knudsen, G. M. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100390 · Cited by 98
Role of Inflammation in Depression: Implications for Phenomenology, Pathophysiology and Treatment
Raison, C. L., & Miller, A. H. (2013) · Modern Trends in Psychiatry · doi:10.1159/000343966 · Cited by 88
Stress induces altered CRE/CREB pathway activity and BDNF expression in the hippocampus of glucocorticoid receptor-impaired mice
Alboni, S., Tascedda, F., Corsini, D., Benatti, C., Caggia, F., Capone, G., Barden, N., Blom, J. M. C., & Brunello, N. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.050 · Cited by 93
Glucocorticoid Receptor Polymorphisms in Major Depression
Claes, S. J. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05012.x · Cited by 84
Elevated Macrophage Migration Inhibitory Factor (MIF) is associated with depressive symptoms, blunted cortisol reactivity to acute stress, and lowered morning cortisol
Edwards, K. M., Bosch, J. A., Engeland, C. G., Cacioppo, J. T., & Marucha, P. T. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.03.011 · Cited by 76
In search of the HPA axis activity in unipolar depression patients with childhood trauma: combined cortisol awakening response and dexamethasone suppression test
Lu, S., Gao, W., Huang, M., Li, L., & Xu, Y. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.03.009 · Cited by 75
Clomipramine in vitro reduces glucocorticoid receptor function in healthy subjects but not in patients with major depression
Carvalho, L. A., Juruena, M. F., Papadopoulos, A. S., Poon, L., Kerwin, R., Cleare, A. J., & Pariante, C. M. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.44 · Cited by 75
Self-citation
The neurobiology of suicide - A Review of post-mortem studies
Furczyk, K., Schutová, B., Michel, T. M., Thome, J., & Büttner, A. (2013) · Journal of Molecular Psychiatry · doi:10.1186/2049-9256-1-2 · Cited by 85
FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls
Hohne, N., Poidinger, M., Merz, F., Pfister, H., Bruckl, T., Zimmermann, P., Uhr, M., Holsboer, F., & Ising, M. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu087 · Cited by 74
Zebrafish models of major depressive disorders
Fonseka, T. M., Wen, X., Foster, J. A., & Kennedy, S. H. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23639 · Cited by 76
Glucocorticoid resistance syndrome: a diagnostic and therapeutic approach
van Rossum, E. F. C., & Lamberts, S. W. J. (2006) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2006.09.005 · Cited by 69
Hormones, Stress, and Cognition: The Effects of Glucocorticoids and Oxytocin on Memory
Wirth, M. M. (2014) · Adaptive Human Behavior and Physiology · doi:10.1007/s40750-014-0010-4 · Cited by 77
Nod-like receptors are critical for gut-brain axis signalling in mice
Pusceddu, M. M., Barboza, M., Keogh, C. E., Schneider, M., Stokes, P., Sladek, J. A., Kim, H. J. D., Torres‐Fuentes, C., Goldfild, L. R., Gillis, S. E., et al. (2019) · The Journal of Physiology · doi:10.1113/jp278640 · Cited by 69
How to measure glucocorticoid receptor’s sensitivity in patients with stress-related psychiatric disorders
Leistner, C., & Menke, A. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.01.023 · Cited by 69
Hypothalamic‐Pituitary‐Adrenal Axis Abnormalities in Response to Deletion of 11β‐HSD1 is Strain‐Dependent
Carter, R. N., Paterson, J. M., Tworowska, U., Stenvers, D. J., Mullins, J. J., Seckl, J. R., & Holmes, M. C. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01899.x · Cited by 68
In vitromodulation of the glucocorticoid receptor by antidepressants
Carvalho, L. A., & Pariante, C. M. (2008) · Stress · doi:10.1080/10253890701850759 · Cited by 69
Self-citation
Are there meaningful biomarkers of treatment response for depression?
Breitenstein, B., Scheuer, S., & Holsboer, F. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.02.002 · Cited by 71
Altered functioning of the HPA axis in depressed postpartum women
de Rezende, M. G., Garcia-Leal, C., de Figueiredo, F. P., Cavalli, R. D. C., Schaufelberger, M. S., Barbieri, M. A., Bettiol, H., de Castro, M., & Del‐Ben, C. M. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.12.065 · Cited by 65
Anti-depressant effects of Xiaoyaosan on rat model of chronic unpredictable mild stress: a plasma metabonomics study based on NMR spectroscopy
Liu, X., Zhou, Y., Li, Z., Cui, J., Li, Z., Gao, X., Sun, H., Zhang, L., Du, G., & Qin, X. (2011) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2011.01412.x · Cited by 62
The role of multi-drug resistance p-glycoprotein in glucocorticoid function: Studies in animals and relevance in humans
Pariante, C. M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.067 · Cited by 58
Self-citation
Regulation of mRNA expression encoding chaperone and co-chaperone proteins of the glucocorticoid receptor in peripheral blood: association with depressive symptoms during pregnancy
Katz, E. R., Stowe, Z. N., Newport, D. J., Kelley, M. E., Pace, T. W. W., Cubells, J. F., & Binder, E. B. (2011) · Psychological Medicine · doi:10.1017/s0033291711002121 · Cited by 58
Icariin attenuates social defeat-induced down-regulation of glucocorticoid receptor in mice
Wu, J., Du, J., Xu, C., Le, J., Xu, Y., Liu, B., & Dong, J. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.01.008 · Cited by 57
Antidepressants, but not antipsychotics, modulate GR function in human whole blood: An insight into molecular mechanisms
Carvalho, L. A., Garner, B., Dew, T. K., Fazakerley, H., & Pariante, C. M. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.02.006 · Cited by 58
Self-citation
Receptor regulation in neuroendocrine–immune communication: Current knowledge and future perspectives
Heijnen, C. J. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.08.008 · Cited by 53
Protection of stress-induced impairment of hippocampal/prefrontal LTP through blockade of glucocorticoid receptors
Mailliet, F., Qi, H., Rocher, C., Spedding, M., Svenningsson, P., & Jay, T. M. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.02.030 · Cited by 60
Effect of the Glucocorticoid Receptor Antagonist Org 34850 on Basal and Stress‐Induced Corticosterone Secretion
Spiga, F., Harrison, L. R., Wood, S. A., Atkinson, H. C., MacSweeney, C. P., Thomson, F., Craighead, M., Grassie, M., & Lightman, S. L. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01605.x · Cited by 53
ABCB1 C3435T polymorphism is associated with susceptibility to major depression, but not with a clinical response to citalopram in a Turkish population
Özbey, G., Yucel, B., Taycan, S. E., Kan, D., Bodur, N. E., Arslan, T., Perçin, E. F., Yüksel, N., Güzey, C., & Uluoğlu, C. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2013.09.004 · Cited by 53
Neuroimmune endocrine effects of antidepressants
Carvalho, L. A. (2012) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s16409 · Cited by 52
Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance
Kumsta, R., Moser, D., Streit, F., Koper, J. W., Meyer, J., & Wüst, S. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30837 · Cited by 55
Relevance of Rodent Models of Depression in Clinical Practice: Can We Overcome the Obstacles in Translational Neuropsychiatry?
Söderlund, J., & Lindskog, M. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy037 · Cited by 54
Pro-inflammatory Monocyte Phenotype and Cell-Specific Steroid Signaling Alterations in Unmedicated Patients With Major Depressive Disorder
Hasselmann, H., Gamradt, S., Taenzer, A., Nowacki, J., Zain, R., Patas, K., Ramien, C., Paul, F., Wingenfeld, K., Piber, D., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02693 · Cited by 50
Biological indicators of illness risk in offspring of bipolar parents: targeting the hypothalamic‐pituitary‐adrenal axis and immune system
Duffy, A. C., Lewitzka, U., Doucette, S., Andreazza, A. C., & Grof, P. (2011) · Early Intervention in Psychiatry · doi:10.1111/j.1751-7893.2011.00323.x · Cited by 52
Mifepristone (RU-486) treatment for depression and psychosis: a review of the therapeutic implications
Gallagher, P., & Young, A. H. (2006) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.a811 · Cited by 48
The antidepressant desipramine requires the ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice
Yau, J. L. W., Noble, J., Thomas, S., Kerwin, R., Morgan, P. E., Lightman, S., Seckl, J. R., & Pariante, C. M. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301389 · Cited by 46
Self-citation
Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment
Mellon, S. H., Wolkowitz, O. M., Schonemann, M. D., Epel, E. S., Rosser, R., Burke, H. B., Mahan, L., Reus, V. I., Stamatiou, D., Liew, C. C., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.79 · Cited by 46
Abnormalities of the HPA axis in affective disorders: clinical subtypes and potential treatments
Porter, R., & Gallagher, P. (2006) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2006.00152.x · Cited by 47
Insulin Resistance and Depressive Symptoms in Young Adult Males: Findings From Finnish Military Conscripts
Timonen, M., Salmenkaita, I., Jokelainen, J. J., Laakso, M., Härkönen, P. K., Koskela, P. U., Meyer‐Rochow, V. B., Peitso, A., & Keinanen-Kiukaanniemi, S. M. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318157ad2e · Cited by 45
Interferon-alpha inhibits glucocorticoid receptor-mediated gene transcription via STAT5 activation in mouse HT22 cells
Hu, F., Pace, T. W. W., & Miller, A. H. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.01.001 · Cited by 42
Mood and metabolic consequences of sleep deprivation as a potential endophenotype’ in bipolar disorder
Aydin, A., Selvi, Y., Besiroglu, L., Boysan, M., Atli, A., Ozdemir, O., Kilic, S., & Balaharoglu, R. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.04.007 · Cited by 40
Mechanistic insights into corticosteroids in multiple sclerosis: War horse or chameleon?☆
Krieger, S. C., Sorrells, S. F., Nickerson, M., & Pace, T. W. W. (2014) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2013.12.021 · Cited by 40
Glucocorticoid receptor gene polymorphisms and glucocorticoid sensitivity of subdermal blood vessels and leukocytes
Kumsta, R., Entringer, S., Koper, J. W., van Rossum, E. F. C., Hellhammer, D. H., & Wüst, S. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2008.04.007 · Cited by 40
Electroconvulsive stimulations normalizes stress-induced changes in the glucocorticoid receptor and behaviour
Hageman, I., Nielsen, M., Wörtwein, G., Diemer, N. H., & Jørgensen, M. B. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.07.037 · Cited by 40
Changes in the Hypothalamic-Pituitary-Adrenal Axis and Leptin Levels during Antidepressant Treatment
Himmerich, H., Zimmermann, P., Ising, M., Kloiber, S. M., Lucae, S., Kunzel, H. E., Binder, E. B., Holsboer, F., & Uhr, M. (2007) · Neuropsychobiology · doi:10.1159/000103573 · Cited by 39
Phosphorylation status of glucocorticoid receptor, heat shock protein 70, cytochrome c and Bax in lymphocytes of euthymic, depressed and manic bipolar patients
Bei, E., Salpeas, V., Pappa, D., Anagnostara, C., Alevizos, V., & Moutsatsou, P. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.03.002 · Cited by 35
Chronic blockade of glucocorticoid receptors by RU486 enhances lipopolysaccharide-induced depressive-like behaviour and cytokine production in rats
Wang, D., Lin, W., Pan, Y., KUANG, X.-Y., Qi, X., & Sun, H. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.01.011 · Cited by 35
Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder
Spíndola, L., Pan, P. M., Moretti, P. N. S., Ota, V., Santoro, M. L., Cogo‐Moreira, H., Gadelha, A., Salum, G. A., Manfro, G. G., Mari, J. D. J., et al. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.03.015 · Cited by 31
Early-Life Adversity Interacts with FKBP5 Genotypes: Altered Working Memory and Cardiac Stress Reactivity in the Oklahoma Family Health Patterns Project
Lovallo, W. R., Enoch, M., Acheson, A., Cohoon, A. J., Sorocco, K. H., Hodgkinson, C. A., Vincent, A. S., & Goldman, D. A. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.347 · Cited by 31
Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients
Watanuki, T., Funato, H., Uchida, S., Matsubara, T., Kobayashi, A., Wakabayashi, Y., Otsuki, K., Nishida, A., & Watanabe, Y. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.01.003 · Cited by 34
IFN-γ Reduction by Tricyclic Antidepressants
Himmerich, H., Fulda, S., Sheldrick, A. J., Plümäkers, B., & Rink, L. (2010) · The International Journal of Psychiatry in Medicine · doi:10.2190/pm.40.4.e · Cited by 29
Resveratrol and quercetin attenuate depressive-like behavior and restore impaired contractility of vas deferens in chronic stress-exposed rats: involvement of oxidative stress and inflammation
ŞAHİN, T. D., Göçmez, S. S., Duruksu, G., Yazır, Y., & Utkan, T. (2019) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-019-01781-5 · Cited by 27
An integrated approach to infer causal associations among gene expression, genotype variation, and disease
Lee, E., Cho, S., Kim, K., & Park, T. (2009) · Genomics · doi:10.1016/j.ygeno.2009.06.002 · Cited by 26
Pedicularis resupinata Extract Prevents Depressive-like Behavior in Repeated Corticosterone-Induced Depression in Mice: A Preliminary Study
Lim, D. W., Han, D., & Lee, C.-H. (2022) · Molecules · doi:10.3390/molecules27113434 · Cited by 26
Ex vivo stimulation of whole blood as a means to determine glucocorticoid sensitivity
Marketon, J. I. W., Burnsides, Corry, J., -, A., Bálint, Cosmar, & Philips (2012) · Journal of Inflammation Research · doi:10.2147/jir.s33569 · Cited by 26
Correlations between changes in the hypothalamic-pituitary-adrenal axis and neurochemistry of the anterior cingulate gyrus in postpartum depression
de Rezende, M. G., Rosa, C. E., Garcia-Leal, C., de Figueiredo, F. P., Cavalli, R. D. C., Bettiol, H., Salmón, C. E. G., Barbieri, M. A., de Castro, M., dos Santos, A. C., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.07.028 · Cited by 25
Corticotropin‐releasing hormone neurons in hypertensive patients are activated in the hypothalamus but not in the brainstem
Goncharuk, V. D., Buijs, R. M., & Swaab, D. F. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21387 · Cited by 24
Gender differences of acute and chronic administration of dehydroepiandrosterone in rats submitted to the forced swimming test
Andrade, S., Silveira, S. L., Gomez, R., Barros, H. M. T., & Ribeiro, M. F. M. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.12.006 · Cited by 23
Differential effect of glucocorticoid receptor antagonists on glucocorticoid receptor nuclear translocation and DNA binding
Spiga, F., Knight, D. M., Droste, S. K., Conway-Campbell, B. L., Kershaw, Y. M., MacSweeney, C. P., THOMSON, F. J., Craighead, M. W., Peeters, B. W. M. M., & Lightman, S. L. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881109348175 · Cited by 24
Mifepristone enhances insulin-stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells
Bernal-Sore, I., Navarro-Márquez, M., Osorio‐Fuentealba, C., Díaz‐Castro, F., del Campo, A., Donoso-Barraza, C., Porras, O. H., Lavandero, S., & Troncoso, R. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.09.028 · Cited by 23
Cognitive and locomotor/exploratory behavior after chronic exercise in the olfactory bulbectomy animal model of depression
Hoomissen, J. D. V., Kunrath, J., Dentlinger, R. B., Lafrenz, A. J., Krause, M. A., & Azar, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.017 · Cited by 21
Differential Effects of Inflammatory and Psychosocial Stress on Mood, Hypothalamic-Pituitary-Adrenal Axis, and Inflammation in Remitted Depression
Niemegeers, P., Boer, P. D., Dumont, G., Eede, F. V. D., Fransén, E., Claes, S. J., Morrens, M., & Sabbe, B. (2016) · Neuropsychobiology · doi:10.1159/000466698 · Cited by 21
Phenytoin: an anti-bipolar anticonvulsant?
Bersudsky, Y. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705006140 · Cited by 21
Salivary alpha-amylase and cortisol responsiveness following electrically stimulated physical stress in bipolar disorder patients
Akiyoshi, J., Tanaka, Y., Ishitobi, Y., Maruyama, Y., Kawano, A., Ando, T., Inoue, A., Imanaga, J., Okamoto, S., Kanehisa, M., et al. (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s48722 · Cited by 21
Antiglucocorticoids, Neurogenesis and Depression
Fitzsimons, C. P., van Hooijdonk, L. W. A., Morrow, J. A., Peeters, B. W. M. M., Hamilton, N. M., Craighead, M. W., & Vreugdenhil, E. (2009) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955709787316001 · Cited by 19
Clinical Pharmacology and Therapeutics of Antidepressants
Ciraulo, D. A., Tsirulnik-Barts, L., Shader, R. I., & Greenblatt, D. J. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-792-5_2 · Cited by 20
Cellular and immunometabolic mechanisms of inflammation in depression: Preliminary findings from single cell RNA sequencing and a tribute to Bruce McEwen
Bekhbat, M., Ulukaya, G. B., Bhasin, M., Felger, J. C., & Miller, A. H. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100462 · Cited by 21
Saliva Estriol Levels in Women with and Without Prenatal Antidepressant Treatment
Suri, R., Hellemann, G., Cohen, L. S., Aquino, A., & Altshuler, L. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.015 · Cited by 19
Estradiol stimulates an anti-translocation expression pattern of glucocorticoid co-regulators in a hippocampal cell model
Malviya, S. A., Kelly, S. D., Greenlee, M. M., Eaton, D. C., Duke, B. J., Bourke, C. H., & Neigh, G. N. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.03.018 · Cited by 17

Authors: Pariante, C. M.
Affiliations: King's College London (GB)
Corresponding author: Pariante, Carmine M.
ORCID: Pariante, Carmine M.
Venue: Stress
Publisher: Informa UK Limited
Published: 2004-12
Volume: 7
Issue: 4
Pages: 209-219
ISSN: 1025-3890 (ISSN-L)
1607-8888
DOI: 10.1080/10253890500069650
OpenAlex: W2056750568
Cited by: 147
References: 100
Citations by year: 2025: 2 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 6 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 7 · 2013: 8 · 2012: 9
FWCI: 3.63
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Stress (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
Rosetrees Trust
Department of Science and Technology, Ministry of Science and Technology, India
Medical Research Council
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: glucocorticoid receptor, major depressive disorder, glucocorticoid resistance, hypothalamic-pituitary-adrenal axis, negative feedback, antidepressant treatment, peripheral tissues, immune function, metabolic function, molecular mechanisms
MeSH terms: Animals, Antidepressive Agents, Major Depressive Disorder, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Receptors, Glucocorticoid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Glucocorticoid Receptor Function In Vitro in Patients with Major Depression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks