The Proinflammatory Cytokine, Interleukin-1α, Reduces Glucocorticoid Receptor Translocation and Function1

Pariante, Carmine M.; Pearce, Bradley D.; Pisell, Tracy L.; Sanchez, Carmen I.; Po, Cecilia; Su, Cindy; Miller, Andrew H.

doi:10.1210/en.140.9.4359

Cited by 232Estrogen and related hormone effectsAdrenal Hormones and DisordersAdipokines, Inflammation, and Metabolic Diseases

The Proinflammatory Cytokine, Interleukin-1α, Reduces Glucocorticoid Receptor Translocation and Function1

Pariante, Carmine M., Pearce, Bradley D., Pisell, Tracy L., Sanchez, Carmen I., Po, Cecilia, Su, Cindy, Miller, Andrew H.·1999·Endocrinology

DOI 10.1210/en.140.9.4359

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IL-1-α treatment is associated with significant upregulation of GR protein that is primarily apparent in the cytosolic compartment.
“IL-1-α treatment was also associated with significant upregulation of GR protein that was primarily apparent in the cytosolic compartment.43”
From Cytokines and Glucocorticoid Receptor Signaling (2009) · cites this paper as [43]
In a mouse L929 fibroblast cell line, administration of IL-1-α induces a significant decrease in DEX-induced GR translocation from cytoplasm to nucleus that is associated with decreased GR-DNA binding and decreased DEX-induced activation of a reporter gene construct with multiple glucocorticoid response elements (GRE) upstream of its promoter region.
“Using a mouse L929 fibroblast cell line, administration of IL-1-α was found to induce a significant decrease in DEX-induced GR translocation from cytoplasm to nucleus that was associated with decreased GR-DNA binding and decreased DEX-induced activation of a reporter gene construct with multiple glucocorticoid response elements (GRE) upstream of its promoter region.43”
From Cytokines and Glucocorticoid Receptor Signaling (2009) · cites this paper as [43]
Effects of IL-1-α on GR function were reversed by co-administration of IL-1 receptor antagonist (IL-1ra).
“Effects were reversed by co-administration of IL-1 receptor antagonist (IL-1ra).”
From Cytokines and Glucocorticoid Receptor Signaling (2009) · cites this paper as [43]
IL-1 inhibits the translocation of the glucocorticoid receptor from the cytoplasm into the cell nucleus and GR-mediated gene transcription.
“In support of this, IL-1 inhibits the translocation of the GR from the cytoplasm into the cell nucleus and GR-mediated gene transcription[39].”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [39]
Cytokines directly affect glucocorticoid receptor function and induce glucocorticoid resistance.
“These findings suggest that cytokines directly affect GR function and induce glucocorticoid resistance.”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [39]

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Printed in U.S.A. Copyright © 1999 by The Endocrine Society The Proinflammatory Cytokine, Interleukin-1�, Reduces
Translocation, G. R., Pariante, C. M., Sanchez, C. I., Po, C., Su, C., Andrew, & Miller, H. (2013)
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Glucocorticoid Receptor [gr] Translocation Regulation by Inflammatory Cytokines
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Authors: Pariante, C. M., Pearce, B. D., Pisell, T. L., Sanchez, C. I., Po, C., Su, C., & Miller, A. H.
Corresponding author: Pariante, Carmine M.
ORCID: Pariante, Carmine M.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1999-09
Volume: 140
Issue: 9
Pages: 4359-4366
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/en.140.9.4359
OpenAlex: W4238812515
Cited by: 40
References: 0
Citations by year: 2024: 1 · 2016: 1 · 2014: 1 · 2013: 2 · 2012: 4
FWCI: 1.22
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords: interleukin-1, inflammatory cytokines, glucocorticoid receptor, receptor translocation, glucocorticoid signaling, inflammation, glucocorticoid resistance

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