Cited by 147Stress Responses and CortisolAdrenal Hormones and DisordersEstrogen and related hormone effects

The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.

Glucocorticoid Receptor Function In Vitro in Patients with Major Depression

Open access

Pariante, Carmine M.·2004·Stress

Open this paper in CoChat — free account Open PDF

Abstract

Clinical studies have demonstrated an impairment of glucocorticoid receptor (GR)-mediated negative feedback on the hypothalamic--pituitary--adrenal (HPA) axis in patients with major depression (GR resistance), and its resolution by antidepressant treatment. Interestingly, a number of studies have also demonstrated that GR function is reduced in vitro, in peripheral tissues of depressed patients, as shown by a decreased sensitivity to the effects of glucocorticoids on immune and metabolic functions. This paper reviews the in vitro studies that have examined GR function in patients with major depression, and the possible molecular mechanisms involved in GR resistance. Since several studies have demonstrated similar regulation of GR in the brain and in peripheral tissues in humans, and given limited access to brain GR in clinical populations, this review claims that in vitro studies are of particular relevance to understand the molecular mechanisms underlying GR abnormalities in patients with major depression and its regulation by antidepressant treatment.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1080/10253890500069650

Cites

100 of 100 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
The Corticosteroid Receptor Hypothesis of Depression
Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181
When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders
Raison, C. L., & Miller, A. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1554 · Cited by 1,197
Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147
Self-citation
Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
Binder, E. B., Salyakina, D., Lichtner, P., Wochnik, G. M., Ising, M., Pütz, B., Papiol, S., Seaman, S., Lucae, S., Kohli, M. A., et al. (2004) · Nature Genetics · doi:10.1038/ng1479 · Cited by 977
Molecular Determinants of Glucocorticoid Receptor Function and Tissue Sensitivity to Glucocorticoids
Bamberger, C. M., Schulte, H. M., & Chrousos, G. P. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-3-245 · Cited by 912
The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions
McEwen, B. S., Biron, C. A., Brunson, K. W., Bulloch, K., Chambers, W. H., Dhabhar, F. S., Goldfarb, R. H., Kitson, R. P., Miller, A. H., Spencer, R. L., et al. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00012-4 · Cited by 837
Minireview: 11 -Hydroxysteroid Dehydrogenase Type 1-- A Tissue-Specific Amplifier of Glucocorticoid Action
Seckl, J. R., & Walker, B. R. (2001) · Endocrinology · doi:10.1210/endo.142.4.8114 · Cited by 741
Untitled work
(2000) · PubMed · Cited by 676
Untitled work
(1996) · PubMed · Cited by 547
Regulation of adult neurogenesis by antidepressant treatment
Duman, R. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00358-x · Cited by 463
Hypocortisolism and increased glucocorticoid sensitivity of pro-Inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder
Rohleder, N., Joksimovic, L., Wolf, J. M., & Kirschbaum, C. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.018 · Cited by 393
Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition
van Rossum, E. F. C. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.333 · Cited by 381
Ligand-independent Activation of the Glucocorticoid Receptor by β2-Adrenergic Receptor Agonists in Primary Human Lung Fibroblasts and Vascular Smooth Muscle Cells
Eickelberg, O., Roth, M., Lörx, R., Bruce, V., Rüdiger, J., Johnson, M., & Block, L.-H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.1005 · Cited by 378
Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior
Boyle, M. P., Brewer, J. A., Funatsu, M., Wozniak, D. F., Tsien, J. Z., Izumi, Y., & Muglia, L. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406458102 · Cited by 378 · cited 1×
“These findings are intriguingly consistent with a recent paper in animals showing that a (induced) reduction of GR levels in the forebrain of mice is associated with behavioural changes resembling depressive symptoms (Boyle et al., 2005).”
Result
Penetration of Dexamethasone into Brain Glucocorticoid Targets Is Enhanced in mdr1A P-Glycoprotein Knockout Mice
Meijer, O. C., de Lange, E. C. M., Breimer, D. D., de Boer, A. G., Workel, J. O., & de Kloet, E. R. (1998) · Endocrinology · doi:10.1210/endo.139.4.5917 · Cited by 375
Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera.
Htun, H., Bársony, J., Renyi, I., Gould, D. L., & Hager, G. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4845 · Cited by 365
Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression
Zobel, A. W., Nickel, T., Sonntag, A., Uhr, M., Holsboer, F., & Ising, M. (2001) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(01)00013-9 · Cited by 354
Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorder
Watson, S., Gallagher, P., Ritchie, J. C., Ferrier, I. N., & Young, A. H. (2004) · British Journal of Psychiatry · doi:10.1192/bjp.184.6.496 · Cited by 343
Depression in cancer: new developments regarding diagnosis and treatment
Raison, C. L., & Miller, A. H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00413-x · Cited by 339
The DST as a predictor of outcome in depression: a meta-analysis
Ribeiro, S. C. M., Tandon, R., Grunhaus, L. J., & Greden, J. F. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.11.1618 · Cited by 321
Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder
Young, A. H., Gallagher, P., Watson, S., Del-Estal, D., Owen, B. M., & Nicol Ferrier, I. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300471 · Cited by 318
24-Hour Profiles of Adrenocorticotropin, Cortisol, and Growth Hormone in Major Depressive Illness: Effect of Antidepressant Treatment*
Linkowski, P., Mendlewicz, J., Kerkhofs, M., Leclercq, R., GOLSTEIN, J., Brasseur, M., Copinschi, G., & Cauter, E. V. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-1-141 · Cited by 318
Mechanisms of glucocorticoid signalling
Schoneveld, O., Gaemers, I. C., & Lamers, W. H. (2004) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/j.bbaexp.2004.09.004 · Cited by 305
Loss of Glucocorticoid Fast Feedback in Depression
Young, E. A. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810320017003 · Cited by 299
Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands
Rupprecht, R., Reul, J. M. H. M., van Steensel, B., Spengler, D., Söder, M., Berning, B., Holsboer, F., & Damm, K. (1993) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(93)90072-h · Cited by 297
Inhibition of P-Glycoprotein by Newer Antidepressants
Weiß, J., Dormann, S.-M. G., Martin‐Facklam, M., Kerpen, C. J., Ketabi‐Kiyanvash, N., & Haefeli, W. E. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.046532 · Cited by 295
Rapid Reversal of Psychotic Depression Using Mifepristone
Belanoff, J. K., Flores, B. H., Kalezhan, M., Sund, B., & Schatzberg, A. F. (2001) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200110000-00009 · Cited by 282
Multidrug Resistance P-Glycoprotein Hampers the Access of Cortisol But Not of Corticosterone to Mouse and Human Brain
Karssen, A. M., Meijer, O. C., van der Sandt, I. C. J., Lucassen, P. J., de Lange, E. C. M., de Boer, A. G., & de Kloet, E. R. (2001) · Endocrinology · doi:10.1210/endo.142.6.8213 · Cited by 281
Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects
Heuser, I. J. E., Schweiger, U., Gotthardt, U., Schmider, J., Lammers, C.-H., Dettling, M., Yassouridis, A., & Holsboer, F. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.1.93 · Cited by 275
Glucocorticoid receptor number and cortisol excretion in mood, anxiety, and psychotic disorders
Yehuda, R., Boisoneau, D., Mason, J. W., & Giller, E. L. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90252-9 · Cited by 253
Depression, Stress and the Adrenal axis
(2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01058.x · Cited by 242
Self-citation
Prediction of Medium-Term Outcome by Cortisol Response to the Combined Dexamethasone-CRH Test in Patients With Remitted Depression
Zobel, A. W., Yassouridis, A., Frieboes, R.-M., & Holsboer, F. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.949 · Cited by 228
Hormonal Response Pattern in the Combined DEX-CRH Test Is Stable over Time in Subjects at High Familial Risk for Affective Disorders
Modell, S. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00144-9 · Cited by 207
Mineralocorticoid Receptor Function in Major Depression
Young, E. A., Lopez, J. F., Murphy-Weinberg, V., Watson, S. J., & Akil, H. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.1.24 · Cited by 204
Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder
Yehuda, R., Golier, J. A., Yang, R.-K., & Tischler, L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.010 · Cited by 196
Do antidepressants regulate how cortisol affects the brain?
Pariante, C. M., Thomas, S. A., Lovestone, S., Makoff, A., & Kerwin, R. W. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.10.009 · Cited by 194
Self-citation
Pituitary volume in psychosis
Pariante, C. M., Vassilopoulou, K., Velakoulis, D., Phillips, L., Soulsby, B., Wood, S. J., Brewer, W., Smith, D., Dazzan, P., Yung, A. R., et al. (2004) · British Journal of Psychiatry · doi:10.1192/bjp.185.1.5 · Cited by 180
Self-citation
Plasma Steroid-Binding Proteins
Rosner, W. (1991) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30240-8 · Cited by 180
The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and holocaust survivors with and without posttraumatic stress disorder
Yehuda, R., Halligan, S. L., Grossman, R., Golier, J. A., & Wong, C. M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01357-4 · Cited by 172
Modulation of glucocorticoid receptor function by protein kinase A
Rangarajan, P. N., Umesono, K., & Evans, R. M. (1992) · Molecular Endocrinology · doi:10.1210/mend.6.9.1435789 · Cited by 166
A Model for the Cytoplasmic Trafficking of Signalling Proteins Involving the hsp90-Binding Immunophilins and p50cdc37
Pratt, W. B., Silverstein, A. M., & Galigniana, M. D. (1999) · Cellular Signalling · doi:10.1016/s0898-6568(99)00064-9 · Cited by 164
Treatment with interferon-α in patients with chronic hepatitis and mood or anxiety disorders
Pariante, C. M., Orrù, M. G., Baita, A., Farci, M. G., & Carpiniello, B. (1999) · The Lancet · doi:10.1016/s0140-6736(98)04793-x · Cited by 164
Self-citation
Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illness
Perlman, W. R., Webster, M. J., Kleinman, J. E., & Weickert, C. S. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.09.006 · Cited by 163
Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters
Pariante, C. M., Makoff, A., Lovestone, S., Feroli, S., Heyden, A., Miller, A. H., & Kerwin, R. W. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704368 · Cited by 159
Self-citation
Corticosterone regulation of Type I and Type II adrenal steroid receptors in brain, pituitary, and immune tissue
Spencer, R. L., Miller, A. H., Stein, M., & McEwen, B. S. (1991) · Brain Research · doi:10.1016/0006-8993(91)90463-6 · Cited by 156
Steroid-Independent Translocation of the Glucocorticoid Receptor by the Antidepressant Desipramine
Pariante, C. M., Pearce, B. D., Pisell, T. L., Owens, M. J., & Miller, A. H. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.4.571 · Cited by 156
Self-citation
Future therapeutic targets in mood disorders: the glucocorticoid receptor
McQuade, R., & Young, A. H. (2000) · The British Journal of Psychiatry · doi:10.1192/bjp.177.5.390 · Cited by 152
How does stress affect you? An overview of stress, immunity, depression and disease
Maddock, C., & Pariante, C. M. (2001) · Epidemiologia e Psichiatria Sociale · doi:10.1017/s1121189x00005285 · Cited by 145
Self-citation
Evidence that the FK506-binding immunophilin heat shock protein 56 is required for trafficking of the glucocorticoid receptor from the cytoplasm to the nucleus
Czar, M. J., Lyons, R. H., Welsh, M. J., Renoir, J., & Pratt, W. B. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.11.8584032 · Cited by 137
Glucocorticoid receptors in depression: relationship to the dexamethasone suppression test
Gormley, G. J., Lowy, M. T., Reder, A. T., Hospelhorn, V. D., Antel, J. P., & Meltzer, H. Y. (1985) · American Journal of Psychiatry · doi:10.1176/ajp.142.11.1278 · Cited by 133
Subsyndromal symptomatic depression: A new concept
Sadek, N., & Bona, J. R. (2000) · Depression and Anxiety · doi:10.1002/1520-6394(2000)12:1 · Cited by 132
Interleukin 1α (IL-1α) induced activation of p38 mitogen-activated protein kinase inhibits glucocorticoid receptor function
Wang, X., Wu, H., & Miller, A. H. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001339 · Cited by 128
Acute Antidepressant Effects of Intravenous Hydrocortisone and CRH in Depressed Patients: A Double-Blind, Placebo-Controlled Study
DeBattista, C., Posener, J. A., Kalehzan, B. M., & Schatzberg, A. F. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.8.1334 · Cited by 114
Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis
Bourgeois, S., Gruol, D. J., Newby, R. F., & Rajah, F. M. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.7.8105374 · Cited by 113
Glucocorticoid resistance in depression: the dexamethasone suppression test and lymphocyte sensitivity to dexamethasone
Lowy, M. T., Reder, A. T., Antel, J. P., & Meltzer, H. Y. (1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.11.1365 · Cited by 110
Glucocorticoid receptors and depression.
Whalley, L. J., Borthwick, N. M., Copolov, D., Dick, H., CHRISTIE, J. E., & Fink, G. (1986) · BMJ · doi:10.1136/bmj.292.6524.859 · Cited by 108
Dynamic Changes in Subcellular Localization of Mineralocorticoid Receptor in Living Cells: In Comparison with Glucocorticoid Receptor using Dual-Color Labeling with Green Fluorescent Protein Spectral Variants
Nishi, M., Ogawa, H., Ito, T., Matsuda, K., & Kawata, M. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.7.0659 · Cited by 108
Stress and the progression of the developmental hypothesis of schizophrenia
Cotter, D., & Pariante, C. M. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.181.5.363 · Cited by 100
Self-citation
Characterization and functional significance of glucocorticoid receptors in patients with major depression: modulation by antidepressant treatment
Calfa, G. D., Kademian, S., Ceschin, D. G., Vega, G., Rabinovich, G. A., & Volosin, M. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00051-3 · Cited by 97
The steroid antagonist RU486 exerts different effects on the glucocorticoid and progesterone receptors
Beck, C. A., Estes, P. A., Bona, B. J., Muro‐Cacho, C., Nordeen, S. K., & Edwards, D. P. (1993) · Endocrinology · doi:10.1210/endo.133.2.8344212 · Cited by 93
Altered glucocorticoid immunoregulation in treatment resistant depression
Bauer, M. E., Papadopoulos, A. S., Poon, L., Perks, P., Lightman, S. L., Checkley, S. A., & Shanks, N. M. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00009-4 · Cited by 91
Decreased expression of mineralocorticoid receptor mRNA in the prefrontal cortex in schizophrenia and bipolar disorder
Xing, G.-Q., Russell, S., Webster, M. J., & Post, R. M. (2004) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145703004000 · Cited by 91
Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transporters
Pariante, C. M., Kim, R. B., Makoff, A., & Kerwin, R. W. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705357 · Cited by 89
Self-citation
ABCB1 (MDR1)-Type P-Glycoproteins at the Blood–Brain Barrier Modulate the Activity of the Hypothalamic–Pituitary–Adrenocortical System: Implications for Affective Disorder
Müller, M. B., Keck, M. E., Binder, E. B., Kresse, A. E., Hagemeyer, T. P., Landgraf, R., Holsboer, F., & Uhr, M. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300257 · Cited by 88
Assessment of glucocorticoid receptor-heat shock protein 90 interactions in vivo during nucleocytoplasmic trafficking.
Yang, J., & DeFranco, D. B. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.1.8838140 · Cited by 86
Psychopharmacological Treatment of Depression, Anxiety, Irritability and Insomnia in Patients Receiving Interferon-α: a Prospective Case Series and a Discussion of Biological Mechanisms
Maddock, C., Baita, A., Orrù, M. G., Sitzia, R., Costa, A., Muntoni, E., Farci, M. G., Carpiniello, B., & Pariante, C. M. (2004) · Journal of Psychopharmacology · doi:10.1177/0269881104040230 · Cited by 85
Self-citation
Effects of glucocorticoids on declarative memory function in major depression
Bremner, J. D., Vythilingam, M., Vermetten, E. H. G. J. M., Anderson, G. M., Newcomer, J. W., & Charney, D. S. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.10.020 · Cited by 85
Dexamethasone augmentation in treatment‐resistant depression
Dinan, T. G., Lavelle, E., Cooney, J., Burnett, F., Scott, L. V., Dash, A. R., Thakore, J. H., & Berti, C. (1997) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1997.tb00374.x · Cited by 83
A novel prednisolone suppression test for the hypothalamic-pituitary-adrenal axis
Pariante, C. M., Papadopoulos, A. S., Poon, L., Checkley, S. A., English, J., Kerwin, R. W., & Lightman, S. L. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01314-2 · Cited by 74
Self-citation
Comparison of in vivo and in vitro glucocorticoid sensitivity in depression: Relationship to the dexamethasone suppression test
Lowy, M. T., Reder, A. T., Gormley, G. J., & Meltzer, H. Y. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90136-9 · Cited by 70
The Antidepressant Clomipramine Regulates Cortisol Intracellular Concentrations and Glucocorticoid Receptor Expression in Fibroblasts and Rat Primary Neurones
Pariante, C. M., Hye, A., Williamson, R., Makoff, A., Lovestone, S., & Kerwin, R. W. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300195 · Cited by 70
Self-citation
Squirrel Monkey Immunophilin FKBP51 Is a Potent Inhibitor of Glucocorticoid Receptor Binding1
Denny, W. B., Valentine, D. L., Reynolds, P. D., Smith, D. F., & Scammell, J. G. (2000) · Endocrinology · doi:10.1210/en.141.11.4107 · Cited by 66
Potentiation of glucocorticoid receptor-mediated gene expression by heat and chemical shock.
Sánchez, E., Hu, J., Zhong, S., Shen, P., Greene, M. J., & Housley, P. R. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.4.8052262 · Cited by 66
Dexamethasone-induced effects on lymphocyte distribution and expression of adhesion molecules in treatment-resistant depression
Bauer, M. E., Papadopoulos, A., Poon, L., Perks, P., Lightman, S. L., Checkley, S., & Shanks, N. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00243-3 · Cited by 62
Involvement of multidrug resistance proteins (MDR) in the modulation of glucocorticoid response
Webster, J. I., & Carlstedt‐Duke, J. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00227-3 · Cited by 60
Interferon Alfa–Induced Adverse Effects in Patients with a Psychiatric Diagnosis
Pariante, C. M., Landau, S., & Carpiniello, B. (2002) · New England Journal of Medicine · doi:10.1056/nejm200207113470221 · Cited by 59
Self-citation
The Phosphodiesterase Type 4 Inhibitor, Rolipram, Enhances Glucocorticoid Receptor Function
Miller, A. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00381-0 · Cited by 57
Real‐time imaging of glucocorticoid receptor dynamics in living neurons and glial cells in comparison with non‐neural cells
Nishi, M., Takenaka, N., Morita, N., Ito, T., Ozawa, H., & Kawata, M. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00616.x · Cited by 56
Four days of citalopram increase suppression of cortisol secretion by prednisolone in healthy volunteers
Pariante, C. M., Papadopoulos, A. S., Poon, L., Cleare, A. J., Checkley, S. A., English, J., Kerwin, R. W., & Lightman, S. L. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1925-4 · Cited by 52
Self-citation
Reserpine-Induced Decrease in Type I and II Corticosteroid Receptors in Neuronal and Lymphoid Tissues of Adrenalectomized Rats
Lowy, M. T. (2008) · Neuroendocrinology · doi:10.1159/000125336 · Cited by 49
The Munich vulnerability study on affective disorders: overview of the cross-sectional observations at index investigation
Lauer, C. J., Schreiber, W., Modell, S., Holsboer, F., & Krieg, J. C. (1998) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(98)00026-0 · Cited by 45
Human fibroblasts as a relevant model to study signal transduction in affective disorders
Manier, D. H., Shelton, R. C., Ellis, T. C., Peterson, C. S., Eiring, A. M., & Sulser, F. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00190-1 · Cited by 45
Circumvention of pleiotropic drug resistance in subcutaneous tumours in vivo with verapamil and clomipramine
Merry, S. P., Hamilton, T. G., Flanigan, P., Freshney, R. I., & Kaye, S. B. (1991) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(91)90054-h · Cited by 43
Lymphocyte glucocorticoid receptor binding in depressed patients with hypercortisolemia
Schlechte, J., & Sherman, B. M. (1985) · Psychoneuroendocrinology · doi:10.1016/0306-4530(85)90086-1 · Cited by 41
Normal lymphocyte responsiveness to lectins but impaired sensitivity to in vitro glucocorticoids in major depression
Wodarz, N., Rupprecht, R., Kornhuber, J., Schmitz, B., Wild, K., Braner, H. U., & Riederer, P. F. (1991) · Journal of Affective Disorders · doi:10.1016/0165-0327(91)90070-9 · Cited by 40
The Proinflammatory Cytokine, Interleukin-1α, Reduces Glucocorticoid Receptor Translocation and Function1
Pariante, C. M., Pearce, B. D., Pisell, T. L., Sanchez, C. I., Po, C., Su, C., & Miller, A. H. (1999) · Endocrinology · doi:10.1210/en.140.9.4359 · Cited by 40
Self-citation
Plasma sialyltransferase levels in psychiatric disorders as a possible indicator of HPA axis function
Maguire, T. M., Thakore, J. H., Dinan, T. G., Hopwood, S., & Breen, K. C. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00223-5 · Cited by 38
Disturbed glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressives pretreated with metyrapone
Rupprecht, R., Kornhuber, J., Wodarz, N., Lugauer, J., Göbel, C., Haack, D., Beck, G., Müller, O. A., Riederer, P. F., & Beckmann, H. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90252-h · Cited by 37
Cell-mediated immunity and its glucocorticoid-sensitivity after clinical recovery from severe major depressive disorder
Wodarz, N., Rupprecht, R., Kornhuber, J., Schmitz, B., Wild, K., & Riederer, P. F. (1992) · Journal of Affective Disorders · doi:10.1016/0165-0327(92)90090-s · Cited by 30
Relationship between dexamethasone-inhibited lysozyme activity in peripheral mononuclear leukocytes and the cortisol and glucocorticoid receptor response to dexamethasone
Yehuda, R., Yang, R.-K., Guo, S. L., Makotkine, I., & Singh, B. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(03)00073-6 · Cited by 29
Mononuclear leukocyte glucocorticoid receptor binding characteristics and down-regulation in major depression
Wassef, A. A. (1990) · Psychoneuroendocrinology · doi:10.1016/0306-4530(90)90047-d · Cited by 23
Lymphocyte glucocorticoid receptor: predictor of sertraline response in adolescent major depressive disorder (MDD).
Sallee, F. R., Nesbitt, L., Dougherty, D. D., Hilal, R. E., Vrindavanam, N. S., & Sethuraman, G. (1995) · PubMed · Cited by 20
In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression
Rupprecht, R., Wodarz, N., Kornhuber, J., Wild, K., Schmitz, B., Braner, H. U., Müller, O. A., Riederer, P. F., & Beckmann, H. (1991) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02193752 · Cited by 16
Lymphocyte glucocorticoid receptor binding in depression: normal values following recovery
Hunter, R. (1988) · Journal of Affective Disorders · doi:10.1016/0165-0327(88)90058-4 · Cited by 16
Vasoconstrictor response to topical beclomethasone in major depression
Cotter, P. A., Mulligan, O. F., Landau, S., Papadopoulos, A. S., Lightman, S. L., & Checkley, S. A. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00065-8 · Cited by 15
Lymphocyte glucocorticoid receptor binding during depression and after clinical recovery
Rupprecht, R., Kornhuber, J., Wodarz, N., Lugauer, J., Göbel, C., Riederer, P. F., & Beckmann, H. (1991) · Journal of Affective Disorders · doi:10.1016/0165-0327(91)90080-c · Cited by 14
Glucocorticoid receptor binding in three different cell types in major depressive disorder: Lack of evidence op receptor binding defect
Wassef, A. A., O'Boyle, M., Gardner, R., Rose, R. M., Brown, A., Harris, A., Nguyen, H. H., & Meyer, W. J. (1992) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(92)90009-4 · Cited by 12
Preservation of hypothalamic‐pituitary‐adrenal axis fast‐feedback responses in depression
Cooney, J. M., & Dinan, T. G. (1996) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1996.tb09889.x · Cited by 8
Beclomethasone-induced vasoconstriction in women with major depressive disorder
Coupland, N. J., Hegadoren, K., & Myrholm, J. (2003) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0344 · Cited by 4

Research works printed but not linked: 17

Bourgeois S., 1993, Mol. Endocrinol., 7, 840
Brooksbank B.W., 1973, Steroids Lipids Res, 4, 162
Coupland N.J., 2003, J. Psychiatry Neurosci., 28, 364
Czar M.J., 1995, Mol. Endocrinol., 9, 1549
Denny W.B., 2000, Endocrinology, 141, 4107, 10.1210/endo.141.11.7785 · DOI · Paper page
Herr A.S., 2003, Antidepressants differentially influence the transcriptional activity of the glucocorticoid receptor in vitro, Neuroendocrinology, 78, 12
de Kloet E.R., 1998, Endocr. Rev., 19, 269
Lopez J.F., 1998, Psychiatry, 43, 547
Miller A.H., 1987, Psychopharmacol. Bull., 23, 502
Miller A.H., 1999, Med. Biol., 461, 107
Nemeroff C.B., 1996, Mol. Psychiatry, 1, 336
Pariante C.M., 1999, Endocrinology, 140, 4359, 10.1210/endo.140.9.6986 · DOI · Paper page
Rangarajan P.N., 1992, Mol. Endocrinol., 6, 1451
Sallee F.R., 1995, Psychopharmacol. Bull., 31, 339
Sanchez E.R., 1994, Mol. Endocrinol., 8, 408
Webster M.J., 2002, Psychiatry, 7, 985
Yang J., 1996, Mol. Endocrinol., 10, 3

Sorted by citations

Salivary cortisol as a biomarker in stress research
Hellhammer, D. H., Wüst, S., & Kudielka, B. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.026 · Cited by 1,925
The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704
The human stress response
Russell, G., & Lightman, S. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0228-0 · Cited by 1,032
Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior
Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000
Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression
Pace, T. W. W., Hu, F., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.08.009 · Cited by 621

See all 147

Authors: Pariante, C. M.
Affiliations: King's College London (GB)
Corresponding author: Pariante, Carmine M.
ORCID: Pariante, Carmine M.
Venue: Stress
Publisher: Informa UK Limited
Published: 2004-12
Volume: 7
Issue: 4
Pages: 209-219
ISSN: 1025-3890 (ISSN-L)
1607-8888
DOI: 10.1080/10253890500069650
OpenAlex: W2056750568
Cited by: 147
References: 100
Citations by year: 2025: 2 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 6 · 2017: 3 · 2016: 4 · 2015: 7 · 2014: 7 · 2013: 8 · 2012: 9
FWCI: 3.63
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Stress (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
Rosetrees Trust
Department of Science and Technology, Ministry of Science and Technology, India
Medical Research Council
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: glucocorticoid receptor, major depressive disorder, glucocorticoid resistance, hypothalamic-pituitary-adrenal axis, negative feedback, antidepressant treatment, peripheral tissues, immune function, metabolic function, molecular mechanisms
MeSH terms: Animals, Antidepressive Agents, Major Depressive Disorder, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Receptors, Glucocorticoid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Glucocorticoid Receptor Function In Vitro in Patients with Major Depression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks