Cited by 352Iron Metabolism and DisordersTrace Elements in HealthFerroptosis and cancer prognosis

The DOI matches its Crossref record; 146 of the 146 references it cites were found in a registry or an index.

Oxidative Stress and Iron Homeostasis: Mechanistic and Health Aspects

Galaris, Dimitrios, Pantopoulos, Kostas·2008·Critical Reviews in Clinical Laboratory Sciences

Open this paper in CoChat — free account

Abstract

Iron is an essential cofactor for important biological activities and biochemical reactions, including the transport of oxygen via red blood cells and its reduction to water during respiration. While iron's bioavailability is generally limited, pathological accumulation of the metal within tissues aggravates the generation of reactive oxygen species (ROS) and elicits toxic effects, which are mainly related to oxidative stress. Here, we describe the role of iron in ROS-induced toxicity and discuss molecular mechanisms and physiological aspects of ROS- and iron-mediated signaling. In addition, we review our current understanding of the regulation of iron homeostasis at the cellular and systemic levels, and focus on the pathogenesis and management of iron overload disorders.

Integrity signals

Registry

Crossref · 10.1080/10408360701713104

Cites

146 of 146 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Superoxide Dismutase
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Hydroperoxide metabolism in mammalian organs.
Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827
A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R., Ellis, M. C., Fullan, A., et al. (1996) · Nature Genetics · doi:10.1038/ng0896-399 · Cited by 3,664
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166
The ferritins: molecular properties, iron storage function and cellular regulation
Harrison, P. M., & Arosio, P. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00022-9 · Cited by 2,667
H 2 O 2 , a Necessary Evil for Cell Signaling
Rhee, S. G. (2006) · Science · doi:10.1126/science.1130481 · Cited by 2,160
Disorders of Iron Metabolism
Andrews, N. C. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912233412607 · Cited by 2,130
Iron, brain ageing and neurodegenerative disorders
Zecca, L., Youdim, M. B. H., Riederer, P., Connor, J. R., & Crichton, R. R. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1537 · Cited by 1,801
Redefining Oxidative Stress
Jones, D. P. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.1865 · Cited by 1,726

Show all 145 references

Sorted by citations

Items 101–200 of 352

Maintaining Mammalian Iron and Oxygen Homeostasis
Salahudeen, A. A., & Bruick, R. K. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05038.x · Cited by 41
Apigenin ameliorates di(2-ethylhexyl) phthalate-induced ferroptosis: The activation of glutathione peroxidase 4 and suppression of iron intake
Han, D., Yao, Y., Chen, L., Miao, Z., & Xu, S. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.113089 · Cited by 41
Glutamyl cysteine dipeptide suppresses ferritin expression and alleviates liver injury in iron-overload rat model
Salama, S. A., Al-Harbi, M. S., Abdel‐Bakky, M. S., & Omar, H. A. (2015) · Biochimie · doi:10.1016/j.biochi.2015.06.006 · Cited by 40
Synthesis of a cell penetrating peptide modified superparamagnetic iron oxide and MRI detection of bladder cancer
Ding, C., Wu, K., Wang, W., Guan, Z., Wang, L., Wang, X., Wang, R., Liu, L., & Fan, J. (2016) · Oncotarget · doi:10.18632/oncotarget.13578 · Cited by 40
Crosstalk between ferroptosis and chondrocytes in osteoarthritis: a systematic review of in vivo and in vitro studies
Cao, S., Wei, Y., Xu, H., Weng, J., Qi, T., Yu, F., Liu, S., Xiong, A., Liu, P., & Zeng, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1202436 · Cited by 42
Major heme proteins hemoglobin and myoglobin with respect to their roles in oxidative stress – a brief review
Sil, R., & Chakraborti, A. S. (2025) · Frontiers in Chemistry · doi:10.3389/fchem.2025.1543455 · Cited by 42
“However, a small portion of O 2 undergoes partial reduction not only in the respiratory chain, but also during other physiological activities, such as phagocytosis, immune activation and xenobiotics metabolism (Galaris and Pantopoulos, 2008).”
Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload
Sun, L., Guo, W., Yin, C., Zhang, S., Qu, G., Hou, Y., Rong, H., Ji, H. L., & Liu, S. (2014) · Gene · doi:10.1016/j.gene.2014.02.023 · Cited by 40
“In terms of the molecular mechanisms, previous studies have demonstrated that intracellular iron retention would cause massive production of reactive oxygen species (ROS) through Fenton reaction (Fridovich, 1978; Galaris and Pantopoulos, 2008; Halliwell and Gutteridge, 1990), and ROS is postulated to be an instigator…”
Background
A high-fat diet modulates iron metabolism but does not promote liver fibrosis in hemochromatotic Hjv−/− mice
Padda, R. S., Gkouvatsos, K., Guido, M., Mui, J., Vali, H., & Pantopoulos, K. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00137.2014 · Cited by 40
Self-citation
Iron overload induced by ferric ammonium citrate triggers reactive oxygen species-mediated apoptosis via both extrinsic and intrinsic pathways in human hepatic cells
Li, S.-W., Cm, L., Guo, J., Marcondes, A. M., Deeg, H. J., Li, X., & Guan, F. (2015) · Human & Experimental Toxicology · doi:10.1177/0960327115597312 · Cited by 39
Involvement of the mitogen activated protein kinase Hog1p in the response of Candida albicansto iron availability
Kaba, H. E., Nimtz, M., Müller, P. P., & Bilitewski, U. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-16 · Cited by 37
“Due to the toxic potential of iron by generating reactive oxygen species (ROS) [21], cellular iron homeostasis is subjected to tight regulation.”
The compound isolated from the leaves of Phyllostachys nigra protects oxidative stress-induced retinal ganglion cells death
Lee, H. J., Kim, K., Kang, K. D., Lee, E. H., Kim, C. Y., Um, B. H., & Jung, S. H. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.03.052 · Cited by 38
Implication of Dietary Iron-Chelating Bioactive Compounds in Molecular Mechanisms of Oxidative Stress-Induced Cell Ageing
Barbouti, A., Lаgopati, N., Veroutis, D., Goulas, V., Evangelou, K., Kanavaros, P., Gorgoulis, V. G., & Galaris, D. (2021) · Antioxidants · doi:10.3390/antiox10030491 · Cited by 40
Self-citation
Iron supplementation at high altitudes induces inflammation and oxidative injury to lung tissues in rats
Salama, S. A., Omar, H. A., Maghrabi, I. A., AlSaeed, M. S., & El-Tarras, A. E. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.10.034 · Cited by 36
Exploring the oxidation and iron binding profile of a cyclodextrin encapsulated quercetin complex unveiled a controlled complex dissociation through a chemical stimulus
Diamantis, D. A., Ramešová, Š., Chatzigiannis, C. M., Degano, I., Gerogianni, P. S., Karadima, K. E., Perikleous, S., Rekkas, D. M., Gerothanassis, I. P., Galaris, D., et al. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.06.006 · Cited by 36
“ly reactive free radicals that are harmful for cell [39].”
BackgroundSelf-citation
The Role of Bilirubin and the Other “Yellow Players” in Neurodegenerative Diseases
Jayanti, S. D., Vı́tek, L., Tiribelli, C., & Gazzin, S. (2020) · Antioxidants · doi:10.3390/antiox9090900 · Cited by 38
Cascades and Networks of Regulatory Genes That Control Antibiotic Biosynthesis
Martin, J. F., & Liras, P. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-5055-5_6 · Cited by 36
Minerals and the Menstrual Cycle: Impacts on Ovulation and Endometrial Health
Kapper, C., Oppelt, P., Ganhör, C., Gyunesh, A. A., Arbeithuber, B., Stelzl, P., & Rezk, M. (2024) · Nutrients · doi:10.3390/nu16071008 · Cited by 51
Leishmania and its quest for iron: An update and overview
Zaidi, A., Singh, K. P., & Ali, V. (2016) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2016.12.004 · Cited by 37
Effect of Fe and Cd Co-Exposure on Testicular Steroid Metabolism, Morphometry, and Spermatogenesis in Mice
Abarikwu, S., Wokoma, A. F., Mgbudom-Okah, C., Omeodu, S., & Ohanador, R. (2018) · Biological Trace Element Research · doi:10.1007/s12011-018-1536-2 · Cited by 32
Differential effects of Fe2+ and Fe3+ on osteoblasts and the effects of 1,25(OH)2D3, deferiprone and extracellular calcium on osteoblast viability under iron-overloaded conditions
Lertsuwan, K., Nammultriputtar, K., Nanthawuttiphan, S., Tannop, N., Teerapornpuntakit, J., Thongbunchoo, J., & Charoenphandhu, N. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234009 · Cited by 32
Zinc inhibits oxidative stress-induced iron signaling and apoptosis in Caco-2 cells
Kilari, S., Pullakhandam, R., & Nair, K. M. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.01.019 · Cited by 32
Mechanism of chronic dietary iron overload-induced liver damage in mice
Liu, D., He, H., Yin, D., Que, A.-L., Tang, L., Liao, Z., Huang, Q., & He, M. L. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1316 · Cited by 32
Iron Chelation for Amelioration of Liver Ischemia-Reperfusion Injury
Arkadopoulos, N. F., Nastos, C., Kalimeris, K. A., Economou, E., Theodoraki, K. A., Kouskouni, E. E., Pafiti, A., Kostopanagiotou, G. G., & Smyrniotis, V. E. (2010) · Hemoglobin · doi:10.3109/03630269.2010.484766 · Cited by 32
The Metal Chelators, Trientine and Citrate, Inhibit the Development of Cardiac Pathology in the Zucker Diabetic Rat
Baynes, J., & Murray, D. B. (2009) · Experimental Diabetes Research · doi:10.1155/2009/696378 · Cited by 32
Coordination of hypoxia adaptation and iron homeostasis in human pathogenic fungi
Chung, D., Haas, H., & Cramer, R. A. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00381 · Cited by 29
Protective effects of grape seed proanthocyanidins against iron overload-induced renal oxidative damage in rats
Yun, S., Chu, D., He, X., Zhang, W., & Feng, C. (2019) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2019.126407 · Cited by 31
Metabolic Rearrangements Causing Elevated Proline and Polyhydroxybutyrate Accumulation During the Osmotic Adaptation Response of Bacillus megaterium
Godard, T., Zühlke, D., Richter, G., Wall, M., Rohde, M., Riedel, K., Poblete‐Castro, I., Krull, R., & Biedendieck, R. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00047 · Cited by 31
Plasmid-Encoded Iron Uptake Systems
Lorenzo, M. D., & Stork, M. (2014) · Microbiology Spectrum · doi:10.1128/microbiolspec.plas-0030-2014 · Cited by 29
“Additionally, free iron is toxic due to the formation of free oxygen radicals that can cause cell damage (1).”
Background
Monitoring of essential and toxic elements in multi-ingredient food supplements produced in European Union
Poniedziałek, B., Niedzielski, P., Kozak, L., Rzymski, P., Wachelka, M., Rzymska, I., Karczewski, J., & Rzymski, P. (2018) · Journal of Consumer Protection and Food Safety · doi:10.1007/s00003-018-1148-y · Cited by 29
Comparative genomics and metagenomics of the metallomes
Zhang, Y., Ying, H., & Xu, Y. (2019) · Metallomics · doi:10.1039/c9mt00023b · Cited by 29
An association of transferrin gene polymorphism and serum transferrin levels with age-related macular degeneration
Wysokiński, D., Danisz, K., Błasiak, J., Dorecka, M., Romaniuk, D., Szaflik, J., & Szaflik, J. P. (2012) · Experimental Eye Research · doi:10.1016/j.exer.2012.10.003 · Cited by 29
“In the presence of hydrogen peroxide, soluble ferrous iron (FeII) may participate in the Fenton and HabereWeiss reactions generating highly reactive hydroxyl radical (Galaris and Pantopoulos, 2008; Jomova and Valko, 2011; Liochev and Fridovich, 2002).”
Background
Tumor cell culture survival following glucose and glutamine deprivation at typical physiological concentrations
Mathews, E. H., Stander, A., Joubert, A. M., & Liebenberg, L. (2013) · Nutrition · doi:10.1016/j.nut.2013.07.024 · Cited by 28
Correction: Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine
Chen, J., Marks, E. S., Lai, B. C. H., Zhang, Z., Duce, J. A., Lam, L. Q., Volitakis, I., Bush, A. I., Hersch, S. M., & Fox, J. H. (2013) · PLoS ONE · doi:10.1371/annotation/67f555f5-35b7-4468-8bab-26d518942803 · Cited by 29
Higher Body Iron Is Associated with Greater Depression Symptoms among Young Adult Men but not Women: Observational Data from the Daily Life Study
Richardson, A. C., Heath, A. M., Haszard, J. J., Polak, M., Houghton, L. A., & Conner, T. S. (2015) · Nutrients · doi:10.3390/nu7085270 · Cited by 27
Iron dysregulates APP processing accompanying with sAPPα cellular retention and β-secretase inhibition in rat cortical neurons
Chen, Y., Chen, W.-Y., Huang, X., Xu, Y., & Zhang, H. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.113 · Cited by 27
Exposure to different fractions of diesel exhaust PM2.5 induces different levels of pulmonary inflammation and acute phase response
Tao, S., Xu, Y., Chen, M., Zhang, H., Huang, X., Li, Z., Pan, B., Peng, R., Zhu, Y., Kan, H., et al. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111871 · Cited by 26
Accelerated CCl4-Induced Liver Fibrosis in Hjv-/- Mice, Associated with an Oxidative Burst and Precocious Profibrogenic Gene Expression
Sebastiani, G., Gkouvatsos, K., Maffettone, C., Busatto, G., Guido, M., & Pantopoulos, K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025138 · Cited by 26
Self-citation
Supplementation of iron alone and combined with vitamins improves haematological status, erythrocyte membrane fluidity and oxidative stress in anaemic pregnant women
Ma, A., Schouten, E. G., Sun, Y. Y., Yang, F., Han, X. X., Zhang, F. Z., Jiang, D. C., & Kok, F. J. (2010) · British Journal Of Nutrition · doi:10.1017/s000711451000259x · Cited by 26
An Aggregation-Induced Phosphorescence-Active “Turn-Off” Nanosensor Based on Ferric-Specific Quenching of Luminescent and Water-Soluble Au(I)–Cysteine Nanocomplexes
Lin, X., Liu, J., Tian, M., Bai, Y., Bao, Y., Shu, T., Su, L., & Zhang, X. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c01358 · Cited by 25
Resveratrol ameliorates iron overload induced liver fibrosis in mice by regulating iron homeostasis
Wang, H., Jiang, C., Yang, Y., Li, J., Wang, Y., Wang, C., & Gao, Y. (2022) · PeerJ · doi:10.7717/peerj.13592 · Cited by 26
Deferoxamine Improves Alveolar and Pulmonary Vascular Development by Upregulating Hypoxia-inducible Factor-1α in a Rat Model of Bronchopulmonary Dysplasia
Choi, C. W., Lee, J. Y., Lee, H. J., Park, H.-S., Chun, Y., & Kim, B. I. (2015) · Journal of Korean Medical Science · doi:10.3346/jkms.2015.30.9.1295 · Cited by 25
Applications of Synchrotron‐Based Spectroscopic Techniques in Studying Nucleic Acids and Nucleic Acid‐Functionalized Nanomaterials
Wu, P., Yu, Y., McGhee, C. E., Tan, L. H., & Lu, Y. (2014) · Advanced Materials · doi:10.1002/adma.201304891 · Cited by 25
The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
Yan, S., Lu, J., Chen, B., Yuan, L., Chen, L., Ju, L., Cai, W., & Wu, J.-Z. (2024) · Antioxidants · doi:10.3390/antiox13080897 · Cited by 26
“…on genes upstream of ALA and other chronic diseases suggest that metal chelation is also one of the primary mechanisms of action of ALA. Metal ions, such as copper and iron, as part of electron transfer and cellular respiration, accumulate at different levels in normal and cancer cells [128,129].”
Background
Nutrition in the prevention and management of sarcopenia - A special focus on Asian Indians
Bhattacharya, S., Bhadra, R., Schols, A. M. W. J., van Helvoort, A., & Sambashivaiah, S. (2022) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2022.12.002 · Cited by 26
“However, excess of iron has the potential to increase the oxidative stress in the body [138,139] through the production of extremely reactive oxygen species.”
Background
The Vital Role Played by Deferiprone in the Transition of Thalassaemia from a Fatal to a Chronic Disease and Challenges in Its Repurposing for Use in Non-Iron-Loaded Diseases
Kontoghiorghes, G. J. (2023) · Pharmaceuticals · doi:10.3390/ph16071016 · Cited by 27
Long-term low-dose exposure of human urothelial cells to sodium arsenite activates lipocalin-2 via promoter hypomethylation
Wang, H.-H., Wu, M., Chan, M. W. Y., Pu, Y., Chen, C., & Lee, T. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1214-x · Cited by 24
Signaling Pathways of ESE-16, an Antimitotic and Anticarbonic Anhydrase Estradiol Analog, in Breast Cancer Cells
Stander, B. A., Joubert, F., Tu, C., Sippel, K. H., McKENNA, R. V., & Joubert, A. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053853 · Cited by 23
Hereditary hemochromatosis: Laboratory evaluation
Moyer, T. P., Highsmith, W. E., Smyrk, T. C., & Gross, J. B. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.04.007 · Cited by 24
Hydroxycinnamic Acids in Crepidiastrum denticulatum Protect Oxidative Stress-Induced Retinal Damage
Ahn, H. R., Lee, H. J., Kim, K., Kim, C. Y., Nho, C. W., Jang, H., Pan, C., Lee, C. Y., & Jung, S. H. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4046232 · Cited by 23
Patterns of cell death induced by metformin in human MCF-7 breast cancer cells
Lopes, N. M. D., Marinello, P. C., Sanches, L. J., Brito, W. A. D. S., Lovo‐Martins, M. I., Pinge‐Filho, P., Luiz, R. C., Cecchini, R., & Cecchini, A. L. (2020) · Pathology - Research and Practice · doi:10.1016/j.prp.2020.153199 · Cited by 23
Iron-dependent formation of reactive oxygen species and glutathione depletion after accumulation of magnetic iron oxide nanoparticles by oligodendroglial cells
Hohnholt, M. C., & Dringen, R. (2011) · Journal of Nanoparticle Research · doi:10.1007/s11051-011-0585-7 · Cited by 23
Nitrative and oxidative modifications of enolase are associated with iron in iron-overload rats and in vitro
Lu, N., Li, X., Li, J., Xu, W., Li, H., & Gao, Z. (2010) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-010-0747-6 · Cited by 23
Nutritional considerations during prolonged exposure to a confined, hyperbaric, hyperoxic environment: recommendations for saturation divers
Deb, S. K., Swinton, P. A., & Dolan, E. (2016) · Extreme Physiology & Medicine · doi:10.1186/s13728-015-0042-9 · Cited by 23
Brain Iron Dysregulation and the Risk of Ageing White Matter Lesions
Gebril, O. H., Simpson, J. E., Kirby, J., Brayne, C., & Ince, P. G. (2011) · NeuroMolecular Medicine · doi:10.1007/s12017-011-8161-y · Cited by 22
Oxidative modification of ferritin induced by hydrogen peroxide
Yoon, J., An, S. H., Kyeong, I.-G., Lee, M.-S., Kwon, S.-C., & Kang, J. H. (2011) · BMB Reports · doi:10.5483/bmbrep.2011.44.3.165 · Cited by 22
Edible Seaweed, Eisenia bicyclis, Protects Retinal Ganglion Cells Death Caused by Oxidative Stress
Kim, K., Kim, S. M., Kang, S. W., Jeon, S. I., Um, B. H., & Jung, S. H. (2012) · Marine Biotechnology · doi:10.1007/s10126-012-9459-y · Cited by 22
The Chemo-Protective Effect of Turmeric, Chili, Cloves and Cardamom on Correcting Iron Overload-Induced Liver Injury, Oxidative Stress and Serum Lipid Profile in Rat Models.
Fadlalla, E. A. S., & El-Razek, F. H. A. (2010) · Cited by 22
Metabolism and adult neurogenesis: Towards an understanding of the role of lipocalin-2 and iron-related oxidative stress
Ferreira, A. C., Sousa, N., Bessa, J. M., Sousa, J. C., & Marques, F. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.014 · Cited by 24
Relationship between lead absorption and iron status and its association with oxidative stress markers in lead-exposed workers
Słota, M., Wąsik, M., Stołtny, T., Machoń-Grecka, A., Kasperczyk, A., Bellanti, F., Dobrakowski, M., Chwalba, A., & Kasperczyk, S. (2021) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2021.126841 · Cited by 21
Isobavachin attenuates osteoclastogenesis and periodontitis-induced bone loss by inhibiting cellular iron accumulation and mitochondrial biogenesis
Li, T., Du, Y., Yao, H., Zhao, B., Wang, Z., Chen, R., Ji, Y., & Du, M. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116202 · Cited by 22
A Vegetarian Diet Is Associated with a Lower Risk of Cataract, Particularly Among Individuals with Overweight: A Prospective Study
Chiu, T. H. T., Chang, C.-C., Lin, C., & Lin, M. (2020) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2020.11.003 · Cited by 20
HFE Gene Polymorphisms and the Risk for Autism in Egyptian Children and Impact on the Effect of Oxidative Stress
Gebril, O. H., & Meguid, N. A. (2011) · Disease Markers · doi:10.1155/2011/605620 · Cited by 20
The Puzzle of Aspirin and Iron Deficiency: The Vital Missing Link of the Iron-Chelating Metabolites
Kontoghiorghes, G. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105150 · Cited by 22
Serum NADPH oxidase concentrations and the associations with iron metabolism in relapsing remitting multiple sclerosis
Doğan, H. O., & Yıldız, Ö. K. (2019) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2019.05.011 · Cited by 20
Iron intake, oxidative stress‐related genes and breast cancer risk
Chang, V. C., Cotterchio, M., Bondy, S. J., & Kotsopoulos, J. (2020) · International Journal of Cancer · doi:10.1002/ijc.32906 · Cited by 19
Comparative Genomics Analysis of the Metallomes
Gladyshev, V. N., & Zhang, Y. (2012) · Metal ions in life sciences · doi:10.1007/978-94-007-5561-1_16 · Cited by 21
Role of ferroptosis in gastrointestinal tumors: From mechanisms to therapies
Si, C., Zhou, X., Deng, J., Ye, S., Kong, L., Zhang, B., & Wang, W. (2022) · Cell Biology International · doi:10.1002/cbin.11804 · Cited by 18
Iron chelation by deferasirox confers protection against concanavalin A-induced liver fibrosis: A mechanistic approach
Adel, N., Mantawy, E. M., Elsherbiny, D. A., & El‐Demerdash, E. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114748 · Cited by 19
Biliverdin reductase deficiency triggers an endothelial-to-mesenchymal transition in human endothelial cells
Klóska, D., Kopacz, A., Piechota-Polańczyk, A., Neumayer, C., Huk, I., Dulak, J., Józkowicz, A., & Grochot‐Przeczek, A. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.108182 · Cited by 18
Effect of procyanidins on lipid metabolism and inflammation in rats exposed to alcohol and iron
Lobo, A., Liu, Y., Song, Y., Liu, S., Zhang, R., Liang, H., & Xin, H. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04847 · Cited by 18
Relationship between hepcidin and oxidant/antioxidant status in calves with suspected neonatal septicemia
ERKILIÇ, E. E., ERDOĞAN, H. M., Ogun, M., KIRMIZIGÜL, A. H., GÖKÇE, E., Kuru, M., & Kükürt, A. (2016) · Veterinary World · doi:10.14202/vetworld.2016.1238-1241 · Cited by 17
Construction of an AuHQ nano-sensitizer for enhanced radiotherapy efficacy through remolding tumor vasculature
Wang, X., Niu, X., Zhang, X., Zhang, Z., Gao, X., Wang, W., & Yuan, Z. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00515d · Cited by 18
Liver Toxicity of Thioacetamide is Increased by Hepatocellular Iron Overload
Ackerman, Z., Pappo, O., Link, G., Glazer, M., & Grozovski, M. (2014) · Biological Trace Element Research · doi:10.1007/s12011-014-0110-9 · Cited by 17
Acute Free-Iron Exposure Does Not Explain the Impaired Haemorheology Associated with Haemochromatosis
McNamee, A. P., Sabapathy, S., Singh, I., Horobin, J. T., Guerrero, J., & Simmonds, M. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146448 · Cited by 18
Protective Effect of Aplysin Supplementation on Intestinal Permeability and Microbiota in Rats Treated with Ethanol and Iron
Ma, Y., Li, R., Liu, Y., Liu, M., & Liang, H. W. (2018) · Nutrients · doi:10.3390/nu10060681 · Cited by 16
Haem oxygenases play a pivotal role in placental physiology and pathology
Peoc’h, K., Puy, V., & Fournier, T. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa014 · Cited by 16
Alpha lipoic acid attenuates iron induced oxidative acute kidney injury in rats
Çavdar, Z., Oktan, M. A., Ural, C., Koçak, A., Çalışır, M., Heybeli, C., Yıldız, S., Özbal, S., Arslan, Ş., Ergür, B. U., et al. (2020) · Biotechnic & Histochemistry · doi:10.1080/10520295.2020.1812001 · Cited by 16
“NTBI is toxic, because it catalyzes generation of free hydroxyl radicals, which are reactive oxygen species (ROS), via the HaberWeiss and Fenton reaction (Galaris and Pantopoulos 2008).”
Background
Hydrogen Peroxide Cycling in High-Temperature Acidic Geothermal Springs and Potential Implications for Oxidative Stress Response
Meslé, M., Beam, J. P., Jay, Z. J., Bodle, B., Bogenschutz, E., & Inskeep, W. P. (2017) · Frontiers in Marine Science · doi:10.3389/fmars.2017.00130 · Cited by 16
The heme-binding protein HbpS regulates the activity of the Streptomyces reticuli iron-sensing histidine kinase SenS in a redox-dependent manner
Bogel, G., Schrempf, H., & Lucana, D. O. D. O. (2008) · Amino Acids · doi:10.1007/s00726-008-0188-5 · Cited by 16
“However, iron is also potentially toxic in the presence of oxygen ( Galaris and Pantopoulos 2008 ).”
Background
Iron overload triggering ECM-mediated Hippo/YAP pathway in follicle development: a hypothetical model endowed with therapeutic implications
Xia, L., Shen, Y., Liu, S., & Du, J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1174817 · Cited by 17
High-Grade Serous Ovarian Cancer—A Risk Factor Puzzle and Screening Fugitive
Wilczyński, J. R., Paradowska, E., & Wilczyński, M. (2024) · Biomedicines · doi:10.3390/biomedicines12010229 · Cited by 15
“The hephaestin gene ( HEPH ) encoding the protein responsible for iron transport regulates the proliferation and apoptosis of cancer cells and facilitates reactive oxygen species (ROS) production [33].”
Background
Hepatic Steatosis Is Associated with Elevated Serum Iron in Patients with Obesity and Improves after Laparoscopic Sleeve Gastrectomy
Ma, B., Sun, H., Zhu, B., Wang, S., Du, L., Wang, X., & Qu, S. (2020) · Obesity Facts · doi:10.1159/000511736 · Cited by 15
Iron overload reduces adiponectin receptor expression via a ROS/FOXO1‐dependent mechanism leading to adiponectin resistance in skeletal muscle cells
Dahyaleh, K., Sung, H. K., Prioriello, M., Palanivel, R., Lam, N. H., Kim, J. B., Gross, S. M., & Sweeney, G. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30240 · Cited by 15
The iron transporter Transferrin 1 mediates homeostasis of the endosymbiotic relationship between Drosophila melanogaster and Spiroplasma poulsonii
Marra, A., Masson, F., & Lemaître, B. (2021) · microLife · doi:10.1093/femsml/uqab008 · Cited by 15
“effect lies in the ability of free iron to produce reactive oxygen species through the Fenton reaction, with deleterious consequences on cells (Galaris and Pantopoulos 2008; Li et al. 2016).”
Background
Ovaries of estrogen receptor 1-deficient mice show iron overload and signs of aging
Schröder, S. K., Krizanac, M., Kim, P., Kessel, J. C., & Weiskirchen, R. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1325386 · Cited by 14
“An imbalance in iron homeostasis leads to tissue iron overload that in turn is capable to catalyze redox reactions, resulting in accumulation of toxic lipid peroxides that negatively affect folliculogenesis (28, 29).”
Background
Protective effects of protocatechuic acid on retinal ganglion cells from oxidative damage induced by H2O2
Wang, Z., Pan, X., Wang, D., Sun, H., Han, F., Lv, C., & Zhang, X. (2014) · Neurological Research · doi:10.1179/1743132814y.0000000421 · Cited by 14
Salsolinol, a catechol neurotoxin, induces oxidative modification of cytochrome c
Kang, J. H. (2013) · BMB Reports · doi:10.5483/bmbrep.2013.46.2.220 · Cited by 14
Effects of short time UV-A exposures on compound eyes and haematological parameters in Procambarus clarkii (Girad, 1852)
El-Bakary, Z., & Sayed, A. E. H. (2011) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2011.01.010 · Cited by 13
“The mechanisms, underlying the role of iron in oxidative stress remain obscure (Galaris and Pantopoulos, 2008), and the understanding of the biology of iron and clarification of the molecular mechanisms of iron-mediated effects in cases of oxidative stressinduced signalling and toxicity in crustacea also need more inv…”
Background
Effects of a moderate iron overload and its interaction with yacon flour, and/or phytate, in the diet on liver antioxidant enzymes and hepatocyte apoptosis in rats
Cocato, M. L., Lobo, A. R., Azevedo‐Martins, A. K., Filho, J. M., de Sá, L. R. M., & Colli, C. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.01.142 · Cited by 13
Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism
Yamauchi, A., Kamiyoshi, A., Sakurai, T., Miyazaki, H., Hirano, E., Lim, H.-S., Kaku, T., & Shindo, T. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e01637 · Cited by 13
“In NAFLD, iron potentiates the onset and progression of the disease by increasing ROS and altering insulin signaling and lipid metabolism, and is thought to be involved in the transition of NAFLD to NASH [24].”
BackgroundInfluential
Structural comparison of two ferritins from the marine invertebrate Phascolosoma esculenta
Ming, T., Huan, H., Su, C., Huo, C., Wu, Y., Jiang, Q., Qiu, X., Lu, C., Zhou, J., Li, Y., et al. (2021) · FEBS Open Bio · doi:10.1002/2211-5463.13080 · Cited by 13
Effect of Iron Supplementation on the Expression of Hypoxia-Inducible Factor and Antioxidant Status in Rats Exposed to High-Altitude Hypoxia Environment
Xu, C., Dong, C., Xu, C., Han, T., Bao, S., & Gao, X. (2014) · Biological Trace Element Research · doi:10.1007/s12011-014-0166-6 · Cited by 13
Proteomic Profiling of Iron Overload-Induced Human Hepatic Cells Reveals Activation of TLR2-Mediated Inflammatory Response
Li, X., Li, S., Lu, M., Yang, G., Shen, Y., & Zhou, X. (2016) · Molecules · doi:10.3390/molecules21030322 · Cited by 13
Modification of hepatic iron metabolism induced by pravastatin during obstructive cholestasis in rats
Kolouchová, G., Doleželová, E., Hirsova, P., Cermanová, J., Fuksa, L., Mokrý, J., Nachtigal, P., Laštůvková, H., & Mičuda, S. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.08.014 · Cited by 13
Ferroptosis: Therapeutic Potential and Strategies in Non-Small Cell Lung Cancer
Lei, Y., Jiang, S., Kong, C., Pang, P., & Shan, H. (2025) · Biology · doi:10.3390/biology14050545 · Cited by 12
“Iron functions as a crucial cofactor involved in various cellular metabolic and physiological processes [10]. processes [10].”
Hepcidin as a key regulator of iron homeostasis triggers inflammatory features in the normal endometrium
Izumi, Y., Kataoka, H., Koshiba, A., Ito, F., Tanaka, Y., Takaoka, O., Maeda, E., Okimura, H., Sugahara, T., Tarumi, Y., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.10.402 · Cited by 12
Iron Oxide Nanoparticle-Induced Neoplastic-Like Cell Transformation in Vitro Is Reduced with a Protective Amorphous Silica Coating
Kornberg, T. G., Stueckle, T. A., Coyle, J. P., Derk, R. C., Demokritou, P., Rojanasakul, Y., & Rojanasakul, L. W. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00118 · Cited by 12
Excess iron undermined bone load-bearing capacity through tumor necrosis factor-α-dependent osteoclastic activation in mice
Li, J., HOU, Y., Zhang, S., Ji, H. L., Rong, H., Qu, G., & Liu, S. (2012) · Biomedical Reports · doi:10.3892/br.2012.6 · Cited by 13
Nanodrug Delivery Systems for Myasthenia Gravis: Advances and Perspectives
Huang, J., Zhao, Y., Song, Y., & Chen, T. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16050651 · Cited by 11
“The rest is mainly found in the liver and skeletal muscle, and other tissues only contain minimal levels of iron [97].”
Background
Mitochondrial dysfunction: the hidden catalyst in chronic kidney disease progression
Chen, J., Zhou, Q., Su, L., & Ni, L. (2025) · Renal Failure · doi:10.1080/0886022x.2025.2506812 · Cited by 11
“…of iron-sulfur clusters and heme, iron also participates in redox reactions, shuttling between its oxidized form (fe 3+ ) and reduced form (fe 2+ ) [98]. in mitochondria, a sufficient quantity of iron is necessary to maintain its normal physiological functions. while iron deficiency can impair…”

Authors: Galaris, D., & Pantopoulos, K.
Affiliations: University of Ioannina (GR)
Lady Davis Institute for Medical Research (CA)
ORCID: Pantopoulos, Kostas
Venue: Critical Reviews in Clinical Laboratory Sciences
Publisher: Informa UK Limited
Published: 2008-01
Volume: 45
Issue: 1
Pages: 1-23
ISSN: 1040-8363 (ISSN-L)
1549-781X
DOI: 10.1080/10408360701713104
OpenAlex: W2094776609
Cited by: 352
References: 145
Citations by year: 2026: 9 · 2025: 17 · 2024: 17 · 2023: 19 · 2022: 22 · 2021: 16 · 2020: 22 · 2019: 22 · 2018: 18 · 2017: 16 · 2016: 21 · 2015: 19 · 2014: 16 · 2013: 25 · 2012: 22
FWCI: 3.06
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Clinical Laboratory Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Keywords: iron homeostasis, oxidative stress, reactive oxygen species, iron overload, iron toxicity, iron bioavailability, iron accumulation
MeSH terms: Animals, Homeostasis, Humans, Iron, Iron Chelating Agents, Liver, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Iron Overload

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oxidative Stress and Iron Homeostasis: Mechanistic and Health Aspects

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks