Cited by 352Iron Metabolism and DisordersTrace Elements in HealthFerroptosis and cancer prognosis

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Oxidative Stress and Iron Homeostasis: Mechanistic and Health Aspects

Galaris, Dimitrios, Pantopoulos, Kostas·2008·Critical Reviews in Clinical Laboratory Sciences

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Abstract

Iron is an essential cofactor for important biological activities and biochemical reactions, including the transport of oxygen via red blood cells and its reduction to water during respiration. While iron's bioavailability is generally limited, pathological accumulation of the metal within tissues aggravates the generation of reactive oxygen species (ROS) and elicits toxic effects, which are mainly related to oxidative stress. Here, we describe the role of iron in ROS-induced toxicity and discuss molecular mechanisms and physiological aspects of ROS- and iron-mediated signaling. In addition, we review our current understanding of the regulation of iron homeostasis at the cellular and systemic levels, and focus on the pathogenesis and management of iron overload disorders.

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Authors: Galaris, D., & Pantopoulos, K.
Affiliations: University of Ioannina (GR)
Lady Davis Institute for Medical Research (CA)
ORCID: Pantopoulos, Kostas
Venue: Critical Reviews in Clinical Laboratory Sciences
Publisher: Informa UK Limited
Published: 2008-01
Volume: 45
Issue: 1
Pages: 1-23
ISSN: 1040-8363 (ISSN-L)
1549-781X
DOI: 10.1080/10408360701713104
OpenAlex: W2094776609
Cited by: 352
References: 145
Citations by year: 2026: 9 · 2025: 17 · 2024: 17 · 2023: 19 · 2022: 22 · 2021: 16 · 2020: 22 · 2019: 22 · 2018: 18 · 2017: 16 · 2016: 21 · 2015: 19 · 2014: 16 · 2013: 25 · 2012: 22
FWCI: 3.06
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Clinical Laboratory Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Keywords: iron homeostasis, oxidative stress, reactive oxygen species, iron overload, iron toxicity, iron bioavailability, iron accumulation
MeSH terms: Animals, Homeostasis, Humans, Iron, Iron Chelating Agents, Liver, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Iron Overload

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Oxidative Stress and Iron Homeostasis: Mechanistic and Health Aspects

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