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Cited by 378Vitamin D Research StudiesNutrition and Health StudiesAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record, with a small difference in title or year; 104 of the 104 references it cites were found in a registry or an index.

Vitamin D Bioavailability: State of the Art

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Borel, P., Caillaud, D., Cano, N. J.·2015·Critical Reviews in Food Science and Nutrition
DOI 10.1080/10408398.2012.688897
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Abstract

There has been renewed interest in vitamin D since numerous recent studies have suggested that besides its well-established roles in bone metabolism and immunity, vitamin D status is inversely associated with the incidence of several diseases, e.g., cancers, cardio-vascular diseases, and neurodegenerative diseases. Surprisingly, there is very little data on factors that affect absorption of this fat-soluble vitamin, although it is acknowledged that dietary vitamin D could help to fight against the subdeficient vitamin D status that is common in several populations. This review describes the state of the art concerning the fate of vitamin D in the human upper gastrointestinal tract and on the factors assumed to affect its absorption efficiency. The main conclusions are: (i) ergocalciferol (vitamin D2), the form mostly used in supplements and fortified foods, is apparently absorbed with similar efficiency to cholecalciferol (vitamin D3, the main dietary form), (ii) 25-hydroxyvitamin D (25OHD), the metabolite produced in the liver, and which can be found in foods, is better absorbed than the nonhydroxy vitamin D forms cholecalciferol and ergocalciferol, (iii) the amount of fat with which vitamin D is ingested does not seem to significantly modify the bioavailability of vitamin D3, (iv) the food matrix has apparently little effect on vitamin D bioavailability, (v) sucrose polyesters (Olestra) and tetrahydrolipstatin (orlistat) probably diminish vitamin D absorption, and (vi) there is apparently no effect of aging on vitamin D absorption efficiency. We also find that there is insufficient, or even no data on the following factors suspected of affecting vitamin D bioavailability: (i) effect of type and amount of dietary fiber, (ii) effect of vitamin D status, and (iii) effect of genetic variation in proteins involved in its intestinal absorption. In conclusion, further studies are needed to improve our knowledge of factors affecting vitamin D absorption efficiency. Clinical studies with labeled vitamin D, e.g., deuterated or (13)C, are needed to accurately and definitively assess the effect of various factors on its bioavailability.

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Research works printed but not linked: 14

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Metadata

Authors
Borel, P., Caillaud, D., & Cano, N. J.
Affiliations
  • Inserm (FR)
  • Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
  • Université Clermont Auvergne (FR)
Corresponding author
Borel, P.
ORCID
Venue
Critical Reviews in Food Science and Nutrition
Publisher
Informa UK Limited
Published
2013-10-02
Volume
55
Issue
9
Pages
1193-1205
ISSN
  • 1040-8398 (ISSN-L)
  • 1549-7852
DOI
10.1080/10408398.2012.688897
OpenAlex
W2029625174
Cited by
378
References
104
Citations by year
2026: 30 · 2025: 48 · 2024: 47 · 2023: 55 · 2022: 41 · 2021: 42 · 2020: 31 · 2019: 25 · 2018: 25 · 2017: 13 · 2016: 12 · 2015: 7 · 2014: 2
FWCI
5.22
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Critical Reviews in Food Science and Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords
vitamin D bioavailability, vitamin D absorption, upper gastrointestinal tract, vitamin D3, vitamin D2, 25-hydroxyvitamin D, fat-soluble vitamins, dietary fat, food matrix, olestra, orlistat, aging, dietary fiber, intestinal absorption, vitamin D status
MeSH terms
Orlistat, Aging, Biological Availability, Cholecalciferol, Ergocalciferols, Fatty Acids, Food, Fortified, Humans, Intestinal Absorption, Lactones, Risk Factors, Sucrose, Vitamin D, Dietary Supplements

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