The DOI matches its Crossref record; 184 of the 184 references it cites were found in a registry or an index.
Dietary Nitrate, Nitric Oxide, and Cardiovascular Health
Open accessAbstract
Emerging evidence strongly suggests that dietary nitrate, derived in the diet primarily from vegetables, could contribute to cardiovascular health via effects on nitric oxide (NO) status. NO plays an essential role in cardiovascular health. It is produced via the classical L-arginine-NO-synthase pathway and the recently discovered enterosalivary nitrate-nitrite-NO pathway. The discovery of this alternate pathway has highlighted dietary nitrate as a candidate for the cardioprotective effect of a diet rich in fruit and vegetables. Clinical trials with dietary nitrate have observed improvements in blood pressure, endothelial function, ischemia-reperfusion injury, arterial stiffness, platelet function, and exercise performance with a concomitant augmentation of markers of NO status. While these results are indicative of cardiovascular benefits with dietary nitrate intake, there is still a lingering concern about nitrate in relation to methemoglobinemia, cancer, and cardiovascular disease. It is the purpose of this review to present an overview of NO and its critical role in cardiovascular health; to detail the observed vascular benefits of dietary nitrate intake through effects on NO status as well as to discuss the controversy surrounding the possible toxic effects of nitrate.
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“Depending on agronomic and storage conditions, it is also one of the richest dietary sources of inorganic nitrate (250–400 mg/100 g fresh weight) [80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [88]
In the citing paper
“Epidemiological and clinical data link the intake of vegetable-derived nitrates with reduced arterial stiffness, lower platelet aggregation, and protection against ischaemia-reperfusion injury. These effects are influenced by dose, microbiome integrity, and redox status [88,89].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [88]
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Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
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Nitrate and Nitrites in Foods: Worldwide Regional Distribution in View of Their Risks and Benefits
Kalaycıoğlu, Z., & Erim, F. B. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b01194 · Cited by 140
Nitric oxide and its derivatives in the cancer battlefield
Kamm, A., Przychodzen, P., Kuban-Jankowska, A., Jacewicz, D., Dabrowska, A. M., Nussberger, S., Wozniak, M., & Gorska-Ponikowska, M. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.09.005 · Cited by 120
Cardiovascular Health Benefits of Specific Vegetable Types: A Narrative Review
Blekkenhorst, L. C., Sim, M., Bondonno, C. P., Bondonno, N. P., Ward, N. C., Prince, R. L., Devine, A., Lewis, J. R., & Hodgson, J. M. (2018) · Nutrients · doi:10.3390/nu10050595 · Cited by 125
Self-citationPolyphenols Regulate Endothelial Functions and Reduce the Risk of Cardiovascular Disease
Yamagata, K. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190722100504 · Cited by 116
Varadharaj, S., Kelly, O. J., Khayat, R. N., Kumar, P. S., Ahmed, N., & Zweier, J. L. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00064 · Cited by 101
Metadata
- Authors
- Bondonno, C. P., Croft, K. D., & Hodgson, J. M.
- Affiliations
- The University of Western Australia (AU)
- Corresponding author
- Bondonno, Catherine P.
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2016-06-27
- Volume
- 56
- Issue
- 12
- Pages
- 2036-2052
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W260652415
- Cited by
- 141
- References
- 183
- Citations by year
- 2026: 17 · 2025: 15 · 2024: 14 · 2023: 18 · 2022: 19 · 2021: 13 · 2020: 14 · 2019: 7 · 2018: 10 · 2017: 8 · 2016: 5
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion)
- UWA Profiles and Research Repository (UWA) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Keywords
- dietary nitrate, nitric oxide, cardiovascular health, blood pressure, endothelial function, arterial stiffness, platelet function, exercise performance, ischemia-reperfusion injury, methemoglobinemia, nitrate toxicity, cancer risk, fruit and vegetable intake
- MeSH terms
- Arginine, Cardiovascular System, Diet, Fruit, Health Promotion, Humans, Nitrates, Nitric Oxide, Vegetables, Nitric Oxide Synthase
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