Conjugated linoleic acid: A potent fatty acid linked to animal and human health
Abstract
Conjugated linoleic acid (CLA) is a mixture of isomers of linoleic acid (C18:2 n-6), which is mostly found in the ruminant meat and dairy products. The CLA is known to have many potential health benefits, and considered a potent powerful fatty acid, which is linked to animal and human health. The present work aims to discuss the source and production, mechanism of action, and effects of CLA on humans, poultry, and ruminants by reviewing the recent studies carried out on CLA. Despite most of the recent studies indicating beneficial effects of CLA on improving body weight control parameters, its effects on reducing risk factors of cardiovascular diseases (CVD), inflammation, blood glucose, and insulin are still controversial, and need to be further studied in different hosts.
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The t10,c12 isomer has the most potent effect of CLA in preventing cell proliferation and inducing apoptosis in cancer cells.
“This isomer is known to have the most potent effect of CLA in preventing cell proliferation and inducing apoptosis in cancer cells [256].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [256]
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- Authors
- Shokryazdan, P., Rajion, M. A., Meng, G. Y., Boo, L. J., Ebrahimi, M., Royan, M., Sahebi, M., Azizi, P., Abiri, R., & Jahromi, M. F.
- Affiliations
- Universiti Putra Malaysia (MY)
- Agricultural Biotechnology Research Institute of Iran (IR)
- Corresponding author
- Rajion, Mohamed Ali
- ORCID
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2015-08-07
- Volume
- 57
- Issue
- 13
- Pages
- 2737-2748
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W1952903824
- Cited by
- 82
- References
- 124
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 12 · 2023: 9 · 2022: 5 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 3 · 2016: 1
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) (acceptedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Meat and Animal Product Quality
- Keywords
- conjugated linoleic acid, linoleic acid isomers, ruminant meat, dairy products, weight management, cardiovascular risk factors, inflammation, blood glucose, insulin, poultry, ruminants, human health effects
- MeSH terms
- Animals, Dairy Products, Fatty Acids, Food Handling, Humans, Insulin Resistance, Meat, Nutritive Value, Linoleic Acids, Conjugated
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