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Cited by 42Natural Antidiabetic Agents StudiesMedicinal Plant ResearchBerberine and alkaloids research

Anti-diabesity middle eastern medicinal plants and their action mechanisms

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Saad, Bashar, Kmail, Abdalsalam, Haq, Sameena Z. H.·2022·Evidence-Based Complementary and Alternative Medicine
DOI 10.1155/2022/2276094PMC PMC9313926
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Abstract

Over the last four decades, the escalation in diabetes and obesity rates has become epidemic all over the world. Diabesity describes the strong link between T2D and obesity. It correlates deeper with the elevated risks of developing cardiovascular disease hypertension, stroke, and several malignancies. Therapeutic usage of medicinal plants and natural products in the treatment of diabetes and obesity has long been known to physicians of Greco-Arab and Islamic medicine. Improved versions of their abundant medicinal plant-based formulations are at present some of the most popular herbal treatments used. Preclinical and clinical data about medicinal plants along with their bioactive constituents are now available, justifying the traditionally known therapeutic uses of products derived from them for the prevention and cure of obesity-related T2D and other health problems. The aim of this review is to systematize published scientific data dealing with the efficiency of active ingredients or extracts from Middle Eastern medicinal plants and diet in the management of diabesity and its complications. Google Scholar, MEDLINE, and PubMed were searched for publications describing the medicinal plants and diet used in the management of T2D, obesity, and their complications. The used keywords were “medicinal plants” or “herbals” in combination with “obesity,” “diabetes,” “diabetes,” or nephropathy. More than 130 medicinal plants were identified to target diabesity and its complications. The antidiabetic and anti-obesity effects and action mechanisms of these plants are discussed here. These include the regulation of appetite, thermogenesis, lipid absorption, and lipolysis; pancreatic lipase activity and adipogenesis; glucose absorption in the intestine, insulin secretion, glucose transporters, gluconeogenesis, and epigenetic mechanisms.

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  • Herbals/botanicals have demonstrated potent anti-diabetic effects via a variety of mechanisms, such as enhancing insulin sensitivity, stimulating insulin secretion, blocking carbohydrate absorption, and reducing oxidative stress.

    “Herbals/botanicals have demonstrated potent anti-diabetic effects via a variety of mechanisms, such as enhancing insulin sensitivity, stimulating insulin secretion, blocking the absorption of carbohydrates, and reducing OS; the inhibition of α-glucosidase enzyme and the generation of advanced glycation products, the transcription of GLUT-4 and PPAR, and the presence of antioxidants.”

    From A critical review on diabetes mellitus type 1 and type 2 management approaches: from lifestyle modification to current and novel targets and therapeutic agents. (2024) · cites this paper as [136]

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Cited by

Sorted by citations

Authors
Saad, B., Kmail, A., & Haq, S. Z. H.
Affiliations
  • Al-Qasemi Academic College of Education (IL)
  • Arab American University (PS)
  • Foundation for Science Technology and Civilisation (GB)
Corresponding author
Saad, Bashar
ORCID
Venue
Evidence-Based Complementary and Alternative Medicine
Publisher
Wiley
Published
2022-07-18
Volume
2022
Pages
1-21
ISSN
  • 1741-427X (ISSN-L)
  • 1741-4288
DOI
10.1155/2022/2276094
PMC
PMC9313926
OpenAlex
W4285801060
Cited by
42
References
12
Citations by year
2026: 5 · 2025: 9 · 2024: 12 · 2023: 13 · 2022: 3
FWCI
1.32
Type
journal article
Language
en
Open access
Licence
Locations
  • Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
Keywords
diabesity, type 2 diabetes, obesity, herbal medicine, antidiabetic mechanism, anti-obesity mechanisms, diabetic nephropathy, thermogenesis, lipolysis, adipogenesis, insulin secretion, glucose transporters, gluconeogenesis, epigenetic mechanisms, pancreatic lipase, appetite regulation, fat absorption

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