The DOI matches its Crossref record, with a small difference in title or year; 115 of the 115 references it cites were found in a registry or an index.
How important is tryptophan in human health?
Abstract
Tryptophan (Trp) is an amino acid and an essential component of the human diet. It plays a crucial role in many metabolic functions. Clinicians can use Trp levels in the course of diagnosing various metabolic disorders and the symptoms associated with those diseases. Furthermore, supplementation with this amino acid is considered in the treatment of depression and sleep disorders, mainly due to the Trp relationship with the synthesis of serotonin (5-HT) and melatonin. It is also used in helping to resolve cognitive disorders, anxiety, or neurodegenerative diseases. Reduced secretion of serotonin is associated with autism spectrum disorder, obesity, anorexia and bulimia nervosa, and other diseases presenting peripherals symptoms. The literature strongly suggests that Trp has a significant role in the correct functionality of the brain-gut axis and immunology. This information leads to the consideration of Trp as an essential dietary component due to its role in the serotonin pathway. A reduced availability of Trp in diet and nutraceutical supplementation should be considered with greater concern than one might expect. This paper constitutes a review of the more salient aspects gleaned from the current knowledge base about the role of Trp in diseases, associated nutritional disorders, and food science, in general.
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Sorted by citations
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Metadata
- Authors
- Kałużna-Czaplińska, J., Gątarek, P., Chirumbolo, S., Chartrand, M. S., & Bjørklund, G.
- Affiliations
- Department of Chemistry, Institute of General and Ecological Chemistry, Lodz University of Technology, Lodz, Poland
- Lodz University of Technology (PL)
- University of Verona (IT)
- DigiCare Behavioral Research, Casa Grande, AZ, USA
- Council for Nutritional and Environmental Medicine (NO)
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2017-09
- Volume
- 59
- Issue
- 1
- Pages
- 72-88
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W2743825815
- Cited by
- 333
- References
- 115
- Citations by year
- 2026: 31 · 2025: 57 · 2024: 73 · 2023: 49 · 2022: 53 · 2021: 27 · 2020: 25 · 2019: 6 · 2018: 12
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- tryptophan, essential amino acids, serotonin synthesis, melatonin, depression, sleep disorders, autism spectrum disorder, obesity, eating disorders, gut-brain axis, neurodegenerative diseases, anxiety, nutraceutical supplementation, tryptophan deficiency, dietary intake
- MeSH terms
- Diet, Food Analysis, Humans, Serotonin, Tryptophan, Dietary Supplements
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