Cited by 333Tryptophan and brain disordersAmino Acid Enzymes and MetabolismFatty Acid Research and Health

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How important is tryptophan in human health?

Kałużna-Czaplińska, Joanna, Gątarek, Paulina, Chirumbolo, Salvatore, Chartrand, Max Stanley, Bjørklund, Geir·2019·Critical Reviews in Food Science and Nutrition

DOI 10.1080/10408398.2017.1357534

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Abstract

Tryptophan (Trp) is an amino acid and an essential component of the human diet. It plays a crucial role in many metabolic functions. Clinicians can use Trp levels in the course of diagnosing various metabolic disorders and the symptoms associated with those diseases. Furthermore, supplementation with this amino acid is considered in the treatment of depression and sleep disorders, mainly due to the Trp relationship with the synthesis of serotonin (5-HT) and melatonin. It is also used in helping to resolve cognitive disorders, anxiety, or neurodegenerative diseases. Reduced secretion of serotonin is associated with autism spectrum disorder, obesity, anorexia and bulimia nervosa, and other diseases presenting peripherals symptoms. The literature strongly suggests that Trp has a significant role in the correct functionality of the brain-gut axis and immunology. This information leads to the consideration of Trp as an essential dietary component due to its role in the serotonin pathway. A reduced availability of Trp in diet and nutraceutical supplementation should be considered with greater concern than one might expect. This paper constitutes a review of the more salient aspects gleaned from the current knowledge base about the role of Trp in diseases, associated nutritional disorders, and food science, in general.

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Authors: Kałużna-Czaplińska, J., Gątarek, P., Chirumbolo, S., Chartrand, M. S., & Bjørklund, G.
Affiliations: Department of Chemistry, Institute of General and Ecological Chemistry, Lodz University of Technology, Lodz, Poland
Lodz University of Technology (PL)
University of Verona (IT)
DigiCare Behavioral Research, Casa Grande, AZ, USA
Council for Nutritional and Environmental Medicine (NO)
ORCID: Gątarek, Paulina
Chirumbolo, Salvatore
Chartrand, Max Stanley
Bjørklund, Geir
Venue: Critical Reviews in Food Science and Nutrition
Publisher: Informa UK Limited
Published: 2017-09
Volume: 59
Issue: 1
Pages: 72-88
ISSN: 1040-8398 (ISSN-L)
1549-7852
DOI: 10.1080/10408398.2017.1357534
OpenAlex: W2743825815
Cited by: 333
References: 115
Citations by year: 2026: 31 · 2025: 57 · 2024: 73 · 2023: 49 · 2022: 53 · 2021: 27 · 2020: 25 · 2019: 6 · 2018: 12
FWCI: 0.79
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Food Science and Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords: tryptophan, essential amino acids, serotonin synthesis, melatonin, depression, sleep disorders, autism spectrum disorder, obesity, eating disorders, gut-brain axis, neurodegenerative diseases, anxiety, nutraceutical supplementation, tryptophan deficiency, dietary intake
MeSH terms: Diet, Food Analysis, Humans, Serotonin, Tryptophan, Dietary Supplements

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