The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Polyphenols and bioavailability: an update
Abstract
Based on many cell culture, animal and human studies, it is well known that the most challenge issue for developing polyphenolics as chemoprevention or anti-diabtetic agents is the low oral bioavailability, which may be the major reason relating to its ambiguous therapeutic effects and large inter-individual variations in clinical trials. This review intends to highlight the unscientific evaluation on the basis of the published data regarding in vitro bioactivity of polyphenols, which may sometimes mislead the researchers and to conclude that: first, bio-accessibilities values obtained in the studies for polyphenols should be highly reconsidered in accordance with the abundant newly identified circulating and excreted metabolites, with a particular attention to colonic metabolic products which are obviously contributing much more than expected to their absorptions; second, it is phenolic metabolites, which are formed in the small intestine and hepatic cells,low molecular weight catabolic products of the colonic microflora to travel around the human body in the circulatory system or reach body tissues to elicit bioactive effects. It is concluded that better performed in vivo intervention and in vitro mechanistic studies are needed to fully understand how these molecules interact with human physiological and pathological processes.
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Cites
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Bioavailability of bioactive food compounds: a challenging journey to bioefficacy
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Daidzein Is a More Bioavailable Soymilk Isoflavone than Is Genistein in Adult Women
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Cited by
Future Antimicrobials: Natural and Functionalized Phenolics
Lobiuc, A., Pavăl, N.-E., Mangalagiu, I. I., Gheorghiță, R., Teliban, G.-C., Amăriucăi-Mantu, D., & Stoleru, V. (2023) · Molecules · doi:10.3390/molecules28031114 · Cited by 418
Caloric Restriction Mimetics in Nutrition and Clinical Trials
Hofer, S. J., Davinelli, S., Bergmann, M., Scapagnini, G., & Madeo, F. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.717343 · Cited by 109
Tanaka, M., Araujo, A. C., Valenti, V. E., Guiguer, E. L., Catharin, V. C. S., Gualhardi, C. M., de Souza Bastos Mazuqueli Pereira, E., de Alvares Goulart, R., de Argolo Haber, R. S., de Carvalho, A. C. A., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052370 · Cited by 13
Metadata
- Authors
- Teng, H., & Chen, L.
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2019-01-07
- Volume
- 59
- Issue
- 13
- Pages
- 2040-2051
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W2789509184
- Cited by
- 336
- References
- 68
- FWCI
- 16.82
- Type
- journal article
- Language
- en
- Open access
- closed
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