Cited by 1,854Tea Polyphenols and EffectsPhytochemicals and Antioxidant ActivitiesCoffee research and impacts

The DOI matches its Crossref record.

Tea Catechins and Polyphenols: Health Effects, Metabolism, and Antioxidant Functions

Higdon, Jane V., Frei, Balz·2003·Critical Reviews in Food Science and Nutrition

Open this paper in CoChat — free account

Abstract

Increasing interest in the health benefits of tea has led to the inclusion of tea extracts in dietary supplements and functional foods. However, epidemiologic evidence regarding the effects of tea consumption on cancer and cardiovascular disease risk is conflicting. While tea contains a number of bioactive chemicals, it is particularly rich in catechins, of which epigallocatechin gallate (EGCG) is the most abundant. Catechins and their derivatives are thought to contribute to the beneficial effects ascribed to tea. Tea catechins and polyphenols are effective scavengers of reactive oxygen species in vitro and may also function indirectly as antioxidants through their effects on transcription factors and enzyme activities. The fact that catechins are rapidly and extensively metabolized emphasizes the importance of demonstrating their antioxidant activity in vivo. In humans, modest transient increases in plasma antioxidant capacity have been demonstrated following the consumption of tea and green tea catechins. The effects of tea and green tea catechins on biomarkers of oxidative stress, especially oxidative DNA damage, appear very promising in animal models, but data on biomarkers of in vivo oxidative stress in humans are limited. Larger human studies examining the effects of tea and tea catechin intake on biomarkers of oxidative damage to lipids, proteins, and DNA are needed.

Integrity signals

Registry

Crossref · 10.1080/10408690390826464

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 801–900 of 999

Tea Phenols in Bulk and Nanoparticle Form Modify DNA Damage in Human Lymphocytes From Colon Cancer Patients and Healthy Individuals Treated In Vitro with Platinum-Based Chemotherapeutic Drugs
Alotaibi, A., Bhatnagar, P., Najafzadeh, M., et al. (2012) · Nanomedicine · doi:10.2217/nnm.12.126 · Cited by 32
Redox Modulations, Antioxidants, and Neuropsychiatric Disorders
Fraunberger, E. A., Scola, G., Laliberte, V. L. M., Duong, A., & Andreazza, A. C. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4729192 · Cited by 36
In Vitro Effects of Tea Polyphenols on Redox Metabolism, Oxidative Stress, and Apoptosis in PC12 Cells
Raza, H., & John, A. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1414.037 · Cited by 32
Metabogenic and Nutriceutical Approaches to Address Energy Dysregulation and Skeletal Muscle Wasting in Duchenne Muscular Dystrophy
Rybalka, E., Timpani, C. A., Stathis, C. G., Hayes, A., & Cooke, M. B. (2015) · Nutrients · doi:10.3390/nu7125498 · Cited by 31
“Made from unfermented leaves, green tea is rich in catechins polyphenols of which epigallocatechin gallate (EGCG) is the most abundant (30%–50% of total polyphenols) [169].”
Background
Investigating the Hydrogen Peroxide Quenching Capacity of Proteins in Polyphenol-Rich Foods
Zhou, L., & Elias, R. J. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201491k · Cited by 32
Introduction to the Proceedings of the Third International Scientific Symposium on Tea and Human Health
Blumberg, J. B. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3244s · Cited by 32
Systemic Absorption of Catechins after Intraruminal or Intraduodenal Application of a Green Tea Extract in Cows
Wein, S., Beyer, B., Gohlke, A., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159428 · Cited by 32
“Possible beneficial health effects of green tea are being extensively investigated and have received a great deal of attention in recent times [20,9,21,22].”
Background
Nutrient composition, phenolic content and free radical scavenging activity of some uncommon vegetables of Pakistan.
Khattak, K. F. (2011) · PubMed · Cited by 32
Prooxidant Effects of the Combination of Green Tea Extract and Sodium Nitrite for Accelerating Lipolysis and Lipid Oxidation in Pepperoni during Storage
Lin, Y., Huang, M., Zhou, G., et al. (2011) · Journal of Food Science · doi:10.1111/j.1750-3841.2011.02187.x · Cited by 32
Rutin attenuates negatively charged surfactant (SDS)-induced lysozyme aggregation/amyloid formation and its cytotoxicity
Khan, M. S., Bhat, S. A., Rehman, M. T., et al. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.07.112 · Cited by 31
Role and mechanism of catechin in skeletal muscle cell differentiation
Li, P., Liu, A., Liu, C., Qu, Z., Xiao, W., Huang, J., Liu, Z., & Zhang, S. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108225 · Cited by 31
Green tea extract containing enhanced levels of epimerized catechins attenuates scopolamine-induced memory impairment in mice
Bae, H. J., Kim, J., Jeon, S. J., Kim, J., Goo, N., Jeong, Y., Cho, K., Cai, M., Jung, S. Y., Kwon, K. J., et al. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112923 · Cited by 32
A Review on Autism Spectrum Disorder: Pathogenesis, Biomarkers, Pharmacological and Non-Pharmacological Interventions
Majhi, S., Kumar, S., & Singh, L. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220428134802 · Cited by 33
N-Acetylcysteine enhances the lung cancer inhibitory effect of epigallocatechin-3-gallate and forms a new adduct
Lambert, J. D., Sang, S., & Yang, C. S. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.12.016 · Cited by 31
Thearubigins protect against acetaminophen-induced hepatic and renal injury in mice: biochemical, histopathological, immunohistochemical, and flow cytometry study
Murad, H. A. S., Habib, H., Kamel, Y., Alsayed, S. A., Shakweer, M. M., & Elshal, M. F. (2015) · Drug and Chemical Toxicology · doi:10.3109/01480545.2015.1070170 · Cited by 30
In VitroAntifungal Activity of Epigallocatechin 3-O-Gallate against Clinical Isolates of Dermatophytes
Park, B. J., Taguchi, H., Kamei, K., et al. (2011) · Yonsei Medical Journal · doi:10.3349/ymj.2011.52.3.535 · Cited by 31
Improvement of green tea polyphenol with milk on skin with respect to antioxidation in healthy adults: a double-blind placebo-controlled randomized crossover clinical trial
Chiu, H., Lin, T., Shen, Y., Venkatakrishnan, K., & Wang, C. (2015) · Food & Function · doi:10.1039/c5fo01271f · Cited by 31
Breast cancer chemopreventive and chemotherapeutic effects of Camellia Sinensis (green tea): an updated review
Rafieian‐Kopaei, M., & Movahedi, M. (2017) · Electronic physician · doi:10.19082/3838 · Cited by 31
“The major Catechins consist of: epicatechin (EC), -epicatechin-3-gallate (ECG), epigallocatechin (EGC), and epigallocatechin-3-gallate (EGCG) (36, 37).”
Background
EPIGALLOCATECHIN‐3‐GALLATE ATTENUATES CARDIAC HYPERTROPHY IN HYPERTENSIVE RATS IN PART BY MODULATION OF MITOGEN‐ACTIVATED PROTEIN KINASE SIGNALS
Chen, D., Dong, Y., Liu, D., & He, J. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05173.x · Cited by 32
“Epidemiological evidence suggests that tea consumption is associated with a reduced risk of cardiovascular disease.(4) Epigallocatechin-3-gallate (EGCG), the most abundant component in green tea, has attracted considerable attention recently for preventing oxidative stress-related diseases, including hypertension.”
Background
The role of cellular oxidoreductases in viral entry and virus infection-associated oxidative stress: potential therapeutic applications
Mathys, L., & Balzarini, J. M. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1068760 · Cited by 29
Protective effects of a catechin-rich extract on the hippocampal formation and spatial memory in aging rats
Rodrigues, J., Assunção, M., Lukoyanov, N., Cardoso, A., Carvalho, F. D., & Andrade, J. P. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.040 · Cited by 29
Pathobiology and Chemoprevention of Bladder Cancer
Tanaka, T., Miyazawa, K., Tsukamoto, T., Kuno, T., & Suzuki, K. A. O. (2011) · Journal of Oncology · doi:10.1155/2011/528353 · Cited by 30
“A transient elevation of the plasma antioxidant activity has been demonstrated with green tea intake, but no proven inhibition of carcinogenesis has yet been clearly established [162].”
Background
Development of polyphenol-enriched vacuum and atmospheric fried matrices: Evaluation of quality parameters and in vitro bioavailability of polyphenols
Dueik, V., & Bouchon, P. (2016) · Food Research International · doi:10.1016/j.foodres.2016.03.032 · Cited by 30
“Numerous epidemiologic studies have addressed the relationships between polyphenol-rich foods and beverages and the incidence of cardiovascular diseases and cancer in humans (Higdon & Frei, 2003).”
Background
Flavonoids and Cardiovascular Health
Babu, P. V. A., & Liu, D. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374228-5.00018-4 · Cited by 34
Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal SIRT1 LEVELS Improving Cognition in Aged Rats
Ramis, M. R., Sarubbo, F., Tejada, S., Jiménez-García, M., Esteban, S., Miralles, A., & Moranta, D. (2020) · Nutrients · doi:10.3390/nu12020326 · Cited by 31
Daily Coffee and Green Tea Consumption Is Inversely Associated with Body Mass Index, Body Fat Percentage, and Cardio-Ankle Vascular Index in Middle-Aged Japanese Women: A Cross-Sectional Study
Yonekura, Y., Terauchi, M., Hirose, A., et al. (2020) · Nutrients · doi:10.3390/nu12051370 · Cited by 30
The supplementation of dietary selenium yeast and green tea‐derived polyphenols improves antioxidant capacity and immune response in juvenile Wuchang bream under ammonia stress
Guo, H., Lin, W., Wang, L., et al. (2020) · Aquaculture Research · doi:10.1111/are.14724 · Cited by 30
Bio-inspired design on EGCG-selective membrane: An anchoring/imprinting strategy based on bi-interactions
Lu, J. Q., & Xu, B. (2022) · Journal of Membrane Science · doi:10.1016/j.memsci.2022.120750 · Cited by 30
Fu brick tea alleviates alcoholic liver injury by modulating the gut microbiota–liver axis and inhibiting the hepatic TLR4/NF-κB signaling pathway
Du, Y., Yang, C., Ren, D., Shao, H., Zhao, Y., & Yang, X. (2022) · Food & Function · doi:10.1039/d2fo01547a · Cited by 29
Green tea polyphenols added to IVM and IVC media affect transcript abundance, apoptosis, and pregnancy rates in bovine embryos
Wang, Z., Fu, C., & Song-dong, Y. (2012) · Theriogenology · doi:10.1016/j.theriogenology.2012.10.002 · Cited by 30
“Further, previous studies have shown that catechins have strong antioxidant activity [55,56] and are potent scavengers of ROS, e.”
Background
Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group
Aihara, Y., Yoshida, A., Furuta, T., et al. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.05.111 · Cited by 30
Antioxidant activity and inhibition of α-glucosidase by hydroxyl-functionalized 2-arylbenzo[b]furans
Hsieh, J., Lin, W.-J., Huang, K.-F., et al. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.02.024 · Cited by 30
Chá: aspectos relacionados à qualidade e perspectivas
Lima, J. D., Mazzafera, P., Moraes, W. D. S., et al. (2009) · Ciência Rural · doi:10.1590/s0103-84782009005000026 · Cited by 30
Epigallocatechin-3-gallate Reduces Scavenger Receptor A Expression and Foam Cell Formation in Human Macrophages
Chen, S., Kao, Y.-H., Li, J., Chuang, Y.-P., Wu, W.-L., Liu, S.-T., Huang, S.-M., Lai, J., Ho, L., Tsai, M., et al. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b05832 · Cited by 30
Phenolic content and antioxidant capacity of four Cnidoscolus species (Euphorbiaceae) used as ethnopharmacologicals in Caatinga, Brazil
Sobrinho, T. J. D. S. P. (2011) · African Journal of Pharmacy and Pharmacology · doi:10.5897/ajpp11.608 · Cited by 30
“They act as efficient scavengers of free radicals and, due to their ability to act as hydrogen donors, they interrupt oxidative chain reactions (Delazar et al., 2006; Higdon and Frei, 2003).”
Background
Calcium desensitizer catechin reverses diastolic dysfunction in mice with restrictive cardiomyopathy
Zhang, L., Nan, C., Chen, Y., et al. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.03.015 · Cited by 29
Efficient α-Glucosylation of Epigallocatechin Gallate Catalyzed by Cyclodextrin Glucanotransferase from Thermoanaerobacter Species
González-Alfonso, J. L., Leemans, L., Poveda, A. M., Jiménez‐Barbero, J., Ballesteros, A. O., & Plou, F. J. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b02143 · Cited by 29
Dummy template surface molecularly imprinted polymers based on silica gel for removing imidacloprid and acetamiprid in tea polyphenols
Chen, J., Huang, X., Wang, L., et al. (2020) · Journal of Separation Science · doi:10.1002/jssc.201901268 · Cited by 29
Entry-inhibitory role of catechins against SARS-CoV-2 and its UK variant
Mhatre, S., Gurav, N., Shah, M., & Patravale, V. B. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.104560 · Cited by 32
Tea and Cancer Prevention
Zhang, X. (2015) · Journal of cancer research updates · doi:10.6000/1929-2279.2015.04.02.4 · Cited by 29
The influence of flavonoid compounds on the in vitro inhibition study of a human fibroblast collagenase catalytic domain expressed in E. coli
Nguyen, T. T. H., Moon, Y., Ryu, Y. B., et al. (2012) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2012.10.001 · Cited by 29
Safety and Chemopreventive Effect of Polyphenon E in Preventing Early and Metastatic Progression of Prostate Cancer in TRAMP Mice
Kim, S. J., Amankwah, E. K., Connors, S. K., Park, H. Y., Rincon, M., Cornnell, H. H., Chornokur, G., Hashim, A. I., Choi, J., Tsai, Y.-Y., et al. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0427-t · Cited by 29
“(6-9) Several epidemiological studies have demonstrated a protective effect of tea consumption against human cancers including PCa.(10-13) In contrast, a few studies have associated an increased risk potentially attributed to confounding factors that include consumption of salted or very hot tea, geographical location…”
Background
Anti-proliferative and apoptosis induction activity of green tea polyphenols on human promyelocytic leukemia HL-60 cells.
Han, D. H., Jeong, J., & Kim, J. H. (2009) · PubMed · Cited by 29
ICP-OES and Micronucleus Test to Evaluate Heavy Metal Contamination in Commercially Available Brazilian Herbal Teas
Schunk, P. F. T., Kalil, I. C., Pimentel-Schmitt, E. F., et al. (2015) · Biological Trace Element Research · doi:10.1007/s12011-015-0566-2 · Cited by 29
Potent inhibition of macrophage migration inhibitory factor (MIF) by myeloperoxidase-dependent oxidation of epicatechins
Dickerhof, N., Magon, N. J., Tyndall, J. D. A., Kettle, A. J., & Hampton, M. B. (2014) · Biochemical Journal · doi:10.1042/bj20140612 · Cited by 30
Effect of green tea mouth rinse on Streptococcus mutans in plaque and saliva in children: An in vivo study
Goyal, A. K., Bhat, M., Sharma, M., Garg, M., Khairwa, A., & Garg, R. (2017) · Journal of Indian Society of Pedodontics and Preventive Dentistry · doi:10.4103/0970-4388.199227 · Cited by 29
Ameliorative Effect of Epigallocatechin Gallate on Cardiac Hypertrophy and Fibrosis in Aged Rats
Muhammed, I., Sankar, S., & Govindaraj, S. (2017) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000545 · Cited by 30
Effects of oral epigallocatechin gallate on the pharmacokinetics of nicardipine in rats
Choi, J., & Burm, J. (2009) · Archives of Pharmacal Research · doi:10.1007/s12272-009-2209-7 · Cited by 29
Pasting, Thermal and Rheological Properties of Rice Starch in Aqueous Solutions with Different Catechins
Wu, Y., Xu, H., Lin, Q., et al. (2015) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.12450 · Cited by 28
Green synthesis of bimetallic Au@Pt nanostructures and their application for proliferation inhibition and apoptosis induction in human cervical cancer cell
Alshatwi, A. A., Athinarayanan, J., & Periasamy, V. S. (2015) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-015-5468-5 · Cited by 28
Associations of tea and coffee consumption with prostate cancer risk
Geybels, M. S., Neuhouser, M. L., & Stanford, J. L. (2013) · Cancer Causes & Control · doi:10.1007/s10552-013-0170-8 · Cited by 28
“While the biological properties of tea are mostly attributed to its polyphenol content [1, 2], coffee is a complex mixture of many potentially chemopreventive agents such as caffeine, cafestol, kahweol, polyphenols, chlorogenic acid, and caffeic acid [3–6].”
Background
Chemoprevention of bladder cancer
Golijanin, D. J., Kakiashvili, D., Madeb, R. R., Messing, E. M., & Lerner, S. P. (2006) · World Journal of Urology · doi:10.1007/s00345-006-0123-x · Cited by 31
“Transient elevation of plasma antioxidant activity has been demonstrated with green tea intake, but proven inhibition of carcinogenesis has not been established [280].”
Background
Comparative Metabolic Responses and Adaptive Strategies of Tea Leaves (Camellia sinensis) to N2 and CO2 Anaerobic Treatment by a Nontargeted Metabolomics Approach
Chen, Q., Zhang, Y., Tao, M., et al. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03067 · Cited by 28
Application of Natural Antioxidants in Meat and Meat Products-A Review
Reddy, D. M., Reddy, G. V. B., & Mandal, P. K. (2018) · Food & Nutrition Journal · doi:10.29011/2575-7091.100073 · Cited by 28
Influence of Feeding Quinoa (Chenopodium quinoa) Seeds and Prickly Pear Fruit (Opuntia ficus indica) Peel on the Immune Response and Resistance to Aeromonas sobria Infection in Nile Tilapia (Oreochromis niloticus)
Ahmed, S., El-Rahman, G. I. A., Behairy, A., Beheiry, R. R., Hendam, B. M., Alsubaie, F. M., & Khalil, S. R. (2020) · Animals · doi:10.3390/ani10122266 · Cited by 28
“PP is rich in ﬂavonoids, including quercetin, taxifolin, and kaempferol, which are known for their ability to promote the formation and excretion of detoxiﬁed metabolites, which confers them with the liver-protective activity [91].”
Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols
Buiten, C. B. V., & Elias, R. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020595 · Cited by 27
Protective effects of tea extracts against alcoholic fatty liver disease in mice via modulating cytochrome P450 2E1 expression and ameliorating oxidative damage
Li, B., Mao, Q., Gan, R., et al. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2526 · Cited by 28
“Furthermore, it has been reported that the effect of tea and green tea catechins on oxidative stress seems very promising in animal models (Higdon & Frei, 2003).”
Background
Strategies for the discovery of anti-aging compounds
Rizvi, S. I., & Jha, R. (2010) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2011.533653 · Cited by 28
“In addition to their antioxidant properties, polyphenols show several interesting effects in animal models and in vitro systems; they trap and scavenge free radicals, regulate NO, decrease leukocyte immobilization, induce apoptosis, inhibit cell proliferation and angiogenesis, and exhibit phytoestrogenic activity [9,1…”
Background
Green tea extract as a local drug therapy on periodontitis patients with diabetes mellitus: A randomized case-control study
Chava, V. K., Gadagi, J. S., & Reddy, V. (2013) · Journal of Indian Society of Periodontology · doi:10.4103/0972-124x.113069 · Cited by 28
“[16] Hence, in the present study, an attempt was made to evaluate the effect of green tea extract as a local antimicrobial agent using hydroxypropyl methylcellulose (HPMC) on chronic periodontitis patients associated with and without diabetes mellitus, using clinical and microbiological parameters.”
Glucose Measurement in the Presence of Tea Polyphenols
Xu, H. N., Leng, X., Wang, M., et al. (2011) · Food Analytical Methods · doi:10.1007/s12161-011-9335-9 · Cited by 28
“Although there have been many studies on TPLs' antioxidation and other biological functions (Higdon and Frei 2003), the actual chemical structure of TPLs under various conditions is essential to their biological functions as TPLs are sensitive to environmental conditions including pH, temperature, oxygen concentration…”
Background
Oolong tea does not improve glucose metabolism in non-diabetic adults
Baer, D. J., Novotny, J. A., Harris, G. K., Stote, K. S., Clevidence, B., & Rumpler, W. V. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.192 · Cited by 28
“Because tea is the most widely consumed beverage worldwide (Higdon and Frei, 2003), and because numerous epidemiological studies have suggested tea may have a role in reducing risk of diabetes (Greenberg et al.”
Background
Isomeric differentiation of green tea catechins using gas-phase hydrogen/deuterium exchange reactions
Niemeyer, E. D., & Brodbelt, J. S. (2007) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2007.07.009 · Cited by 28
“Green tea consumption has been correlated with inhibition of certain types of cancer (primarily of the digestive system) [37, 38] and the prevention of heart disease [ 37 , 39].”
BackgroundInfluential
Intakes of selected food groups and beverages and adult acute myeloid leukemia
Li, Y., Moysich, K. B., Baer, M. R., Weiss, J. R., Brasure, J., Graham, S., & McCann, S. E. (2006) · Leukemia Research · doi:10.1016/j.leukres.2006.03.017 · Cited by 28
A study on the role of (+)-catechin in suppression of HepG2 proliferation via caspase dependent pathway and enhancement of itsin vitro and in vivo cytotoxic potential through liposomal formulation
Jain, P. V., Kumar, N., Josyula, V. R., et al. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.08.005 · Cited by 28
Antioxidant, tyrosinase inhibitory, and acetylcholinesterase inhibitory activities of green tea (Camellia sinensis L.) seed and its pericarp
Jo, Y.-H., Yuk, H., Lee, J.-H., Kim, J., Kim, R., & Lee, S. (2012) · Food Science and Biotechnology · doi:10.1007/s10068-012-0099-9 · Cited by 28
Association of Catechin Molecules in Water: Quantitative Binding Study and Complex Structure Analysis
Ujihara, T., & Hayashi, N. (2015) · Journal of Natural Products · doi:10.1021/acs.jnatprod.5b00658 · Cited by 28
Roles for Epigallocatechin Gallate in Cardiovascular Disease and Obesity: An Introduction
McKay, D. L., & Blumberg, J. B. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719624 · Cited by 28
“While flavonoids are commonly defined as dietary antioxidants and catechins can quench reactive oxygen and nitrogen species [9], their bioactivity may result as well from other mechanisms of action [10], e.”
Background
Multiple Antioxidants and L-Arginine Modulate Inflammation and Dyslipidemia in Chronic Renal Failure Rats
Korish, A. A. (2010) · Renal Failure · doi:10.3109/08860221003592820 · Cited by 28
Inhibition of Gap Junctional Intercellular Communication by the Green Tea Polyphenol (−)-Epigallocatechin Gallate in Normal Rat Liver Epithelial Cells
Kang, N. J., Lee, K., Lee, K. M., et al. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf801981w · Cited by 28
Concise synthesis of catechin probes enabling analysis and imaging of EGCg
Yoshida, A., Hirooka, Y., Sugata, Y., et al. (2010) · Chemical Communications · doi:10.1039/c0cc03676e · Cited by 27
Bioavailability of Tea Components
Yashin, A. Y., Nemzer, B. V., & Yashin, Y. I. (2012) · Journal of Food Research · doi:10.5539/jfr.v1n2p281 · Cited by 27
Effects of nitrogen substitute and Hypericum perforatum extract on the ethanol fermentation of traditional Chinese medicine dregs
Ma, H., Li, H., Zhang, F., et al. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.11.021 · Cited by 27
Identification of pesticide residues on black tea by fluorescence hyperspectral technology combined with machine learning
Sun, J., Yan, H. U., Yulin, Z. O. U., Geng, J., Wu, Y., Fan, R., & Zhiliang, K. A. N. G. (2022) · Food Science and Technology · doi:10.1590/fst.55822 · Cited by 27
Epigallocatechin gallate ameliorates tetrahydrochloride-induced liver toxicity in rats via inhibition of TGFβ / p-ERK/p-Smad1/2 signaling, antioxidant, anti-inflammatory activity
Mostafa‐Hedeab, G., Hassan, M. E., Halawa, T. F., & Wani, F. A. (2022) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2022.06.021 · Cited by 27
“Several reports demonstrated the beneﬁcial effects of catechins’ and their effectiveness against tumor cell growth and neurodegenerative diseases (Higdon and Frei 2003).”
Preparation, characterization and application of antioxidant packaging films based on chitosan-epicatechin gallate conjugates with different substitution degrees
Yong, H., Wang, Z., Huang, J., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129568 · Cited by 27
Recent Advances in the Specialized Metabolites Mediating Resistance to Insect Pests and Pathogens in Tea Plants (Camellia sinensis)
Zhang, J., Yu, Y., Qian, X., et al. (2024) · Plants · doi:10.3390/plants13020323 · Cited by 27
Senescence mediated redox imbalance in cardiac tissue: Antioxidant rejuvenating potential of green tea extract
Kumaran, V. S., Arulmathi, K., & Kalaiselvi, P. (2009) · Nutrition · doi:10.1016/j.nut.2009.02.005 · Cited by 27
“The protective effect of green tea in cardiovascular diseases is thought to stem from its antioxidant activity [11,12].”
Background
Green tea catechins in chemoprevention of cancer: A molecular docking investigation into their interaction with glutathione S-transferase (GST P1-1)
Artali, R., Beretta, G., Morazzoni, P., Bombardelli, E., & Meneghetti, F. (2008) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360802177282 · Cited by 27
“Green tea polyphenols, mainly catechins like epigallocatechin gallate (EGCG), epicatechin gallate (ECG) and epicatechin (EC), have been implicated, in protection against cancer, diabetes, cardiovascular and neurodegenerative disorders [27].”
Background
Effects of antioxidants on boar spermatozoa during sorting and storage
Vallorani, C., Spinaci, M., Bucci, D., et al. (2010) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2010.07.007 · Cited by 27
“The antioxidants tested were: SOD, sodium pyruvate n association with catalase and epigallocatechin-3-gallate EGCG), a green tea polyphenol that exhibits antioxdant activities (Higdon and Frei, 2003; Spinaci et l., 2008).”
Background
Plant polyphenols and multidrug resistance: Effects of dietary flavonoids on drug transporters in Caco-2 and MDCKII-MDR1 cell transport models
Rodriguez‐Proteau, R., Mata, J. E., Miranda, C. L., et al. (2006) · Xenobiotica · doi:10.1080/00498250500433545 · Cited by 27
“However, a lack of clear scientific evidence of green tea or its constituents from wellcontrolled clinical trials precludes its recommended use for the aforementioned benefits (Higdon and Frei 2003).”
Background
Pro-oxidative effects of tea and polyphenols, epigallocatechin-3-gallate and epigallocatechin, on G6PD-deficient erythrocytes in vitro
Ko, C., Li, K., Ng, P. C., et al. (2006) · International Journal of Molecular Medicine · doi:10.3892/ijmm.18.5.987 · Cited by 27
“However, the oxidative effects of tea and its components on cellular systems in vitro have been controversial as other reports suggested their anti-oxidative properties (48-50).”
Background
Synthesis of epicatechin glucosides by a β-cyclodextrin glycosyltransferase
Aramsangtienchai, P., Chavasiri, W., Ito, K., et al. (2011) · Journal of Molecular Catalysis B Enzymatic · doi:10.1016/j.molcatb.2011.07.013 · Cited by 27
In Vitro Electrocardiographic and Cardiac Ion Channel Effects of (−)-Epigallocatechin-3-Gallate, the Main Catechin of Green Tea
Kang, J., Cheng, H. C., Ji, J., et al. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.169391 · Cited by 27
“Green tea, prepared from the leaves of Camellia sinensis, is a popular beverage that is purported to have a number of beneficial health effects including antithrombotic, anti-inflammatory, and anticancer activities (Higdon and Frei, 2003; Wolfram, 2007; Clement, 2009).”
Hypolipidemic effects of crude green tea polysaccharide on rats, and structural features of tea polysaccharides isolated from the crude polysaccharide
Nakamura, M., Miura, S., Takagaki, A., et al. (2016) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2016.1232376 · Cited by 27
“…and that tea polyphenols, especially catechins, show a variety of health benefit functions including antioxidative (Nanjo et al. 1993, 1996, 1999; Higdon & Frei 2003), blood cholesterol lowering (Muramatsu et al. 1986), hypoglycemic (Matsumoto et al. 1993), cancer preventive (Yang et al. 2006),…”
Background
Evidence of similar protective effects afforded by white tea and its active component ‘EGCG’ on oxidative-stress mediated hepatic dysfunction during benzo(a)pyrene induced toxicity
Rangi, S., Dhatwalia, S. K., Bhardwaj, P., et al. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.04.044 · Cited by 27
Stimuli‐Responsive Tannin–FeIII Hybrid Microcapsules Demonstrated by the Active Release of an Anti‐Tuberculosis Agent
Bartzoka, E. D., Lange, H., Poce, G., & Crestini, C. (2018) · ChemSusChem · doi:10.1002/cssc.201801546 · Cited by 27
Fabrication of a novel azamacrocycle-based adsorbent for solid-phase extraction of organophosphorus pesticides in tea drinks
Li, G., Liu, L., Sun, Y., et al. (2019) · Microchemical Journal · doi:10.1016/j.microc.2019.104364 · Cited by 27
Effects of EGCG on voltage-gated sodium channels in primary cultures of rat hippocampal CA1 neurons
Deng, H.-M., Yin, S., Yan, D., et al. (2008) · Toxicology · doi:10.1016/j.tox.2008.07.053 · Cited by 27
Neuroprotective effects of flavonoids: endoplasmic reticulum as the target
Amiri, B., Tabrizi, M. Y., Naziri, M., Moradi, F., Arzaghi, M., Archin, I., Behaein, F., Pour, A. B., Ghannadikhosh, P., Imanparvar, S., et al. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1348151 · Cited by 27
“Studies suggest that anthocyanins can modulate the circulatory, nervous, digestive, urinary, sensory, endocrine, and immune systems (Elias et al., 1999; Higdon and Frei, 2003; Liu et al., 2021).”
Background
Analysis of the effect of the active compound of green tea (EGCG) on the proliferation of peripheral blood mononuclear cells
Saleh, F., Raghupathy, R., Asfar, S., Oteifa, M., & Al-Saleh, N. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-322 · Cited by 26
“Green tea contains polyphenols, particularly catechins, the most abundant of which is Epigallocatechin-3-gallate (EGCG) [1-4].”
Background
The flavan-3-ol fraction of cocoa powder suppressed changes associated with early-stage metabolic syndrome in high-fat diet-fed rats
Osakabe, N., Hoshi, J., Kudo, N., & Shibata, M. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.07.041 · Cited by 27
Role of EGCG in Containing the Progression of Lung Tumorigenesis – A Multistage Targeting Approach
Dhatwalia, S. K., Kumar, M., & Dhawan, D. K. (2018) · Nutrition and Cancer · doi:10.1080/01635581.2018.1445762 · Cited by 26
“enging the ROS or by inducing the detoxifying enzymes (phase II enzymes) (18,23,29); upregulating signal transduction pathways, apoptotic proteins (Bax, MDM2, etc.”
Background
Bioactive food and exercise in chronic kidney disease: Targeting the mitochondria
Mafra, D., Gidlund, E., Borges, N. A., Magliano, D. C., Lindholm, B., Stenvinkel, P., & von Walden, F. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.13020 · Cited by 26
“MB, is still largely unknown, but studies have postulated that it acts as a powerful antioxidant and ROS scavenger.(74) Although abundant evidence supports the efficiency of EGCGs as antioxidants in in vitro studies, the evidence for effects in vivo is still lacking.”
Background
Effect of different tea polyphenol products on egg production performance, egg quality and antioxidative status of laying hens
Zhu, Y. F., Wang, J. P., Ding, X., Bai, S., Qi, S., Zeng, Q., Xuan, Y., Su, Z. W., & Zhang, K. (2020) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2020.114544 · Cited by 27
Thunbergia laurifolia Leaf Extract Inhibits Glutamate-Induced Neurotoxicity and Cell Death through Mitophagy Signaling
Vongthip, W., Sillapachaiyaporn, C., Kim, K., Sukprasansap, M., & Tencomnao, T. (2021) · Antioxidants · doi:10.3390/antiox10111678 · Cited by 26
“Our data show that epicatechin is the most abundant bioactive compound in TLE, which could directly inhibit ROS and increase the gene expression of antioxidant enzymes [54,55].”
Background
Charged metabolite biomarkers of food intake assessed via plasma metabolomics in a population-based observational study in Japan
Shibutami, E., Ishii, R., Harada, S., Kurihara, A., Kuwabara, K., Kato, S., Iida, M., Akiyama, M. O., Sugiyama, D., Hirayama, A., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246456 · Cited by 26
“Also, although tea catechins were likely to be characteristic components of green tea [76], they were not suitable for measurement via CE-MS because they are non-polar high-molecular-weight polyphenols.”
Background
Physicochemical analysis, sensorial evaluation, astringent component identification and aroma-active compounds of herbaceous Peony (Paeonia lactiflora Pall) black tea
Wang, X., Xiong, H., Wang, S., Zhang, Y., Song, Z., & Zhang, X. (2022) · Industrial Crops and Products · doi:10.1016/j.indcrop.2022.116159 · Cited by 26
Coffee and tea consumption in relation to prostate cancer prognosis
Geybels, M. S., Neuhouser, M. L., Wright, J. L., Stott‐Miller, M., & Stanford, J. L. (2013) · Cancer Causes & Control · doi:10.1007/s10552-013-0270-5 · Cited by 26
“Potential beneficial compounds in tea are monomeric polyphenols such as catechins and flavonols [7, 8].”
Effects of γ-radiation on microbial load and antioxidant proprieties in black tea irradiated with different water activities
Fanaro, G. B., Hassimotto, N. M. A., Bastos, D. H. M., et al. (2013) · Radiation Physics and Chemistry · doi:10.1016/j.radphyschem.2013.11.036 · Cited by 26
Investigation of the interaction between soluble antioxidants in green tea and insoluble dietary fiber bound antioxidants
Çelik, E. E., & Gökmen, V. (2014) · Food Research International · doi:10.1016/j.foodres.2014.02.026 · Cited by 26

Authors: Higdon, J. V., & Frei, B.
Affiliations: Oregon State University (US)
Venue: Critical Reviews in Food Science and Nutrition
Publisher: Informa UK Limited
Published: 2003-01
Volume: 43
Issue: 1
Pages: 89-143
ISSN: 1040-8398 (ISSN-L)
1549-7852
DOI: 10.1080/10408690390826464
OpenAlex: W2116597521
Cited by: 1,854
References: 0
Citations by year: 2026: 33 · 2025: 47 · 2024: 79 · 2023: 94 · 2022: 77 · 2021: 81 · 2020: 110 · 2019: 72 · 2018: 98 · 2017: 80 · 2016: 89 · 2015: 104 · 2014: 97 · 2013: 98 · 2012: 107
FWCI: 38.41
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Food Science and Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Tea Polyphenols and Effects
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Keywords: tea catechins, polyphenols, epigallocatechin gallate, green tea, antioxidant activity, oxidative stress, oxidative DNA damage, plasma antioxidant capacity, cancer risk, cardiovascular risk, functional foods, dietary supplements, reactive oxygen species
MeSH terms: Animals, Antioxidants, Biological Availability, Cardiovascular Diseases, Catechin, Chronic Disease, Flavonoids, Humans, Neoplasms, Phenols, Polymers, Tea, Biomarkers, Free Radical Scavengers, Reactive Oxygen Species, Oxidative Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Tea Catechins and Polyphenols: Health Effects, Metabolism, and Antioxidant Functions

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks