Cited by 1,854Tea Polyphenols and EffectsPhytochemicals and Antioxidant ActivitiesCoffee research and impacts

The DOI matches its Crossref record.

Tea Catechins and Polyphenols: Health Effects, Metabolism, and Antioxidant Functions

Higdon, Jane V., Frei, Balz·2003·Critical Reviews in Food Science and Nutrition

Open this paper in CoChat — free account

Abstract

Increasing interest in the health benefits of tea has led to the inclusion of tea extracts in dietary supplements and functional foods. However, epidemiologic evidence regarding the effects of tea consumption on cancer and cardiovascular disease risk is conflicting. While tea contains a number of bioactive chemicals, it is particularly rich in catechins, of which epigallocatechin gallate (EGCG) is the most abundant. Catechins and their derivatives are thought to contribute to the beneficial effects ascribed to tea. Tea catechins and polyphenols are effective scavengers of reactive oxygen species in vitro and may also function indirectly as antioxidants through their effects on transcription factors and enzyme activities. The fact that catechins are rapidly and extensively metabolized emphasizes the importance of demonstrating their antioxidant activity in vivo. In humans, modest transient increases in plasma antioxidant capacity have been demonstrated following the consumption of tea and green tea catechins. The effects of tea and green tea catechins on biomarkers of oxidative stress, especially oxidative DNA damage, appear very promising in animal models, but data on biomarkers of in vivo oxidative stress in humans are limited. Larger human studies examining the effects of tea and tea catechin intake on biomarkers of oxidative damage to lipids, proteins, and DNA are needed.

Integrity signals

Registry

Crossref · 10.1080/10408690390826464

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 301–400 of 999

A stability study of green tea catechins during the biscuit making process
Sharma, A., & Zhou, W. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.11.044 · Cited by 94
Bioadhesive and antibacterial edible coating of EGCG-grafted pectin for improving the quality of grapes during storage
Huang, X. Y., Hong, M., Wang, L., Meng, Q., Ke, Q., & Kou, X. (2022) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2022.108255 · Cited by 95
Studies on the protective effect of green tea against cisplatin induced nephrotoxicity
Khan, S. A., Priyamvada, S., Khan, M. W., et al. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.07.007 · Cited by 92
Effect of Green Tea Catechins on the Postprandial Glycemic Response to Starches Differing in Amylose Content
Liu, J., Wang, M., Peng, S., & Zhang, G. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf200355q · Cited by 92
Catechin Suppresses an Array of Signalling Molecules and Modulates Alcohol-Induced Endotoxin Mediated Liver Injury in a Rat Model
Bharrhan, S., Koul, A., Chopra, K., & Rishi, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020635 · Cited by 90
Chitosan/sulfobutylether-β-cyclodextrin nanoparticles as a potential approach for tea polyphenol encapsulation
Liu, F., Antoniou, J., Li, Y., et al. (2016) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2016.01.024 · Cited by 92
Green tea polyphenol extract attenuates colon injury induced by experimental colitis
Mazzon, E., Muià, C., Paola, R. D., Genovese, T., Menegazzi, M., Sarro, A. D., Suzuki, H., & Cuzzocrea, S. (2005) · Free Radical Research · doi:10.1080/10715760500197177 · Cited by 93
“The antioxidant properties of GTE have attracted considerable attention for the prevention of oxidative stress-related diseases such as ischemic diseases [21].”
Background
The pharmacogenetics of natural products: A pharmacokinetic and pharmacodynamic perspective
Rao, T., Tan, Z., Peng, J., Guo, Y., Chen, Y., Zhou, H., & Ouyang, D. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104283 · Cited by 94
Effects of fermentation time on phenolic composition, antioxidant and antimicrobial activities of green, oolong, and black teas
Salman, S., Öz, G., Felek, R., et al. (2022) · Food Bioscience · doi:10.1016/j.fbio.2022.101884 · Cited by 91
PLA films loaded with green tea and rosemary polyphenolic extracts as an active packaging for almond and beef
Andrade, M. A., Barbosa, C. H., Cerqueira, M. Â., Azevedo, A. G., Barros, C., Machado, A. V., Coelho, A., Furtado, R., Correia, C. B., Saraiva, M., et al. (2022) · Food Packaging and Shelf Life · doi:10.1016/j.fpsl.2023.101041 · Cited by 94
Green tea decoction improves glucose tolerance and reduces weight gain of rats fed normal and high-fat diet
Snoussi, C., Ducroc, R. A., Hamdaoui, M. H., Dhaouadi, K., Abaidi, H., Cluzeaud, F., Nazaret, C., Gall, M. L., & Bado, A. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.01.006 · Cited by 92
Capillary electrophoresis of phytochemical substances in herbal drugs and medicinal plants
Gotti, R. (2010) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2010.11.041 · Cited by 90
Pineapple (Ananas comosus L. Merr.), Waste Streams, Characterisation and Valorisation: An Overview
Hikal, W. M., Mahmoud, A. A., Ahl, H. A. H. S., et al. (2021) · Open Journal of Ecology · doi:10.4236/oje.2021.119039 · Cited by 90
“The functional bioactivity of a plant extract, in general, depends upon the presence of compounds such as polyphenols, carotenoids and chlorophyll [14] [107], due to the antioxidant activity of polyphenolic compounds [108].”
Background
Application of image texture for the sorting of tea categories using multi-spectral imaging technique and support vector machine
Wu, D., Yang, H., Chen, X., et al. (2008) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2008.03.005 · Cited by 90
Chemical Composition, Plant Secondary Metabolites, and Minerals of Green and Black Teas and the Effect of Different Tea-to-Water Ratios during Their Extraction on the Composition of Their Spent Leaves as Potential Additives for Ruminants
Ramdani, D., Chaudhry, A. S., & Seal, C. J. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4002439 · Cited by 93
An injectable co-assembled hydrogel blocks reactive oxygen species and inflammation cycle resisting myocardial ischemia-reperfusion injury
Liao, X., Song, X., Li, J., Li, L., Fan, X., Qin, Q., Zhong, C., Yang, P., Zhan, J., & Cai, Y. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.06.039 · Cited by 92
Low molecular proanthocyanidin dietary biofactor Oligonol: Its modulation of oxidative stress, bioefficacy, neuroprotection, food application and chemoprevention potentials
Aruoma, O. I., Sun, B., Fujii, H., Neergheen, V. S., Bahorun, T., Kang, K., & Sung, M. (2006) · BioFactors · doi:10.1002/biof.5520270121 · Cited by 87
Long-term treatment with green tea polyphenols modifies the gut microbiome of female sprague-dawley rats
Wang, J., Tang, L., Zhou, J., Zhou, J., Glenn, T. C., Shen, C., & Wang, J.-S. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.01.005 · Cited by 90
“Green tea polyphenols (GTP), a mixture of natural flavonoids found in brewed green tea, offer a spectrum of health benefits to animals and humans, including protections from cardiovascular diseases [1], cancers [2,3], neurodegenerative diseases [1], and improving bone health [4].”
BackgroundInfluential
Antioxidant Activity and Main Chemical Components of a Novel Fermented Tea
Tong, T., Liu, Y.-J., Kang, J., Zhang, C., & Kang, S. (2019) · Molecules · doi:10.3390/molecules24162917 · Cited by 89
“transcription factors and enzyme activities [11].”
Optimization of ultrasound-assisted extraction of bioactive properties from date palm (Phoenix dactylifera L.) spikelets using response surface methodology
Almusallam, I. A., Ahmed, I. A. M., Babiker, E. E., Juhaimi, F. A., Fadimu, G. J., Osman, M. A., Maiman, S. A. A., Ghafoor, K., & Alqah, H. A. S. (2020) · LWT · doi:10.1016/j.lwt.2020.110816 · Cited by 89
The phenolic compounds and the antioxidant potential of infusion of herbs from the Brazilian Amazonian region
Ports, P. D. S., Chisté, R. C., Godoy, H. T., & Prado, M. A. (2013) · Food Research International · doi:10.1016/j.foodres.2013.02.010 · Cited by 87
Effect of tea polyphenols on chitosan packaging for food preservation: Physicochemical properties, bioactivity, and nutrition
Ma, M., Gu, M., Zhang, S., & Yuan, Y. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.129267 · Cited by 88
Investigation of Adsorption Behavior of (−)-Epigallocatechin Gallate on Bovine Serum Albumin Surface Using Quartz Crystal Microbalance with Dissipation Monitoring
Wang, X., Ho, C., & Huang, Q. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf070590l · Cited by 87
Catechin content and the degree of its galloylation in oolong tea are inversely correlated with cultivation altitude
Chen, G.-H., Yang, C.-Y., Lee, S.-J., Wu, C., & Tzen, J. T. C. (2014) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2013.12.001 · Cited by 90
“They are mainly classified into green tea (unfermented), oolong tea (semi-fermented), and black tea (fully fermented) according to the degree of fermentation during their preparations, where the term “fermentation” refers to natural browning reactions induced by oxidative enzymes in the cells of tea leaves [4].”
Background
Effects of baking and aging on the changes of phenolic and volatile compounds in the preparation of old Tieguanyin oolong teas
Chen, Y.-J., Kuo, P., Yang, M.-L., Li, F.-Y., & Tzen, J. T. C. (2012) · Food Research International · doi:10.1016/j.foodres.2012.07.007 · Cited by 85
Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease
Teixeira, J., Chavarria, D., Borges, F., Wojtczak, L., Wieckowski, M. R., Karkucińska‐Więckowska, A., & Oliveira, P. J. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170529101810 · Cited by 88
Transcriptional profiling of catechins biosynthesis genes during tea plant leaf development
Guo, F., Guo, Y., Wang, P., Wang, Y., & Ni, D. (2017) · Planta · doi:10.1007/s00425-017-2760-2 · Cited by 85
A review of plant metabolites with metal interaction capacity: a green approach for industrial applications
Nobahar, A., Carlier, J., Miguel, M. G., & Costa, M. C. (2021) · BioMetals · doi:10.1007/s10534-021-00315-y · Cited by 93
“In addition to their well-established metalchelating properties, polyphenolic compounds like catechins are known as radical scavengers of oxygen and nitrogen species and therefore, regulate the cellular redox state (Higdon and Frei 2003).”
Background
A subacute toxicity evaluation of green tea (Camellia sinensis) extract in mice
Hsu, Y., Tsai, C.-F., Chen, W., et al. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.07.007 · Cited by 86
“A subacute toxicity evalu considerable amount of research as they are believed to have beneficial effects on health due to their antioxidant (Higdon and Frei, 2003), antifungal, antibacterial (Friedman et al., 2006) and anticancer properties (Bode and Dong, 2009).”
Background
Analysis of catechins from milk–tea beverages by enzyme assisted extraction followed by high performance liquid chromatography
Ferruzzi, M. G., & Green, R. J. (2005) · Food Chemistry · doi:10.1016/j.foodchem.2005.08.010 · Cited by 85
Effects of Green Tea Polyphenol on Cognitive and Acetylcholinesterase Activities
Kim, H. K., Kim, M., Kim, S., Kim, M., & Chung, J. H. (2004) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.68.1977 · Cited by 87
Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla
Hou, W., Lin, R., Chen, C.-T., & Lee, M. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.03.017 · Cited by 85
Tea catechins enhance the mRNA expression of uncoupling protein 1 in rat brown adipose tissue
Nomura, S., Ichinose, T., Jinde, M., Kawashima, Y., Tachiyashiki, K., & Imaizumi, K. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.11.005 · Cited by 86
“The main tea polyphenols are tea catechins (TCs), which have been reported to have antioxidant, antihypertensive, anticarcinogenic and hypocholesterolemic activities [2–4].”
Background
Modifying Bitterness in Functional Food Systems
Gaudette, N. J., & Pickering, G. J. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.542511 · Cited by 87
“1Can include epigallocatechin gallate and (+)-catechin (Higdon and Frei, 2003).”
Prospective cohort study of tea consumption and risk of digestive system cancers: results from the Shanghai Women's Health Study
Nechuta, S., Shu, X., Li, H. L., Yang, G., Ji, B., Xiang, Y.-B., Cai, H., Chow, W., Gao, Y.-T., & Zheng, W. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.031419 · Cited by 85
“For example, EGCG is the most abundant catechin and may reduce DNA damage by reactive oxygen species (13, 16) and inhibit tumor cell growth, invasion, and angiogenesis (7, 8, 10, 11).”
Background
Effect of natural antioxidants on kinetic behavior of acrylamide formation and elimination in low-moisture asparagine–glucose model system
Zhang, Y., & Zhang, Y. (2007) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2007.07.013 · Cited by 85
Free Radical Scavenging Effect of Pu-erh Tea Extracts and Their Protective Effect on Oxidative Damage in Human Fibroblast Cells
Jie, G., Lin, Z., Zhang, L., Lv, H., He, P., & Zhao, B. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061663o · Cited by 85
Comparison of Major Phenolic Constituents and in Vitro Antioxidant Activity of Diverse Kudingcha Genotypes from Ilex kudingcha, Ilex cornuta, and Ligustrum robustum
Zhu, F., Cai, Y., Sun, M., Ke, J., Lu, D., & Corke, H. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf901020h · Cited by 85
Comparison of the antioxidant activity of roasted tea with green, oolong, and black teas
Satoh, E., Tohyama, N., & Nishimura, M. (2005) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637480500398835 · Cited by 85
“Many studies have shown that green and black teas have antioxidant properties (Higdon & Frei 2003; McKay & Blumberg 2002; Wiseman et al. 1997).”
Background
The Microbiota Is Essential for the Generation of Black Tea Theaflavins-Derived Metabolites
Chen, H., Hayek, S. A., Guzman, J. R., Gillitt, N. D., Ibrahim, S. A., Jobin, C., & Sang, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051001 · Cited by 86
(‐)‐Epigallocatechin‐3‐gallate decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion and exacerbates weight loss
Bitzer, Z. T., Elias, R. J., Vijay–Kumar, M., & Lambert, J. D. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201501042 · Cited by 85
Polyphenolic antioxidant profiles of yellow camellia
Song, L., Wang, X., Xueqin, Z., & Huang, D. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.04.083 · Cited by 85
Epigallocatechin-3-gallate prevents oxidative stress-induced cellular senescence in human mesenchymal stem cells via Nrf2
Shin, J., Jeon, H., Park, J., & Chang, M. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2694 · Cited by 87
“In addition to the ability to act as a neutralizing agent of excessive ROS, EGCG exerts antioxidant, anti‑inflammatory and anti‑tumorigenic effects (15).”
Green tea polyphenol inhibits Mycobacterium tuberculosis survival within human macrophages
Anand, P., Kaul, D., & Sharma, M. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.10.021 · Cited by 84
Tea Polyphenols in Parkinson’s Disease
Caruana, M., & Vassallo, N. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-18365-7_6 · Cited by 88
“1 Anti-oxidant and Iron-Chelating Activity Substantial evidence of the potent anti-oxidant effects of the main tea polyphenols (flavanols and theaflavins) comes from in vitro studies, where they were shown to: (i) directly scavenge reactive oxygen (ROS) and nitrogen oxygen (NOS) species; (ii) inhibit 'pro-oxidant' enz…”
Background
The protective effect of green tea extract on lead induced oxidative and DNA damage on rat brain
Khalaf, A. A., Moselhy, W. A., & Abdel-Hamed, M. I. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.02.003 · Cited by 82
“Many of these compounds are monomeric catechins, which have been shown to exert antioxidant effects acting directly as radical scavengers or metal-chelators and indirectly through modulation of transcription factors or enzymes (Cabrera et al., 2006; Higdon and Frei, 2003).”
Background
Rapid and effective sample clean-up based on magnetic multiwalled carbon nanotubes for the determination of pesticide residues in tea by gas chromatography–mass spectrometry
Deng, X., Guo, Q., Chen, X., et al. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.08.137 · Cited by 82
Dietary supplementation with selenium yeast and tea polyphenols improve growth performance and nitrite tolerance of Wuchang bream (Megalobrama amblycephala)
Long, M., Lin, W., Hou, J., et al. (2017) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2017.07.017 · Cited by 82
“TP 462 have strong antioxidant activity and are considered as potent scavengers of ROS 463 [64]-[66].”
Background
Potential health benefits of (poly)phenols derived from fruit and 100% fruit juice
Ho, K. K. H. Y., Ferruzzi, M. G., & Wightman, J. D. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz041 · Cited by 81
“Coffee contains primarily chlorogenic acids, and tea contains catechins (flavan-3ols) and larger, polymerized/oxidized catechins (theaflavins and thearubigens) in “fermented” or processed teas (ie, oolong and black tea).(18,22,23) Fruit (poly)phenol profiles differ depending on the fruit type, genetic pedigree, growin…”
Background
Cancer cachexia: medical management
Mantovani, G., & Madeddu, C. (2009) · Supportive Care in Cancer · doi:10.1007/s00520-009-0722-3 · Cited by 81
“The polyphenols, in particular quercetin, were included for their high activity as antioxidants [45].”
Background
Adherence to a Mediterranean Diet Influences the Fecal Metabolic Profile of Microbial-Derived Phenolics in a Spanish Cohort of Middle-Age and Older People
Gutiérrez‐Díaz, I., Fernández-Navarro, T., Salazar, N., Bartolomé, B., Moreno-Arribas, M. V., deAndrés‐Galiana, E. J., Fernández‐Martínez, J. L., Reyes‐Gavilán, C. G. D. L., Gueimonde, M., & González, S. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04408 · Cited by 90
Antioxidant activity and phenolic profile of a collection of medicinal plants from Tunisian arid and Saharan regions
Benabderrahim, M. A., Yahia, Y., Bettaieb, I., Elfalleh, W., & Nagaz, K. (2019) · Industrial Crops and Products · doi:10.1016/j.indcrop.2019.05.076 · Cited by 82
Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity
Yoxall, V., Kentish, P., Coldham, N. G., Kuhnert, N., Sauer, M. J., & Ioannides, C. (2005) · International Journal of Cancer · doi:10.1002/ijc.21191 · Cited by 81
Effects of tea or tea extract on metabolic profiles in patients with type 2 diabetes mellitus: a meta‐analysis of ten randomized controlled trials
Li, Y., Wang, C., Huai, Q., Guo, F., Liu, L., Feng, R., & Sun, C. (2016) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2641 · Cited by 80
“EGCG as the most abundant compound of catechin in green tea is known with beneficial effects on human health [28].”
Background
Dietary tea polyphenol supplementation improved egg production performance, albumen quality, and magnum morphology of Hy-Line Brown hens during the late laying period1
Wang, X., Wang, X., Wang, J., Wang, H., Zhang, H., Wu, S., & Qi, G. (2018) · Journal of Animal Science · doi:10.1093/jas/skx007 · Cited by 81
“Most polyphenols are catechins, which make up close to 70% of total flavonoids (Kim et al., 2000; Higdon and Frei, 2003).”
Background
Geographical traceability of Chinese green tea using stable isotope and multi‐element chemometrics
Liu, Z., Yuan, Y., Zhang, Y., et al. (2019) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.8405 · Cited by 80
A review for physiological activities of EGCG and the role in improving fertility in humans/mammals
Zhang, Y., Lin, H., Liu, C., Huang, J., & Liu, Z. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110186 · Cited by 81
Neuroprotective Multifunctional Iron Chelators: From Redox-Sensitive Process to Novel Therapeutic Opportunities
Weinreb, O., Amit, T., Mandel, S. A., Kupershmidt, L., & Youdim, M. B. H. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2929 · Cited by 80
“The main pharmacological and iron-chelating properties of ﬂavonoids have been accumula-tively and comprehensively summarized (119, 235, 251).”
Diabetes of the Liver: The Link Between Nonalcoholic Fatty Liver Disease and HFCS‐55
Collison, K. S., Saleh, S. M., Bakheet, R., Al‐Rabiah, R. K., Inglis, A. L., Makhoul, N. J., Maqbool, Z. M., Zaidi, M. Z., Al‐Johi, M. A., & Al-Mohanna, F. A. (2009) · Obesity · doi:10.1038/oby.2009.58 · Cited by 78
“Green tea polyphenols have been shown to decrease ROM production in several other published observations reviewed by Higdon and Frei (51).”
Background
Anti-obesity effects of epigallocatechin-3-gallate, orange peel extract, black tea extract, caffeine and their combinations in a mouse model
Huang, Y.-W., Liu, Y., Dushenkov, S., Ho, C., & Huang, M. (2009) · Journal of Functional Foods · doi:10.1016/j.jff.2009.06.002 · Cited by 80
Quercetin and Epigallocatechin Gallate in the Prevention and Treatment of Obesity: From Molecular to Clinical Studies
Carrasco‐Pozo, C., Cires, M. J., & Gotteland, M. (2019) · Journal of Medicinal Food · doi:10.1089/jmf.2018.0193 · Cited by 81
Ação antioxidante de chás e condimentos de grande consumo no Brasil
de Morais, S. M., Cavalcanti, E. S. B., Costa, S. M. O., et al. (2009) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2009000200023 · Cited by 79
New Insights Into the Mechanisms of Green Tea Catechins in the Chemoprevention of Prostate Cancer
Connors, S. K., Chornokur, G., & Kumar, N. B. (2011) · Nutrition and Cancer · doi:10.1080/01635581.2012.630158 · Cited by 79
A novel approach of proteomics and transcriptomics to study the mechanism of action of the antioxidant–iron chelator green tea polyphenol (-)-epigallocatechin-3-gallate
Weinreb, O., Amit, T., & Youdim, M. B. H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.011 · Cited by 78
Resveratrol and Epigallocatechin-3-gallate addition to thawed boar sperm improves in vitro fertilization
Gadani, B., Bucci, D., Spinaci, M., Tamanini, C., & Galeati, G. (2016) · Theriogenology · doi:10.1016/j.theriogenology.2016.11.020 · Cited by 80
Flavonoid subclasses and type 2 diabetes mellitus risk: a meta-analysis of prospective cohort studies
Guo, X., Ruan, Y., Li, Z.-H., & Li, D. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1476964 · Cited by 81
“Free radicals and reactive oxygen species (ROS), which are derived from normal oxygen metabolism and exogenous damage, can attract various inflammatory mediators and are associated with etiology and pathology of chronic diseases (Higdon and Frei, 2003).”
Background
Green tea catechins EGCG and ECG enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition
Tian, J., Geiss, C., Zarse, K., Madreiter‐Sokolowski, C. T., & Ristow, M. (2021) · Aging · doi:10.18632/aging.203597 · Cited by 81
“Besides triggering a mitohormetic response through their effects on transcription factors and enzyme activities, catechins were speculated to exert direct antioxidant potential by scavenging ROS [43, 44].”
Background
Nuclear Magnetic Resonance and Chemometrics to Assess Geographical Origin and Quality of Traditional Food Products
Consonni, R., & Cagliani, L. R. (2010) · Advances in food and nutrition research · doi:10.1016/s1043-4526(10)59004-1 · Cited by 80
“Green tea has been studied during the last 10 years because of its health-related properties and for quality evaluation even thought its antioxidant, anticarcinogenic, antitumorigenic properties, and the cardiovascular disease protection are still to be demonstrated in vivo (Higdon and Frei, 2003).”
Background
Cs-miR156 is involved in the nitrogen form regulation of catechins accumulation in tea plant (Camellia sinensis L.)
Fan, K. C., Fan, D., Ding, Z., et al. (2015) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2015.10.026 · Cited by 78
EGCG inhibits cardiomyocyte apoptosis in pressure overload-induced cardiac hypertrophy and protects cardiomyocytes from oxidative stress in rats
Sheng, R., Gu, Z., Xie, M., Wen-xuan, Z., & Ci-yi, G. (2007) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2007.00495.x · Cited by 78
Fluoride in teas of different types and forms and the exposure of humans to fluoride with tea and diet
Koblar, A., Tavčar, G., & Ponikvar‐Svet, M. (2011) · Food Chemistry · doi:10.1016/j.foodchem.2011.07.037 · Cited by 78
Epigallocatechin gallate, the major component of polyphenols in green tea, inhibits telomere attrition mediated cardiomyocyte apoptosis in cardiac hypertrophy
Sheng, R., Gu, Z., & Xie, M. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.07.083 · Cited by 77
“Epigallocatechin gallate (EGCG), the major component of polyphenols in green tea, has attracted considerable attention for its antioxidative, anti-inflammatory, antitumorigenic and antisenescent properties [13].”
Background
Green tea leaf extract improves lipid and glucose homeostasis in a fructose-fed insulin-resistant hamster model
Li, R., Douglas, T. D., Maiyoh, G. K., Adeli, K., & Theriault, A. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.08.045 · Cited by 78
Antimalarial properties of green tea
Sannella, A. R., Luigi Messori, A., Casini, A., Vincieri, F. F., Bilia, A. R., Majori, G., & Severini, C. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.005 · Cited by 78
Encapsulation of Epigallocatechin-3-gallate (EGCG) Using Oil-in-Water (O/W) Submicrometer Emulsions Stabilized by ι-Carrageenan and β-Lactoglobulin
Ru, Q., Yu, H., & Huang, Q. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf101798m · Cited by 78
Catechin attenuates diabetic autonomic neuropathy in streptozotocin induced diabetic rats
Addepalli, V., & Suryavanshi, S. V. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.179 · Cited by 79
RETRACTED: Quantification and Evaluations of Catechin Hydrate Polymeric Nanoparticles Used in Brain Targeting for the Treatment of Epilepsy
Ahmad, N., Ahmad, R., Alrasheed, R. A., Almatar, H. M. A., Al-Ramadan, A., Amir, M., & Sarafroz, M. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12030203 · Cited by 78
“, polyphenolic flavonoid compounds) in the green tea [14,16].”
Retracted
A Prospective Study of Green Tea Consumption and Oral Cancer Incidence in Japan
Ide, R., Fujino, Y., Hoshiyama, Y., Mizoue, T., Kubo, T., Pham, T., Shirane, K., Tokui, N., Sakata, K., Tamakoshi, A., et al. (2007) · Annals of Epidemiology · doi:10.1016/j.annepidem.2007.04.003 · Cited by 77
Role of oxidative stress in diabetes-induced complications and their management with antioxidants
Singh, H. B., Singh, R., Singh, A., Singh, H., Singh, G., Kaur, S., & Singh, B. (2023) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2023.2243651 · Cited by 86
“Since the molecules contain several hydroxyl groups, they have properties (cardoso et al. 2020). eGcG has been shown to increase the antioxidant activity in various mouse organs (Higdon and Frei 2003).”
Molecular Basis for Cancer Chemoprevention by Green Tea Polyphenol EGCG
Tachibana, H. (2009) · Forum of nutrition/Bibliotheca Nutritio et dieta · doi:10.1159/000212748 · Cited by 77
Tea variety and brewing techniques influence flavonoid content of black tea
Peterson, J., Dwyer, J. T., Jacques, P. F., et al. (2004) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2004.03.022 · Cited by 77
Pine Bark and Green Tea Concentrated Extracts: Antioxidant Activity and Comprehensive Characterization of Bioactive Compounds by HPLC–ESI-QTOF-MS
Cádiz‐Gurrea, M. D. L. L., Fernández‐Arroyo, S., & Segura‐Carretero, A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151120382 · Cited by 77
“effectiveness of catechins in a number of systems [52].”
Background
Effect of (−)-epigallocatechin gallate (EGCG) extracted from green tea in reducing the formation of acrylamide during the bread baking process
Fu, Z., Yoo, M. J. Y., Zhou, W., Zhang, L., Chen, Y., & Lu, J. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.09.050 · Cited by 77
Epigallocatechin gallate attenuates experimental non‐alcoholic steatohepatitis induced by high fat diet
Kuzu, N., Bahçecioğlu, İ. H., Dağlı, A. F., Özercan, İ. H., Üstündağ, B., & Şahin, K. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05052.x · Cited by 77
Effects of epigallocatechin gallate on the oral bioavailability and pharmacokinetics of tamoxifen and its main metabolite, 4-hydroxytamoxifen, in rats
Shin, S., & Choi, J. (2009) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e32832d6834 · Cited by 76
Protective effect of black tea extract on the levels of lipid peroxidation and antioxidant enzymes in liver of mice with pesticide‐induced liver injury
Khan, S. M. (2005) · Cell Biochemistry and Function · doi:10.1002/cbf.1246 · Cited by 76
“Among these the free radical scavenging and antioxidant properties are cited as important contributors.(9) Black tea extract contains many active polyphenolic compounds in different concentrations.”
Background
Treatment with oligonol, a low-molecular polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism
Noh, J. S., Park, C. H., & Yokozawa, T. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511001322 · Cited by 76
“Actually, oligonol comprises catechin-type monomers and oligomers, which have well-recognised antioxidant and radical-scavenging effects in vitro and in vivo (24,25) .”
Background
Balancing virtual land imports by a shift in the diet. Using a land balance approach to assess the sustainability of food consumption. Germany as an example
Meier, T., Christen, O., Semler, E., Jahreis, G., Voget-Kleschin, L., Schrode, A., & Artmann, M. (2013) · Appetite · doi:10.1016/j.appet.2013.11.006 · Cited by 79
“Finally, nutritional studies have shown that an increased intake of stimulants (cocoa, coffee, tea, wine) is beneficial from a health perspective (Corti, Flammer, Hollenberg, & Luscher, 2009; Guilford & Pezzuto, 2011; Higdon & Frei, 2003, 2006).”
Background
Oxidation of Tea Extracts and Tea Catechins by Molecular Oxygen
Roginsky, V. A., & Alegrı́a, A. E. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf040382i · Cited by 75
Modulatory effects of catechin hydrate against genotoxicity, oxidative stress, inflammation and apoptosis induced by benzo(a)pyrene in mice
Shahid, A., Ali, R., Ali, N., Hasan, S. K., Bernwal, P., Afzal, S. M., Vafa, A., & Sultana, S. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.03.021 · Cited by 76
Rapid and non-destructive discrimination of special-grade flat green tea using Near-infrared spectroscopy
Li, C., Guo, H., Zong, B., He, P., Fan, F., & Gong, S. (2018) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2018.07.085 · Cited by 75
Simultaneous analysis of theanine, chlorogenic acid, purine alkaloids and catechins in tea samples with the help of multi-dimension information of on-line high performance liquid chromatography/electrospray–mass spectrometry
Zhu, X., Chen, B., Ma, M., Luo, X., Zhang, F., Yao, S., Wan, Z., Yang, D., & Hang, H. (2004) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(03)00605-8 · Cited by 75
A high performance liquid chromatography method for simultaneous detection of 20 bioactive components in tea extracts
Nian, B., Chen, L., Yi, C., Shi, X., Jiang, B., Jiao, W., Liu, Q., Lv, C., Ma, Y., & Zhao, M. (2019) · Electrophoresis · doi:10.1002/elps.201900154 · Cited by 76
Dietary Grape Pomace Supplementation in Dairy Cows: Effect on Nutritional Quality of Milk and Its Derived Dairy Products
Ianni, A., & Martino, G. (2020) · Foods · doi:10.3390/foods9020168 · Cited by 77
“In humans, only a modest and transient increase in plasma antioxidant potential has been evidenced as a consequence of dietary catechins intake; however, promising results have been obtained from studies on animal models in which the effects on biomarkers of oxidative stress were evaluated, with specific regard to oxi…”
Result
In vitro and in vivo anti-inflammatory effects of ethanol extract from Acer tegmentosum
Yu, T., Lee, J., Lee, Y. G., Byeon, S. E., Kim, M. H., Sohn, E., Lee, Y. J., Lee, S. G., & Cho, J. Y. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.12.042 · Cited by 75
Chiral capillary electrophoresis in food analysis
Herrero, M., Simó, C., García‐Cañas, V., Fanali, S., & Cifuentes, A. (2010) · Electrophoresis · doi:10.1002/elps.200900770 · Cited by 74
Catabolism of (+)-Catechin and (−)-Epicatechin by Rat Intestinal Microbiota
Takagaki, A., & Nanjo, F. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf304431v · Cited by 74
Thermo‐Reversible Green Tea Catechin Gel for Local Application in Chronic Periodontitis: A 4‐Week Clinical Trial
Chava, V. K., & Vedula, B. D. (2012) · Journal of Periodontology · doi:10.1902/jop.2012.120425 · Cited by 74
Green tea averts age-dependent decline of hippocampal signaling systems related to antioxidant defenses and survival
Assunção, M., Santos‐Marques, M. J., Carvalho, F. D., & Andrade, J. P. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.01.003 · Cited by 73
The War against Tuberculosis: A Review of Natural Compounds and Their Derivatives
Maiolini, M., Gause, S., Taylor, J., Steakin, T., Shipp, G. M., Lamichhane, P., Deshmukh, B., Shinde, V. M., Bishayee, A., & Deshmukh, R. R. (2020) · Molecules · doi:10.3390/molecules25133011 · Cited by 78

Authors: Higdon, J. V., & Frei, B.
Affiliations: Oregon State University (US)
Venue: Critical Reviews in Food Science and Nutrition
Publisher: Informa UK Limited
Published: 2003-01
Volume: 43
Issue: 1
Pages: 89-143
ISSN: 1040-8398 (ISSN-L)
1549-7852
DOI: 10.1080/10408690390826464
OpenAlex: W2116597521
Cited by: 1,854
References: 0
Citations by year: 2026: 33 · 2025: 47 · 2024: 79 · 2023: 94 · 2022: 77 · 2021: 81 · 2020: 110 · 2019: 72 · 2018: 98 · 2017: 80 · 2016: 89 · 2015: 104 · 2014: 97 · 2013: 98 · 2012: 107
FWCI: 38.41
Type: journal article
Language: en
Open access: closed
Locations: Critical Reviews in Food Science and Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Tea Polyphenols and Effects
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Keywords: tea catechins, polyphenols, epigallocatechin gallate, green tea, antioxidant activity, oxidative stress, oxidative DNA damage, plasma antioxidant capacity, cancer risk, cardiovascular risk, functional foods, dietary supplements, reactive oxygen species
MeSH terms: Animals, Antioxidants, Biological Availability, Cardiovascular Diseases, Catechin, Chronic Disease, Flavonoids, Humans, Neoplasms, Phenols, Polymers, Tea, Biomarkers, Free Radical Scavengers, Reactive Oxygen Species, Oxidative Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Tea Catechins and Polyphenols: Health Effects, Metabolism, and Antioxidant Functions

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks