The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Life with Carbon Monoxide
Abstract
This review focuses on how microbes live on CO as a sole source of carbon and energy and with CO by generating carbon monoxide as a metabolic intermediate. The use of CO is a property of organisms that use the Wood-L jungdahl pathway of autotrophic growth. The review discusses when CO metabolism originated, when and how it was discovered, and what properties of CO are ideal for microbial growth. How CO sensing by a heme-containing transcriptional regulatory protein activates the expression of CO metabolism-linked genes is described. Two metalloenzymes are the cornerstones of growth with CO: CO dehydrogenase (CODH) and acetyl-CoA synthase (ACS). CODH oxidizes CO to CO2, providing low-potential electrons for the cell, or alternatively reduces CO2 to CO. The latter reaction, when coupled to ACS, forms a machine for generating acetyl-CoA from CO2 for cell carbon synthesis. The recently solved crystal structures of CODH and ACS along with spectroscopic measurements and computational studies provide insights into novel bio-organometallic catalytic mechanisms and into the nature of a 140 A gas channel that coordinates the generation and utilization of CO. The enzymes that are coupled to CODH/ACS are also described, with a focus on a corrinoid protein, a methyltransferase, and pyruvate ferredoxin oxidoreductase.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The emergence of life from iron monosulphide bubbles at a submarine hydrothermal redox and pH front
RUSSELL, M. J., & HALL, A. J. (1997) · Journal of the Geological Society · doi:10.1144/gsjgs.154.3.0377 · Cited by 822
Activated Acetic Acid by Carbon Fixation on (Fe,Ni)S Under Primordial Conditions
Huber, C., & Wächtershäuser, G. (1997) · Science · doi:10.1126/science.276.5310.245 · Cited by 714 · cited 3×
“This follows from the hypothesis that the first organisms were autotrophic (Huber & Wachtershauser, 1997; Russell et al., 1998; Russell & Hall, 1997).”
BackgroundPyruvate Ferredoxin Oxidoreductase and Its Radical Intermediate
Ragsdale, S. W. (2003) · Chemical Reviews · doi:10.1021/cr020423e · Cited by 259
Self-citationGreat Metalloclusters in Enzymology
Rees, D. C. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135406 · Cited by 220
Andreesen, J. R., Schaupp, A., Neurauter, C., Brown, A., & Ljungdahl, L. G. (1973) · Journal of Bacteriology · doi:10.1128/jb.114.2.743-751.1973 · Cited by 200
Menon, S., & Ragsdale, S. W. (1996) · Biochemistry · doi:10.1021/bi9615598 · Cited by 81
Self-citationRoberts, D. L., James-Hagstrom, J. E., Garvin, D. K., Gorst, C. M., Runquist, J. A., Baur, J. R., Haase, F. C., & Ragsdale, S. W. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.1.32 · Cited by 56
Anderson, M. E., DeRose, V. J., Hoffman, B. M., & Lindahl, P. A. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00078a085 · Cited by 39 · cited 2×
“In addition, cyanide, which is a competitive inhibitor of CO oxidation with respect to CO, binds specifically to the C-Cluster (Anderson et al., 1993).”
Background
Cited by
A review of catalysts for the electroreduction of carbon dioxide to produce low-carbon fuels
Qiao, J., Liu, Y., Hong, F., & Zhang, J. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60323g · Cited by 2,990
Frontiers, Opportunities, and Challenges in Biochemical and Chemical Catalysis of CO 2 Fixation
Appel, A. M., Bercaw, J. E., Bocarsly, A. B., Dobbek, H., DuBois, D. L., Dupuis, M., Ferry, J. G., Fujita, E., Hille, R., Kenis, P. J. A., et al. (2013) · Chemical Reviews · doi:10.1021/cr300463y · Cited by 2,193
Self-citationOn the origin of biochemistry at an alkaline hydrothermal vent
Martin, W., & Russell, M. J. (2007) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1881 · Cited by 771
Drake, H. L., Gößner, A. S., & Daniel, S. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1419.016 · Cited by 578
Serpentinization as a source of energy at the origin of life
RUSSELL, M. J., HALL, A. J., & MARTIN, W. (2010) · Geobiology · doi:10.1111/j.1472-4669.2010.00249.x · Cited by 527
Metadata
- Authors
- Ragsdale, S. W.
- Venue
- Critical Reviews in Biochemistry and Molecular Biology
- Publisher
- Informa UK Limited
- Published
- 2004-01
- Volume
- 39
- Issue
- 3
- Pages
- 165-195
- ISSN
- 0045-6411 (ISSN-L)
- 1040-9238
- 1549-7798
- OpenAlex
- W2141066579
- Cited by
- 397
- References
- 8
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Life with Carbon Monoxide. https://app.cochat.ai/papers/10.1080/10409230490496577
- The paper
- Ragsdale, S. W. (2004). Life with Carbon Monoxide. Critical Reviews in Biochemistry and Molecular Biology. https://doi.org/10.1080/10409230490496577
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
