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The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease

Open access
Fadeel, Bengt, Xue, Ding·2009·Critical Reviews in Biochemistry and Molecular Biology

Abstract

A common feature of all eukaryotic membranes is the non-random distribution of different lipid species in the lipid bilayer (lipid asymmetry). Lipid asymmetry provides the two sides of the plasma membrane with different biophysical properties and influences numerous cellular functions. Alteration of lipid asymmetry plays a prominent role during cell fusion, activation of the coagulation cascade, and recognition and removal of apoptotic cell corpses by macrophages (programmed cell clearance). Here we discuss the origin and maintenance of phospholipid asymmetry, based on recent studies in mammalian systems as well as in Caenhorhabditis elegans and other model organisms, along with emerging evidence for a conserved role of mitochondria in the loss of lipid asymmetry during apoptosis. The functional significance of lipid asymmetry and its disruption during health and disease is also discussed.

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Metadata

Authors
Fadeel, B., & Xue, D.
Venue
Critical Reviews in Biochemistry and Molecular Biology
Published
2009-09-25
Volume
44
Issue
5
Pages
264-277
ISSN
  • 0045-6411 (ISSN-L)
  • 1040-9238
  • 1549-7798
OpenAlex
W2096474273
Cited by
392
References
7
FWCI
0.80
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease. https://app.cochat.ai/papers/10.1080/10409230903193307
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Fadeel, B., & Xue, D. (2009). The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease. Critical Reviews in Biochemistry and Molecular Biology. https://doi.org/10.1080/10409230903193307

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.