Health Effects with Consumption of the Flax Lignan Secoisolariciresinol Diglucoside
Open accessAbstract
Flaxseed is the richest source of the lignan secoisolariciresinol diglucoside (SDG). After ingestion, SDG is converted to secoisolariciresinol, which is further metabolised to the mammalian lignans enterodiol and enterolactone. A growing body of evidence suggests that SDG metabolites may provide health benefits due to their weak oestrogenic or anti-oestrogenic effects, antioxidant activity, ability to induce phase 2 proteins and/or inhibit the activity of certain enzymes, or by mechanisms yet unidentified. Human and animal studies identify the benefits of SDG consumption. SDG metabolites may protect against CVD and the metabolic syndrome by reducing lipid and glucose concentrations, lowering blood pressure, and decreasing oxidative stress and inflammation. Flax lignans may also reduce cancer risk by preventing pre-cancerous cellular changes and by reducing angiogenesis and metastasis. Thus, dietary SDG has the potential to decrease the incidence of several chronic diseases that result in significant morbidity and mortality in industrialised countries. The available literature, though, makes it difficult to clearly identify SDG health effects because of the wide variability in study methods. However, the current evidence suggests that a dose of at least 500 mg SDG/d for approximately 8 weeks is needed to observe positive effects on cardiovascular risk factors in human patients. Flaxseed and its lignan extracts appear to be safe for most adult populations, though animal studies suggest that pregnant women should limit their exposure. The present review discusses the potential health benefits of SDG in humans, with supporting evidence from animal studies, and offers suggestions for future research.
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Lignans and their derivatives act as anti-aging agents.
“In addition to their numerous biological activities (antioxidant, anti-inflammatory, and antitumoral), as well as their ability to protect against the onset of chronic and metabolic diseases, lignans and their derivatives are also known to act as anti-aging agents [403].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [403]
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- Authors
- Adolphe, J. L., Whiting, S. J., Juurlink, B. H. J., Thorpe, L. U., & Alcorn, J.
- Affiliations
- University of Saskatchewan (CA)
- Alfaisal University (SA)
- Corresponding author
- Alcorn, Jane
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-12-15
- Volume
- 103
- Issue
- 7
- Pages
- 929-938
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2130479712
- Cited by
- 314
- References
- 88
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 14 · 2023: 25 · 2022: 20 · 2021: 26 · 2020: 15 · 2019: 22 · 2018: 17 · 2017: 28 · 2016: 22 · 2015: 21 · 2014: 23 · 2013: 19 · 2012: 14
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Saskatchewan Health Research Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant-derived Lignans Synthesis and Bioactivity
- Physical Sciences › Engineering › Biomedical Engineering › Lignin and Wood Chemistry
- Health Sciences › Medicine › Pathology and Forensic Medicine › Phytoestrogen effects and research
- Keywords
- secoisolariciresinol diglucoside, flaxseed lignans, secoisolariciresinol, enterodiol, enterolactone, lignan metabolism, cardiovascular risk, metabolic syndrome, chemoprevention, angiogenesis, metastasis, oxidative stress, inflammation, blood pressure, dietary dose
- MeSH terms
- Animals, Antioxidants, Butylene Glycols, Cardiovascular Diseases, Diabetes Mellitus, Diet, Enzyme Inhibitors, Female, Glucosides, Humans, Lignin, Neoplasms, Pregnancy, Flax, Enzyme Activators, Phytoestrogens
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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